Refine your search

Search Results within category "Prevention"

Search all categories
Study matches: 18

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Penn State Hershey Sitting and Health Study

This study aims to examine the effect of pedaling a compact elliptical device at the desk on employees' work productivity. This study also aims to evaluate the effect of different types of incentives on promoting desk-based pedaling.
Liza Rovniak at activitystudy@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Penn State Hershey full time employee
Overweight or obese
Spend at least 5 hours per day sitting at a desk
Have eligible overweight/obese coworker who can do study together with you
18-70 years old
Exclusion Criteria:
Currently pregnant
Planned surgical or medical treatment that will prevent ability to complete study
Heart condition, or chest pain during physical activity
Planned travel or relocation during study period
Already have desk cycling device or treadmill at desk
Show full eligibility criteria
NCT03274635
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Feasibility and acceptability of mind-body strategies to increase physical activity and reduce health disparities in rural breast cancer survivors

The purpose of this study is to explore feasibility and acceptability of mind-body strategies to increase physical activity and reduce health disparities in rural cancer survivors and inform the cultural-adaptation of a physical activity intervention for rural breast cancer survivors.
Hannah Guthrie at hdpar@psu.edu or 8148630132
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
At least 18 years of age
Received a cancer diagnosis previously
Lives in central Pennsylvania
Exclusion Criteria:
Below the age of 18
No history of cancer
Lives outside of the Penn State Cancer Institute's 28-county catchment area
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team

The Effect of Chronic Consumption of Popular Spices on Risk Factors for Cardiovascular Disease (CVD), Inflammation & Immune Function, and Diet Satisfaction

We propose to conduct a 3-period crossover, controlled feeding study designed to evaluate the effects of the most commonly consumed spices in the U.S. on CVD risk factors, inflammation & immune function, and diet satisfaction in participants at risk for CVD. The three test diets that will be fed to the study participants are: a Low Spice Diet (SD-Low; < 0.5 g/day of all spices); a Moderate Spice Diet (SD-Mod; 3 g/day of all spices, which approximates average spice intake in the U.S.); and a Culinary Spice Diet (SD-Culinary; 9 g/day of all spices). All three diets will be based on an Average American Diet (AAD), which will be designed to represent the usual dietary intake in U.S. The test diets will be designed to provide approximately 32% calories from fat (which reflects current total fat intake), 11% of calories from SFA and 3400 mg/day of sodium. The SD-Culinary will provide a culinary quantity of spices, 9 g/day per 2000 calories (which is 3 times the average spice consumption in the U.S.). All test diets will be designed with the same foods but will only vary in the quantity of spices provided. All test diets will be fed for 4 weeks each followed by a minimum 2-week break between test diets (during which time participants will follow their self-selected habitual diets). The spices will be incorporated into familiar foods in a highly palatable manner. The objective of the present study is to evaluate the effects of a spice blend on major CVD risk factors (LDL-C, BP, vascular health, inflammation and oxidative stress), as well as diet satisfaction.
Kristina Petersen at kup63@psu.edu or 814 863 8622
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
30-75 years of age
BMI 25-35 kg/m2
Not taking cholesterol, glucose or blood pressure lowering medication
Not currently smoking
Free from cardiovascular disease, stroke, kidney or blood vessel disease
Exclusion Criteria:
BMI <25 kg/m2
Taking anti-hypertensive, lipid or glucose lowering medication
Vegan or vegetarian
Pregnancy or lactation
Weight loss of >10% of body weight in the last 6 months
Show full eligibility criteria
NCT03064932
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

E-cigarette Use among College-Age Individuals in Association with Biomarkers of Bone Health

Vitamin D and cigarette use are well-known to influence bone health. However, we know little about whether e-cigarettes may also play a role. We invite you to help us learn more about whether e-cigarette use may influence vitamin D levels and/or bone health. Participation requires one in-person visit (approximately 20 minutes in length) and questionnaire completion (approximately 40 minutes in length).
Cyndi Flanagan at chf117@psu.edu or 814-863-7126
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 18 to 35
Female
e-Cigarette User
Exclusion Criteria:
Cancer
Liver Disease
Kidney Disease
Taking Drugs that Interfere with Vitamin D Metabolism
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Acoustical Model of Mach Cut-off Flight

