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21 Study Matches

NASH AMPK Exercise Dosing (AMPED) Trial

The purpose of this trial is to test different levels of exercise needed to reduce liver fat in patients with NASH.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04987879
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Inclusion Criteria:
Adults age >18 years
NASH diagnosis
BMI 30-45 kg/m2
sedentary lifestyle
Exclusion Criteria:
pregnancy
Active cardiac symptoms
Cancer that is active
Inability to provide informed consent
Other liver disease
Digestive Systems & Liver Disease
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Location
Hershey, PA

IMpact of PRehabilitation in Oncology Via Exercise – Breast cancer

It is well known that breast cancer patients suffer from many cancer- and treatment-related side effects that all worsen overall quality of life. Besides dealing with existing treatment-related side-effects, there is the idea of prehabilitation a process on the cancer continuum of care that occurs between the time of cancer diagnosis and the beginning of acute treatment. IMPROVE-B will evaluate an exercise prehabilitation approach with regard to safety, feasibility, acceptability and effectivity in breast cancer patients (n=30) prior surgery.
Joachim Wiskemann at jwiskema@phs.psu.edu or 717-531-0003, ext=289736
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Scheduled for breast cancer surgery
Not metastatic (stage <4)
more than 2 weeks till surgery
Exclusion Criteria:
Receiving neoadjuvant chemotherapy or radiotherapy
Pregnant
• Engaging in systematic intense exercise training (at least 1h twice per week)
Cancer
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Location
Hershey, PA

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
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Location
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Exercise Ability

To determine if the sympathetic and blood pressure (BP) responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease (PAD).
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
healthy females and males
all minorities and ethnicies included
free of acute or chronic medical conditions
over 21 years old
Exclusion Criteria:
Females who are pregnant or lactating
under 21 years old
Decisional impairment
Heart & Vascular
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Location
Hershey, PA

Exercise Therapy and Radiation Therapy (EXERT) for metastatic prostate cancer

This is a randomized controlled trial examining the effects exercise therapy has on radiation toxicity and physical function in men diagnosed with metastatic prostate cancer.
Sara Garrett at smg6282@psu.edu or 717-531-0003, ext=289437
Male
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04556045
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Inclusion Criteria:
Males 18 years of age or older diagnosed with metastatic prostate cancer
Receiving first course of radiation therapy for metastatic prostate cancer at the Penn State Cancer Institute
Prior treatment with hormone therapy
Speaks and writes in English
Able to provide informed consent
Exclusion Criteria:
Receiving radiation therapy at a location other than Penn State Cancer Institute
Already exercising more than 90 minutes per week
History of heart disease
Patients at a high risk of breaking bones or with an unstable spine
Children
Men's Health, Cancer
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Hershey, PA

A double-blind randomized placebo-controlled study on the analgesic properties of amiloride in exercise-induced skeletal muscle pain

To determine if the drug Amiloride will reduce exercise related muscle pain and improve exercise tolerance in healthy volunteers.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
healthy males and females
between 21-40 years old
any race or ethnicity
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
high blood pressure
opiod use
taking amiloride or similar medication
Heart & Vascular
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Location
Hershey, PA

Impact of Prehabilitation in Oncology Via Exercise- Bone Marrow Transplant

The purpose of this study is to assess feasibility, safety, and acceptability of a prehabilitation exercise program for hematopoietic stem cell transplant patients. The second purpose of this study is to assess changes in physical function, fatigue, pain, quality of life, and transplant-related symptoms and complications in hematopoietic stem cell transplant patients.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03886909
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Inclusion Criteria:
Hematological cancer (e.g. Acute Myeloid Leukemia, Multiple Myeloma, Chronic Lymphocytic Leukemia, etc.)
Females and males, 18 years of age and older
Fluent in written and spoken English
Scheduled for an inpatient autologous or allogeneic stem cell transplant at Penn State Cancer Institute
At least 2 weeks until scheduled transplant
Exclusion Criteria:
Not fluent in written and spoken English
Severe cardiovascular issues
Uncontrolled hypertension
Transplant physician does NOT approve
Cancer
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Study Locations

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Location
Harrisburg, PA
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Sympathetic Response

The purpose of this study is to examine if nervous system and blood pressure responses to exercise will be less with heat exposure in patients with peripheral artery disease (PAD) and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
free of acute medical conditions
any race or ethnicity
women or men
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
age < 21 years old
Heart & Vascular
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Study Locations

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Location
Hershey, PA

In Vivo Assessment of the Effect of Bench Press Exercise on Glenohumeral Cartilage Deformation

The goal of this project is to investigate the impact of high-load exercise, like the bench press with a large amount of weight as opposed to an exercise like the push-up, on the shoulder joint cartilage , tissue on the ends of our bones that cushion and protect them from damage, as well as assess how well qualitative assessments of personal pre- and post-exercise pain coordinate with cartilage structure. We predict that there will be a significant difference in pre- and post-exercise cartilage thickness.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy adults between the ages of 18-35
English speaking
Exclusion Criteria:
Previous injury or surgery to either shoulder
Inability to undergo MRI
Inability to perform exercise protocol
Pregnant
Under the age of 18 or over the age of 35
Muscle & Bone
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Location
Hershey, PA

fMRI based mapping of the supraspinal projections of the exercise pressor reflex

This study will examine how the brain controls blood pressure responses during exercise, and will include 2 separate visits. In one visit, you will perform a series of handgrip exercises followed by inflation of a blood pressure cuff while we collect muscle nerve activity and blood pressure. In the other two sessions you will perform a similar task while laying in an MRI machine.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
age between 21 and 40 years
healthy
able to perform handgrip execise
normal blood pressure
Exclusion Criteria:
claustrophobic
have metal implants
taking heart medication
pregnant/nursing
smoker
Heart & Vascular
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Study Locations

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Location
Hershey, PA

Examining views associated with physical exercise and its connection to diet, social connectivity, and stress reduction: Online Focus Groups

The primary objective of this study is to examine, via online focus groups, the perceptions that are held by potentially-eligible subjects in the PSH DPP program in regard to the importance of physical exercise, particularly within the context of diet, social connectivity, and stress reduction. These perspectives will then be used to help develop, test, and refine additional motivational text messages that can be used in a text messaging intervention. Participants will receive a $25.00 gift card.
Selena Ortiz at suo13@psu.edu or 814-863-8041
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Be at least 18 years old and under age 65
Body Mass Index ≥25 kg/m2 (≥23 kg/m2 if Asian)
Have no previous diagnosis of type 1 or type 2 diabetes
Fluent in English
Exclusion Criteria:
Under 18 years old and over age 65
Body Mass Index <25 kg/m2 (<23 kg/m2if Asian)
Previous diagnosis of type 1 or type 2 diabetes
Not fluent in English
Prevention, Education, Diabetes & Hormones
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The Effect of Resistance Exercise on Craving and Cannabis Use in Individuals with Cannabis Use Disorder

Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of problematic cannabis use, identifying effective behavioral strategies for individuals experiencing problems with addiction would offer significant benefits. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD. No prior study has investigated the effects of an acute bout of resistance exercise on cannabis craving and consumption, nor has prior research identified what psychobiological mechanisms may underlie these exercise potentiated effects. The aims of this proposal seek to address these issues by implementing an acute resistance exercise protocol in men and women who have severe cannabis use disorder. This proposal will examine the acute effects of resistance exercise on craving, mood, anxiety, and markers of reward and stress regulation. In addition, this proposal will examine the trajectory of these effects in the subsequent days.
Gwendolyn Thomas at gat112@psu.edu or 814-863-3172
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03867786
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Inclusion Criteria:
Cannabis Use
Between 18-30 years old
Recreationally trained
Able to read write English and complete study evaluations
Provide negative toxicology screenings for nicotine or alcohol at intake
Exclusion Criteria:
Women who are pregnant or lactating
Known endocrine disorder
Blood clotting disorders
Any psychiatric disorder or current psychiatric symptoms
Inability to give informed consent
Addiction & Substance Abuse
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Location
State College, PA

AWS-PSU: Active Women's Study at Penn State University

AWS-PSU: Active Women's Study at Penn State University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 16-29.9
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Food & Nutrition, Muscle & Bone, Women's Health
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Study Locations

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Location
State College, PA

AYA-UNITE (Utilizing Novel Information Technology to Promote Exercise and Well-Being) in Adolescents and Young Adults with Cancer

Adolescents and young adults (AYAs) with cancer have many needs for supportive care that differ from younger and older patients. This includes age-appropriate psychological support for management of distress, as well as supports for the social isolation many AYAs experience. One exciting intervention that may provide AYAs with cancer improved psychosocial support, as well as increased physical strength, is physical activity. This feasibility project aims to evaluate the safety, feasibility and acceptability of a physical activity training in AYAs with cancer delivered via a socially interactive videoconferencing platform.
Pooja Rao at prao2@pennstatehealth.psu.edu or 717-531-6012
All
All
This study is NOT accepting healthy volunteers
NCT03778658
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Inclusion Criteria:
Participant age 15-29 years old at time of cancer diagnosis

Participant diagnosis of cancer who is currently undergoing active treatment for cancer, or who is within 3 years of end of cancer treatment at the time of enrollment
Participant must have access to a computer or smartphone
Exclusion Criteria:
Cardiovascular or respiratory disease

Absolute contraindication to exercise
Pregnant women
Patients with relapsed cancer
atients who have undergone allogeneic stem cell transplant
Sports Medicine, Mental & Behavioral Health, Cancer
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Using Exercise to Relieve Arthralgia (Joint Pain) and Improve AI Adherence in Older Survivors (REJOIN): A Pilot Study

Briefly, the purpose of this study is to use a self-management approach (combining education and exercise) to help older breast cancer survivors manage joint pain, a common side effect of aromatase inhibitors (AIs), a medication used to reduce hormones that might increase risk of recurrence and mortality following primary cancer treatment. We believe that reducing joint pain might help survivors take their medication longer and thus improve survival outcomes, compared to standard care.
Shirley Bluethmann at szb332@psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03955627
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Inclusion Criteria:
Age 65 and older
Female
Breast Cancer Survivor
Preparing to Start AI medication
ER+ diagnosis
Exclusion Criteria:
Already taking AI medication (greater than 2 weeks)
Gross Cognitive Impairment
Recent Joint Surgery
Cardiac event/Stroke within last 6 months
Not willing to come to HMC for Exercise Sessions
Cancer
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Location
Hershey, PA

The changes in insulin resistance and metabolic health among young, middle aged, and older adults meeting the current aerobic exercise training recommendations.

The overall purpose of this research is to evaluate the difference the national cardiorespiratory exercise recommendations have on metabolic and cardiovascular health over 6 weeks in previously sedentary young, middle aged, and older adults matched for obesity. The participants will complete moderate intensity exercise for 30 minutes per day, 5 days per week for 6 weeks. Pre- and post-intervention testing will be completed to evaluate changes in metabolic and cardiovascular health.
Nicole Gilbertson at nmg46@psu.edu or 814-949-5016
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Ages 19-24 and 45-79 years
Physically inactive
Able to walk for at least 30 minutes
Obese
Exclusion Criteria:
Currently participating in planned, structured physical activity
Lost or gained more than 10 lbs in 6 months
Females currently pregnant or breastfeeding
Currently smoking/using tobacco products or have within the past 6 months
Having signs/symptoms or diagnosed with cardiovascular, lung, kidney, metabolic, or mental health disease
Heart & Vascular, Sports Medicine, Diabetes & Hormones
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Location
Altoona, PA

Active Men's Study

Description: This research study is to assess energetic status, reproductive health, and bone health in a population of young exercising men. Secondarily, this study will also explore how diet, fitness, cardiovascular function, eating behaviors, stress, cognitive function, and sleep related to energy and reproductive outcomes in exercising men. Eligible young men (age 18-35) are those who are generally healthy and either a) exercising or b) not exercising.
Christine Bowlus at cub94@psu.edu
Male
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 18-35 years
BMI between 16-29.9 kg/m2
Non-smoker
For sedentary participants: less than 150 minutes of purposeful exercise per week
For exercising participants: at least 150 minutes of purposeful exercise per week (moderate to high intensity aerobic and/or resistance training).
Exclusion Criteria:
BMI >29.9 kg/m2 or <16 kg/m2
Procedures using contrast material within the past 7 days, including X-rays, MRI scans, CT scans, barium studies, nuclear medicine exams.
Currently a smoker or history of regular smoking
Prostheses
Vasectomy
Food & Nutrition, Muscle & Bone, Mental & Behavioral Health
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Location
State College, PA

The Muscle Reflex: MRI Studies

This research is being done to examine how the response to leg exercise measured with MRI is different between patients with Peripheral Arterial Disease (PAD) and healthy volunteers.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
have ferromagnetic metal implants
are claustrophobic
Heart & Vascular
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Location
Hershey, PA

Understanding Prenatal Hydration Behaviors

To examine women’s self-reported pregnancy hydration behaviors, especially during a global pandemic. This study will also examine other lifestyle behaviors (e.g., weight gain, exercise, eating behaviors, sleep, pain management). It is hypothesized that hydration behaviors will decrease due to lifestyle changes related to the pandemic. Secondary outcomes will also be influenced by hydration behaviors and pandemic lifestyle changes.
Abigail Pauley at amp34@psu.edu
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Pregnant
Women
18-45
English speaking
Exclusion Criteria:
Non-pregnant
Men
Younger than 18
Non-English speaking
Food & Nutrition, Mental & Behavioral Health, Women's Health
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NASH Fitness Intervention for Thrombosis (NASHFit) Trial

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States. The most advanced forms of NAFLD are associated with increased liver-related mortality and lower overall survival. The current standard of care for NAFLD is lifestyle changes through diet and exercise. The human genome and regulation of gene expression is influenced by physical activity. NAFLD is a prothrombotic state with derangements in all three phases of hemostasis leading to clinically important clotting events. Exercise can improve coagulation in healthy persons. In this proposal, we seek to begin a line of work to answer the question “Can lifestyle changes effectively mitigate the increased risk of clotting in patients with NAFLD?” focusing initially on the at-risk population genetically susceptible to advanced disease.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03518294
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Inclusion Criteria:
Nonalcoholic fatty liver disease (NAFLD)
Evidence of hepatic steatosis by imaging
Exclusion Criteria:
>90 minutes/week of at least moderate intensity exercise over the previous three months
Pregnancy
Active cardiac symptoms
Uncontrolled diabetes (changes in medication dosing over the previous three months or hemoglobin A1c >9%)
Blood Disorders, Digestive Systems & Liver Disease, Sports Medicine
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Location
Hershey, PA

Identification of Critical Thermal Environments for Aged Adults

The earth’s climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely exercise in warm and/or humid conditions. It is important to learn about safe limits of heat and humidity for older adults to exercise. Also, nearly 40% of adults over age 50 take aspirin to lower their risk for heart disease. Our lab has shown that aspirin lowers the control of body heat. In this study, we will determine critical temperature and humidity environments above which normal body temperature cannot be maintained in young and older adults. We will also look at how aspirin may change critical temperature and humidity thresholds in older adults.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04284397
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Inclusion Criteria:
Healthy subjects 18-35 or 65-85 years of age
Asymptomatic and no signs/symptoms of disease
Exclusion Criteria:
Have any conditions to advise against low-intensity physical activity
Received a prior diagnosis of cancer, cardiovascular disease, diabetes, or metabolic syndrome
Medications that could alter cardiovascular responses or body temperature regulation during exercise (blood pressure reducers, fever reducers, anti-depressants, etc.)
Tobacco or recreational drug use
Post-menopausal women taking hormone replacement therapy
Heart & Vascular, Sports Medicine
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Study Locations

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Location
State College, PA