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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

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Visceral Pain Sensation and Nav1.8

We wish to investigate the role of a specific gene in visceral pain sensation and perception. This gene, Nav1.8 has a known change present in 10% of the population which may affect the way we feel inflammatory pain in the gut. This is an important symptom in inflammatory bowel disease (IBD). Some patients feel high levels of pain we would like to control, other patients feel little to no pain in the presence of very active disease, which can lead to dangerously under-treated disease. In this study, we will use healthy volunteers of a known genotype for Nav1.8, and test their sensitivity using rectal balloon dilation. Research subjects will be asked to fast, skipping solid foods and opaque liquids for 6 hours before the testing. Usually this means skipping 1 meal. At the beginning of the study visit. they will use an over the counter enema to clear their rectum of any stool. Then. a trained physician on the research team will insert a thin, lubricated tube into the rectum, which will be inflated to specific pressures. Most of these tests will be designed to measure any change in sensation, then the need to use the toilet, followed by urgent need or discomfort, and lastly the lower threshold of pain. Patients will be able to stop testing at any time, should they become too uncomfortable. The testing takes between 1 and 1 and a half hours, and volunteers are compensated $200 for their time.
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy lower digestive tract
Had a colonoscopy in HMC health record within the past 2 years for any reason
Exclusion Criteria:
Any lower GI disease
Any significant abdominal pain and/or changes in bowel habits in the past year
Any peripheral neuropathy or neuromodulating/opioid medications
Any autoimmune disease
Infectious Diseases & Immune System, Digestive Systems & Liver Disease, Pain Management
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Hershey, PA