Researchers in the Graduate Program in Acoustics are looking for participants for a study related to aircraft noise. The experiment will take approximately 1-1.5 hours of your time. The experiment will consist of listening to aircraft flyovers. You will be asked to rate the stimuli on a variety of scales. The signals will be played at a controlled volume. The compensation for your voluntary participation is $15 (in the form of a gift card) and a chance to win a $50 gift card (odds are about 1 in 40).
Nicholas Ortega at njo5068@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Normal hearing (at or below 25 dB HL)
Exclusion Criteria:
Less sensitive hearing (above 25 dB HL)
Participation in the previous study
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Ground reaction forces in running: effects of grade and surface

Overuse injuries in running are very common among all levels of running. Although influenced by many factors, two variables that may play a large roll in running injury risk are running surface and grade. A high impact peak on a vertical ground reaction force (GRF) profile is associated with an increased risk of injury. Just recently, has the ability to measure GRF in real world become available. Therefore, this study will investigate the effects of running surface (grass and pavement) and running slope (uphill, downhill) on the vertical GRF profile in recreational runners outdoors.
Heather Porter at hjp9@psu.edu or 724-679-1487
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Aged 18-50 years
No current cardiovascular conditions; heart condition, high blood pressure, chest pain
No lower body musculoskeletal injuries in the previous 3 months
Reports running more than or equal to an average of 10 miles per week for the past year
Exclusion Criteria:
Known or suspected heart disease or angina, and uncontrolled hypertensio
Pregnancy women
Individuals who are not yet adults, all subjects must be over 18 years old
Adults unable to consent -No cognitively impaired adults will be involved in the study
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Randomized Feasibility Study of Patient Navigation for Women Identified with Dense Breast Tissue on a Breast Cancer Screening Mammogram - AWARE

This research is being done to find whether a telephone-based navigation improves knowledge, attitude, and behaviors related to dense breast tissue, and if the navigation changes the rate at which the women receive supplemental breast cancer screening, compared to usual care. Approximately 60 women between 40 and 74 years of age with dense breasts will take part in this research study across central Pennsylvania. Participants will be completing surveys by phone up to four times over the 12-week study.
Sol Rodriguez-Colon at srodriguez@psu.edu or 717-531-5190
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Female
Age: between 40 and 74 years of age
Had a screening mammogram with the following findings: negative or benign, heterogeneously dense or extremely dense breasts
Exclusion Criteria:
History of breast cancer
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team

Brain Mechanisms of Overeating in Children

Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Marissa Reynolds at mlr5246@psu.edu or 8148655285
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
No learning disabilities
Right handed
Age 7 or 8
No medications known to influence cognative function, taste, appetite or blood flow
The biological mother and biological father must have a body mass index either between 18.5
•25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 (high-risk group) and must be available to attend the visits with their child.
Exclusion Criteria:
Children would be excluded if they are not within the age requirements (< than 7 years old or > than 8 years-old at baseline).
Children will be excluded if they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow.
Children will be excluded if they are left handed,
Children will be excluded if they report being claustrophobic
Families will be excluded if the biological mother/father has a body mass index < 18.5 kg/m2 or between 25-29.9 kg/m2.
Show full eligibility criteria
NCT03341247
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Pilot testing of fMRI protocols in children

Pilot testing of fMRI protocols in children
Marissa Reynolds at mlr5246@psu.edu or 8148655285
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Children must be between the ages of 6-10 years-old at the time they participate in the phone screening.
All children will be physically healthy and without diagnosed learning disorders.
Exclusion Criteria:
Children will be excluded if they are younger than age 6 or older than age 10 years.
Children will be excluded if they have a diagnosed learning disorder or are not physically healthy.
Show full eligibility criteria
NCT03338634
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Patient Centered Exercise Coaching into Primary Care

