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1 Study Matches

Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers

This study will examine the health effects of lowering the nicotine content in cigarettes while having access to an electronic cigarette.

There are a total of 8 study visits, 5 are in person and 3 are done virtually through a phone or computer. At the third visit you will be randomly assigned to one of two study cigarette groups AND one of two e-cigarette groups for 16 weeks. You will use the study cigarettes and e-cigarette throughout the study. During study visits you will be asked to complete questionnaires, provide urine samples, and complete other health measurements. You will record your cigarette and e-cigarette use every day.


Jonathan Foulds
Candace Bordner - at or 717-531-0003, ext=282798

18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Ages 21-70
Smoke 5 or more cigarettes per day
Must be willing to both switch to a different type of cigarette and try an electronic cigarette
No serious quit attempt or use of smoking cessation medication in the past 30 days
Meet diagnostic criteria for current or lifetime mental health condition

Exclusion Criteria:
Women who are pregnant, nursing, or trying to become pregnant
Any known allergy to propylene glycol or vegetable glycerin
History of difficulty providing blood samples
Other member of the household currently participating in the study
Unstable or significant medical condition in the past 3 months
Smoking, Vaping, Nicotine and Tobacco, Addiction & Substance Abuse, Mental & Behavioral Health
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Location Contacts
Hershey, PA ,