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Discovery of multimodal biomarkers for parkinsonian syndromes, their progression, and pathological relevance
Parkinson’s disease and a number of similar conditions, such as progressive supranuclear palsy and multiple system atrophy, often look very similar clinically, particularly early in the disease. Since there is no objective way to diagnose these disorders definitively, the current practice is to follow patients over time to allow the disease to reveal itself. Evidence indicates, however, that even the best movement disorder specialist can provide the wrong diagnosis approximately 25 percent of the time. This lack of diagnostic certainty has limited both clinical practice and research.
The goal of this longitudinal study is to determine whether specific MRI and biofluid measures, such as proteins in blood and cerebrospinal fluid, can help better diagnose Parkinson’s, progressive supranuclear palsy and multiple system atrophy patients.
Autumn Collier at TBRC@pennstatehealth.psu.edu or 717-531-0003, ext=281168
All
18 year(s) or older
N/A
Neurology