This 36-month study will enroll 2,100 adults who are 65 years old or older, and who have had a fragility fracture (typically due to osteoporosis, or weak bones). The study will compare future fragility fractures and serious fall-related injuries in participants who are randomly assigned to either a coached exercise program, or a control group. Participants will also be asked about a variety of topics, including their ability to do daily tasks, concerns about falling, loneliness, and depression. All participants will receive educational materials. Participants will visit the Hershey Medical Center twice (at the beginning and end of the study), and be asked to complete a brief phone survey related to falls and injuries every 4 months. Participants may also receive a bone density scan. Participants in the coached exercise program will work with a coach and do moderate-intensity strength and balance training, and light aerobic activity, either in a community-based group setting, or in their home.
Abbey Fisher at wisestudy@pennstatehealth.psu.edu or 844-598-9598
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
65 years and older
Previous fragility fracture in past 10 years
Willing to try exercising
Exclusion Criteria:
Blood pressure reading is equal or greater to 180 systolic or equal or greater to 110 diastolic or heart rate is equal or greater to 120 bpm
Health care professional has told you to not exercise or only exercise when supervised by a professional
Unable to obtain PCP's consent to participate
Unable to walk 100 feet without using special equipment (eg. walker)
Show full eligibility criteria
NCT02714257
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging

Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sean Shank at sqs6071@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Men and Women aged 18-30 and 65-80 years old
Healthy weight
Not taking high cholesterol/high blood pressure medication
Non-diabetic
Exclusion Criteria:
Tobacco use
Illegal/recreational drug use
Pregnant or breastfeeding
Allergy to latex
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

GLNE 010: Validation and Comparison of Biomarkers for the Early Detection of Colorectal Adenocarcinoma

The purpose of this study is to see if stool, urine or blood can be used to find colon cancer as early or earlier than colonoscopy can. The researchers want to use these samples to learn about specific proteins or genes (also called biomarkers) that may indicate if someone has colon polyps (pre-cancer), colon cancer, or an increased risk for developing colon cancer. The researchers are part of a National Cancer Institute program called the Early Detection Research Network (EDRN). We have some biomarkers that are very promising, so we are testing them (“validating them”) in this study.
Jessica Wright at jwright3@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Scheduled for colonoscopy in the next 4 months
age 50 and older who are undergoing their first ever screening colonoscopy
adults age 70 and older with colonoscopy more than 9.5 years ago
willing to provide blood, urine and stool samples
able to tolerate removal of 5 tubes (3.5 tablespoons) of blood
Exclusion Criteria:
positive stool blood test (FIT/FOBT) in the past year
ever had colon or rectal cancer
history of inflammatory bowel disease
confirmed hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, HIV or chronic viral hepatitis
cancer diagnosis or treatment in past year
Show full eligibility criteria
NCT01511653
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Can more sleep lead to improved metabolism in college students?

The purpose of this study is to examine how a sleep extension protocol affects glucose metabolism in college students. Study participants will be asked to participate in 2-week protocol with three in-person visits. Sleep will be measured in naturalistic settings using wearable devices (actigraphy). The first week will be a baseline assessment of habitual sleep followed by a second week of sleep extension. At the first visit we will obtain consent, collect subject information, and distribute study materials and devices. The second and third visits will take place the Clinical Research Center and will include an evaluation of collected sleep data and a meal response test, in which participants will eat a standardized breakfast and blood samples will collected frequently for approximately 3 hours.
Nikki Nahmod at sweetsleep@psu.edu or 814-867-5977
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Undergraduate student ages 18-25
Able to extend sleep by 1 hour per night for 1 week
Available for two consecutive weeks
Sleep less than 7 hours per night, on average, per week
Willing and able to fast for 12 hours, willing and able to eat a standardized breakfast
Exclusion Criteria:
Uses tobacco or nicotine products (including cigarettes, chewing tobacco, e-cigarettes, vaping)
Medical diagnosis or history of cardiovascular disease, diabetes, or other chronic disease
Certain medications
Diagnosed sleep disorder
Recent history of working nightshifts
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Prevention of the Onset or Worsening of Psychiatric Disorders Subsequent to Child Maltreatment

The current application is an initial evaluation of delivering two active treatment components of well-established behavioral interventions for traumatized populations as brief, stand-alone interventions following an allegation of child maltreatment. These components were selected based on their hypothesized effect in engaging causal mechanisms of comorbid psychiatric disorders in this population. Results will provide data on the feasibility of these components as preventive interventions, as well as their preliminary effect on causal mechanisms, to support a future grant application to demonstrate clinical efficacy.
Chad Shenk at ces140@psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 4-17
Prior allegation of child abuse or neglect
Stable home environment for two months
Willingness to be randomized to treatment condition
Exclusion Criteria:
Active psychosis, suicidal or homicidal ideation
Currently receiving counseling services for child abuse and neglect
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 2 locations

