This phase III trial compares the effect of giving triptorelin vs no triptorelin in preventing ovarian damage in adolescents and young adults (AYAs) with cancer receiving chemotherapy with an alkylating agents. Arm A: Patients receive triptorelin intramuscularly (IM) up to 14 days prior to standard chemotherapy. For patients whose chemotherapy exceeds 24 weeks, a second dose of triptorelin may be given 24 weeks after the first dose at the treating physician's discretion. Patients also undergo blood sample collection throughout the study. Arm B: Patients receive standard chemotherapy. Patients also undergo blood sample collection throughout the study.

A blood sample taken for the study; about 15 mL (one tablespoon of blood) will be drawn at each of these four times: before cancer treatment begins; at the end of cancer treatment;1 year after the end of cancer treatment; 2 years after the end of cancer treatment.

This is a drug study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL).

All subjects on study will be treated with the medicine blinatumomab. Some subjects will also receive an additional medicine, nivolumab. Subjects will receive treatment on this study for about 1.5-2.5 months. Treatment is divided into 1-2 cycles. Before the start of therapy, patients will have a bone marrow evaluation for Immunophenotyping and will have their bone marrow tested for MRD on Day 36 of cycle 1 and Day 36 of cycle 2 during treatment.

This study aims to understand how parents make decisions about enrolling their child in an early phase or precision medicine cancer clinical trial. We will explore parents’ decision-making process, values, goals, and views of risks and benefits, as well as their psychosocial outcomes. Participants will be asked to complete a set of questionnaires, and they may choose to take part in an optional interview to discuss their decision-making in more depth. Please note that parents whose child was offered a upfront standard of care clinical trial at diagnosis (i.e., a phase III trial comparing treatments that are already accepted and evidence-based, rather than novel or experimental agents) are not be eligible to participate.

This study entails completing an anonymous questionnaire asking items related to you and your child’s demographic information, how you are doing on key psychosocial outcomes (e.g., psychological distress, anxiety, depression), your perceived moral obligation, your emotional expressivity and authenticity, your coping style, your level of trust in the provider, and your perceived social support. This survey may take up to 1 hour to complete. At the end of the questionnaire you will be asked if you would be interested in participating in a one-time 30-60 minute conversation to provide a more in depth discussion on these topics. If you are interested, a study team member will reach out to you to provide more information and have you sign a separate consent form for that part of the study.

This study examines how physical health and emotional well-being differ across ages in children, adolescents, and young adults with cancer, cancer survivors, and individuals without a history of cancer. The goal of the study is to better understand how experiences such as fatigue, pain, sleep, physical activity, mood, anxiety, and quality of life vary at different ages and at different points in the cancer journey (during treatment versus after treatment), and how factors like treatment intensity and family resources may influence these experiences. Participants will be asked to complete a set of online questionnaires about their physical health, daily functioning, and emotional well-being. No medical procedures or treatments are involved.

Participants will be asked to complete a set of online questionnaires about their physical health, daily functioning, and emotional well-being. No medical procedures or treatments are involved. The questionnaires will take approximately 45 minutes to complete. - For children aged between 2 and 7 years old, we ask that parents report on behalf of their child. - For children/adolescents aged between 8 and 17 years old, we ask that they complete the survey themselves. Parents may also report on behalf of their child if the child is unwilling or unable to complete the survey themselves. - For young adults aged between 18 and 24 years old, we ask that they complete the survey themselves. Parents may not complete the survey on their behalf.

This study is being done to answer the following question: How can a home-based physical activity program best meet the unique language and cultural preferences of Hispanic or Latino/a AYA survivors of cancer? In order to develop a culturally-tailored physical activity program that works well, we know we must address the unique language and cultural needs of Hispanic or Latino/a AYA survivors of childhood cancer. We are doing this study because we want to find out what ideas work best to encourage Hispanic or Latino/a childhood cancer survivors to stay physically active after receiving cancer treatment.

complete participant contact forms, surveys and questionnaires, social media interaction with participant group, wearing an exercise tracker (FitBit).

