We are trying to better understand the ways in which people contract their muscles. Specifically, we want to learn more about how connections between our muscles influence how they produce forces. Participants in this study will have their calf muscle group activated while we record the individual muscles' electrical activity and the length of the muscle fibers. This research will help us to understand the underlying mechanical function of muscles in a more realistic context. This understanding may also have profound implications for current computer models of muscles, which most often ignore the connectivity between muscles.

There will be one in-person visit. At this visit, participants will have their calf muscle group activated while we record the individual muscles' electrical activity and the length of the muscle fibers.

$50

The goal of this study is to explore how different ways of practicing, as well as paying attention, affect learning to walk while using an ankle exoskeleton. This pilot study will look at whether changing the settings of the exoskeleton and walking conditions frequently or not very often helps people walk better in follow-up tests. It will also examine if asking people to focus on their body (internal focus) or on their surroundings (external focus) improves their walking.

There will be three in-person visits over two days, walking in a lower limb exoskeleton will occur at all three visits.

$40.00

The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs (Selective Serotonin reuptake inhibitors) and those with depression who are prescribed and taking SNRIs (Serotonin-Norepinephrine reuptake inhibitors).

For this study, you will be asked to come into the lab for a screening visit, a maximal exercise test visit, and one experimental visits. *Before the experimental visit, you will be asked to swallow a temperature-sensing capsule to measure your internal body temperature 1-2 hours prior to arriving at the lab. During the passive heat stress experiment, you will wear a suit lined with tubing through which hot water will run, causing your body to warm up. We measure your sweat and skin blood flow responses.

50

The purpose of this voluntary research study is to learn more about an investigational drug (also known as the “study drug”) called ivaltinostat as a possible treatment for metastatic pancreatic adenocarcinoma.

Participants will be required to attend all study visits, receive drug treatment, have blood drawn, imaging assessments and tumor biopsy if needed

Adults recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, we are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load amongst adults.

At their home, participants will perform three nasal and oral rinses per day for 4 days and self-swab the nose and mouth before and after each morning rinse to collect specimens under the guidance of a zoom visit. On the morning of the 5th day participants will also self swab the nose and mouth for a final collection specimen. Participants will answer questions on an app and online platform.

100

Most individuals with ALS experience changes in speech and swallowing over the course of the disease. In some, these are their initial indication of ALS. Identifying these changes, which may be rapid in some individuals, is complicated by the recent acceleration of virtual care delivery. This is a longitudinal home study of ALS patients to assess speech and swallowing function through use of smartphone application. The overall hypothesis is that this monitoring protocol can be used in a way that, 1) is satisfactory to the patient, 2) performs at least as well as standard clinical measures of dysarthria and dysphagia, and 3) resolves the development of emergence of speech and swallowing pathologies in ALS. Patients enrolling in this study will participate for approximately 24 weeks, during which they will have swallowing and speech tests performed, complete surveys, and perform audio recordings of speech on their cellphone. Healthy controls will be enrolled to judge the intelligibility of speech samples provided by patients in the study.

Patients enrolling in this study will participate for approximately 24 weeks, during which they will have swallowing and speech tests performed, complete surveys, and perform audio recordings of speech on a cellphone.

340

In this study, we will evaluate the factors that affect how well human listeners can perceive connected speech despite variability in the speech signal. Participants in the study will be asked to judge speech segments presented to you over headphphones. For instance, we may ask you to indicate whether the sound you hear a "pa" or "ba".

The purpose of this project is to screen potential participants for multiple research studies being conducted by tobacco researchers at Penn State Hershey. Since there are multiple IRB approved studies enrolling at Penn State Hershey with similar but not identical inclusion/exclusion criteria, it is more efficient for the researchers and participants to have one phone number to call initially for basic screening. After completing this, the participant can be redirected for more specific screening if they are found to be potentially eligible for one of the studies.

Participants will fill out a 5-minute survey on tobacco use in order to find out which study they may be eligible for.

