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Site for PSCI 22-127 NRG-BN012: A RANDOMIZED PHASE III TRIAL OF PRE-OPERATIVE COMPARED TO POST-OPERATIVE STEREOTACTIC RADIOSURGERY IN PATIENTS WITH RESECTABLE BRAIN METASTASES

Individuals with cancer that has spread to their brain who have 1-4 lesions, or breast cancer history and may or may not have treatment and are within 8 weeks of surgery, will be randomized to either surgery first followed by radiation or radiation first followed by surgery.

Subjects are expected to come to all Radiation/Gamma Knife appointments and continue onto surgery/resection.

Sean Mahase
PSCI-CTO at PSCI-CTO@pennstatehealth.psu.edu or 717-531-5471
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05438212
SITE00001293
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Inclusion Criteria:
Radiographic confirmation of 1-4 brain metastases, one of which requires resection, as defined by MRI with contrast obtained within 14 days prior to registration
Known active or history of invasive non-CNSprimary cancer based on documented pathologic diagnosis within the past 3 years.
All brain metastases must be located ≥ 5 mm from the optic chiasm and outside the brainstem.
Lesions chosen for surgical therapy must be deemed appropriate targets for safe, gross total resection by the treating surgeon
Age ≥ 18
Exclusion Criteria:
Prior cranial radiotherapy,
Evidence of leptomeningeal disease
Primary histology of germ cell tumor, small cell carcinoma or lymphoma
Inability to undergo MRI with contrast.
More than one brain metastasis planned for resection
Cancer
Not applicable
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Location Contacts
Hershey, PA ,