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567 Study Matches

Using Exercise to Relieve Arthralgia (Joint Pain) and Improve AI Adherence in Older Survivors (REJOIN): A Pilot Study

Briefly, the purpose of this study is to use a self-management approach (combining education and exercise) to help older breast cancer survivors manage joint pain, a common side effect of aromatase inhibitors (AIs), a medication used to reduce hormones that might increase risk of recurrence and mortality following primary cancer treatment. We believe that reducing joint pain might help survivors take their medication longer and thus improve survival outcomes, compared to standard care.

Attend 4 in person visits, blood will be drawn at each visit.Complete physical function tests and surveys.Wear accelerometer for 7 days following each visit.Randomly selected participants will attend group exercise sessions twice a week for eight weeks via video call and record exercise activities between visits.

$160

Yes
 

Nancy Olsen
Nancy Olsen - at nolsen@pennstatehealth.psu.edu
Medicine: Rheumatology (HERSHEY)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03955627
STUDY00010776
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Inclusion Criteria:
Age 60 and older
Female
Breast Cancer Survivor
Preparing to Start AI medication
ER+ diagnosis

Exclusion Criteria:
Already taking AI medication (greater than 24 weeks)
Gross Cognitive Impairment
Recent Joint Surgery
Cardiac event/Stroke within last 6 months
Not willing to come to HMC for Exercise Sessions
Cancer
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Hershey, PA ,

The association between perceived parenting styles, intolerance of uncertainty, and anxiety among young adults

This study aims to understand the association between young adults' perceived parenting, intolerance of uncertainty, and trait anxiety. Participant will be asked to complete a questionnaire that aims to answer the environment and parenting beliefs around which they were brought up, and if they face stressors and anxieties associated with them. This is a correlational study

No
 

Aishwarya Sastry
Aishwarya Sastry - at ams9680@psu.edu
Behavioral Sciences and Education (HARRISBURG)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015652
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Inclusion Criteria:
18-34 years old
Geographical location: USA
All genders
All ethnicities

Exclusion Criteria:
Individuals below 18 years
Individuals over 34 years
Individuals residing outside USA
Prevention, Education, Mental & Behavioral Health
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The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).

Yes
 

Lacy Alexander
Gabie Dillon - at gad27@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00012607
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Inclusion Criteria:
Men and women aged 18-40 years

Exclusion Criteria:
•Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
•Individuals that use nicotine-containing products
Illicit or recreational drug-use
•Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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State College, PA ,

TMIST_EA1151

This study is being done to answer the following question:Can tomosynthesis mammography, three-dimensional x-ray imaging of the breast, lower your chance of developing life-threatening breast cancer through routine screening compared with digital mammography, two-dimensional x-ray imaging of the breast?We are doing this study because we want to find out which of the two usual approaches to breast cancer screening are better in the early detection of life-threatening breast cancers.

Yes
 

Rebecca Sivarajah
Swati Shah - at sshah@pennstatehealth.psu.edu
Radiology (HERSHEY)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03233191
SITE00000587
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Inclusion Criteria:
Women age 45 or older and under age 75 at the time of study entry
Patients must be scheduled for, or have intent to schedule, a screening mammogram.
Patients must be able to tolerate digital breast tomosynthesis and fullfield digital mammographic imaging required by protocol.
Patients must be willing and able to provide a written informed consent.

Exclusion Criteria:
Women of childbearing potential must not be known to be pregnant or lactating.
Patients must not have new symptoms or signs of benign or malignant breast disease
Patients must not have had a screening mammogram within the last 11 months prior to date of randomization.
Patients must not have previous personal history of breast cancer including ductal carcinoma in situ
Patients must not currently have breast enhancements (e.g., implants or injections).
Prevention, Cancer, Women's Health
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Hershey, PA ,

Breaking the Model Minority Mold: Storying the Experiences of Asian Americans labeled dis/abled

This is a qualitative study that will examine the educational experiences of Asian American individuals who have been labeled as dis/abled or academically struggling at some point throughout their educational career. The study will focus on the narrated stories and discussions from the participants as they reflect on various moments from their education.