Depends on study

We are trying to characterize the movement of a shooter in a VR environment.

The study consists of one visit lasting approximately 30-40 minutes: 10 minutes for VR setup, 15 minutes for simulated test, and 5-15 minutes for post-experiment survey. During the simulated test, participants will be asked to move around in the environment and shoot NPCs.

$20

This study will examine the impact of age, sex, and racial/ethnic background on vascular function.

There will be three (3) in-person visits: one screening, one experimental visit, and one visit to return equipment. Equipment includes a 24-hour Ambulatory Blood Pressure monitor and an 8-day accelerometer (physical activity tracker). Blood will be drawn at the screening and experimental visit. Participants will undergo tests for cardiovascular measures during the experimental visit.

$100

The propose of this voluntary research study is to look at the effect of little cigars on biomarkers of potential harm with a focus on oxidative stress and inflammation.

Subjects will attend 3 in-person study visits over 3 weeks. Starting at week 1, they will be asked to smoke a certain little cigar or their own cigarette each week for each of their visits. They will be asked to answer a series of questionnaires and to provide biosamples (Exhaled Carbon Monoxide, Exhaled Breath Condensate, Blood, Saliva, Buccal Cells, Urine and SIFT-MS).

600

The purpose of this study is to examine how various factors, such as the acoustics of the environment and background noise, affect the understanding of speech.

Researchers in the Graduate Program in Acoustics are looking for participants for a study related to speech intelligibility and room acoustics. The experiment will take approximately 1.5-2 hours of your time. The experiment will consist of listening to sentences and transcribing them under different acoustic and noise conditions. Your head movement will also be measured through a motion sensor. The compensation for your voluntary participation is a $25 Amazon gift card.

$25 Amazon gift card

The purpose of this study is to determine whether patients with high-risk smoldering multiple myeloma when treated with daratumumab in addition to lenalidomide and dexamethasone live longer when compared to patients with high-risk smoldering multiple myeloma patients treated with lenalidomide and dexamethasone. We would also like to know whether the period of time in which patients are free of multiple myeloma symptoms differs between the two treatment groups. Daratumumab is already approved by the FDA for use in combination with lenalidomide and dexamethasone in people who have received at least one prior medicine to treat multiple myeloma. It is not, however, approved for treatment of smoldering multiple myeloma, either alone or when combined with the treatment regimen of lenalidomide and dexamethasone, and therefore is considered experimental. Lenalidomide and dexamethasone are approved for treatment of multiple myeloma (symptomatic) but not for the treatment of smoldering multiple myeloma and therefore is also considered an experimental treatment.

We are asking you to take part in a research study because you have high-risk smoldering multiple myeloma. We do research studies to try to answer questions about how to prevent, diagnose, and treat diseases like cancer.

This study aims to evaluate the effect of providing one avocado per day for consumption over a six month period on established health parameters, including visceral adiposity, hepatic lipid content, markers of metabolic syndrome and high sensitivity C-reactive protein (hsCRP), compared to habitual diet. The primary aim of this study is to determine whether providing one avocado per day for consumption for six months will produce a greater decrease in visceral adiposity as measured by magnetic resonance imaging (MRI) in Americans with an increased waist circumference as compared to habitual diet.

The is a drug study to compare the progression free survival of the three drug combination Ibrutinib-Obinutuzumab-Venetoclax (IOV) to Ibrutinib-Obinutuzumab (IO) in untreated CLL patients younger than 70 years of age.

pt will either get ibrutinib and obinutuzumab, plus venetoclax for up to 19 months or will get ibrutinib and obinutuzumab until doctor decides disease is getting worse or the side effects become too severe. After 19 cycles completed, doctor will follow condition every 90 days until progression and watch for side effects. They will check pt every 3 months for 2 years. After that, they will check pt every 6 months for 3 years. After that, they will check pt every 12 months for 5 years

In this study, we investigate a recommender system for public, local events in Centre County, PA. Currently, there is no platform that aggregates all the events that take place in a community. The data is fragmented among many platforms and it can be difficult for people to find interesting things to do. Participants will interact with our software system and discuss their experiences through a survey and/or interview.

