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Inflammatory, Behavioral and Neural Markers of Anhedonia in Major Depressive Disorder

The purpose of this study is to investigate the underlying biological causes of the loss of pleasure in individuals diagnosed with depression. This study will examine brain, behavioral, and inflammatory markers of depression. Participants will answer questions, give blood and saliva, undergo fMRI and perform computer tasks. The study is also recruiting healthy controls with no history of major mental illnesses. Participants will be compensated $130 in total. To limit time in-person, the first portion of the study will be conducted remotely (1.5hrs), followed by an in-person appointment (2hrs). Mandatory COVID-19 precautions will be taken to ensure safety for the in-person appointment.
Sarah Shahriar at sshahriar1@pennstatehealth.psu.edu or 717-531-0003, ext=285189
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18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Major Depressive Disorder
Failed two lines of anti depressant treatment
Between 18-65 years of age
Exclusion Criteria:
Any metallic implant
Bipolar Disorder or Psychotic Disorder
Heavy alcohol or recreational drug use
Inflammatory disease like Lupus, Rheumatoid Arthritis
Infectious Diseases & Immune System, Prevention, Mental & Behavioral Health
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Location
Hershey, PA