Search Results
Aging and Language
The purpose of this study is to investigate how language is organized in neurologically normal adults using magnetic resonance imaging (MRI) and behavioral measures. Our overarching goal is to characterize the behavioral and MRI responses associated with language production and language comprehension in older and younger adults, and to examine the relations between age, behavior, cognition, and neural factors.
Participants will complete a remote visit and two in person visits at the University park campus. Visit activities will include answering questions, completing computer-based tasks, and completing an MRI scan.
$100
Native Monolingual English Speaker
Right-handed
Taking medications that affect the brain of blood flow
Contraindications to MRI (e.g., pacemaker)
Claustrophobia
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.
The Penn State Personalized Research for Innovation, Discovery, and Education (PRIDE) Program.The aims of the PRIDE Program are to:1. Create a centralized Biorepository using extra blood obtained from a clinically-ordered, or another IRB approved research protocol initiated blood draw, leftover biospecimens that are removed during medically indicated procedures or a saliva sample from consented participants that do not have clinically ordered blood draws or a medical procedure.2. Construct a dynamic database of health and related data (via both manual and electronic abstraction) from consented participants.3. Establish a mechanism for approving use of the banked biospecimens for future research.
The participant will meet with PRIDE Program team member in person to join the study.The participant with supply a saliva sample for the program.There is no compensation for joining the PRIDE Program.
Ability of patient, child and/or parent to understand or complete the consent process
STEEL: A Randomized Phase II Trial of Salvage Radiotherapy with Standard vs Enhanced Androgen Deprivation Therapy (with Enzalutamide) in Patients with Post-Prostatectomy PSA Recurrences with Aggressive Disease Features
Radiation treatment and hormonal therapy vs. Radiation treatment, hormonal therapy plus Enzalutamide in post-prostatectomy cancer recurrences.
Radiation treatment and hormonal therapy vs. Radiation treatment, hormonal therapy plus Enzalutamide in post-prostatectomy cancer recurrences
PSA level (≥0.2 ng/mL) within 90 days prior to registration.
Hemoglobin ≥9.0 g/dL, independent of transfusion and/or growth factors within 90 days prior to registration.
At least 1 of the following features: • Gleason score of 8-10 • Seminal vesicle invasion • Locoregional node involvement at radical prostatectomy • Persistently elevated PSA post-RP nadir
Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
Development of Lighting Application Efficacy Measurement Framework
This study seeks to analyze how subjects perceive brightness. For this purpose, separate studies will be conducted in a real setting in the Lighting Lab. In experiment one, subjects will be asked to judge the brightness of projected scenes on a wall two by two in comparison to one another. In experiment two, subjects will be asked to judge the brightness of scenes displayed on a monitor by comparing them to a reference scene, by assigning a value between 0 to 100 to the brightness level.
The experiment will take place in 302 Engineering Unit C. The participants will judge the brightness of displayed scenes on a monitor.
$20 for the current experiment
normal or corrected to normal visual acuity (participants need to have their prescription glasses or contact lenses on them during the experiments).
inability to distinguish certain shades of color
participants without glasses or contact lenses prescribed for their visual acuity
lacking clear visual acuity
Examining contextual factors associated with food-related reward and eating restraint
Rates of obesity have risen sharply throughout the world over the past several decades. The increase in the availability of highly palatable, high-calorie foods may be one factor that has contributed to this trend. That is, the availability of such foods may lead to their over-consumption and corresponding weight gain. Currently, relatively little is known about how the availability of foods, per se, affects things such as the motivation to eat and the ability to resist doing so. The current study is designed to help address this knowledge gap by examining the effects of food availability in people with high levels of dietary restraint. Dietary restraint, which refers to the intention to restrict food intake deliberately in order to prevent weight gain or to promote weight, is linked to problematic patterns of eating. This project uses laboratory tasks and brain imaging to study the effects of food availability on various outcomes, including food choices, food craving, and responses in brain areas linked to motivation.
