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Study matches: 139

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Pilot Urushiol Sensitivity Patch Test Evaluation and Urushiol Dose Confirmation

A study to evaluate the safety of a Patch test applied for a reaction at specific time points to poison ivy, poison sumac or poison oak. There are 7 visits to the research office
Longenecker -alongenecker@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
2 episodes of contact dermatitis reaction to poison ivy, poison sumac or poison oak.
Reactions must have lasted up to 2 weeks
1 Reaction must have been within the past 5 years
Exclusion Criteria:
Use of oral or topical antihistamines in the previous 14 days
History of asthma, including subjects with asthma who require acute or maintenance inhaled or oral steroid use for control of symptoms
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N/A
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Location
Hershey, PA

Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial

This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Allen -ballen1@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Child between the ages of 6 and 17
Child has a history of physical abuse, sexual abuse, or other type of maltreatment
Child displays posttraumatic stress symptoms
Primary caregiver willing to participate in treatment
Exclusion Criteria:
Child has a developmental or intellectual delay.
Uncontrolled allergy to or fear of dogs on part of either the child or caregiver.
CHild or caregiver has a history of aggression toward animals
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NCT03135119
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Harrisburg, PA

A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric And Young Adult Patients with Previously Treated Solid Tumors

A study of the safety and effectiveness of cobimetinib in patients with previously treated solid tumors.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A solid tumor that has not responded to previous treatment.
Age must be 6 months or older to younger than 18 years of age.
Disease must be measurable by accepted tests.
Availability of tumor tissue at study enrollment is mandatory.
Exclusion Criteria:
Prior treatment with cobimetinib or other similar drug.
Treatment with high-dose chemotherapy and stem-cell rescue within 3 months prior to the study.
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NCT02639546
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Hershey, PA

Beneficial effects of moderate heating on cardiovascular control in heart failure

The purpose of this project, is to examine if moderate whole body heating will effect the resting muscle sympathetic nerve activity (MSNA) and the MSNA response to the stimulation of muscle mechanoreceptors in chronic heart failure patients.
Blaha -cblaha@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
non-smoker
Heart failure patients
•may be on medications
Healthy subjects
•no blood pressure or cholesterol meds
Exclusion Criteria:
pregnant or nursing women
uncontrolled blood pressure
recent heart attack in past 6 months
on kidney dialysis
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Location
Hershey, PA

Non-pharmacological improvement of sleep structure in older people

Wrist actigraphy has emerged as a popular alternative to polysomnography because of its low level of invasiveness, its manageable cost, and its ease of monitoring sleep-wake cycles. Unfortunately, actigraphy is not useful for measuring sleep quality in aging populations with fragmented and abnormal sleep patterns because of the very low specificity of actigraphy to detect quiet wake. This application proposes to develop and test a new algorithm that will use actigraphy, photoplethysmography and sensory stimulation during sleep to improve detection of sleep stage in midlife and older adults. The main goal of this project is to conduct the proof-of-principal study in a group of midlife volunteers to demonstrate the superiority of the new method to other non-polysomnography based methods of determining sleep stages. Please note that the protocol attached is only for Phase I on the grant. A future revision to encompass Phase II will come at a later date. This protocol is for a three-day study and will be amended before beginning the study.
Gray -SoundSleeping@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy adults age 45-60 years old
Regular sleep wake cycle (regular bedtime and wake time +/- 2 hours/day).
Completed at least 8 years of education
Body mass index < 30kg/m2
Subject is willing to comply with study procedures
Exclusion Criteria:
Acute, chronic, or debilitating medical conditions
History of mental illness
Hearing impairments
Disordered or irregular sleep
Substance abuse
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Location
State College, PA

A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia

A study of the safety and efficacy of ruxolitinib with routine chemotherapy for children with leukemia with specific genetic changes.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
All
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A diagnosis of leukemia, specifically de novo high B-ALL with eligible genetic changes.
Age must be greater than 1 year old and less than or equal to 21 years old at leukemia diagnosis.
Have completed an acceptable induction therapy either on study or by hospital standard of care.
Exclusion Criteria:
Had any other chemotherapy before induction therapy, with exceptions.
Down Syndrome.
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NCT02723994
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Hershey, PA

