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576 Study Matches

Nursing home staff risk perceptions and experiences associated with restricted social activities during SARS-CoV-2.

The purpose of this study is to improve understanding of direct-care nursing home (NH) staff risk perceptions and experiences associated with NH operations and culture of care defined as restricted activities (communal dining, social engagement, walking in hallway, visitors during illness).

Liza Behrens
Liza Behrens - at llb237@psu.edu or 814-865-0743
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00018958
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Inclusion Criteria:
Be employed as nursing staff in NH as a social work, activities, or nursing staff (RN, LPN, CNA)
Be 18 years or older
Be willing and able to attend the semi-structured interview off shift
English speaking
Self-report of SARS-CoV-2 hot spot in place of employment (any region showing a 14-day rolling average test positivity rate of more than 12% during the pandemic)

Exclusion Criteria:
Any individual that does not meet inclusion criteria
Individuals 89 years of age and older
COVID-19, Education
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My Character is...Myself? Exploring Attachment Styles, View of Self, Virtual Self-Discrepancy, & Character Attachment

The goal of this research is to confirm the relationships between virtual self-discrepancy, character attachment, view of self, attachment styles, and the potential for a moderating variable within the relationships as a starting point for future research tying in player/character relationship and gaming addiction.

Jessica Smith
Jessica Cornelius Smith - at jjc6618@psu.edu or 870-403-7817
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00016362
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Inclusion Criteria:
Must be 18 years of age or older.
Players that engage in role-play gaming using a character they have spent a significant amount of time creating.
Participants that can understand English

Exclusion Criteria:
Participants younger than 18 years of age.
Players that do not engage in role-play gaming using a character they have spent a significant amount of time creating.
People who do not speak and read English.
Mental & Behavioral Health
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A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax in combination with Azacitidine after allogeneic Stem Cell Transplantation in Subjects with Acute Myeloid Leukemia (AML)(M19-063)

This study is to determine the recommended Phase 3 dose of venetoclax in combination with azacitidine in Acute Myeloid Leukemia patients when given as maintenance therapy following allogeneic stem cell transplantation. It also is to determine if venetoclax can be effective in combination with azacitidine to improve Relapse Free Survival in Acute Myeloid Leukemia patients compared to Best Supportive Care (BSC) when given as maintenance therapy following allogeneic stem cell transplantation.

There are different phases of this study. The first phase is Screening, then there is the Treatment phase as well as a Follow up phase. Each phase will have testing and procedures that will require you to come to the study center.

50.00 Travel expenses

Shin Mineishi
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04161885
STUDY00015638
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Inclusion Criteria:
Adult male or female ≥ 18 years old; and, for Part 2 only, male or female at least 12 years old.
Subject must be diagnosed with Acute Myeloid Leukemia by World Health Organization (WHO) criteria (2017) and either be planning for allogeneic stem cell transplantation or have received allogeneic transplantation within the past 14 days.
Subjects that have previously been treated with venetoclax, can only be included if there was no history of disease progression during venetoclax treatment.
Grafts must be from one of the following sources: Bone marrow or peripheral blood stem cells or cord blood cells irrespective of degree of matching.
Subjects and/or their legally authorized representative (where permitted per local regulations) must voluntarily sign and date an informed consent form (and assent form for minors if required by applicable regulations)

Exclusion Criteria:
No malabsorption syndrome or other condition that precludes oral route of administration.
No history of any other malignancy within 2 years prior to study entry
Subject has no known evidence indicating leukemia relapse, which may include immunophenotype, cytogenetic or molecular methods.
No psychiatric illness/social situation that would limit compliance with the study.
No evidence of other clinically significant uncontrolled systemic infection.
Cancer
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Hershey, PA ,

Site for Phase 2 Study of Bladder-SparIng ChemoradiatioN with Durvalumab in Clinical Stage 3, node PosItive BladdeR CancEr (INSPIRE) (PSCI# 19-072) (EA8185)

The purpose of this study is to compare the usual treatment of chemotherapy and radiation to adding MEDI4736 (durvalumab) immunotherapy to the usual treatment. The addition of MEDI4736 (durvalumab) immunotherapy to the usual treatment may help shrink your cancer better than the current standard of care or usual approach for bladder cancer. But, it could also cause side effects, which are described in the risks section. This study will help determine if this different approach is better than the usual approach. To decide if it is better, the study doctors will be looking to see if the study approach increases the life of patients by 6 months or more compared to the usual approach.

If you decide to take part in this study, you will either get chemotherapy and radiation for 6-8 weeks, or you will get durvalumab immunotherapy in addition to chemotherapy and radiation for 6.5-8 weeks. After you finish your study treatment, your doctor will continue to follow you for up to 3 years. The follow-up will consist of visits to his or her office and CT scans of the bladder.

Monika Joshi
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04216290
SITE00000823
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Inclusion Criteria:
Patient must have an ECOG Performance Status of 0-2 at the time of registration.
Patient must have histologically proven pure or mixed urothelial cancer of the bladder.
Patient must be ≥ 18 years of age.
Must have adequate renal function as evidenced by calculated (Cockcroft’s formula) creatinine clearance or 24 hours actual creatinine clearance ≥ 30mL/min.
Patient must have a life expectancy of at least 12 weeks, as determined by the treating physician.