Participants will be asked to fill out some online questionnaires and complete some computerized behavioral tasks. They will be asked to attend a one-hour virtual screening/baseline session via Zoom, and a 3-hour MRI session in the Penn State campus, University Park. In the MRI session, participants will be performing on a task involving asking them to view a series of colorful food pictures inside an MRI scanner while their brain activity is being scanned.
80
Participants must be right handed.
Participants must be fluent English speakers.
Participants must have a body mass index (BMI) >= 25.
Participants must have experienced food eating/weight issues.
If participant have a lifetime history of diagnosed eating disorders, diabetes, hyperglycemia, high levels of triglycerides, or high cholesterol or other related medical conditions.
If participants have any known risk from exposure to high-field strength magnetic fields (e.g., pace makers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments.
If participants report that they are vegetarian/vegan.
If participants are not willing to refrain from using alcohol for 24 hours or from using nicotine products/recreational drugs for 3 weeks, or unwilling to fast from food for 5 hours prior to two of three lab visits.
Self and community spiritual resilience in LGBTQ+ and gender nonconforming individuals
The goal of this research is an assessment of spirituality as a coping mechanism related to self and community stigmatization faced by gender nonconforming individuals and those in the LGBTQ+ community. Examination of discriminatory events, spiritual coping, and sense of community belonging will also be conducted.
Participants will complete a series of online questionnaires
Not straight but don't identify as LGBTQ+
Effect of Nitrate Supplementation on Cerebrovascular function and Cognitive Function in Older Adults with Metabolic Syndrome
The aim of this study is to determine the impact of cardiometabolic disease risk factors on cognitive performance and brain vascular function, as well as, to see if beetroot juice supplementation can improve these outcomes and reduce risk of cognitive decline and brain vascular dysfunction that is seen with aging and disease.
Participants with and without high blood pressure, high cholesterol, and high blood sugar will be recruited. These are all considered cardiovascular disease risk factors.Individuals without multiple cardiovascular disease risk factors will have 2 visits and complete cognitive and blood vessel function assessments. There involves a blood draw in each visit. All study assessments are non-invasive. Total compensation is $30. Individuals with cardiovascular disease risk factors will have 5 total visits and complete cognitive and blood vessel function assessments. Additionally, participants will drink beetroot juice for 4 weeks to determine the potential health benefits on cognitive, blood vessel function, and metabolic health. There will involve blood draws and all assessments are non-invasive. Total compensation is up to $170.
$30 -170
high blood pressure and/or high cholesterol and/or high cholesterol
the above criteria does not apply for the control group
Severe visual impairment
Individuals with any overt cardiovascular, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
22-061 Relugolix Versus Leuprolide in Patients with Prostate Cancer: A Randomized, Open-Label Study to Assess Major AdverseCardiovascular Events (REPLACE-CV)
The purpose of this research study is to compare and see if medications used in ADT treatment, either relugolix or leuprolide acetate, lower the risk of cardiovascular events in patients with prostate cancer. You (or your caregiver) will be asked to complete questionnaires electronically (such as computer, tablet, or smartphone) and/or share information via phone calls every three months until the end of your participation in the study. You will receive the study medications for treatment (either relugolix or leuprolide acetate)
Participants will be required to complete questionnaires electronically (such as computer, tablet, or smartphone) and/or share information via phone calls every three months until the end of your participation in the study. You will receive the study medications for treatment (either relugolix or leuprolide acetate)
$150 per year
Is a male and 18 years of age or older on the day of signing and dating the informed consent form;
Patient has sufficient cognitive function in the investigator’s opinion to complete the questionnaires and other activities related to the study
Has histologically or cytologically confirmed diagnosis of adenocarcinoma of the prostate
Is, in the opinion of the investigator, a candidate for at least 1 year of continuous ADT for the management of prostate cancer with one of the following clinical disease state presentations:Evidence of biochemical (prostate-specific antigen
Any major cardiovascular or cerebrovascular procedures planned within 1 month after enrollment;
Patients with QT interval corrected for heart rate (QTc) determined using Fridericia’s formula (QTcF; QTcF = QT/[R-R interval {RR}^0.33]) > 470 msec within 6 months of screening
Uncontrolled hypertension (systolic blood pressure > 180 mm Hg or diastolic blood pressure > 110 mm Hg) at the time of screening
Previously received GnRH receptor agonist
PSCI 22-156 HCRN BRE17-141
The purpose of this voluntary research study is to see if neratinib, endocrine therapy, and trastuzumab completely shrink breast tumors before having breast cancer surgery. You will need to have the following exams, tests, or procedures: blood draws, ECG, Echo or MUGA, ultrasound, MRI, receive study treatment, and breast biopsy.