This is a user study to investigate the environmental characteristics of virtual reality (VR). This study will provide empirical evidence of the essential characteristics based on users’ feedbacks. During your visit, you will receive a brief training about using a VR headset and navigating in the virtual environment. After the training, you will explore the virtual environment, complete tasks in VR, and answer questions regarding your feelings to our VR application.

Participants in this study will receive a drug called ribociclib with the endocrine therapy of your physician’s choice. Ribociclib is taken as a pill. Endocrine therapy is taken as a pill or given as a shot. You will have tests, exams and procedures that are part of your regular care and for study purposes. Also, as part of routine care, you will be checked every 4 to 12 weeks to make sure your cancer hasn’t come back. You will receive ribociclib combined with endocrine therapy for up to 3 years. After that you will continue endocrine therapy alone for another 2 years (5 years total) as part of your regular care.

Participants will be required to: - receive ribociclib along with standard endocrine therapy drugs - have blood drawn - imaging scans (CT, PET-CT, bone scans, mammograms, MRI) - keep a medication diary - optional biopsy - ECG-a test that looks at the way your heart beats - ECHO-a test that looks at the way your heart pumps

This research is being done to find out the safety of propranolol and, identify the maximum tolerated dose of propranolol that can be administered in combination with pembrolizumab in patients with unresectable stage III and stage IV melanoma. This study will evaluate this novel combination of pembrolizumab and propranolol to see what effect it may have on how your cancer responds to the treatment combination.

Phase II *propranolol twice a day. *pembrolizumab by an infusion every 3 weeks. *May receive treatment with pembrolizumab and propranolol for up to 24 months from the time they began treatment with the combination. Procedures to be done:.  A medical history  A physical exam  ECOG Performance Status  Perceived Stress Scale questionnaire  An assessment of tumor by scan. Scans may include: o Computed tomography (CT), with or without contrast. o Magnetic resonance imaging (MRI) or head CT with IV contrast  Blood tests: o Approximately 2 tablespoons for routine testing, such as a complete blood count and a comprehensive metabolic panel  Pregnancy test  Urinalysis  Electrocardiogram  A sample of tumor from a previous biopsy or sample taken Phase 1 portion of the study, these evaluations/tests will also occur on Day 8 of Cycle 1  Review concomitant medications.  Physical Exams  ECOG Performance Status  Perceived Stress Scale questionnaire  Blood tests: o Every 3 weeks o At 3 weeks and 6 months or discontinuation of treatment (whichever comes sooner) and at disease progression o Every 3 weeks: Approximately 1 tablespoon for tests that monitor your blood sugar levels and thyroid function o Every week for the first 6 weeks then every cycle for another 6 weeks  Assessment of cancer by CT or MRI. These assessments will be performed every 12 weeks(± 14 days). The first assessment will be after completing Cycle 4. If their cancer is found to be improving, repeat the CT and MRI scans in about 12 weeks.  EKG: Once treatment begins, this will be done every cycle prior to receiving pembrolizumab for the first 5 cycles.  Adverse events  Tumor Biopsy: A tumor biopsy (only in phase II) will be obtained at the 12 weeks after initiation of treatment.Tumor biopsy will be optional for phase II patients.. Safety Follow-Up: After all study treatment has stopped, end of treatment visit, which will be approximately 30 days after their last dose of study drug or before starting a new treatment  Medical History:  Concomitant medications  complete physical examination  ECOG Performance Status  Perceived Stress Scale assessment  Adverse events  Survival status  Blood tests: o Follow- Up Phase 3 Month and 6 Month Follow- up After Treatment blood collected. The following assessments will be performed at 3 months and 6 months after the safety follow-up visit. Review concomitant medications  Physical examination  ECOG Performance Status  Adverse events  Survival Status  Blood tests:  CT of chest, abdomen and pelvis, or other areas as needed Long Term Survival Follow- Up: After your 3 month and 6 month follow up visits or if they progress, will be contacted every 6 months (±30 days)

