Refine your search

Search Results

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

46 Study Matches

Improving Autism Screening with Brain-Related miRNA

The central aim of this project is to characterize the expression of exosomal microRNA (miRNA) and nucleic acids in children with autism spectrum disorder (ASD). We propose to measure the expression of extracellular miRNA and nucleic acids in children with ASD. Expression levels of miRNA and nucleic acids from blood and saliva will be compared between children with autism and normally developing controls. The goal of this study will be to identify genetic regulatory mechanisms involved in ASD and provide potential biomarkers for diagnostic screening.
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT02712853
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Age: 1-4 years
Confirmed Diagnosis of Autism or Developmental Delay or Healthy Child
Exclusion Criteria:
Wards of the state
Sensory Impairment (blindness/deafness)
Confounding neurological condition (cerebral palsy, epilepsy)
Gastrostomy Tube Dependence
Active Peridontal Disease
Children's Health, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Brain Mechanisms of Overeating in Children

Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kara Hickok at kih5334@psu.edu or 814-865-5169
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03341247
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
The child must be age 7-8 when the first study visit is completed
The child must not have any food allergies to foods used in the study, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia.
The child must not be taking any medications known to influence cognitive function, taste, appetite or blood flow
The child's BMI must be below the 90th percentile at the first visit
The biological mother and father must have a BMI between 18.5-25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers and greater than or equal to 25 kg/m2 for fathers (high-risk group) and 1 parent must attend all visits.
Exclusion Criteria:
Children will be excluded if they are not within the age requirements (< than 7 years old or > than 8 years-old at the first visit).
Children will be excluded if they have any food allergies, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia
Children will be excluded if they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow
Children will be excluded if their BMI is above the 90th percentile at the first visit
Families will be excluded if the biological mother or father do not fit the BMI requirements
Food & Nutrition, Prevention, Neurology
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

PA CURE Phase 1: Biomarkers of Traumatic Brain Injury (TBI)

The study seeks to identify the characteristics of brain function after traumatic brain injury (TBI). The data obtained through this study aims to help physicians better understand the characteristics of specific products released into the blood and cerebrospinal fluid (CSF) following a TBI, called biomarkers. In addition, we will store blood and CSF samples for later testing as new information becomes available. The long-term goal of this study is to provide physicians with the tools they need to diagnose brain injuries. This information may help doctors judge how severe a head injury is, if treatment needs to be adjusted, and it may help predict how well a patient recovers from the injury.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Traumatic brain injury within the preceding 24 hours requiring admission to the ICU
Current age 18-60 years
Head CT with acute intracranial pathology
Ability to undergo MR and PET imaging
Exclusion Criteria:
Penetrating TBI due to gunshot wound, shrapnel, or other metallic substance that would preclude patient from undergoing MR imaging
Pre-existing neurologic or neurodegenerative disorder or history of psychiatric conditions, such as major depressive disorder or psychosis
Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with neuropsychological testing
Contra-indication to MR imaging, such as ferrous metal, pacemakers, body weight above 125 kg, or concerns about claustrophobia
Non-native English speakers (translations are not available/validated for most neuropsychological test measures).
Neurology
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Brain potential reveals the effect of language immersion on L2 learning

In this project, we aim to understand how the environment influence language learning. Research in bilingualism and second language acquisition has demonstrated the high adaptability of the human brain in response to environmental input and behavioral experience. However, in the previous studies on second language (L2) learning, environmental factors that may lead to structural and functional changes in the brain have rarely been systematically investigated. The length of residence in an L2 environment (LoR), which strongly relates to the amount of language experience, is one environmental factor that can impact neural mechanisms underlying L2 processing. Thus, this project will examine the effect of LoR on the neural processing of English by native speakers of Mandarin.
Haoyun Zhang at hxz153@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
18-years of age or older

Right handed
Normal or corrected-to-normal vision
Either Native Monolingual English Speakers or Mandarin learners of English who do not know a third language
Exclusion Criteria:
A history of neurological disorders or language disorders
< 12 years of education
illiteracy
Language & Linguistics
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Regional Brain Manganese Accumulation and Functional Consequences in Welders