Participants will be required to receive study treatments, laboratory assessments, undergo breast biopsy, and radiologic assessments,
HER2-positive (by most recent ASCO-CAP criteria)
ER > 50% and PR > 50%.
Resectable breast cancer in which pre-operative therapy is appropriate (T > 10mm and/or node-positive).
Archival tissue from the diagnostic pre-treatment biopsy is required.
Evidence of metastatic disease.
Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen are not eligible for this trial:
Active infection requiring systemic therapy.
Requirement for use of a moderate or strong CYP3A4 inhibitor or inducer during the study
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900, an Oral Plasma Kallikrein Inhibitor, for On-demand Treatment of Angioedema Attacks in Adolescent and Adult Patients with Hereditary Angioedema Type I or II
KONFIDENT-S is a trial to evaluate the long-term safety of KVD900 in patients who are 12 years of age or older with HAE type I or II. This trial will be conducted on an outpatient basis and includes in-clinic visits and televisits. The study will have multiple centers that will be participating in the study. Subjects will receive the study drug as this study does not include a placebo drug.
There will be 10 in-person visits and 14 televisits. Blood will be drawn at all of the in-person visits. The patient will need to complete a daily diary, and complete electronic questionnaires.
Have had at least 2 documented HAE attacks within 3 months prior to the enrollment visit.
Must have been on a stable dose and regimen with one of the protocol-allowed therapies for long-term prophylactic treatment for at least 6 months prior to the enrollment visit.
Male or Female
Must be 12 years of age and older.
Use of attenuated androgens (e.g. stanozolol, danazol, oxandrolone, methyltestosterone, testosterone), or anti-fibrinolytics (e.g. tranexamic acid) within 28 days prior to the Enrollment Visit.
Any clinically significant comorbidity or systemic dysfunction, which in the opinion of the Investigator, would jeopardize the safety of the patient by participating in the trial.
History of substance abuse or dependence that would interfere with the completion of the trial, as determined by the Investigator.
Any pregnant or breastfeeding patient.
NRG-GU007, Randomized Phase II Trial of Niraparib with Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) (NADIR*) (NCT 04037254) (PSCI# 20-104)
The purpose of this study is to compare the usual treatment alone to using the study drug niraparib plus the usual treatment. The addition of niraparib to the usual treatment could prevent your cancer from growing or returning. But, it could also cause side effects, which are described in the risks section below. This study will help the study doctors find out if this different approach is better, the same, or worse than the usual approach. To be better, the study approach should increase the chance of remaining cancer free to 50 out of 100 participants after 2 years, or a 20% improvement compared to the usual approach.
This study will help the study doctors find out if this different approach is better, the same, or worse than the usual approach. To be better, the study approach should increase the chance of remaining cancer free to 50 out of 100 participants after 2 years, or a 20% improvement compared to the usual approach.
Age is greater than or equal to 18 years old
Pretreatment serum PSA, obtained prior to any androgen suppression therapy and within 180 days of registration
Adequate hematologic, renal, and hepatic function within 90 days prior to registration
Men of child-producing potential must be willing to consent to use effective contraception while on treatment and for at least 3 months afterwards
Definitive clinical or radiologic evidence of metastatic disease
Pathologically positive lymph nodes or nodes > 1.5 cm short axis on CT or MR imaging
Prior radical prostatectomy, cryosurgery for prostate cancer, or bilateral orchiectomy for any reason
Prior systemic therapy for prostate cancer; note that prior therapy for a different cancer is allowable
Acute to Chronic Pain Signatures in Traumatic Injury
The goal of the proposed project is to identify biosignatures that predict resilience or vulnerability to the transition from acute to chronic pain in a cohort of patients recovering from an acute musculoskeletal trauma.
