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Study matches: 192

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Natural History Study of the Development of Type 1 Diabetes

Natural History Study of the Development of Type 1 Diabetes
Carper -pcarper@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
aged 1-45 years and a sibling, offspring, or parent of an individual with type 1 diabetes
aged 1-20 years and a niece, nephew, aunt, uncle, grandchild, cousin, or half sibling of an individual with Type 1 diabetes
willing to have blood drawn
Exclusion Criteria:
Have previous or current use of medications for the control of hyperglycemia
Currently use immunosuppressive or immunomodulatory therapies
Has diabetes
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NCT00097292
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Location
Hershey, PA

Cognitive Processes in Bilinguals: ERP Studies

In this study, we examine how people read words and sentences in their first language or in their second language (if they speak or are learning a second language). We use behavioral (e.g., button presses or recording people's eye movements) or neuroscience methods (e.g., recording of brain waves using electrodes) to collect our data. Participants receive monetary compensation for their participation. I hope you contact us to participate!
Dussias -pdussias@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Adults 18 years or older
Right handed
Normal or corrected-to-normal vision
No history of neurological disorders or language disorders
Participants will be recruited from the following language groups: monolingual English speakers; bilinguals whose native language is English; native speakers of Spanish whose second language is English
Exclusion Criteria:
Children under the age of 18
Left handed or ambidextrous
Uncorrected vision
A history of neurological disorders or language disorders
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N/A
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Location
State College, PA

Establishing a Normal Database for Comparison to Specialized Populations; Oxygen consumption

This study will examine the cardiovascular and respiratory responses to exercise testing on a treadmill, stationary bike or arm bike to determine overall aerobic fitness capacity. This will contribute to a database of healthy adults to compare to persons with disabilities.
Slavoski, MS -PMR_research@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
Claustrophobia
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N/A
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Location
Hershey, PA

A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric And Young Adult Patients with Previously Treated Solid Tumors

A study of the safety and effectiveness of cobimetinib in patients with previously treated solid tumors.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A solid tumor that has not responded to previous treatment.
Age must be 6 months or older to younger than 18 years of age.
Disease must be measurable by accepted tests.
Availability of tumor tissue at study enrollment is mandatory.
Exclusion Criteria:
Prior treatment with cobimetinib or other similar drug.
Treatment with high-dose chemotherapy and stem-cell rescue within 3 months prior to the study.
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NCT02639546
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Hershey, PA

Observing treatment outcomes for patients with hidradenitis suppurativa

Following HS patients over time to observe any differences in outcomes based on different treatments
Butt -mbutt1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Patient with Hidradenitis Suppurativa
18 years of age or older
Have access to email and internet for follow-up surveys
Speak, read, and write in English
Exclusion Criteria:
Protected populations (prisoners, pregnant women, persons with cognitive disabilities)
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N/A
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Location
Hershey, PA

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Horne -ahorne@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
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NCT01957722
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Hershey, PA

Characterizing the gait mechanics of adolescents

The purpose of this study is to characterize the effect of weight on walking and running in adolescents. A better understanding of the mechanical consequences of weight will allow us to design training programs to minimize injuries and improve participation in physical activity.
Singles -ara5093@psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between 12 and 16 years old
Exclusion Criteria:
Any major injuries or surgeries
Cannot walk or run independently
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N/A
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Study Locations

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Location
Reading, PA

Dietary Intervention for Bipolar Disorder

We will conduct a 2-arm, parallel group, randomized, controlled 24-week dietary intervention to evaluate the therapeutic efficacy of two dietary interventions in patients with BD. After a two-week baseline-monitoring period, we will randomize 80 patients with chronic BD to augment usual treatment with either a high omega-3, low omega-6 (H3-L6) intervention or a control diet with average US intakes of n-3 and n-6 fatty acids. Subjects in both groups will remain under the care of their physician for the full duration of the trial. During the first phase of the trial (12 weeks), the intervention will be intense, during the second phase (12 weeks), a less intense intervention will be delivered, and after the two phases of intervention there will be a 24-week follow-up period.
Ball -bpresearch@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Bipolar Disorder
Current psychiatric treatment
Exclusion Criteria:
Active substance dependence
Active eating disorder
Current Pregnancy
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N/A
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Location
Hershey, PA