During the COVID-19 pandemic, Asian Americans have faced a rise in overt racism, with thousands of hate incidents reported. This has had a bigger impact on young Asian American adults, leading to emotional distress and health problems. A theory by Harrell suggests that experiencing racial discrimination can harm mental and physical well-being due to stress. Past studies have shown a connection between racial discrimination stress and health issues like obesity and mental disorders. However, there's a need to understand the cultural and emotional factors involved. This research aims to explore how racial discrimination affects Asian Americans' food choices by looking at stress responses and cultural influences. Using surveys, experiments, psychophysiology, and virtual reality, the study will investigate how cultural identity affects stress reactions and subsequent food decisions after racial discrimination experiences.

Hello, We are recruiting Asian Americans with Japanese, Chinese, or Korean heritage for a paid research study. We want to understand how racism affects food choice in a virtual reality (VR) environment. To participate in this study, you will need to complete an informed consent form, and answer questions prior to your arrival at the lab. You will have to come to the lab to watch a video of anti-Asian racism incidents that happened during the COVID-19 pandemic, and answer questions before and after the video. Last, you will make food choices in the VR environment. Participation will require three hours or more of fasting before arrival at the lab. You will be paid $25 in a gift card for your participation. If you come to the lab but do not complete the study, you will still be paid. Please continue to the next page to read the informed consent if you are interested in participating. If you are not, please exit this page. https://redcap.link/lp1wq7uu

$25 Amazon gift card

This research looks at whether atherosclerosis, which is the buildup of fatty deposits in the arteries, affects how nitric oxide works to control blood pressure. Nitric oxide is a substance in the body that helps blood vessels relax and widen. By studying how these two factors interact, we hope to better understand them, which could lead to improved treatments for patients in the future. However, this study does not provide treatment for patients with heart or blood vessel diseases.

You will be asked to participate in one visit and to receive a medication called sublingual nitroglycerin. Various physiological measurements will be recorded during this time including microneurography, blood pressure, heart rate and blood flow.

You will receive $25 per hour for your participation in this research study

Using micro-RNA in saliva coupled with survey data as a prognostic tool with the ability to guide clinical management of concussions

During their baseline visit participants will complete a saliva swab, surveys, balance test and brief neurocognitive test. Day 7, participants will complete a saliva swab and 2 surveys. Day 30, participants will complete a saliva swab and 4 surveys. The baseline visit is the only in-person visit, day 7 and day 30 are done remotely. All surveys are completed online and day 7 and day 30 saliva swabs are sent home with the participants and sent back in a prepaid mailer on day 30.

$40

The purpose of this study is to collect normative data related to orofacial (lip/tongue) somatosensation (touch sensation) in healthy adults across the adult lifespan. This data will be compared to a select clinical population, those with Parkinson's disease.

There will be one data collection session lasting approximately 90 minutes. Participants may be invited back for a second session approximately 4 weeks later to repeat the testing session During the sessions, participants will answer a series of questions about their eating and drinking preferences, they will be asked to provide a speech sample by repeating a series of syllables, words, and sentences, as well as providing a spontaneous speech sample. All participants will be asked to complete a series of sensory tests where small plastic objects are placed on their lip, tongue, and finger tip. Participants will be asked when they feel the pressure/texture and when they do not.

The purpose of this voluntary research study is to find out more about changes in the brain as we age. This study is trying to determine if magnetic resonance imaging (MRI), genetic variations, amyloid positron emissions tomography (PET), neuropsychological testing, and smell tests can be used to evaluate memory loss and cognitive impairment.

