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Search Results within category "Heart & Vascular"

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Suggestions within category "Heart & Vascular"


13 Study Matches

Cardiovascular Effects of Angiotensin 1-7 in Obesity Hypertension

The purpose of this study is to see if the hormone angiotensin-(1-7) improves the function of blood vessels and lowers blood pressure in obese subjects with hypertension.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03604289
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Inclusion Criteria:
Age 18-60 years
Obesity (defined as body mass index between 30-40 kg/m2)
Hypertension (defined as seated blood pressure greater than 130/80 mmHg)
Able and willing to give informed consent
Exclusion Criteria:
Pregnant or breastfeeding women
Current smokers
Type I or type II diabetes
History of major cardiovascular disease, immune or liver diseases, impaired renal or liver function
Age less than 18 years or greater than 60 years
Heart & Vascular
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Location
Hershey, PA

Assessing the Feasibility of Implementing a Storytelling Intervention among African Americans with Hypertension: A Pilot Study

Personal narratives or storytelling is an approach that has been used to promote healthy behaviors among people with diabetes, breast cancer, and high blood pressure. There is a need for low-cost, culturally-tailored interventions that promote healthy behaviors and improve health outcomes in the African American community. The objective of this project is to develop a storytelling intervention for African Americans with high blood pressure. Participants will be filmed sharing their experiences living with high blood pressure, and the videos will be shared with other African Americans with high blood pressure. We are recruiting 6-8 African American adults with high blood pressure, age 18-80, that have been diagnosed with high blood pressure and are taking medications to manage high blood pressure.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-7178
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosis of hypertension
Prescribed anti-hypertensive medication
Age greater than or equal to 18 years
African American
Exclusion Criteria:
Pregnancy
Unable to speak or read English
Mental status precluding ability to provide informed consent
Heart & Vascular
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Location
Harrisburg, PA
Hershey, PA

The peripheral vascular effects of sulfhydryl-containing antihypertensive pharmacotherapy on microvascular function and vessel remodeling in hypertensive humans

High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have poor results with medical treatment for hypertension. We examine the impact of different classes of drugs that doctors use to treat high blood pressure (hypertension) on blood vessel remodeling. Some drugs that doctors prescribe for their patients contain a “sulfhydryl group” (a sulfur atom bonded to a hydrogen atom). Drugs that have the sulfhydryl group may reduce blood vessel remodeling more that drugs that do not. For this study, participants who have high blood pressure perform the experiments, take a drug for 16-weeks to lower blood pressure, and repeat the experiments. We randomly assign one of three drugs to participants who have high blood pressure: a diuretic (“water pill”), a drug containing a sulfhydryl group, or a drug that does not contain a sulfhydryl group. Participants who do not have high blood pressure perform the experiments, but do not take any of the drugs. In some of our experiments, we use a technique called “microdialysis” (MD). With MD, we perfuse some research drugs into the skin on the forearm through tiny tubing that mimics capillaries. These MD drugs mimic or block substances the body naturally makes to control the small blood vessels in the skin. The drugs remain in nickel-sized areas around the tubing and do not go into the rest of the body. We also analyze very small skin samples (skin biopsy) obtained from the forearm. Lastly, we use a standard technique called “flow mediated dilation” (FMD) that uses blood pressure cuffs and ultrasound to look at the health of larger blood vessels in the body. FMD includes placing a small tablet of nitroglycerin under the tongue during part of the test.
Susan Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03179163
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Inclusion Criteria:
Women and men
40-65 years
May or may not have high blood pressure
Women who are post-menopausal are not taking hormone replacement therapy
· May or may not be taking a drug to lower blood pressure
Exclusion Criteria:
Current medications which could conceivably alter the cardiovascular or thermoregulatory control or responses (e.g. beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers)
Allergy to latex
Use of tobacco products
Use of illegal/recreational drugs
Pregnancy or breastfeeding
Heart & Vascular
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Location
State College, PA

Pilot Study to Assess Medication Adherence, Health Literacy, and Technological Literacy among African Americans and Latinos with Hypertension

This pilot study aims explore the health literacy and medication adherence found among African Americans and Latinos with hypertension receiving care at Hamilton Health Center in Harrisburg PA. We also aim to determine the feasibility of the iPad or smartphone as a tool for accessing health related information among African American and Latino patients with hypertension receiving care at clinics at Hamilton Health Center in Harrisburg PA. The expected outcomes of this project are to obtain a better understand of the literacy levels and adherence behaviors of African Americans and Latinos in Harrisburg, Pennsylvania. The findings from this study will provide valuable insights into the health management behaviors of this community and determine if there is a need to develop a mobile health application for the management of hypertension.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-2044
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with high blood pressure
Prescribed medication for high blood pressure
African American/Black (Hispanic or Non-Hispanic) or White (Hispanic)
21 years and older
Able to speak and read English
Exclusion Criteria:
Unable to provide consent to participate in the study
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Mechanisms of autonomic blood pressure control after acute exercise