This study is looking at the effects of welding fumes on brain health. Our group has found brain structure and functional changes using brain MRI and other tests for movement and function in active welders. Now, we are very interested to see if the brain function and structural changes persist in welders, particularly after they retire. This is an independent study sponsored by the National Institute of Environmental Health Sciences, with no affiliation to any private entities such as law firms. In this study participants will be asked to undergo clinical tests (blood draw, motor examination, memory tests), complete lifestyle questionnaires, and undergo an MRI scan during a baseline visit and again for an 18 month follow-up visit.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Welders: Boilermakers, pipefitters, etc.
Controls: No past exposure to welding
Controls: Males ages 40-70
Fluent in English
Consent to MRI
Exclusion Criteria:
Severe memory impairment or signs of dementia
Claustrophobia or unwillingness to participate in a MRI
Significant medical and neurological defects
Significant recreational drug use or alcohol abuse
Neurology
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Examining elderly traumatic brain injury and risk for neurodegeneration

The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI: 


Frank Hillary at fgh3@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
>54 years of age
sustained a traumatic brain injury
Exclusion Criteria:
<55 years of age
history of neurological disorder such as stroke, epilepsy, or multiple sclerosis
history of bipolar
Neurology
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Perception of Brain Injuries: Viewpoints from college students

The purpose of this study is to learn more about the knowledge, thoughts, and experiences of college students regarding brain injuries through a semi-structured interview.
Nicole Etter at nme2@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
18 years and older
Current college student
English and Hearing sufficient to complete a semi-structured interview
Exclusion Criteria:
Does not meet inclusion criteria
Education, Neurology, Sports Medicine
  Email this study information to me
  Contact the study team

Application of graph theory to both resting-state and task-based fMRI data to uncover brain-behavior relationships related to therapy outcomes in aphasia

This project will use fMRI to examine changes in the brain related to behavioral therapy outcomes in persons with aphasia. We aim to recruit twenty persons with aphasia. Each participant will receive 4 MRI scans. Between scan 1 and scan 2, no therapy will be provided (10 week break). Between scan 2 and scan 3, ten weeks of word finding therapy will be provided. Between scan 3 and scan 4, no therapy will be provided (10 week break). The therapy used is abstract word retrieval training. The results of this project will help inform rehabilitation practices in aphasia.
Chaleece Sandberg at cws18@psu.edu or 814-863-2006
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Diagnosis of aphasia
Sustained stroke at least 6 months ago
Right-handed
Native English speaker
Completed at least a high school education
Exclusion Criteria:
History of neurodegenerative disease (e.g., Alzheimer's)
History of other acquired neurological disorder (e.g., TBI)
History of developmental disorder (e.g., autism)
History of psychological disorder (e.g., schizophrenia)
Unsafe to receive MRI (e.g., pacemaker)
Neurology, Language & Linguistics
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Assessing cognitive and psychosocial mechanisms of Useful Field of View cognitive training using ecological momentary assessment

We are interested in how brain games impact everyday life in healthy older adults. Participants will play 20 hours of brain games on a study-provided laptop, and we will examine how the brain games impact everyday life. This study will be performed remotely in participants homes using study-provided laptops. Some participants may also participate in 2 optional visits with brain MRI scans at Penn State University and at home sleep monitoring.
Michelle Huerbin at mlh5955@psu.edu or 814-865-4773
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00000000
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
65 or older
no diagnosis of dementia
available for 6 months
Exclusion Criteria:
64 or younger
dementia or motor movement disorder diagnosis
cognitive training within past 2 years
Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  See more information

The Neural Basis of Pattern Learning in Human Adults

This research investigates how the human adult brain exploits patterns and regularities in the environment to learn.
Elisabeth Karuza at ekaruza@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Between 18-30 years old
Minimum High School education
Right-handed
Normal or corrected-to-normal vision/hearing
Fluent in English
Exclusion Criteria:
Individuals with a history of neurological injury or disease
Individuals taking medications that affect the brain or blood flow
Individuals greater than 300 lbs
Individuals who are claustrophobic
Individuals with contraindications to MRI scanning such as an implanted device
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Examining Cortical Lateralization of Motor Learning through High Definition Transcranial Direct Current Stimulation

The aim of this study is to understand how brain stimulation affects learning of a novel task on a virtual reality system. Participation involves playing virtual reality games during non-invasive brain stimulation.
Brooke Fosaaen at brooke.fosaaen@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
right-handed
18-40 years old
Exclusion Criteria:
left handed or ambidextrous
neurological disease
movement disorder
major psychiatric diagnosis
orthopedic damage to the arms
Neurology, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 2 locations

Study Locations

Hide all locations
Location
Hershey, PA
State College, PA

Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
over the age of 18
Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
  Email this study information to me
  Contact the study team
  Show all 2 locations

