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Search Results within category "Arthritis & Rheumatic Diseases"

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Suggestions within category "Arthritis & Rheumatic Diseases"


3 Study Matches

Study of Antimalarials in Incomplete Lupus Erythematosus (SMILE)

This is a study to test whether a widely-used drug, hydroxychloroquine, might slow the progression of lupus like features in individuals who are at high risk for developing systemic lupus erythematosus. This will be measured by the accumulation of clinical and laboratory features of lupus. The study will randomize subjects to the active drug, hydroxychloroquine, or placebo, with an equal chance of receiving either treatment. The study treatment lasts approximately 2 years with visits approximately every 3 months.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-4921
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This study is NOT accepting healthy volunteers
NCT03030118
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Inclusion Criteria:
Positive for ANA (antinuclear antibodies)
Age 18 to 45 years, inclusive
Have never taken hydroxychloroquine
Exclusion Criteria:
Previous use of immunosuppressive drugs
Diagnosis of systemic lupus erythematosus
Arthritis & Rheumatic Diseases
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Hershey, PA

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of CC-220 in Subjects with Active Systemic Lupus Erythematosus

This study is for patients with SLE (systemic lupus erythematosus) to determine the effectiveness and safety of drug CC-220 on improving SLE and to see how well the body tolerates the medication.
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18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03161483
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Inclusion Criteria:
Diagnosis of Systemic Lupus Erythematosus
Exclusion Criteria:
Diagnosis of Fibromyalgia
Active or history of recurrent bacterial, viral or fungal infections
History of latent or active tuberculosis
History of blood clots in the past year
Infectious Diseases & Immune System, Arthritis & Rheumatic Diseases, Muscle & Bone
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Hershey, PA

A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy, Safety, and Tolerability of JBT-101 in Systemic Lupus Erythematosus

This study is for patients with Systemic Lupus Erythematosus (SLE) to test the effect, safety, and tolerability of the experimental drug JBT-101 in people with SLE to see if JBT-101 stops inflammation and how well JBT-101 is tolerated. The study will evaluate whether JBT-101 will decrease the pain associated with active arthritis or tendonitis in SLE patients.
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18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03093402
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Inclusion Criteria:
Be willing to not start or stop any NSAID or disease modifying treatments for SLE during the study
Be wiling to not use any legal or illegal cannabinoids, including FDA-approved cannabinoids during study participation
If female of child-bearing potential must be willing to use highly effective contraception during study participation
Exclusion Criteria:
Treatment with steroids in the past 28 days
Actively listed on organ transplant list or have received an organ transplant other than a corneal transplant
Have active or chronic infections
Have a history of cancer (except cervical treated successfully with curative therapy or basal cell carcinoma)
Have a history of significant heart disease
Arthritis & Rheumatic Diseases
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Study Locations

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Location
Hershey, PA