This study may help to describe how blood pressure is controlled in healthy adults. Results from this study may be important for designing exercise programs for people who suffer from poor blood pressure control.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
healthy
normal blood pressure
can perform 20 continuous min of cycling
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
blood pressure over 150/100
taking medications that affect the heart
unable to perform 20 continuous min of cycling
Heart & Vascular
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Location
Hershey, PA

A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit in Subjects with Hypertension

The purpose of this study is to evaluate the safety and effectiveness of renal denervation while still on blood pressure medications. Renal denervation is the destruction of nerve fibers that run along the kidney blood vessels. This causes an interruption of nerve signals that may cause high blood pressure. Therefore, the effectiveness of the study catheter and the alcohol (Peregrine Kit) will be assessed by how well the treatment reduces blood pressure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02910414
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Inclusion Criteria:
age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
Exclusion Criteria:
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder
Heart & Vascular
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Location
Hershey, PA

fMRI based mapping of the supraspinal projections of the exercise pressor reflex

This study will examine how the brain controls blood pressure responses during exercise, and will include 3 separate visits. In one visit, you will perform a series of handgrip exercises followed by inflation of a blood pressure cuff while we collect muscle nerve activity and blood pressure. In the other two sessions you will perform a similar task while laying in an MRI machine.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
age between 21 and 40 years
healthy
able to perform handgrip execise
normal blood pressure
Exclusion Criteria:
claustrophobic
have metal implants
taking heart medication
pregnant/nursing
smoker
Heart & Vascular
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Study Locations

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Location
Hershey, PA

The role of nuclear factor from activated T-cells (NFAT) in microvascular dysfunction

High blood pressure can lead to cardiovascular disease (CVD). CVD is a leading cause of illness and death in the United States. This research explores some of the ways high blood pressure impairs blood vessel function. This study uses minimum-risk procedures (flow meditated dilation, skin biopsy, and microdialysis) to explore the mechanisms underlying the impaired blood vessel function. We conduct experiments before and after 7-day treatment with FDA-approved drugs Telmisartan (prescribed to treat high blood pressure) and Tacrolimus (prescribed to treat eczema). The results of this study could suggest new ways to diagnose and treat high blood pressure. The expression of NFAT isoforms are altered in essential hypertensive vascular tissue and that short term telmisartan decreases NFAT-mediated cytokine production in hypertensive adults. We predict that 7 days of Telmisartan will alter the expression profiles of NFATc1 and NFATc3 and improve endothelial function and vascular smooth muscle cell responsiveness.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women, 40-70 years of age
Normal or high blood pressure
Non-obese, BMI ≤ 32
Normal HbA1C of <6.5%
Not pregnant or breastfeeding
Exclusion Criteria:
Rash, skin disease, disorders of pigmentation
Diabetes, kidney, liver disease
Taking heart and blood pressure drugs
Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
Low blood pressure, < 90/60 mmHg
Heart & Vascular
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Study Locations

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Location
State College, PA

The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-40 years
Exclusion Criteria:
• Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
• Individuals that use nicotine-containing products
Illicit or recreational drug-use
• Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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Location
State College, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Exercise Ability

To determine if the sympathetic and blood pressure (BP) responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease (PAD).
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
healthy females and males
all minorities and ethnicies included
free of acute or chronic medical conditions
over 21 years old
Exclusion Criteria:
Females who are pregnant or lactating
under 21 years old
Decisional impairment
Heart & Vascular
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Study Locations

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Location
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Sympathetic Response

The purpose of this study is to examine if nervous system and blood pressure responses to exercise will be less with heat exposure in patients with peripheral artery disease (PAD) and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
At least 21 years old
free of acute medical conditions
any race or ethnicity
women or men
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
age < 21 years old
Heart & Vascular
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Location
Hershey, PA

Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.
Yasina Somani at yfs5057@psu.edu or 814-954-2930
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03644472
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Inclusion Criteria:
Women within 1-5 years following menopause
Exclusion Criteria:
Individuals taking hormone therapy
Individuals with resting blood pressure > or = 130/80 mmHg
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
Food & Nutrition, Heart & Vascular, Women's Health
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Location
State College, PA

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Women, Ages 18-45
Do or do not have endometriosis
Have normal blood pressure
Exclusion Criteria:
Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
High Blood Pressure
Abnormal liver function
Known allergy statins (Lipitor)
Pregnant or Breastfeeding
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Location
State College, PA