Study Locations

Hide all locations
Location
Hershey, PA
State College, PA

Functional magnetic resonance imaging (fMRI) and psychophysical studies of sensory perception and cognition

The purpose of this study is (1) to understand how the brain processes sensory information and (2) how this is affected by factors like blindness or synesthesia. In addition to behavioral testing, the study will use functional magnetic resonance imaging (fMRI) which enables us to take pictures of the brain while you are doing a task, using an instrument called an MRI scanner.
Simon Lacey at slacey2@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Healthy adults over 18 years old
Normal or corrected-to-normal vision
No other sensory deficits
Adults who experience synesthesia
Must pass MRI safety screen (if applicable)
Exclusion Criteria:
Pregnant women (excluded from fMRI studies)
Minors under the age of 18
Individuals who fail the MRI safety screen (may still do behavioral studies)
Neurology, Language & Linguistics, Vision & Eyes
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

A Pilot Study to evaluate the pharmacokinetic, pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas

This research is being done to understand how much of two drugs (dabrafenib and trametinib) is able to enter brain tumors and how well the drugs are able to turn off this pathway in brain tumors. The study will also look at how tumors lose sensitivity to this treatment. People with primary brain tumors who are already taking dabrafenib and trametinib and who need a brain surgery are eligible for this study. Biospecimens (tissue, blood, and cerebrospinal fluid (CSF)) taken during the surgery will help us understand how much of these two study drugs actually get into the brain, their effect, and how the tumors become resistant to treatment.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 18 years old
Subjects must have a history of primary brain tumor (including but not limited to glioblastoma (GBM), anaplastic astrocytoma (AA), anaplastic ganglioglioma (AG), and anaplastic pleomorphic xanthoastrocytoma (PXA)).
Subjects must have a BRAF-V600 mutation identified in previous tissue analysis (may be IHC or PCR based). Allowable mutations include V600E, V600K, V600R, and V600D.
Subjects must be taking dabrafenib at a dose of at least 50mg twice daily (adults only) and / or trametinib at a dose of at least 1mg daily (adults only) for at least 7 days prior to surgery as prescribed by their treating physician.
Subjects must be undergoing surgery for clinical purposes
Exclusion Criteria:
Younger than 18 year old
Subjects who are receiving any other investigational agents or chemotherapeutic agents.
Neurology, Cancer
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Memory and Aging Study

This research is being done to find out more about changes in the brain as we age and to determine if MRI, genetic (DNA) variations, and neuropsychological tests can be used to evaluate memory loss and cognitive impairment.
Lauren Spreen at lspreen@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Diagnosis of Alzheimer's disease
Diagnosis of Mild Cognitive Impariment
Normal Controls-Cognitively normal functioning
Exclusion Criteria:
Neurological disease (e.g., stroke, tumor, Parkinson's disease, etc.)
Psychiatric disorder (e.g., bi-polar, schizophrenia, etc.)
History of chemotherapy
Presence of a cold or viral infection
Presence of a pacemaker, aneurysm clips, or any metal in body
Neurology
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Amanda Miller at aross1@pennstatehealth.psu.edu or 717-531-7676
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04137757
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Exclusion Criteria:
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)
Heart & Vascular, Neurology
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction

This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number of people with large hemispheric infarction (LHI). These studies suggested that the study drug was safe, did not cause serious side effects or discomfort, and may reduce brain swelling, disability, and death in subjects with LHI. In this study, we want to investigate the study drug in a larger number of subjects (hundreds) to know more about it. LHI is a type of stroke. An ischemic stroke occurs when blood flow to parts of the brain is blocked, such as by a blood clot. This can cause damage to the brain. In LHI a large portion of the brain is damaged. People who have LHI can develop swelling of the brain called cerebral edema, which can worsen the symptoms and outcomes of LHI. Currently, there are no medications available to specifically reduce brain swelling caused by LHI. In this study, we want to investigate how well the study drug works to improve functional outcomes (the ability to do normal daily activities, such as walking and getting dressed) in subjects with LHI. This study will also look at the long-term effects of the study drug over time and see how safe the study drug is.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02864953
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
A clinical diagnosis of acute ischemic stroke in the MCA territory within 10 hours of symptom onset
Aged 18 to 85 years old, inclusive, at the time of informed consent
Screening NIHSS ≥10
Exclusion Criteria:
In the judgment of the Investigator, the subject is likely to have supportive care withdrawn in the first day
Commitment to decompressive craniectomy (DC) prior to enrollment
Evidence (clinical or imaging) of concurrent infarction in the contralateral hemisphere deemed by the Investigator to be sufficiently serious so as to affect functional outcome
Clinical signs of herniation and/or loss of other brain stem reflexes, attributable to edema or herniation according to the Investigator’s judgment
Brain hemorrhage (other than small petechial/punctate hemorrhages) on NCCT/MRI
Neurology
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Predicting Concussion Outcomes with Salivary miRNA