No
 

Kaela Fuentes-Packnick
Kaela Fuentes-Packnick - at knf115@psu.edu
Education Administration Office (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016985
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Inclusion Criteria:
Identify as Asian American
Identify or have been labeled as disabled
Received the majority of K-12 education within the United States
Over the age of 18

Exclusion Criteria:
Under the age of 18
Received majority of K-12 education outside of the United States
Do not identify as Asian American
Education, Mental & Behavioral Health
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CCTG MA.39- A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer

Purpose of this study is to compare any good and bad effects of not using regional radiotherapy to using radiotherapy. The study will help researcher learn if not giving regional radiotherapy is just as good as using regional therapy to treat node positive breast cancer in women.

Blood will be drawn at two time points and number of visits will be determined by the individual radiation treatment plan.

Yes
 

Marc Rovito
Michelle Eschbach - at meschbach@pennstatehealth.psu.edu or 610-378-2336
Cancer Institute (ST. JOSEPH)
 

Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03488693
AFFILCCTGMA39
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Inclusion Criteria:
Estrogen Receptor Positive / Her2 Negative Breast Cancer
No evidence of metastasis
1 - 3 positive lymph nodes
May have had breast conserving surgery or mastectomy
35 years of age or older

Exclusion Criteria:
Nodal disease limited to micromets or isolated cells
History of ipsilateral breast cancer or DCIS
Synchronous or contralateral breast cancer
pT4 disease
Neoadjuvant Chemotherapy for breast cancer
Cancer
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Reading, PA ,

Longitudinal Associations Between Food Insecurity, Diet, Mental Health, Sleep and Academic Outcomes in College Students

This is a questionnaire study that seeks to discover the prevalence of food insecurity at PSU's University Park campus over the course of a semester and the relationship between long-term food insecurity and academic outcomes, as mediated by mental health and sleep outcomes.

No
 

Muzi Na
Kiara Smith - at kxs782@psu.edu
Nutritional Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015990
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Inclusion Criteria:
Must be a Penn State student at University park
Must be in their 2nd semester during Spring 2021
Must have internet access
Must be at least 18 years old
Must not have children or other dependents

Exclusion Criteria:
Has diagnosed learning or mental disabilities
Has diagnosed mental disorders
Is unable to read, write or understand English fluently
Food & Nutrition, Sleep Management, Mental & Behavioral Health
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Immersive Virtual Reality Storm Surge: Scale and Risk Perception

Evaluating if an immersive virtual reality experience of storm surge flooding gives people an understanding of the scale of the flooding and increases their risk perception of such flooding compared to a non-immersive desktop experience.

Yes
 

Mark Simpson
Mark Simpson - at marksimpson@psu.edu or 575-491-5512
Geography (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011093
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Inclusion Criteria:
Normal or corrected-to-normal vision
English-speaking

Exclusion Criteria:
Under age 18
Education
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State College, PA ,

A Phase II Pilot Trial to Estimate Survival After a Non-Total Body Irradiation (TBI) Based Conditioning Regimen in Patients Diagnosed with B-Acute Lymphoblastic Leukemia (ALL) Who Are Pre-Allogeneic Hematopoietic Cell Transplantation (HCT) Next-Generation-Sequence (NGS) Minimal Residual Disease (MRD) Negative

A study of the safety and efficacy of removing the total body irradiation part of the treatment of pediatric patients with B-ALL who are negative before their transplant to a sensitive sequencing test which measures minimal residual disease.

•Bone marrow and blood tests: for about a year extra bone marrow and blood will be collected for the disease NGS-MRD (next-generation-sequence minimal residual disease) testing to detect if you have any leukemia.•Let the research team record information from your medical record related to your condition and the treatment you receive.•If your NGS-MRD testing before your transplant shows that you are eligible for the Non-TBI (Total Body Irradiation) Arm of the study, it will be explained to you in a different consent form.

Yes
 

Robert Greiner
Suzanne Treadway - at streadway@pennstatehealth.psu.edu or 717-531-3097
Pediatrics: Hematology/Oncology (HERSHEY)
 

All
All
This study is NOT accepting healthy volunteers
NCT03509961
STUDY00021337
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Inclusion Criteria:
Age 1 to 25 years at the time of screening
Diagnosis of High Risk B-ALL (Acute Lymphoblastic Leukemia) in CR1 (complete remission) after first-line treatment

Exclusion Criteria:
Bone Marrow blast count is above the required range
Philadelphia chromosome positive (Ph+) ALL (Acute Lymphoblastic Leukemia)
Prior tyrosine kinase inhibitor therapy
Cancer
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Hershey, PA ,

Atrophy of Olfactory Bulb in Early-stage Parkinson’s disease

This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with early- stage Parkinson’s disease.