There is one in person visit that will include a 30-min MRI scan, sensory testing, and blood draw. Two follow-up surveys will be sent to the participants at 3- and 6-months following their injury.
$200
Presence of acute traumatic blunt chest trauma with multiple (≥ 2) closed fractures of the ribs
Non-surgical treatment of rib fractures
Able and willing to provide informed consent
Must be able to read and communicate in English sufficiently to complete all study requirements
Open rib fractures
Pregnant women
Single, isolated rib fractures
Presence of implanted ferromagnetic materials or devices
Regional Brain Manganese Accumulation and Functional Consequences in Welders
Inhalation of welding fumes has been known to cause tremor, muscle rigidity and abnormal gait similar to what is seen in Parkinson's disease. Previous studies by the Translational Brain Research Center have used measures such as brain MRIs and tests for movement and function to investigate the effect of these welding fumes on brain health in active welders. The center is currently expanding its efforts to investigate brain health in retired welders.This is an independent study sponsored by the National Institute of Environmental Health Sciences, with no affiliation to any private entities such as law firms.In this study participants will be asked to undergo clinical tests (blood draw, motor examination, memory tests), complete lifestyle questionnaires, and undergo an MRI scan during a baseline and 18 month follow-up visit. Participants also will be mailed a welding exposure questionnaire to complete every three months between their baseline and follow-up visit.
Participants will attend a screening call with the study team, an in-person baseline visit and an in-person follow up visit (at 18 months). Participants will complete questionnaires, undergo clinical tests (blood draw, motor evaluations, memory tests), and undergo MRI scan. Participants will also have the option to complete mobile phone assessments and undergo four skin punch biopsies.
Up to $750 per participant
No obvious signs of parkinsonism (e.g., tremor, impaired speech)
Fluent in written and spoken English
No metal eye fragments
Able to tolerate a brain MRI
Claustrophobia or unwillingness to undergo an MRI
Significant medical and neurological deficits (e.g., brain tumor, seizures, stroke, etc.)
Significant recreational drug use or alcohol abuse
History of chronic paint and solvent exposure
Understanding Practices on Social Network Sites and Social Relationships
Social network site (SNS) use has been very integrated into our daily practices. The distinctions between offline and online social relationship management become blurred with the mediation of SNSs. We are interested in how people perceive and use SNS and engage in social relationship management, such as self-disclosure or privacy management. Users may appropriate technological features to meet their own needs and such practices may be different from how others use the sites. The discrepancy of usage may in turn influence social relationship maintenance.
18 years and older
Below 18 years old
The Influences of Performance Expectancy on Cryptocurrency Traders’ Behavior in Initial Coin Offering (ICO) Projects
The study's primary objective is to see how people react to the influences of performance expectancy in Initial Coin Offering (ICO) projects. As a participant in this study, you will be asked to answer 28 questions about your experiences with ICO projects. Then, at the end of the survey, participants will be briefed on the potential correlations between performance expectancy and how this phenomenon influences participants' behaviors toward ICO projects.
The participant will be asked to complete a questionnaire composed of 28 questions about ICO projects during the study. Then, at the end of the survey, participants will be debriefed on the potential correlations between performance expectancy and ICO projects.
Active cryptocurrency traders.
18 years of age or more
Residing in The US
Non active cryptocurrency traders
Less than 18 years of age
Not residing in the US
Challenging Veteran Stereotypes: An Investigation Around Veteran Status and Its Influence on Aggression, Ostracism, Stress, and Counterproductive Work Behaviors
The purpose of this study is to better understand how civilian stereotypes about veterans impact veterans' feelings about themselves and others, and how that influences veteran behavior in the workplace.
Age 18 or older
Under age 18
The effect of video job description on recruitment: A comprehensive study
The purpose of this study is to see how online job advertisements can influence people to apply for jobs. Participants will see job advertisements and answer questions regarding each job ad.