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows: 1) Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years. 2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Jessica Beiler at jbeiler@pennstatehealth.psu.edu
All
All
This study is also accepting healthy volunteers
NCT02901821
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
5 to 23 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Exclusion Criteria:
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI
Children's Health, Neurology, Sports Medicine
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study

This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation. Children and their parents will complete questionnaires. Children will complete computer tasks during EEG and in an MRI scanner. Parents can also complete the MRI scan if interested.
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Ages 12--16 years
Fluent in English
No history of treatment for psychiatric disorders
Exclusion Criteria:
Intellectual or developmental disabilities
Visual or hearing impairments
Inability to complete MRI scan due a pacemaker, aneurysm clips or any metal in body (e.g., braces, surgical devices)
Currently pregnant or lactating
Neurological disease (e.g., stroke, tumor, Parkinson’s disease, etc.)
Children's Health, Neurology, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Establishing the effect of flavor on the addictive potential of electronic cigarettes

For the current study, smokers will use an electronic cigarette in addition to their usual cigarettes for 4 weeks. The electronic cigarette will contain sweet or tobacco flavored liquid that may or may not contain nicotine. Participants will complete functional magnetic resonance imaging scans at the beginning and end of the study to measure how the brain responds to the electronic cigarette flavor.
Kenneth Houser at abl@pennstatehealth.psu.edu or 717-531-5473
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03905928
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
21-60 years old
Smoke at least 5 cigarettes per day
Smoke regular tobacco flavored cigarettes
Not currently interested in quitting smoking
Exclusion Criteria:
Unstable or significant medical conditions
Pregnant or nursing
Regular use of flavored tobacco products
Regular use of electronic cigarettes
Implanted metal in the body
Addiction & Substance Abuse
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Testing conflicting theories of semantics by constructing neuroinformatic networks of keywords using fMRI data

This is a brain imaging study that will examine how people mentally organize word meanings. Participants will perform a language task while in an MRI scanner, and their brain imaging data will be used to create networks of words that will be used to test conflicting theories of word meaning.
Dominick DiMercurio at dimercurio@psu.edu or 814-867-4341
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Age 18-30
Right-handed
Native speaker of English
At least a high school education
Exclusion Criteria:
History of neurogenic or psychiatric illness
Pacemaker or other metal implant
Claustrophobia
Medications that affect cognition
Language & Linguistics
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Collaborative Research: Measuring and Enhancing Scientific Creative Thinking for STEM Education and Research: Classroom-Aligned Assessment and Network Neuroscience-Based Mechanisms

The project is interested in understanding how the brain supports creative thinking in the context of solving scientific problems. During functional magnetic resonance imaging (fMRI) and behavioral experiments, participants will be presented with open-ended scientific questions and asked to produce responses.
James Lloyd-Cox at jll487@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Over 18 in age
English is first language
Right-handed
No history of neurological injury or disease
Under 300 lbs in weight
Exclusion Criteria:
Claustrophobic
Taking medication that affects brain or blood flow
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

Investigating Face Processing Behavior and Neural Circuitry

The ability to recognize faces differs across people. We are studying this variability in behavior and in brain responses in young adults (ages 18-25 years) in the Lab of Developmental Neuroscience at Penn State. If eligible, you will do face recognition tasks on the computer and answer survey questions. You may also be asked to participate in another session in which we take pictures of your brain using MRI. Volunteers are paid $10/hr for time in the lab. Interested participants can start the screening processing by clicking on this confidential screening link here: https://pennstate.qualtrics.com/jfe/form/SV_9NPJ20bQAPd0VKZ
Dr. Suzy Scherf at suzyscherf@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
18-25 years of age
Native English speaker
Free of neurological and psychiatric disorders
Free of concussions with loss of consciousness
Exclusion Criteria:
Family history of autism spectrum disorders (in parents or full siblings)
Neurology, Mental & Behavioral Health, Vision & Eyes
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