Yes
 

Jian-Li Wang
Jianli Wang - at jwang2@pennstatehealth.psu.edu
Radiology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00005422
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Inclusion Criteria:
A physician-documented parkinsonian symptom onset between the ages of 40-59 will
Patients should not have reached their 65th birthday.
Patients that have tremor, rigidity, and bradykinesia unilaterally

Exclusion Criteria:
Dementia
Autonomic dysfunction
Parkinson-plus syndrome
Postural instability
History of exposure to substances that cause parkinsonism
Neurology
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Hershey, PA ,

Evaluating the consequences of mistimed light-emitting device use on cardiac activity and sleep health

The study is being done to find out whether wearing blue light-blocking glasses in the evening improves subsequent sleep. This is a 21-day study where participants will be asked to wear a sleep-monitoring “actiwatch”, an activity monitor, and a heart tracker, as well as to provide screenshots of their smartphone’s screen time app for three weeks. Participants will also be given the option to wear a blood pressure cuff on their arm for three days during the second half of each week, for a total of nine days.

Study participants will be asked to wear small devices on their wrist, hip, and shirt collar, and provide screenshots of their smartphone screen time app for three weeks. During the second and third weeks, participants will be asked to wear a pair of blue light-blocking glasses. Halfway through each week, participants will also be asked to wear a blood pressure monitor for 3 days/nights.There will be a total of seven in-person visits. At the first visit we will explain the study, ask interested participants to sign a consent form, collect information, and distribute study materials and devices. During all subsequent visits, participants will answer questionnaires and be provided additional study materials and devices.

150.00

Yes
 

David Reichenberger
David Reichenberger - at phonesleep@psu.edu or 817-521-0634
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05342662
STUDY00019746
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Inclusion Criteria:
Healthy, sighted individuals
Own an iOS smartphone (iPhone)
Willingness to update smartphone to access the current version of the Screen Time application
Willingness to participate in surveys, wear health monitoring devices, and provide screenshots of their smartphone’s screentime application throughout the entire study
Age 18 to 29 years old

Exclusion Criteria:
Individuals who are blind or wear corrective lenses
Taking prescribed medications that affect sleep
Recent shift work
Sleep disorder diagnosis or any cardiovascular disease
Primarily use an Android smartphone
Heart & Vascular, Sleep Management, Vision & Eyes
Approved device(s)
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State College, PA ,

A082002 Randomized Phase II/III of immunotherapy with or without SBRT PD-L1 negative NSCLC (22-026)

To assess if SBRT improves the progression free survival (PFS, phase II portion) and overall survival (OS, phase III portion) of advanced stage NSCLC patients with PD-L1 TPS <1% who receive immunotherapy with or without chemotherapy

We are asking you to take part in a research study. This study has public funding from the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) in the United States Department of Health and Human Services. We do research studies to try to answer questions about how to prevent, diagnose, and treat diseases like cancer.

Yes
 

Joseph Miccio
psci-cto@pennstatehealth.psu.edu 717-531-5471
Radiation Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04929041
SITE00001209
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Inclusion Criteria:
Age ≥ 18 years
No prior systemic chemotherapy or immunotherapy for advanced NSCLC
Not pregnant and not nursing
No known history of Hepatitis B or Hepatitis C
Platelet Count ≥ 100,000/mm3

Exclusion Criteria:
Live vaccine within 30 days prior to registration
Current pneumonitis or history of non-infectious pneumonitis that required steroids
Prior allogeneic tissue/solid organ transplant.
Age < 18 years
ECOG Performance Status over 3
Cancer
Not applicable
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Hershey, PA ,

Livestreaming, Content Creation, and Playing and Learning Online

This study surveys how different viewers, livestreamers and content creators learn and engage online. We are recruiting people who view or create content on livestreaming platforms such as Twitch, YouTube or Mixer (past or present). This study involves filling out a survey which should take 15-20 minutes to complete. Participants will be entered into a drawing to win one of 20 $75 e-gift cards for their participation.