Knowing English
Being interested to pursue employment in one of these three categories of jobs: academic (lecturer, professor), computer-related (programmer, cyber-security, etc.), or service-based (laborer, operator, technician, etc.)
Younger than 18 years of age.
A011801 THE COMPASSHER2 TRIALS (COMPREHENSIVE USE OF PATHOLOGIC RESPONSE ASSESSMENT TO OPTIMIZE THERAPY IN HER2-POSITIVE BREAST CANCER): COMPASSHER2 RESIDUAL DISEASE (RD), A DOUBLE-BLINDED, PHASE III RANDOMIZED TRIAL OF T-DM1 AND PLACEBO COMPARED WITH T-DM1 AND TUCATINIB (PSCI# 21-155)
The purpose of this study is to compare the usual treatment with T-DM1 alone to T-DM1 plus tucatinib. The addition of tucatinib to the usual treatment could prevent the breast cancer from returning
The purpose of this study is to compare the usual treatment with T-DM1 alone to T-DM1 plus tucatinib. The addition of tucatinib to the usual treatment could prevent the breast cancer from returning.
ECOG Performance Status 0-1
Patients must have received neoadjuvant chemotherapy with one of the following regimens: THP, TMP, AC-TH(P); TCH(P); FAC-TH(P), or FEC-TH(P).
HER2-positive breast cancer per pathology
Prior treatment must have consisted = 6 cycles of chemotherapy and HER2-directed therapy, with a total duration of = 12 weeks, including at least 9 weeks of preoperative taxane and trastuzumab with or without pertuzumab (or FDA-approved biosimilars).
Patients with known active and/or untreated Hepatitis B or Hepatitis C or chronic liver disease are ineligible.
Stage IV (metastatic) breast cancer
History of any prior (ipsi- or contralateral) invasive breast cancer within 3 years of registration
Patients with ER+ HER2+ residual invasive disease that is lymph node-negative per the surgical pathology report
Cabazitaxel with Abiraterone versus Abiraterone alone Randomized Trial for Extensive Disease following Docetaxel: the CHAARTED2 Trial
To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can improve PFS compared toabiraterone acetate alone.
To assess whether the addition of 6 cycles of cabazitaxel toabiraterone acetate in patients with CRPC that have previouslyreceived docetaxel and ADT for HSPC can improve PFS compared toabiraterone acetate alone.
Histologically confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate).
Previous chemotherapy with at least 3 cycles of docetaxel for hormone-sensitive metastatic prostate cancer.
Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/MRI of abdomen/pelvis, bone scintigraphy or NaF PET/CT).
Ability to swallow abiraterone acetate tablets as a whole.
Pure small cell or other variant (non-adenocarcinoma) prostate cancer histology for which treatment with abiraterone would not be considered appropriate.
Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy.
Any medical condition for which prednisone (corticosteroid) is contraindicated.
Active infection requiring treatment with antibiotics.
Understanding the relationship of financial difficulties and mental health among a sample of American Undergraduate Students.
Aim is to explore how student's financial status and experiences influence their emotional, psychological, and social well being while being in university.
Participants, upon their consent, will be required to fill a Qualtrics survey on their personal laptop or computer.
18 years or older
Penn State Undergraduate Student
Fluent in English
Non U.S Citizen
Non Penn State Undergraduate Student
A Survey to Estimate the Socio-Economic Impact of the Novel Corona Virus (COVID-19) Pandemic
We are experiencing global outbreak of coronavirus (COVID-19) recently. Millions of people are suffering and dying every day, in spite of putting our best efforts. We are doing this survey to understand people’s reaction to this situation. The survey will ask about your knowledge, practices and worries. Your response will help us to understand how to better control these situations. Your feedback is highly important to us, as we need to find out the best way to stop the disease from spreading and killing thousands of lives, and to reduce the stress among the population.
Adult
Mentally impaired
Participants from Europe or European Union (EU)
How do cues from the environment affect sound perception?
This study is about investigating how certain elements of urbanconfiguration affects people's subjective perception of noise in urbanenvironments.This section of the study assesses participants' subjective reactions tonoise intensity when the tree density changes in various spaces.