You will be asked to come to the research site once a year for 5 years. Annual (and semi-annual) procedures include completing smell tests, neuropsychological tests, magnetic resonance imaging (MRI), interview. One-time procedures include provide blood sample, amyloid PET scan (if indicated), and optional lumbar puncture.

Up to $300 a year

This research is being done to find out the effects of head cooling on cognition, brain activity as seen in EEG scans, inflammation of the brain, and mood in healthy subjects. What is specifically meant by healthy subjects in the context of this study is subjects who are not currently recovering from a traumatic brain injury.

This study includes an 8-day regimen of head cooling or rest at an average of 30 minutes per day, non-invasive cheek swabs used to collect saliva samples, and non-invasive brain activity testing and questionnaires.

$40

Using small focus groups, this work aims to understand the experiences, challenges, perceptions, and opportunities for the use of conversational agents (e.g Amazon Alexa and Siri) for users with visual or hearing impairments, with the goal of developing more accessible and inclusive systems.

This study will examine various factors within the home of children adopted from the child welfare system between the ages of 4 and 10 that may impact their development. The first visit will occur remotely via Penn State Health Microsoft Teams; the second visit is optional and will occur within 4 weeks of the first visit at the Transforming Lives of Children Center in Harrisburg, PA; and the third visit will occur one year after the first visit, when research staff will travel to participants' homes. This research will help understand the factors that impact the development of children adopted from the child welfare system and how we may better serve these children and their families.

The child and parent will be asked to complete interviews, questionnaires and various tasks. Parents may also be asked to complete questionnaires online. Participation will last for one year and include the following: -One visit occurring remotely via PSH Microsoft Teams -One visit at the Transforming the Lives of Children Center in Harrisburg, PA, four weeks after Zoom visit (optional) -Final visit at home will occur one year after the first Zoom visit

$225

This is a multicenter evaluation of seladelpar, administered as a once-daily oral capsule, in a placebo-controlled study in subjects with Primary Biliary Cholangitis (PBC). This study (156 weeks) will enroll approximately 192 subjects. The population to be studied is patients with PBC and compensated cirrhosis restricted to Child-Pugh (CP)-A or CP-B. Primary Objectives Efficacy: To evaluate the effect of seladelpar compared to placebo. Safety: To evaluate the safety of seladelpar over 156 weeks of treatment compared to placebo. Study visits: up to 18 in person visits. Blood samples will be collected at each visit for safety measures as well and questions about your health and medicines you might be taking.

There will be 18 in person visits. safety assessments will be conducted at each visit. Participants will be required to take study drug as directed.

$1350

This study will involve elderly humans walking on a treadmill transitioning through prechosen speeds.

There will be one, two hour in person visit. Participants will change into specific lab provided clothing for study and reflective stickers will be placed on participants by the researcher. Participants will then get on the treadmill and will walk at prescribed constant speeds for about 5 minutes total. Then participants will perform 10 speed transition trials each of which lasts about 4 minutes.

$15

Crohn's disease is a chronic, incurable inflammatory disease of the digestive system. Current treatment advancements need to be improved to meet patient's needs. This study is a 24-week treat-through design (meaning Induction and Maintenance treatment without re-randomization) using either monotherapy (single drug) or combination therapies (two drugs) in moderate to severe Crohn's disease. The participants who are responders will be able to continue treatment in Long Term Extension (LTE) study phase, weeks 24 to 96. This study aims to evaluate the safety and effectiveness of each combination therapy compared to conventional monotherapy.

Subjects will be required to sign the informed consent, and attend in person visits. They will be required to complete daily eDiary, and have tests and procedures done per protocol timeline. Procedures include blood tests, colonoscopies with biopsies, ECG, vitals and physical exam. Pregnancy testing will be done for WOCBP.

$77 per completed visit and $100 for completed endoscopy. Travel will be reimbursed up to $52 for each visit. You will be given $24 for meal if the visit required fasting.