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1 Study Matches

Site for Phase 1b, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of MEDI5752 in Combination with Axitinib in Subjects with Advanced Renal Cell Carcinoma

Determine the maximum tolerated dose or maximum administered dose of MEDI5752 combined with axitinib Assess the safety and tolerability of MEDI5752 combined with axitinib Assess the antitumor activity of MEDI5752 combined with axitinib
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Body weight > 35 kg
Histologically or cytologically proven advanced RCC
Advanced RCC not previously treated in that setting
Must have at least 1 measurable lesion according to RECIST v1.1
Life expectancy ≥ 12 weeks
Exclusion Criteria:
Previous treatment with axitinib
Previous treatment with mTOR inhibitors, PD-1, PD-L1, or CTLA-4 inhibitors for RCC
History of active primary immunodeficiency
History of organ transplant
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Study Locations

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Hershey, PA