Gender: all
no visual or hearing impairments
The HEALthy Brain and Child Development Study (HBCD)
This multi-site consortium research study, entitled the HEALthy Brain and Child Development (HBCD) study, willprospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatallythrough age 10 years. The study will determine the short- and long-term impacts of a variety of potentially harmfulas well as protective environmental factors. These include prenatal substance use, mental health, stress,sociodemographics, biological and genetic factors, and parent/child interaction. The overall goal of this study is tounderstand the neurodevelopmental trajectories of children growing up in diverse environments. A sample of~7,500 pregnant women will be recruited from 25 sites across the U.S. and they and their liveborn children will befollowed for 10 years.
If you agree for you and your child to participate, we will ask you to take part in completing visits from pregnancy through the first 10 years of your child’s life. These visits will take place both in-person and remotely. The length of visits will vary and may last between approximately one to nine hours per visit (which can be broken up into multiple visits). Over the first four years of the study, all study visits will require about 33-37 hours total. This will include interviews, questionnaires and other tests about yourself and your child. We will ask you and your child to wear small devices for a few days to measure heart rate and or movement. We will ask you and your child to provide some biological samples. Because this study is looking at how a child’s brain develops in the first years of life, we will ask that you allow your child to have brain scans and other measures of how your child’s brain is developing. This study is being offered in both State College, PA at the University Park campus and in Hershey, PA at the College of Medicine campus. You may choose to complete this study at either site.
$1,350
Speaks English or Spanish
Does not speak English or Spanish
Sleep and eating behaviors in rural preadolescent children (Tween SPACE [Sleep Patterns, Appetite Control, and Environment])
The goal of this study is to learn about how children's sleep is related to their eating behaviors the next day. We are also interested in learning about factors that relate to eating behaviors and sleep health that are specific to preadolescent children living in rural communities. Participants will complete two virtual study visits via Zoom, answer surveys, and wear sleep and physical activity monitors for 2 weeks in their own homes.
- Study materials will be mailed to participants- Parent and child will attend a Zoom visit with a researcher to go over study procedures and measure child's height and weight- Child will wear a sleep monitor on their wrist and physical activity monitor around their waist continuously for 14 days- Child will attend a second Zoom visit to complete questionnaires- Parent will complete an online survey- Participants will return study materials via provided, prepaid shipping packaging
$200
Living in a rural zip code in United States (as defined by Health Resources & Services Administration)
Child BMI-for-age >=85th percentile OR BMI-for-age >=15th percentile plus one biological parent with overweight
Able to read and answer questions in English
Unable to connect to Zoom session via internet or cell-phone data
Unable to receive and sign for package with study supplies
Parent/child living in the same household as a previous or current participant in the study
Testing the Risk Preferences of Engineering Students under Conditions of Limited Information, Sleep, Optimism, and Time Constraints
This is a study that will examine how engineers make decisions under certain conditions and the factors that drive these decisions. The game will be used to simulate different engineering scenarios. All you need to do is play an online game with 3 different scenarios and choose what you feel is the better design based on the available information.
Over 18 years old
Speaks English
Graduate Students
Non-Engineering Majors
Home telemonitoring of bulbar function by acoustic measurement of swallowing and speech sounds in ALS
Most individuals with ALS experience changes in speech and swallowing over the course of the disease. In some, these are their initial indication of ALS. Identifying these changes, which may be rapid in some individuals, is complicated by the recent acceleration of virtual care delivery. This is a longitudinal home study of ALS patients to assess speech and swallowing function through use of smartphone application. The overall hypothesis is that this monitoring protocol can be used in a way that, 1) is satisfactory to the patient, 2) performs at least as well as standard clinical measures of dysarthria and dysphagia, and 3) resolves the development of emergence of speech and swallowing pathologies in ALS. Patients enrolling in this study will participate for approximately 24 weeks, during which they will have swallowing and speech tests performed, complete surveys, and perform audio recordings of speech on their cellphone. Healthy controls will be enrolled to judge the intelligibility of speech samples provided by patients in the study.
