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Digital tools for assessment of motor functions and falls in ALS

This is a 48-week single arm study that incorporates digital tools for assessing motor function in amyotrophic lateral sclerosis (ALS). During the study, neck- and wrist-worn “activity sensors” (PAMSys, BioSensics, Newton, MA) will be worn by subjects while performing tasks of daily living. Subjects will also complete a motor, speech, and handwriting assessment during site visits. They will complete a digital home assessments of speech, handwriting, and pattern tracing tasks throughout the study, and report any falls which occur on the study tablet. We will explore whether sensor-based functional changes are sensitive to self-reported changes over the length of the study.
Wint Nandar at
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), or progressive muscular atrophy (PMA)
18 years of age or older
Walking with or without mobility support (such as a cane or walker)
Fluent in written and spoken English
Exclusion Criteria:
Neurological or orthopedic problems independent of inclusionary diagnosis that affects gait
Pregnant or nursing woman
Prisoner or institutionalized individuals
Have any clinically relevant medical history of other disease or diseases that, in the opinion of the research team, exclude the subject from participation (including severe cognitive dysfunction).
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Hershey, PA