No
 

Gabriela Richard
G. Richard - at gamingstudy@psu.edu
Non-PSU Site
 

All
All
This study is also accepting healthy volunteers
STUDY00015114
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Inclusion Criteria:
people who livestream
people who watch livestreams
aged 13 or older (if not yet legally adults, with parental/guardian permission)
online content creators
gamers or esports viewers

Exclusion Criteria:
under 13 years of age
cannot read, communicate or provide consent in English
does not livestream or watch livestreams or create content online
if a minor, does not have parental/legal guardian permission
Education
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A PROSPECTIVE MULTICENTER STUDY TO ASSESS THE CLINICAL OUTCOMES OF CURRENT PHACOEMULSIFICATION APPROACH TO CATARACT EXTRACTION VERSUS THE MICOR SYSTEM DEVICE USING LOW ENERGY LENS EXTRACTION IN PATIENTS UNDERGOING CATARACT SURGERY

Research study to assess visual outcomes after cataract surgery between different devices. 3 trial groups open to males and females over the age of 18 who are to undergo cataract surgery.

There will be 3 in person visits per surgery eye.Vision will be checked at 2 of these visitsCataract surgery will be done at 1 of these visits

Yes
 

Seth Pantanelli
Kathleen Scruggs - at kscruggs@pennstatehealth.psu.edu or 717-531-4696
Ophthalmology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05729477
SITE00001269
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Inclusion Criteria:
Willing to follow all instructions
Must have a cataract that qualifies for surgery

Exclusion Criteria:
Has participated in other clinical trial up to 30 days prior.
Not Pregnant
Other eye conditions may not be allowed to participate, study coordinator will discuss further
Vision & Eyes
Prefer not to display
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Hershey, PA ,

Phase II, questionnaire for “BRITE Synergy: Developing and Validating a Framework for Measuring Resilience in Low-Income Housing in the Post-Pandemic World”

This study includes the questionnaire related to "BRITE Synergy: Developing and Validating a Framework for Measuring Resilience in Low-Income Housing in the Post-Pandemic World" which has been previously submitted. The objective of this part of the research is examining the extent to which energy burden linked to the use of inefficient appliance within the context of a changing climate can be a good proxy for community resilience and if the ongoing building electrification drive.

Participants will be asked to complete an online survey via a link that will be accessed.

10 random participants will receive $20 gif cards.

No
 

Esther Obonyo
Esther Obonyo - at eao4@psu.edu
School of Engineering Design and Innovation (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020844
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Inclusion Criteria:
Must be 18 years or older
Subjects must be living in the US

Exclusion Criteria:
Under 18 of age
Living outside the US
Education
Not applicable
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(NIVOLUMAB) AND IPILIMUMAB FOLLOWED BY NIVOLUMAB VS. VEGF TKI CABOZANTINIB WITH NIVOLUMAB (PSCI# 19-109) (A031704)

The purpose of this study is to compare the usual treatment of advanced kidney cancer (treatment with ipilimumab and nivolumab followed by nivolumab alone) to the usual treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib. This study will help the study doctors find out if this different approach is better than the usual approach. To decide if it is better, the study doctors will be looking to see if adding cabozantinib to nivolumab can increase the percentage of patients alive at 3 years from 60% to 70%.

We are asking you to take part in a research study. We do research studies to try to answer questions about how to prevent, diagnose, and treat diseases like cancer.We are asking you to take part in this research study because you have advanced or metastatic kidney cancer.

Yes
 

Monika Joshi
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03793166
SITE00000692
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Inclusion Criteria:
Histologic documentation of renal cell carcinoma with clear cell component
Age ≥ 18 years
Karnofsky performance status greater than or equal to 70%
Hemoglobin ≥8 g/dL
Platelet Count ≥ 100,000/mm3

Exclusion Criteria:
No prior previous systemic therapy for renal cell carcinoma.
No cancer therapy less than 28 days prior to registration; this includes radiation therapy.
Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic, and teratogenic effects.
No history of HIV or active hepatitis B/C, or tuberculosis
No uncontrolled hypertension (systolic BP >150mmHg or diastolic BP
Cancer
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Hershey, PA ,

A Phase 2b, Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy and Safety of Saroglitazar Magnesium in Subjects with Nonalcoholic Steatohepatitis and Fibrosis

To evaluate the effect of Saroglitazar Magnesium compared with Placebo on liver scarring in patients with NASH.