A Single-arm, Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD

A study of the safety and effectiveness of remestemcel-L in pediatric subjects with acute Graft versus Host Disease (aGVHD) following transplant (HSCT) that has failed to respond to steroid treatment.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A diagnosis of acute GVHD.
2 months of age and older to under 18 years of age.
Patient has failed to respond to steroid treatment.
Exclusion Criteria:
Has had any second line therapy to treat aGVHD.
Severe hepatic veno-occlusive disease (VOD).
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NCT02336230
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Hershey, PA

The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
Mills -smills1@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
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N/A
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Location
Hershey, PA

Exercise in Genetic Cardiovascular Conditions. Lifestyle and Exercise in Hypertrophic Cardiomyopathy "LIVE-HCM", Lifestyle and Exercise in Long QT Syndrome: "LIVE-LQTS"

To compare the composite risk of death, cardiac arrest, ventricular arrhythmias, or syncope in patients with hypertrophic cardiomyopathy or the long QT syndrome who are participating in moderate or vigorous exercise with sedentary patients.
Jefferson -PSHVIResearchCoordinators@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Scheduled to have heart valve implant
Have history of atrial arrhythmia
18 to 60 years of age
Exclusion Criteria:
Heart failure
Health issues that would limit your ability to exercise
Left ventricular hypertrophy or prolonged QT which occur as part of multi-system disorder
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NCT02549664
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Harrisburg, PA

P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI): Phase IIb Clinical Study

The purpose of this study is to determine a safe and effective dose of a new, investigational contrast agent, P03277 developed by Guerbet, a pharmaceutical company specialized in the discovery and manufacturing of contrast media for medical imaging. Investigational means that it has not been approved by the United States Food and Drug Administration (FDA). P03277 will be compared to another contrast agent, MultiHance® (Gadobenate Dimeglumine), which is approved by most health authorities including the FDA in the United States. This comparison will allow the sponsor to assess the effective dose (the dose that will allow the best contrast of images) and the safety of the study contrast agent (if this dose is well tolerated by subjects).
Shah -sshah@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Presenting with known or highly suspected focal areas of disrupted Blood Brain Barrier, including at least 1 expected enhancing lesion of minimum 5 mm. This lesion must have been detected on a previous imaging procedure.
Subject scheduled for a routine CNS contrast-enhanced MRI examination for clinical reasons and agreeing to have a second contrast-enhanced MRI examination for the purpose of the study.
Subject able and willing to participate to the study.
Subject having read the information and having provided his/her consent to participate in writing by dating and signing the informed consent prior to any study related procedure being conducted.
Subject affiliated to national health insurance according to local regulatory requirements.
Exclusion Criteria:
Subject presenting with acute or chronic Grade III (at least) renal insufficiency, defined as an estimated eGFR <60 mL/min/1.73 m² based on one eGFR assessment performed the day of the MRI prior to the first contrast agent injection.
Subject presenting with known class III/IV congestive heart failure according to the New York Heart Association classification (NYHA).
Pregnant or breast-feeding female
Subject having received any investigational medicinal product within 30 days prior to study entry.
Subject having received any contrast agent (MRI or CT) within 3 days prior to study products administration, or scheduled to receive any contrast agent during the course of the study or within 24 hours after the second study product administration.
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NCT02633501
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Location
Hershey, PA

The Sexual Relationships Study

The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following: Aim 1. Examine the heterogeneity in relationship quality among female college students. Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence? Aim 2. Examine the association between relationship characteristics and latent class membership. Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality? Aim 3. Examine the association between latent classes of relationship quality and condom use. Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex? Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Salas-Brooks -jis5940@psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Be enrolled at Pennsylvania State University (University Park Campus)
Be between the ages of 18-22 years
Be a female college student
Be sexually active with male partners in the previous 3 months
Exclusion Criteria:
Are not enrolled at Pennsylvania State University (University Park Campus)
Are under the age of 18 or over the age of 22.
Are not a female college student
Are not sexually active with male partners in the previous 3 months
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N/A
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A randomized, double blind controlled factorial clinical trial of edetate disodium-based chelation and high-dose oral vitamins and minerals to prevent recurrent cardiac events in diabetic patients with a prior myocardial infraction

We are trying to find out if chelation therapy in the vein and oral vitamins and minerals by mouth lower the risk of new heart problems, including another heart attack, chest pains, or heart surgery to open blood vessels. The therapy, chelation, is a drug given by vein that that sticks to heavy metals, like lead and cadmium, and takes them out of the body in the urine. These metals may lead to heart disease. A prior study suggested benefit with chelation therapy when given to patients who have had a myocardial infarction and have diabetes.
Loffredo -PSHVIResearchCoordinators@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
History of diabetes
History of myocardial infarction
Equal to or greater than 50 years of age
Exclusion Criteria:
Myocardial infarction within the past 6 weeks
Heart failure hospitalization within the past 6 months
Cigarette smoking within the past 3 months
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NCT02733185
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Hershey, PA

A Pilot Trial of Subtyping Pediatric Conduct Problems by the Presence of Severe Persistent Irritability and Callous Unemotional Traits

Youth with irritable and aggressive behaviors, or conduct problems, are thought to be sensitive to rewards and insensitive to punishments. Parents and children will complete rating scales and computer tasks that will assess for sensitivity to rewards and punishments. This study will help to target interventions for treating children with conduct problems.
Mills -smills1@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Ages 7--12 years
Elevated degree of conduct problems
IQ greater than 80
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, ASD, or a pervasive developmental disorder
Sever suicidality
Visual or hearing impairments
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N/A
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Location
Hershey, PA

Inflammation and Neural Processing of Reward in Adolescent Depression

This study evaluates the the effects of stress, inflammation, and emotional processing and response to rewards on depressive symptoms in adolescents. Participants will complete questionnaires, clinical assessments, and computer tasks. Participants may also be asked to give a small blood sample. Outcomes of this study may improve identification, prevention, and early intervention for adolescent depression.
Carroll -acarroll@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Participants aged 12-17 years
Having at least subthreshold symptoms of depression or no symptoms of depression
Fluent in English
Exclusion Criteria:
Having a serious autoimmune condition
Having evidence of a viral or bacterial infection within the past 30 days
Participants treated for substance use disorder
Having an intellectual or developmental disability or psychosis
Participants currently taking mood stabilizers or medications known to effect the immune system
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N/A
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Location
Hershey, PA

A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 with Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects with Newly Diagnosed Glioblastoma (GBM) with Epidermal Growth Factor Receptor (EGFR) Amplification

Phase 2b: To determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide plus adjuvant temozolomide prolongs Progression Free Survival (PFS) among subjects with newly diagnosed GBM harboring EGFR amplification. Phase 3: To determine whether the addition of ABT-414 to concomitant radiotherapy and temozolomide plus adjuvant temozolomide prolongs Overall Survival (OS) among subjects with newly diagnosed GBM harboring EGFR amplification.
Shah -nshah3@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
EGFR amplification in tumor tissue confirmed by central assessment.
Histologically confirmed GBM
Ability to receive local radiation
Peformance Status above 70%
Exclusion Criteria:
Subject has multifocal GBM.
Any prior therapy for glioblastoma
Subject has recurrent GBM
Prior invasive malignancy
Prior radiotherapy to the head or neck
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NCT02573324
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Hershey, PA

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
Behe -abehe@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of ulcerative colitis for at least 90 days
Demonstrated an inadequate response to, loss of response to, or intolerance to steroids, immunosuppressants and/or biologic therapies
Exclusion Criteria:
Have a current diagnosis of Crohn's disease, fulminant colitis and/or toxic megacolon
History of total colectomy or ileostomy
Taking a probiotic and has not been on a stable dose for at least 10 days
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NCT02819635
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State College, PA

Standardization and normative data of the symbol digit modalities test (SDMT) - oral version

The symbol digit modalities test (SDMT) is a paper test given to people to see how quickly they process information. The purpose of this research study is establish updated accurate data on healthy individuals to use as a comparison for cognitive (thinking) impairment associated with Multiple Sclerosis (MS).
Guty -exg5204@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between ages of 25-74
15 years of education or less
Medically Healthy
Exclusion Criteria:
Significant mental health disorder (e.g. bipolar, psychosis)
Diagnosed learning disability
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N/A
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Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA

Effects of Freeze Dried Strawberry Powder Supplementation on Vascular Function and Blood Markers of Cardiovascular Risk

This is a clinical study that will examine the effects of supplementation with freeze dried strawberry powder on multiple markers of cardiovascular disease risk.
Teeter -dls5001@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 35-65
BMI = 25 and = 39 kg/m2
LDL-C > 116 mg/dL
Non-smokers
Exclusion Criteria:
History of acute or chronic inflammatory conditions or heart disease, kidney disease, liver disease, autoimmune disorders, or thyroid disease (unless controlled by medication and blood results within the previous 6 months are provided)
History of diabetes mellitus (and/or a fasting glucose >126 mg/dL at screening)
Stage II hypertension (blood pressure = 160/100 mm Hg)
Use of medications/supplements for elevated lipids, blood pressure, or glucose
Chronic use of non-steroidal anti-inflammatory or immunosuppressant medication or conditions requiring the use of steroids
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NCT02557334
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State College, PA