A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia

A study of the safety and efficacy of ruxolitinib with routine chemotherapy for children with leukemia with specific genetic changes.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
A diagnosis of leukemia, specifically de novo high B-ALL with eligible genetic changes.
Age must be greater than 1 year old and less than or equal to 21 years old at leukemia diagnosis.
Have completed an acceptable induction therapy either on study or by hospital standard of care.
Exclusion Criteria:
Had any other chemotherapy before induction therapy, with exceptions.
Down Syndrome.
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NCT02723994
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Hershey, PA

Validation of the PLS Functional Rating Scale (PLSFRS)

Multi-Site Test-Retest Reliability and Validity Study of PLS-Specific Clinimetric Scale, PLS Functional Rating Scale (PLSFRS)
Haines -thaines@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of primary lateral sclerosis (PLS)
Onset of symptoms within last 15 years
At least 20 years old
Exclusion Criteria:
Upper motor neuron symptoms and signs only in the legs
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N/A
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Location
Hershey, PA

A Single-arm, Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD

A study of the safety and effectiveness of remestemcel-L in pediatric subjects with acute Graft versus Host Disease (aGVHD) following transplant (HSCT) that has failed to respond to steroid treatment.
Treadway, MS, RN, CCRP -streadway@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
A diagnosis of acute GVHD.
2 months of age and older to under 18 years of age.
Patient has failed to respond to steroid treatment.
Exclusion Criteria:
Has had any second line therapy to treat aGVHD.
Severe hepatic veno-occlusive disease (VOD).
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NCT02336230
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Location
Hershey, PA

Martial Arts

This study seeks to determine if there are personality differences associated with participation in martial arts; specifically:. Do those who train in martial arts differ in personality from those who do not? Are there similarities in personality among black belts who have taught martial arts for two years or more? Do these highly-accomplished black belts differ from the beginning martial arts students?
Teitsort -sot5221@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
1. Successful martial artists: people over the age of 18 who have obtained at least one black belt in a martial art in addition to teaching in that discipline.
2. People over the age of 18 who train in martial arts at any level
3. People over the age of 18 who have never trained in martial arts
Exclusion Criteria:
Persons under the age of 18
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N/A
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The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
Mills -smills1@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
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N/A
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Study Locations

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Location
Hershey, PA

PIRE II (Translating cognitive and brain science research to the field and education settings): How Children and Adults Understand Sentences

The focus of the research being conducted asks how bilingual Spanish-English children who are growing up in a Spanish-speaking environment (Granada) but who attend a private school in which they are instructed solely in English, process syntactic ambiguity in Spanish and English. The study is motivated by two questions that the parents of these children have concerning their children’s language development. These are: (1) Whether their children are learning to process English natively; and (2) What effect learning English has on the children’s ability to process Spanish. In this respect, the results have the potential to inform decisions about bilingual education ( translation al implication). In addition to testing bilingual Spanish-English children in Granada, we will also test: bilingual Spanish-English children in the US; bilingual Spanish-English adults in the US; bilingual Spanish-English adults in Spain; monolingual Spanish adults; monolingual English adults; monolingual Spanish children; monolingual English children to serve as our control groups.
Dussias -pdussias@psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Monolingual adults whose native language is English OR Spanish-English bilingual adults
Be 18 years or older (adults)
Have normal to corrected vision
Monolingual children whose native language is English OR Spanish-English bilingual children
Be between 4-14 years old (children)
Exclusion Criteria:
Children who are not monolingual native English speakers or who are not Spanish-English bilinguals
Children outside of the target age range
Adults who are under the age of 18
Children who are not typically developing
Monolingual adults whose native language is not English or adults who are not Spanish-English bilingual speakers
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N/A
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Study Locations

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Location
State College, PA

Exercise in Genetic Cardiovascular Conditions. Lifestyle and Exercise in Hypertrophic Cardiomyopathy "LIVE-HCM", Lifestyle and Exercise in Long QT Syndrome: "LIVE-LQTS"

To compare the composite risk of death, cardiac arrest, ventricular arrhythmias, or syncope in patients with hypertrophic cardiomyopathy or the long QT syndrome who are participating in moderate or vigorous exercise with sedentary patients.
Jefferson -PSHVIResearchCoordinators@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Scheduled to have heart valve implant
Have history of atrial arrhythmia
18 to 60 years of age
Exclusion Criteria:
Heart failure
Health issues that would limit your ability to exercise
Left ventricular hypertrophy or prolonged QT which occur as part of multi-system disorder
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NCT02549664
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Location
Harrisburg, PA

A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-GenE trial

The dal-GenE trial is evaluating the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with a documented recent heart attack or hospitalization due to severe coronary artery disease. Dalcetrapib is an investigational drug (not approved by the United States Food and Drug Administration) that has been evaluated in several large clinical trials, most notably dal-OUTCOMES, a study of over 15,000 patients which was designed to evaluate its effect in patients with recent ACS. The results of this large study demonstrated that treatment with dalcetrapib did not change the risk of cardiovascular disease in the majority of patients with recent ACS. However, after the study was over, researchers identified a group of patients that had a significant benefit. Specifically, the group of patients who had a particular variant (AA) of a gene that all humans share (ADCY9) had their risk of having another cardiovascular event reduced by 39%. Approximately 1 in 5 patients studied had this genetic variant. Those individuals with the AA variant of the will continue in the study and will be started on study drug 4-12 weeks after their index event.
Gardner -PSHVIResearchCoordinators@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Male or female age 45 or greater
Admitted to hospital due to blockages in arteries of the heart
Exclusion Criteria:
Bypass surgery to treat your most recent heart event
Severe liver and/or kidney disease
Hemoglobin A1c greater than 10%
Triglyceride level greater than 500mg/dL
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NCT02525939
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Location
Hershey, PA

The Sexual Relationships Study

The purpose of this study is to examine the sexual relationships among heterosexual female college students (ages 18-22) via Qualtrics (a web-based survey). Utilizing latent class analysis with a distal outcome, the proposed cross-sectional study seeks to do the following: Aim 1. Examine the heterogeneity in relationship quality among female college students. Research question 1: Is there a latent class structure that adequately represents the heterogeneity in relationship quality among female undergraduate students participating in penile-vaginal sex? If so, what are the types and their corresponding prevalence? Aim 2. Examine the association between relationship characteristics and latent class membership. Research question 2: Are relationship characteristics (partner type, relationship duration, exclusivity/monogamy, and frequency of sex) predictive of membership in latent classes of relationship quality? Aim 3. Examine the association between latent classes of relationship quality and condom use. Research question 3: Which identified latent class of relationship quality is significantly associated with condom use at last penile-vaginal sex? Please note that the indicators measuring relationship quality will include the following variables: 1) trust, 2) love, 3) passion, 4) commitment, 5) relationship satisfaction, 6) sexual satisfaction, 7) intimacy, and 8) decision-making dominance.
Salas-Brooks -jis5940@psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Be enrolled at Pennsylvania State University (University Park Campus)
Be between the ages of 18-22 years
Be a female college student
Be sexually active with male partners in the previous 3 months
Exclusion Criteria:
Are not enrolled at Pennsylvania State University (University Park Campus)
Are under the age of 18 or over the age of 22.
Are not a female college student
Are not sexually active with male partners in the previous 3 months
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N/A
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Memory Specificity across Cultures

This is a behavioral study that will look at culture-related differences in memory performance.
Gray -cxg428@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
For East Asian Participants: Originally be from East Asia (China, including Hong Kong and Taiwan, Japan, Korea, or a Southeast Asian nation)
For East Asian Participants: Have lived in the United States for less than 5 years
For Western Participants: Originally from the United States & English is first language
For Western Participants: Have not lived outside of the country for more than 2 years in a non-Western country
For All participants between the ages of 18-35
Exclusion Criteria:
For Western Participants: Asian ethnicity
For Western Participants: Living in an East Asian country for more than 2 years.
For East Asian Participants: Living in the United States for more than 5 years.
For East Asian Participants: English as a first and native language.
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N/A
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Study Locations

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Location
State College, PA

Parental Stress and Coping Post-NICU Discharge: Perceptions of Daily Stress and Psychobiological Patterns of Response to Stress Challenge