There will be 11 in person visits, various procedures will be completed such as a fibroscan, liver biopsy, blood draws and DXA scan. You will be randomly assigned by chance (like the flip of a coin) to receive either Saroglitazar 4 mg or Saroglitazar 2 mg or placebo (inactive substance).

1,325

Yes
 

Jonathan Stine
Nataliya Smith - at nsmith9@pennstatehealth.psu.edu or 717-531-0003, ext=320223
Medicine: Gastroenterology and Hepatology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05011305
STUDY00020176
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Inclusion Criteria:
Age 18-75
NASH diagnosis
Stage 2 or 3 fibrosis

Exclusion Criteria:
causes of chronic liver disease other than NAFLD
Chronic alcohol or drug abuse
Cirrhosis
Inability to provide informed consent
history of liver transplant
Digestive Systems & Liver Disease
Experimental drug compared to an approved drug
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Hershey, PA ,

Characterizing resilience to food-cue induced overeating in children

This is a behavioral and neuroimaging study that will examine how food commercials affect the way a child eats and responds to food. Children enrolled in the study will complete 5 in-lab sessions that include eating meals and snacks, watching TV, and playing computer games. For one of these sessions, children will complete an fMRI scan. On the first and last visit to the lab, children will receive a DXA scan to assess their body composition.

We are looking for children to help us learn about how kids respond to different types of foods and food advertisements. The study consists of 5 visits to our facilities in Noll and Chandlee Labs, located on the University Park Campus. For 3 visits your child will eat test meals and snack buffets in our laboratory. On 1 visit we will use fMRI to take pictures of your child’s brain. We will use a DXA to scan for lean muscle and conduct an IQ test. These procedures are not harmful. You and your child will fill out questionnaires.Your child will also play computer games and watch commercials.

$250.00-450.00

Yes
 

Kathleen Keller
Jonathan Bauman - at jmb7118@psu.edu or 814-865-9841
Nutritional Sciences (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT05073185
STUDY00015835
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Inclusion Criteria:
In order to be enrolled, children must be of good health based on parental self-report.
Be 7-9 years-old at enrollment.
Not be taking any medications known to influence body weight, taste, food intake, behavior, or blood flow.
Have no learning disabilities (e.g., ADHD).
The biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 (high-risk group).

Exclusion Criteria:
They are not within the age requirements (< than 7 years old or > than 9 years-old at baseline).
If they have a learning disability, ADD/ADHD, language delays, autism or other neurological or psychological conditions.
If they have a pre-existing medical condition such as diabetes, rheumatoid arthritis, Cushing’s syndrome, Down’s syndrome, severe lactose intolerance, Prader-Willi syndrome, HIV, cancer, renal failure, cerebral palsy, or can't engage in moderate exercise.
If they don’t speak English.
Biological mother must have a body mass index either between 18.5 - 25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers (high-risk group), or they are excluded.
Children's Health, Food & Nutrition, Prevention
Not applicable
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State College, PA ,

Contempt as a Mixed Emotion

This study will investigate whether contempt is a positive, negative, or mixed emotion.

No
 

Michelle Yarwood
Victor Ellis - at vde5011@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016610
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Inclusion Criteria:
age 18 years or older

Exclusion Criteria:
younger than 18 years of age
Mental & Behavioral Health
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Study of Angelica gigas dietary supplements (Cogni.Q) and potential effects on human immune cells

This human study will test the impact of dietary supplement vegicaps containing Korean Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and other germs and natural killer (NK) cells that kill virus-infected cells and cancers. We had done an earlier study with Korean Angelica supplement and discovered even a single dose of it increased blood neutrophils and NK cells within 24 h. In the new study, Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo) capsules. This is to make sure the immune boosting actions are really from the Korean Angelica supplement.Approximately 40 men will take part in this research study at Hershey Medical Center.