A Joint Intervention for Behavior and Sleep in School aged Children (JIBS)

It is well known that many children with ADHD also have problems sleeping and that not getting enough sleep can make a child’s behavior worse. This research is being done to find out how to best treat children with both behavior and sleep problems. Parents will complete assessments of their child's behaviors and sleeping patterns and attend 4 therapy sessions that assist with problematic behaviors in their child.
Mills -smills1@pennstatehealth.psu.edu
All
Younger than 18 year(s) old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 5-10 years
Diagnosis of ADHD, Conduct Disorder, and/or Oppositional Defiant Disorder
Difficulty falling or staying asleep
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, Autism, or a pervasive developmental disorder
Diagnosis of sleep disordered breathing (e.g. sleep apnea) or other medical condition (e.g. asthma)
Use of anti-psychotic medications
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N/A
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Location
Hershey, PA

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven Phase III study to investigate the efficacy and safety of finerenone on the reduction of cardiovascular morbidity and mortality in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease in addition to standard of care.

The purpose of this study is to evaluate whether finerenone is effective and safe in treating patients with type 2 diabetes mellitus and Diabetic Kidney Disease (DKD) in addition to regular therapy.
Hitz -khitz1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
type 2 diabetes
clinical diagnosis of diabetic kidney disease
treatment with ACE or ARB
Exclusion Criteria:
HbA1c > 12%
uncontrolled hypertension
dialysis
current or scheduled kidney transplant
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NCT02545049
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Hershey, PA

Feasibility of detecting visual cues for television watching

The objective of this study is to determine the feasibility of using sensors and new analytic methods to identify the visual cues that trigger television watching.
Oliveira -nvo5058@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Fluent in written and spoken English
Age 18 and older
Owns a television, home computer (including laptop), and smartphone
Watches 20+ hrs TV/week
Exclusion Criteria:
Needing to wear glasses with corrective lenses (not including contact lenses)
Not capable of standing/moving without assistance
Living with other people during the time of data collection
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N/A
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Location
State College, PA

Reward function as a mechanism linking personality and intermittent smoking

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. The study requires one visit to the lab that lasts approximately three hours. In order to be eligible for the study, individuals must be between 18 and 25 years and must smoke on some (but not all) days.
Ashe -mla233@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
18-25 years of age
Right handed
Native English speaker
Smoke cigarettes on some (but not all) days
Exclusion Criteria:
Attempting to quit smoking
Serious cardiovascular or respiratory disease
MRI conraindications
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N/A
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Location
Altoona, PA
State College, PA

Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis. To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim. To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
Hoffman -dhoffman1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age >/=35 years
Do you have documented stenosis of your carotid?
Have you had any neurologic symptoms on the same side as your stenosis
No medical history of stroke or TIA on the same side as the stenotic vessel in the previous 180 days
If female, not pregnant
Exclusion Criteria:
Prior stroke with residual disability
Symptomatic ICH within past 12 months
Chronic afib
Ejection fraction < 30%
Do you use an anticoagulant? What medication?
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NCT02089217
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Location
Hershey, PA

Mobile Eye-tracking as a Tool for Studying Socioemotional Development: Threat-related Attention in Social Context

This is cross-sectional correlational study in 5- to 6-year-olds comparing threat-related attention assessed in screen-based and naturalistic contexts by using stationary and mobile eye tracking respectively.
Fu -xuf104@psu.edu
All
Younger than 18 year(s) old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Between five to six years of age
Speak English
No Gross developmental delays or serious neurological illnesses
Have been born within three weeks of due date
Weighed more than approximately five pounds at birth
Exclusion Criteria:
Outside of the age range of 5-6 years
Have gross developmental delays or serious neurological illnesses
Weighed less than 5 pounds at birth
Have not been born within three weeks of their due date
Do not speak English
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N/A
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Location
State College, PA

