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1 Study Matches

von Willebrand Factor in Pregnancy (VIP) Study: A Multicenter Study of Wilate Use in von Willebrand Disease for Childbirth

Specific guidance is lacking for pregnant women with von Willebrand Disease (VWD) and delivery planning in terms of how high a von Willebrand factor (VWF) level should be achieved. Specifically, guidance is lacking on whether replacement therapy drugs (Wilate & Tranexamic Acid) should target a VWF minimum level. This study is a prospective study to document the rate of primary postpartum hemorrhage (PPH) and the effectiveness of the dosing of Wilate, looking to provide increased management and guideline recommendations.
Cynthia Campbell-Baird at or 717-531-5777
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
VWD patients defined prepartum as Type 1 per National Heart, Lung & Blood Institute
Written informed constent from the patient prepartum
VWF & FVIII patient levels in gestational week 34-38 will determine enrollment group
Exclusion Criteria:
Age<18 years
Presence of liver disease or renal disears , clinical suspicion of or diagnosis of pre-eclampsia/eclampsia, HELLP syndrome, TTP, DIC, etc.
Presence of other concurrent disorder of hemostasis, platelet dysfunction or collagen disorders
Blood Disorders
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Hershey, PA