Yes
 

Junxuan Lu
Deepkamal Karelia - at dkarelia@pennstatehealth.psu.edu or 717-531-0003, ext=285476
Pharmacology (HERSHEY)
 

Male
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00008009
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Inclusion Criteria:
Male subjects 21 to 65 years of age
Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in the range of 19=< BMI >=30
Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR).
Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg)

Exclusion Criteria:
Subjects positive for HIV, HBV and HCV (self-reported)
Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded.
Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study.
Non-English-speaking subjects
Infectious Diseases & Immune System, Blood Disorders, Food & Nutrition
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Hershey, PA ,

PSCI 21-026 A Phase III Randomized, Open-Label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab in Combination With Tremelimumab and Enfortumab Vedotin or Durvalumab in Combination With Enfortumab Vedotin for Perioperative Treatment in Patients Ineligible for CisplatinUndergoing Radical Cystectomy for Muscle Invasive Bladder Cancer(VOLGA)

A clinical trial for adults with Muscle Invasive Bladder Cancer. The study is looking at alternative treatments for those persons who cannot tolerate certain forms of chemotherapy.

This protocol contains two portions. The safety run in (SRI) and the main portion of the trial. The SRI will take place over three cycles of treatment prior to having cystectomy or 9 cycles if you have had a previous cystectomy. The main study will have the same schedule of activities. The only difference between the two is the SRI will look at how safe the drug combinations are and the main trial will look at how effective they are on treating muscle invasive bladder cancer.,

Yes
 

Monika Joshi
CI-CTO at psci-cto@pennstatehealth.psu.edu or 717-531-5471
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04960709
STUDY00018157
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Inclusion Criteria:
Bladder Cancer
body weight above 30kg/66 pounds

Exclusion Criteria:
Metastatic disease
history or an organ transplant
inflammatory bowel disease
Cancer
Approved drug(s)
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Hershey, PA ,

Asymmetric neurodegeneration of central olfactory system in early-stage Parkinson’s disease

This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with H&amp;Y stage 1 or 2 Parkinson’s disease compared to that of healthy volunteers.

In this study, you will receive a clinical evaluation and an MRI examination. After that, you will be followed every 12 months for up to 4 years.

up to a total of $250.00.

Yes
 

Jian-Li Wang
Heather Klemick - at hklemick@pennstatehealth.psu.edu or 717-531-0003, ext=323023
Radiology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00005378
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Inclusion Criteria:
Cognitively-normal H&Y stage 1 PD patients. A physician-documented parkinsonian symptom onset between the ages of 40-59. 1st visit prior to age 65. PD stage I diagnosis must be documented for a min of 2 years.
Cognitively-normal H&Y stage 2 PD patients. H&Y stage 2, as defined by an exam in the practically defined “off” state, and have a diagnosis of PD at the age of 59 or younger. 1st visit prior to age 65
Healthy participants between ages 40-64 at their first visit.
Able and willing to provide informed consent
Fluent in written and spoken English

Exclusion Criteria:
Parkinson-plus syndrome
Dementia
Previous antipsychotic or anti-dopamine drug therapy
Traumatic head injury
Other neurological diseases or disorders
Neurology
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Hershey, PA ,

The Role of Emojis in Generating and Responding to Critiques of Work

An online survey about emojis for text feedback on a short story or design. You categorize emojis for this task, write a critique with emojis, and then answer a survey for an Amazon gift card.

No
 

Chulakorn Aritajati
Chulakorn Aritajati - at cya5092@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00011180
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Inclusion Criteria:
18 year old or older
Can read and write English

Exclusion Criteria:
Under 18 years
Education, Language & Linguistics
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Examining executive functioning deficits, affective deficits, and social functioning to better understand disruptive behaviors and callous-unemotional traits

This research seeks to better understand functioning in children who differ in symptoms of Attention-Deficit Hyperactivity Disorder (ADHD), conduct problems (CP), and callous-unemotional (CU) traits, ages 6 - 13. Specifically, this research is being done to find out how these different types of behaviors impact cognitive skills (like attention, impulsivity, working memory, emotion identification) and social functioning to help inform future treatment with these children.