fMRI based mapping of the supraspinal projections of the exercise pressor reflex

This study will examine how the brain controls blood pressure responses during exercise, and will include 3 separate visits. In one visit, you will perform a series of handgrip exercises followed by inflation of a blood pressure cuff while we collect muscle nerve activity and blood pressure. In the other two sessions you will perform a similar task while laying in an MRI machine.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
age between 21 and 40 years
healthy
able to perform handgrip execise
normal blood pressure
Exclusion Criteria:
claustrophobic
have metal implants
taking heart medication
pregnant/nursing
smoker
Heart & Vascular
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Interactions between the olfactory, auditory, visual, and trigeminal systems

The purpose of this study is to use fMRI to identify and characterize the olfactory, auditory, visual and trigeminal-related brain networks. This research will then be use to enhance human health by laying the foundation to develop sensitive biomarkers to identify people who are at risk of developing brain disorders such as Alzheimer’s disease and Parkinson’s disease, where olfactory deficits are known preclinical symptoms.
Michelle Douthitt at mld43@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Healthy subjects (non-synesthetic) with normal olfactory, visual, and hearing abilities
Healthy subjects (synesthetic) with normal olfactory, visual, and hearing abilities
Clear sinuses
Exclusion Criteria:
Non-English speaking
Pregnant or lactating
Presence of a pacemaker, aneurysm clips or any metal in the body
A history of welding, grinding, and or claustrophobia
Neurological disease (stroke, tumor, Parkinson's) or Psychiatric disorder (bipolar, schizophrenia, etc)
Neurology
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Site for Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin

The purpose of this study is to compare any good and bad effects of usual radiation plus the study treatment drug (durvalumab), to the usual therapy of radiation plus the drug (cetuximab) in patients with head and neck cancer who cannot take the drug cisplatin.
Irina Geier at iug29@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03258554
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
squamous cell carcinoma
18 or older
Adequate hematologic function
Adequate hepatic function
Adequate renal function
Exclusion Criteria:
invasive malignancy within the past 3 years
Prior radiotherapy
Prior immunotherapy
Major surgery within 28 days prior to Step 1 registration
Uncontrolled hypertension
Cancer
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
james waxmonsky at jwaxmonsky@pennstatehealth.psu.edu or 717-531-8646
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
Children's Health, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Reducing Perception Error in Diagnostic Radiology

This research is being done to find out the relationship between an individual’s mental state and how well they perform visual-perceptual tasks. This will allow us to understand the brain processes related to errors in image perception, to understand how mental states impact medical image interpretation. Overall, this research will help us develop training programs to reduce the amount of perceptual errors in diagnosing images
Lauren Spreen at lspreen@pennstatehealth.psu.edu or 717-531-5857
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Radiologists with different levels of experience
Healthy adults, with college or advanced degree
Normal or corrected to normal vision
Exclusion Criteria:
Non-English speaking
Pregnant or lactating
Presence of pacemaker, aneurysm clips, or any metal in the body
A history of welding or grinding
Claustraphobia
Education
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Learning about Girls’ Emotions Study

In this study, we hope to better understand whether certain behaviors, reactions and feelings associated with Borderline Personality Disorder (BPD) are found in girls, and how these things may or may not be related to ADHD and brain activity patterns. BPD is a condition that usually is found in adults, and is linked to emotional and behavior problems in children. In doing so, we are asking girls between the ages of 8-12 years and their parents to participate in our research.
Attention and Behavior Clinic Research Group at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285966
Female
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Ages 8-12 years
Female
With or without ADHD Diagnosis
Speak fluent English
Exclusion Criteria:
Younger than 8 years old
Older than 12 years old
Male
Neurology, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Characterizing the Visual Pathway in Epilepsy

This research is being done to determine whether the way your brain processes vision is involved in the epilepsy disease process. There has been recent evidence suggesting that epilepsy patients, compared to healthy controls, have thinner retinas, specifically a layer called the retinal nerve fiber layer, the inner most layer of the retina. This study will expand on that finding by investigating any differences in all of the retinal layers, as well as visual function, between epilepsy patients and healthy controls.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
All: 18-65 years of age
Patients only: Clinical diagnosis of epilepsy
Exclusion Criteria:
All: Those who cannot complete the eye scan or visual tests
All: Those who have diabetes
All: Those who have glaucoma
Neurology, Vision & Eyes
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA