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Examining elderly traumatic brain injury and risk for neurodegeneration

The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI: 


Frank Hillary at fgh3@psu.edu
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18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
>50 years of age
sustained a traumatic brain injury
Exclusion Criteria:
<50 years of age
history of neurological disorder such as stroke, epilepsy, or multiple sclerosis
history of bipolar
Neurology
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Location
State College, PA