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Saliva microRNA signatures in infants with wheezing associated respiratory illness

Wheezing is a common symptom of respiratory distress in infants and children. Infants who wheeze are at increased risk of being diagnosed with asthma, the most common chronic disease of childhood. This study will aims to yield an objective measure of asthma risk using molecular markers obtained from saliva. Saliva miRNA (markers used in this study) levels will be measured using HiSeq technology. Refinement and validation of this measure in future large-scale studies could allow clinicians to accurately predict for families an infant’s risk of asthma and optimize medical management to prevent future hospitalizations.
Ramin Beheshti at rbeheshti@pennstatehealth.psu.edu or 727-324-9947
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Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Less than or equal to 12 months of age
Presence of respiratory illness symptoms (cough, congestion, shortness of breath, runny nose)
Exclusion Criteria:
Congenital lower respiratory tract malformation or anomalies
Concurrent pneumonia (bacterial lung infection) at the time of enrollment
Ongoing use of steroids (inhaled or oral)
Allergies, Children's Health, Infectious Diseases & Immune System
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Location
Hershey, PA