Study Locations

Hide all locations
Location
Harrisburg, PA
Hershey, PA

Communication preferences related to over screening for cancer among older adults

The overall objective of this study is to explore the perspectives of older adults on incorporating and communicating risks, benefits and life expectancy into cancer screening decisions. The findings from this study will inform development of an intervention to reduce over-screening for breast, cervical, or colorectal cancers among average risk older adults who are not recommended for screening by current guidelines based on age. Average risk, including age, is defined by screening recommendations. A person is at average risk if they have not had cancer (as defined in the exclusion criteria) or colorectal polyp (within 10 years) or breast biopsy (within 10 years) and they are within the age range. Our hypothesis is that subjects will be more willing to discuss cessation of regular cancer screening risks, benefits, and life expectancy are incorporated into an ongoing dialogue between provider and subject.
Sol Rodriguez-Colon at srodriguezcolon@pennstatehealth.psu.edu or 717-531-5190
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
65 years or older
Willing to participate in focus group discussion
Exclusion Criteria:
Diagnosed with non-skin cancer within the past 5 years
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 2 locations

Study Locations

Hide all locations
Location
Hershey, PA
State College, PA

Establishing a Normal Database for Comparison to Specialized Populations; Pulmonary Function Tests

This study will evaluate lung function by measuring volumes, flow, capacity and other variables by completing various breathing tests into a machine. This will contribute to a database of healthy adults to compare to persons with disabilities.
Kristin Slavoski at PMR_Research@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Pregnancy
High Blood Pressure
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Randomized, double-blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate (110mg or 150 mg, oral b.i.d) versus acetylsalicycllic acid (100 mg oral q.d.) in patients with Embolic Stroke of Undetermined Source (RESPECT ESUS)

To demonstrate that the efficacy of dabigatran etexilate (110 mg b.i.d. or 150 mg b.i.d., with dosing according to age and renal function), is superior to ASA (100gm once daily) for the prevention of stroke recurrence in patents with embolic stroke of undetermined source. The trial will also characterize the safety of dabigatran etexilate in this setting.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
age >/= 60 must have had ischemic stroke in past 3 months
age 18
•59 must also have mild to mod HF or diabetes mellitus or hypertension requiring medication
both groups must have an absence of atrial fibrillation
stroke must be visualized by CT imaging 24
•48 hours post stroke
Exclusion Criteria:
major cardioembolic source risks
any indication that requires treatment with an anticoagulant
primary intracerebral hemorrhage
conditions associated with an increased risk of bleeding
modified rankin score of 4 or greater
Show full eligibility criteria
NCT02239120
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Normalizing preteen HPV vaccination with practice-based communication strategies (Protect Them)

This study seeks to adapt and test a culturally-relevant, web-based game intervention to motivate Spanish-speaking preteens to initiate and complete human papillomavirus (HPV) vaccination. The present study will adapt an existing web-based game developed as an educational tool on HPV vaccination for English-speaking preteens in North Carolina. The study includes the recruitment of paired dyads (Spanish-speaking preteens and parents) to focus groups to evaluate the acceptability of cultural adaptations to the existing web-based game intervention. We will recruit up to 25 parents and preteens ages 11-12 who will receive a link to the Spanish game to play for 7-10 days in advance of the focus group discussions. The focus groups will ask participants about cultural and language adaptations to the existing game and how they react to a game that will serve as an interactive, educational tool on HPV vaccination. The focus groups will take place in Harrisburg, PA between January and March of 2018. No health information will be collected as part of this study.
William Calo at wcalo@phs.psu.edu or 717-531-3535
All
All
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Pretens 11 or 12 years old
Not vaccinated with the HPV vaccine
Have computer, tablet, or smartphone
Exclusion Criteria:
Having received the HPV vaccine
Show full eligibility criteria
N/A
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Harrisburg, PA