Patients enrolling in this study will participate for approximately 24 weeks, during which they will have swallowing and speech tests performed, complete surveys, and perform audio recordings of speech on a cellphone.
340
Possess a diagnosis of amyotrophic lateral sclerosis (ALS)
Have symptom onset within the last 6 years
Demonstrate changes in speech or swallowing as a result of ALS.
Possess a smartphone capable of running the study application or have home wireless internet service capable of transmitting study data from a study-issued smartphone.
Possess abnormal speech or swallowing processes due to a condition independent of their ALS diagnosis
Recruitment for Nicotine and Tobacco Related Research at Penn State Hershey
The purpose of this project is to screen potential participants for multiple research studies being conducted by tobacco researchers at Penn State Hershey. Since there are multiple IRB approved studies enrolling at Penn State Hershey with similar but not identical inclusion/exclusion criteria, it is more efficient for the researchers and participants to have one phone number to call initially for basic screening. After completing this, the participant can be redirected for more specific screening if they are found to be potentially eligible for one of the studies.
Participants will fill out a 5-minute survey on tobacco use in order to find out which study they may be eligible for.
Depends on study
Current tobacco user
An Open-label Study to Evaluate the Long-term Safety and Efficacy of CSL312(Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema
This phase 3b study will evaluate long-term safety and efficacy ofCSL312 (also known as garadacimab) when administeredsubcutaneously (SC) once monthly for at least 12 months.Subjects entering CSL312_3002 will be from 3 sources:• Subjects who participated in Study CSL312_2001• Subjects who participated in Study CSL312_3001• CSL312-naïve HAE subjects who have not participated ineither of the above studies
During the study, you will be expected to self-administer the study medication by injection under the skin once a month, complete a daily diary, provide blood and urine samples, complete questionnaires, undergo physical exams and have your vital signs recorded.You will visit the site 12 times.
$80.00 plus travel reimbursement
Male or female
Diagnosed with clinically confirmed C1-INH HAE
Experienced ≥ 3 HAE attacks during the 3 months before Screening, as documented in the subject's medical record.
Aged ≥ 12 at the time of providing written informed consent or assent for minors
Use of C1-INH products, androgens, antifibrinolytics or other small molecule medications for routine prophylaxis against HAE attacks at least 2 weeks before the first day of the Run-in Period.
Use of mAbs such as lanadelumab (Takhzyro®) 3 months before the first day of the Run-in Period.
Female subjects’ use of estrogen-containing medications with systemic absorption (eg, oral contraceptive or hormonal replacement therapy within 4 weeks prior to the Run-in Period).
Female or male subjects who are fertile and sexually active not using or not willing to use an acceptable method of contraception to avoid pregnancy during the study and for 3 months after receipt of the last dose of CSL312.
Developing a Recommendation System for Local Community Events
In this study, we investigate a recommender system for public, local events in Centre County, PA. Currently, there is no platform that aggregates all the events that take place in a community. The data is fragmented among many platforms and it can be difficult for people to find interesting things to do. Participants will interact with our software system and discuss their experiences through a survey and/or interview.
Must be a University Park student or local resident of Centre County
Persons who do not live in Centre County, PA
Seamless, Adaptive, Phase2b/3, Double-blind, Randomized, Placebo-controlled, Multicenter, International Study Evaluating the Efficacy and Safety of Belapectin (GR-MD-02) for the Prevention of Esophageal Varices in NASH Cirhosis
This trial will evaluate the study drug Belapectin in patients with NASH (Non-Alcoholic Steatohepatitis) Cirrhosis. The purpose of this voluntary research study is to find out about the safety and efficacy of the study drug and for the prevention of esophageal varices in NASH Cirrhosis..
If you consent to participate, you will be asked to have some screening tests and procedures, as described in the table below. This period of up to 3 visits within 2 months is called Screening Period. Based upon results of tests and procedures completed during these visits, your study doctorwill be able to decide if you meet the requirements to participate in this study. If you meet the study requirements to participate in this study, your study doctor will discuss with you when you should start the study treatment.
early stage cirrhosis
diagnosis of NASH
substance abuse
other liver disease
history of organ transplant