Yes
 

Dan Waschbusch
Delshad Shroff - at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285968
Psychiatry and Behavioral Health (HERSHEY)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00005703
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Inclusion Criteria:
Children ages 6 to 13 years old
Estimated IQ of 80 or above
Willing and able to discontinue psychoactive medication treatment for the experiemental session, if relevant
Caregiver and child must be fluent in written and spoken English

Exclusion Criteria:
Current or past diagnosis of intellectual disability, any psychotic disorder or autism spectrum disorder, or schizophrenia or rleated disorders
Psychiatric symptoms requiring urgent treatment, such as mania or suicidal ideation/homicidal ideation
Unable to be tested off medication
Physical disabilities that are incompatible with completing laboratory tasks such as hearing or speech impairments, or visual impairments that cannot be corrected with visual aids
Mental & Behavioral Health
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Hershey, PA ,

Penn State Exercising Women's Study

This study aims to assess energy status in young sedentary and exercising women as it is related to menstrual status, bone health, psychological health, sleep variables, and cardiovascular function.

There will be three to four visits to the laboratory. Procedures include questionnaires, a blood draw, providing a hair sample, providing two saliva samples, cardiovascular measurements, and bone scans, as well as resting metabolic rate, cognitive, aerobic fitness, and countermovement jump testing. Participants will be asked to collect urine samples throughout one menstrual cycle, or 28 days for amenorrheic females. Exercise and physical activity will be recorded and monitored for seven days via logs and wearables. Food intake will be recorded for three days. Collegiate athletes will be tested twice; in-season and off-season.

Yes
 

Mary Jane De Souza
Ana Carla Chierighini Salamunes - at akc6247@psu.edu or 814-863-4488
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019437
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Inclusion Criteria:
Women
Age 18-30 years
Body Mass Index between 16-29.9 kg/m2
For sedentary participants: less than 2 hours of purposeful exercise per week and regular menstrual cycles for the last 6 months (i.e. cycles between 26 and 35 days in length)
For exercising participants: exercise at least 2 hours per week AND/OR participate in collegiate athletics. Exercising participants can have regular or irregular menstrual cycles for the last 6 months.

Exclusion Criteria:
Pregnant or lactating
Currently a smoker or history of regular smoking
Taking any hormonal medication in the past six months, other than oral contraceptives
Serious or chronic health condition (including heart condition, thyroid illness, metabolic disease)
Hysterectomy or oophorectomy
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA ,

Effects of antibiotic use on fecal microbiome and resistome

This study will investigate the changes in the human fecal microbiomes and resistomes in response to antibiotic treatment.

No
 

Jasna Kovac
Jasna Kovac - at jzk303@psu.edu or 814-699-1680
Food Science (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011756
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Inclusion Criteria:
over age 18
English speaking/reading
Books a medical appointment for upper respiratory tract infection

Exclusion Criteria:
Patient took antibiotics in the past week
Patient participated in STUDY00012891 previously
Reason for medical visit is not upper respiratory tract infection
Patient is pregnant
Patient has a medical history that includes diagnosis of any intestinal related disease
Infectious Diseases & Immune System, Lung Disease & Asthma
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Testing Responses of Young Adults to Intervention Messages (TRY AIM) Trial

The purpose of this voluntary research study is to determine the effects of different methods of promoting physical activity with wearable devices and technology.

Participants will participate in an 18-month study with virtual study visits.-Use provided digital tools (activity tracker and messages) to monitor physical activity-Set goals to increase physical activity levels based on national guidelines-Monitor weight and complete questionnaires at five times throughout the study (at the beginning, 3 months, 6 months, 12 months and 18 months)

Up to $235 and a Fitbit tracker and BodyTrace scale

No
 

David Conroy
Gabrielle Ryan - at tryaim@psu.edu or 814-865-7935
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05794178
STUDY00019311
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Inclusion Criteria:
Participants capable of reading, speaking and understanding English and of giving informed consent.
Participants between the ages of 18-29 years.
Participants must be free of visual impairment that would interfere with the receipt of text messages on their phone.
Participants must be willing to wear a Fitbit tracker almost continually (23.5 hours/day) for a 12- month period of time.
Participants interested in setting goals to increase their physical activity levels over the 12-month study.