Parental stress levels following discharge from the neonatal intensive unit (NICU) can have impacts on mental health and relationship functioning. The current practice and understanding of Family-centered NICU care often does not address interventions to facilitate parental means to cope with this stress, be it through religious/spiritual means or traditional forms of coping, both of which are tied to their babies’ functioning outside of the NICU. Thus, parental experiences of stress as assessed through self-perceptions and biological and behavioral indicators of stress and coping strategies is an important first-step in future development of a psychospiritual intervention, which is thus far lacking in family-centered NICU care.
Gardner -fgardner1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Parent of a former preterm infant hospitalized in NICU within the past 12 months with parental custody of the infant
Fluent in written and spoken English
Exclusion Criteria:
Chronic illness impacting cardiovascular or autonomic stress measurement (autoimmune disorders- e.g., Lupus, RA, Crohn’s disease)
Advanced cardiovascular disease (e.g., CHD, CHF, arrhythmia, pacemaker, history of MI)
Individuals with endocrine disorders impacting stress hormonal measures (e.g., Cushing’s Disease, Addison’s Disease, IDDM)
Mental illness (e.g., schizophrenia, psychosis, panic disorder)
Pregnant women
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N/A
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Study Locations

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Location
Hershey, PA

Improving Autism Screening with Brain-Related miRNA

The central aim of this project is to characterize the expression of exosomal microRNA (miRNA) in children with autism spectrum disorder (ASD). We propose to measure the expression of extracellular miRNA in children with ASD. Expression levels of miRNA from blood and saliva will be compared between children with autism and normally developing controls. The goal of this study will be to identify genetic regulatory mechanisms involved in ASD and provide potential biomarkers for diagnostic screening.
Vallati -jvallati@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Age: 24 Months
•6 Years
Confirmed Diagnosis of Autism or Developmental Delay or Healthy Child
Exclusion Criteria:
Wards of the state
Underlying Seizure Disorder
Underlying Genetic Disorder
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NCT02712853
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A Pilot Trial of Subtyping Pediatric Conduct Problems by the Presence of Severe Persistent Irritability and Callous Unemotional Traits

Youth with irritable and aggressive behaviors, or conduct problems, are thought to be sensitive to rewards and insensitive to punishments. Parents and children will complete rating scales and computer tasks that will assess for sensitivity to rewards and punishments. This study will help to target interventions for treating children with conduct problems.
Mills -smills1@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 7--12 years
Elevated degree of conduct problems
IQ greater than 80
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, ASD, or a pervasive developmental disorder
Sever suicidality
Visual or hearing impairments
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N/A
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Location
Hershey, PA

Memory and Aging Study

This research is being done to find out more about changes in the brain as we age and to determine if MRI, genetic (DNA) variations, and neuropsychological tests can be used to evaluate memory loss and cognitive impairment.
Spreen -lspreen@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Diagnosis of Alzheimer's disease
Diagnosis of Mild Cognitive Impariment
Normal Controls-Cognitively normal functioning
Exclusion Criteria:
Neurological disease (e.g., stroke, tumor, Parkinson's disease, etc.)
Psychiatric disorder (e.g., bi-polar, schizophrenia, etc.)
History of chemotherapy
Presence of a cold or viral infection
Presence of a pacemaker, aneurysm clips, or any metal in body
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N/A
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Study Locations

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Location
Hershey, PA

Phase 2 Study of RVT-501 in Adult and Adolescent Subjects with Atopic Dermatitis

Atopic dermatitis study: Topical mediation applied 2 times a day. Ages 12-17yr olds, 8 visits over 5 weeks. Compensation provided for time and travel.
Gettle -sgettle2@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Atopic Dermatitis present for at least 12 months
Exclusion Criteria:
certain treatments for Atopic Dermatitis are not allowed coordinator will discuss specific treatments.
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NCT02950922
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Location
Hershey, PA

Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis. To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim. To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
Hoffman -dhoffman1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age >/=35 years
Do you have documented stenosis of your carotid?
Have you had any neurologic symptoms on the same side as your stenosis
No medical history of stroke or TIA on the same side as the stenotic vessel in the previous 180 days
If female, not pregnant
Exclusion Criteria:
Prior stroke with residual disability
Symptomatic ICH within past 12 months
Chronic afib
Ejection fraction < 30%
Do you use an anticoagulant? What medication?
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NCT02089217
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Location
Hershey, PA

Development of a caregiver-report instrument to assess child behavior.