Cognitive Processes in Bilinguals: ERP Studies

In this study, we examine how people read words and sentences in their first language or in their second language (if they speak or are learning a second language). We use behavioral (e.g., button presses or recording people's eye movements) or neuroscience methods (e.g., recording of brain waves using electrodes) to collect our data. Participants receive monetary compensation for their participation. I hope you contact us to participate!
Dussias -pdussias@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Adults 18 years or older
Right handed
Normal or corrected-to-normal vision
No history of neurological disorders or language disorders
Participants will be recruited from the following language groups: monolingual English speakers; bilinguals whose native language is English; native speakers of Spanish whose second language is English
Exclusion Criteria:
Children under the age of 18
Left handed or ambidextrous
Uncorrected vision
A history of neurological disorders or language disorders
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N/A
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Location
State College, PA

Natural History Study of the Development of Type 1 Diabetes

Natural History Study of the Development of Type 1 Diabetes
Carper -pcarper@pennstatehealth.psu.edu
All
All
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
aged 1-45 years and a sibling, offspring, or parent of an individual with type 1 diabetes
aged 1-20 years and a niece, nephew, aunt, uncle, grandchild, cousin, or half sibling of an individual with Type 1 diabetes
willing to have blood drawn
Exclusion Criteria:
Have previous or current use of medications for the control of hyperglycemia
Currently use immunosuppressive or immunomodulatory therapies
Has diabetes
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NCT00097292
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Location
Hershey, PA

PEDS-PLAN – Pediatric Precision Laboratory Advanced Neuroblastoma Therapy A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy followed by maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma

A study of the safety and feasibility of using molecularly guided therapy in combination with standard therapy followed by maintenance therapy with DFMO in patients with newly diagnosed high risk neuroblastoma.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
All
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A confirmed diagnosis of neuroblastoma.
Must be 21 years of age or younger when diagnosed.
No prior systemic therapy with some exceptions.
Tumor samples will be obtained only in a non-significant risk manner and not solely for the purpose of the study.
Exclusion Criteria:
Receiving another study drug while on this study.
Female patients who are lactating are not eligible unless they agree not toe breast feed.
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NCT02559778
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Hershey, PA

Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism

R61 Aims: First, we will complete development of the intervention game and design an active control game. This involves completing 1-hour usability sessions in the lab where adolescents play several levels of the game, followed by completion of usability self-report measures. Second, we will conduct a small exploratory experimental trial (intervention vs. natural history groups) to test whether the intervention can 1) improve sensitivity to detect eye gaze cues and 2) increase attention to human faces in adolescents with autism. We will use eye tracking technology to enhance our understanding of how teaching adolescents about eye gaze cues in the context of the game may alter the way they attend to human faces and process eye gaze information.
Carlson -smc5068@psu.edu
All
Younger than 18 year(s) old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Autism Diagnosis
Ages 10-18
3rd Grade Reading Level
Computer Use
Good Medical Health
Exclusion Criteria:
Typically Developing
Seizure Disorder
Motion Sickness
Sensory Impairments (uncorrected vision/hearing loss)
Severe Intellectual Disability
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NCT02968225
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Location
Altoona, PA
Carlisle, PA
DuBois, PA
Harrisburg, PA
Hershey, PA
State College, PA

A Phase 2, Multicenter, Single-Arm, Open- Label Study To Evaluate The Activity, Safety and Pharmacokinetics Of Lenalidomide (Revlimid) in Pediatric Subjects from 1 To = 18 Years of Age with Relapsed Or Refractory Acute Myeloid Leukemia

A study of the safety and effectiveness of lenalidomide for pediatric leukemia (AML) that has returned or is not responding to treatment.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
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All
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A diagnosis of acute myeloid leukemia (AML) that has returned or not responded to treatment.
One year of age up to and including 18 years of age.
Has recovered from the effects of previous treatment.
Exclusion Criteria:
Down syndrome.
Subject has had prior treatment with lenalidomide.
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NCT02538965
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Location
Hershey, PA

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven phase III study to investigate the efficacy and safety of finerenone, in addition to standard of care, on the progression of kidney disease in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease.

The purpose of this study is to evaluate whether finerenone is effective and safe in treating patients with type 2 diabetes mellitus and Diabetic Kidney Disease (DKD) in addition to regular therapy.
Hitz -khitz1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
type 2 diabetes
diabetic kidney disease
treatment with ACE or ARB
Exclusion Criteria:
HbA1c > 12%
uncontrolled hypertension
dialysis
current or scheduled kidney transplant
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NCT02540993
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Location
Hershey, PA