($30 per each qualitative interview completed

The GAME-ONc Study aims to explore how video games can support teens and young adults going through cancer treatment. We will talk with adolescents and young adults with cancer, their parents, and healthcare providers to better understand what emotional, social, and practical challenges young people face during treatment, and how a video game intervention might help. The study will also ask participants what kinds of game features they’d like to see, such as whether the game should be single-player or involve someone else, what topics it should include (like coping strategies, health behaviors, or ways to connect with others), and how to make it easy and enjoyable to use. Ultimately, the feedback from this project will guide the design of a video game prototype tailored for teenagers and young adults with cancer, setting the stage for future testing and development.

Participants will complete a brief demographic and gameplay preferences questionnaire and then take part in a one-time focus group session (approximately 1-1.5 hours) conducted via Microsoft Teams or in person. During the focus group, participants will discuss psychosocial needs of adolescents and young adults with cancer and share their opinions on desired features, content, and usability of a proposed video game intervention. The session will be audio and video recorded for research purposes.

100

The overall goal of this study is to determine the effects, good and/or bad, of a new treatment regimen that combines dasatinib or imatinib to chemotherapy with blinatumomab in patients with Ph+ and ABL-class Ph-like B-ALL. In this study, you will receive blinatumomab with chemotherapy and dasatinib or imatinib.

The overall goal of this study is to determine the effects, good and/or bad, of a new treatment regimen that combines dasatinib or imatinib to chemotherapy with blinatumomab in patients with Ph+ and ABL-class Ph-like B-ALL. In this study, you will receive blinatumomab with chemotherapy and dasatinib or imatinib. All patients on this study will receive the immunotherapy medicine blinatumomab in addition to chemotherapy plus dasatinib or imatinib. The treatment on this study takes about 2 years. It is divided into 7-8 phases of therapy. Participants will be asked to do some optional tests that will help to learn more about their immune system. To do these tests, we would like to take about 2 teaspoons (6-10 ml) of peripheral blood and about 1 teaspoon (3-5 ml) of bone marrow (at the time of standard procedures) at different time points. These tests will not require additional needle sticks or additional procedures. There will also be optional collection of bone marrow and/or blood for banking for future research.

This is a dietary treatment study that looks into the effects of the consumption of yogurt on child brain activity, behavioral control, memory, and gut health. This knowledge may help us better understand the health benefits of fermented dairy like yogurt. 60 children, ages 8-10 years-old, will complete 2 in-lab sessions that include problem-solving games, learning tasks, and IQ tests. This study also uses child-friendly brain scanning technology that uses light to record brain activity. Between the two sessions, children will consume either 1-2 yogurt or juice beverages per day for 4-weeks and also collect a stool sample before each session. Throughout the study, parents and children will complete a series of surveys that assess child behaviors, behavioral control, sleep habits, and more.

We are looking for children to help us learn about how different beverages can affect brain and gut health. The study consists of 2 visits to our facility in Chandlee Lab, located on the University Park Campus. In both visits, your child will play problem-solving games, take an IQ test, and wear a functional near-infrared spectroscopy (fNIRS) cap which uses light to measure your child's brain activity while playing a computer game. You and your child will also fill out questionnaires. We will provide you with supplies of a beverage to take home that your child will drink each day between the 2 visits (about 4 weeks). We also ask that you collect two stool samples from your child using our provided stool sample collection kits.

$300.00-380.00

This study examines how children plan and correct their speech while describing pictures. Children between the ages of 6 and 8 will complete several language and thinking tasks and then describe pictures in different situations. Researchers will listen for natural speech behaviors such as pauses, repetitions, and self-corrections. The goal is to understand whether these speech patterns are related to children’s language abilities. The findings may help researchers and clinicians better understand how children produce sentences and may eventually support improved methods for identifying children who may need help with language development.

There will be one session (60-75 minutes including breaks) in person or via Zoom. Parent completes a 5-10 minute questionnaire. Child completes language tasks (TONI and TILLS subtests) and a picture description task with audio recordings. A second 45-minute session may be scheduled if the child needs a longer break in the first session or could not finish it.

$50

We are developing a tool to help parents of young children practice communication, relationship building, and listening skills.

This is an online study where parents will be asked how they might verbally respond to common situations that come up in everyday life. Participants will also complete questionnaires on their and their child's thoughts, feelings, and behaviors.

$100 maximum