Exclusion Criteria:
Participants engaging in 150 or more minutes of moderate- or greater intensity PA /week as assessed by a research grade accelerometer.
Participants with contraindications to normal physical activity on the Physical Activity Readiness Questionnaire.
Participants who require an assistive device for mobility or have any other condition that may limit or prevent participation in moderate-intensity physical activity.
Participants with a prior diagnosis of cancer, cardiovascular disease, diabetes or metabolic syndrome.
Participants who are pregnant or planning to become pregnant within the next 12 months.
Men's Health, Prevention, Women's Health
Prefer not to display
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Minoritization and transnational social hierarchies: Caste and race in the Indian immigrant context

The study looks to understand how caste and race play out among Indian students, especially Indian immigrant students. Caste is the predominant social category in India. However, as Indian students migrate into to the USA, the social category of race is introduced and social category of caste is not understood outside of the Indian community. Through qualitative interviewing, it is aimed in this study to determine how migrating to the USA and becoming a minority and a person of color can potentially change how Indians view caste and caste identities in India. The primary hypothesis of the study is that the process of becoming becoming a minority through immigration can be used to think back on caste, and to think forward on race in both India and the USA.

No
 

Ashwin Mohan
Ashwin Mohan - at akm73@psu.edu or 518-992-8324
Curriculum and Instruction (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017989
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Inclusion Criteria:
Adults 18 years old or above
Citizen/Resident of India for at least 5 years OR one or both parents have been citizens of India for at least 5 years
Students/Faculty members at Penn State

Exclusion Criteria:
Subjects who do not meet the inclusion criteria
Subjects who do not speak English
Education
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The effect of repetitive thinking on emotional reactivity to daily events in depression and generalized anxiety disorder: Application of the contrast avoidance model

This is an ecological momentary assessment study that will examine the relationship between daily events, emotion, and repetitive thinking using a mobile application. The participants will be required to answer 2 minutes questionnaire and monitor their heart rate 8 times a day for 8 consecutive days.

If you are eligible based on the screening survey, there will be one Zoom study session where you will complete a brief videotaped clinical interview to further determine your eligibility to participate in the study. If you are eligible and decide to continue in the study, you will complete a brief questionnaire and be trained on how to complete the study. Starting the next day, you will complete eight 2-minutes questionnaires per day and monitor your heart rate using smartphone application for 8 days.

Up to $20 (Amazon gift card)

Yes
 

Seung Baik
Seung Yeon Baik - at sbb5887@psu.edu
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017148
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Inclusion Criteria:
Adults aged 18 years and above.
Owns iPhone.
Scores high or low on depression and anxiety symptoms measure
Fluent in the English language in terms of speaking, listening, reading, and writing

Exclusion Criteria:
Alcohol or substance abuse occurring within 6 months
Meets diagnostic criteria for bipolar disorder or schizophrenia-related disorders
Has suicidal thoughts
Unable to speak, read, listen, and write English fluently.
Mental & Behavioral Health
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State College, PA ,

Expanding Family Foundations to 2nd-Time Parenthood - Focus Group

This focus group study, funded by Penn State's Social Science Research Institute, brings together couples with preschool-aged firstborns who are pregnant with their 2nd child or who have given birth to their 2nd child within the last 12 months. Couples will be interviewed about how they worked together as a team (as coparents) to prepare their firstborn for the birth of the second child and to prepare themselves for 2nd-time parenthood.

Yes
 

Douglas Teti
Douglas Teti - at dmt16@psu.edu or 814-863-9570
Human Development and Family Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015968
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Inclusion Criteria:
1.Two-caregiver families, any race or ethnicity, with one or two children: a.One subgroup with one child < 6 years of age and pregnant with a 2nd child b.One subgroup with one child < 6 years of age and an infant between 1-to-12 months of age.
2.Each caregiver is over 18 years of age.
3.Caregivers are living together in the same household and are either married or living with a partner.
4.Families living independent of parents’ families of origin.
5.Both caregivers fluent in communicating in English.

Exclusion Criteria:
1.One or the other caregiver cannot understand or speak English
2.Caregivers are under 18 years of age.
3.Caregivers not living together
4.Caregivers not living independently of their families of origin
5.Single-parent families with no live-in partner.
Children's Health, Prevention, Mental & Behavioral Health
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Study Locations

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Location Contacts
Altoona, PA ,
Carlisle, PA ,
DuBois, PA ,
Erie, PA ,
Greater Philadelphia Area, PA ,
Greater Pittsburgh Area, PA ,
Harrisburg, PA ,
Hazleton, PA ,
Hershey, PA ,
Mont Alto, PA ,
Reading, PA ,
Schuylkill Haven, PA ,
Sharon, PA ,
State College, PA ,
Wilkes-Barre/Scranton Area, PA ,
Williamsport, PA ,
York, PA ,