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Discovery of multimodal biomarkers for parkinsonian syndromes, their progression, and pathological relevance

Parkinson’s disease and a number of similar conditions, such as progressive supranuclear palsy and multiple system atrophy, often look very similar clinically, particularly early in the disease. Since there is no objective way to diagnose these disorders definitively, the current practice is to follow patients over time to allow the disease to reveal itself. Evidence indicates, however, that even the best movement disorder specialist can provide the wrong diagnosis approximately 25 percent of the time. This lack of diagnostic certainty has limited both clinical practice and research. The goal of this longitudinal study is to determine whether specific MRI and biofluid measures, such as proteins in blood and cerebrospinal fluid, can help better diagnose Parkinson’s, progressive supranuclear palsy and multiple system atrophy patients.
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18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Able to tolerate a brain MRI
At least 21 years of age
Clinical diagnosis of possible or probable Parkinson's disease (PD), multiple system atrophy (MSA) or progressive supranuclear palsy (PSP)
Exclusion Criteria:
Condition that precludes a routine MRI, such as a pacemaker or severe scoliosis
Inability to participate in the study's required components, such as the fasting blood draw
Major medical problems, such as kidney or liver failure
History of cerebrovascular disease, such as a stroke
History of schizophrenia or neuroleptic use
Neurology
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Location
Hershey, PA