It is commonly agreed that school-aged children display observable attachment behavior, although it is difficult to elicit in laboratory tasks. However, caregivers will observe this behavior on a regular basis when it occurs and can provide useful information regarding the structure and function of that behavior. The goal of the current proposal is to define a potential caregiver-reported instrument assessing early school-age children’s attachment behavior and collect initial data sufficient to examine the factor structure and reliability of the measure. Data collection will utilize anonymous online survey methodology and recruit through schools and preschools.
Allen -ballen1@pennstatehealth.psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Adult caregiver of a child between the ages of 4 and 8
Adult caregiver is at least 18 years of age
Adult caregiver is the primary caregiver of the child.
Exclusion Criteria:
Child has an autism spectrum disorder, intellectual disability, or other developmental delay.
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N/A
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A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABT-494 for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis

This study is for patients who have been diagnosed with moderate to severe ulcerative colitis (UC) who are experiencing bloody diarrhea, abdominal pain, and a sudden and constant feeling of needing to move their bowels. Additionally, patients have been unable to tolerate or have had an insufficient response to treatment with medications that help reduce inflammation associated with UC. This research is being done to evaluate the safety of different doses of ABT-494 (study medication) and determine how well it works, as well as how the study medication is absorbed, distributed and eliminated in the body over time.
Behe -abehe@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Diagnosis of ulcerative colitis for at least 90 days
Demonstrated an inadequate response to, loss of response to, or intolerance to steroids, immunosuppressants and/or biologic therapies
Exclusion Criteria:
Have a current diagnosis of Crohn's disease, fulminant colitis and/or toxic megacolon
History of total colectomy or ileostomy
Taking a probiotic and has not been on a stable dose for at least 10 days
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NCT02819635
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Location
State College, PA

Deprexis Study: An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial

An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial
Roman -car342@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Multiple Sclerosis
Depression
No current treatment
Internet access
Willingness to participate in an online treatment for depression
Exclusion Criteria:
No diagnosis of MS
Current psychotherapy for depression
Substantial neurocognitive impairments
Very severe depression
Started anti-depressants in the last 2 months
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N/A
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Study Locations

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Location
State College, PA

Evaluating changes of muscle stiffness in patients with compartment syndrome

The objective of this study is to quantify changes in muscle stiffness using ultrasound shear wave elastography (SWE) in patients with exertional compartment syndrome (CS).
Cortes -researchsubjects@mne.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Exertional Compartment Syndrome (Leg)
Needle Manometry
Exclusion Criteria:
Sensitivity to Ultrasound Gels
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N/A
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Location
State College, PA

Procalcitonin Antibiotic Consensus Trial

The study objective is to target emergency department (ED) patients with clinically diagnosed lower respiratory tract infection (LRTI) and test the effects of implementation of a procalcitonin antibiotic guideline for LRTI.
Campbell RN -ncampbell1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Lower respiratory lung infection < 28 days
Exclusion Criteria:
no antibiotic use for 72 hours before enrollment
no other infections
no cancer
no dialysis
no major surgery in past 7 days
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NCT02130986
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Location
Hershey, PA

Behavioral and Attitudinal Products of Gender Threat

We aim to explore whether threats to masculinity also lead to physiological arousal, as well as emotional experiences of public discomfort and anger. In addition, the proposed research will examine whether images that encourage men to male gender role dominance may more rapidly appease that threat. We will use randomly assigned feedback regarding a gender knowledge test to threaten or affirm masculinity then measure public discomfort and anger. Finally, participants will be shown vintage ads in which males are dominate or control ads featuring animals. During the study participants will be wearing noninvasive wristwatches which will monitor heart rate and other physiological markers.
Lewis -kal40@psu.edu
Male
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
18 and older
males
Exclusion Criteria:
Under 18
not males
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N/A
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Study Locations

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Location
State College, PA