Exclusion Criteria:
Patients with clinical N3 disease are ineligible.
Patient must not have received any previous radiation therapy to the pelvic area.
Women must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.
Patients with a negative biopsy of nodes determined to be suspicious on imaging are not eligible.
Small cell carcinoma is excluded, however other variant histologies are permitted provided a component of urothelial carcinoma is present.
Cancer
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Hershey, PA ,

Mental wellbeing during the Covid-19 pandemic: a study of essential workers and social media use

Through in-depth interviews, we examine how the Covid-19 pandemic has impacted the daily lives and mental well-being of essential workers, as well as their use of social media.

Saeed Abdullah
Johnna Blair - at jlb883@psu.edu
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00015851
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Inclusion Criteria:
Considered an “essential worker”---working outside of their homes during the Covid-19 pandemic (e.g. front line medical professionals, paramedics, hospital workers, grocery store employees, delivery drivers, factory workers, etc.)
Social media users (e.g. Twitter, Instagram, Facebook)
Adults 18 or older
Social media users

Exclusion Criteria:
Considered "non-essential" workers during the Covid-19 pandemic
those working from home during the Covid-19 pandemic
minors (those under 18)
those who do NOT use social media
Men's Health, Mental & Behavioral Health, Women's Health
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"Alexa, I’m in pain! "A Real-Time Mindfulness Intervention to Control Pain: Delivery Through a Conversational Agent

We are interested in learning about people’s experiences with using the Amazon Alexa for delivery of a real-time mindfulness intervention to help with chronic pain management. Participation will include a free day-long introductory mindfulness training followed by daily use of mindfulness practices using the Amazon Alexa to establish a habit of use. The participants will use our developed Amazon Alexa app ("skill") and provide assessments. We will ask participants to complete short daily surveys and a follow-up interview.

Saeed Abdullah
Sanjana Mendu - at spm6450@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011701
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Inclusion Criteria:
Individuals who had some experience with chronic pain over the last 6 months
Living in homes with internet access
Willing to use a smart-home device (Amazon Alexa)
Have access to a smart phone
Read, write, and speak English

Exclusion Criteria:
Under 18 years old
Major mental health issue that is not currently under advisement of a doctor/therapist
Actively struggling with addiction to substances or newly in recovery
Participants who currently report using mindfulness practices more than 1x a month
Pain Management
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State College, PA ,

Hand Action and Perception in Parkinsons Disease

The purpose of this research study is 1.) to determine if Parkinson’s Disease (PD) causes changes in the way that people sense the movements of and forces produced by their bodies, and to connect any of these changes in sensation to changes in the brain, and 2.) to identify how changes in movement might come from different parts of the nervous system. This study will use a combination of electromyography, via electrodes placed on the skin, and finger force recordings to infer how PD effects patients' sense of force production, and the neural mechanisms underlying this change.

This study requires a single in-person visit and will use adhesive skin sensors on the forearms to measure muscle activity while subjects press on sensors which record force levels. Subjects will be asked to match force levels between hands and to move an on-screen cursor into a target.

40

Joseph Ricotta
Joe Ricotta - at ricotta@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020063
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Inclusion Criteria:
Persons with Parkinson's disease, age 50-85, or subjects without Parkinson's disease, age 21-85
No history of earning disability, neurodevelopmental disorder, seizures, multiple concussion (> 3), cerebrovascular disease, brain tumor, hydrocephalus, or any CNS disease other than PD.
No present carpal tunnel syndrome, cervical myelopathy, brachial plexopathy, hand pain, or another neuromusculoskeletal disorder affecting hand function
No history of alcohol and/or drug abuse.
Right handedness.

Exclusion Criteria:
History of specialized hand training such as professional musicianship.
Neurology
Not applicable
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Hershey, PA ,

Site for Large scale genome sequencing and integrative analyses to define genomic predictors of recurrent pregnancy loss

The purpose of this study is to find genetic causes of recurrent pregnancy loss (RPL). RPL is defined by two or more miscarriages under 20 weeks gestation and affects approximately 5% of women. The causes of RPL are not well understood. After all the currently recommended testing for RPL has been done, about half of women with RPL will still have no identifiable cause. This lack of knowledge makes it difficult to provide effective medical care for couples with RPL. This study will compare reading about 20000 genes in the entire human genetic library by whole genome sequencing in the miscarriage material and also your and your partner’s DNA from blood samples. The DNA in a person is a combination of the DNA from each of their biological parents. If you have healthy children we may ask your consent for them to give a blood sample for DNA extraction and testing. Similarly, we may ask the same for other family members such as grandparents if necessary. We may also request your permission to use stored DNA or miscarriage material from previous pregnancy loss if available. Testing of family members or previous miscarriage materials may help to understand DNA sequence variants or changes identified in the miscarriage sample.

There will be a one time collection of blood samples.

Sarah Horvath
OBGYNResearch@pennstatehealth.psu.edu
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
SITE00001050
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Inclusion Criteria:
Women with current pregnancy loss
Two or more prior losses of clinically recognized pregnancies
Prior losses are unexplained

Exclusion Criteria:
Known cause for pregnancy loss and/or prior losses
Pregnancy & Infertility
Prefer not to display
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Hershey, PA ,

Voice Perception Study

This is a voice perception study that asks participants to listen to voices and rate on various attributes such as attractiveness, social status, health, and others.

Toe Aung
Toe Aung - at txa96@psu.edu or 775-225-1747
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00009763
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Inclusion Criteria:
Age 18-40
Gender/Sex: Men/Male; Women/Female
Education: PSU students and participants recruited online

Exclusion Criteria:
Uncorrected severe defects of hearing
Participants who already completed the survey
Participants who took the survey on the mobile phone
Men's Health, Women's Health
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Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion

This research is being conducted to determine how oxygen extraction within exercising muscles is altered in younger and older women when beta-1 receptors (receptors that contribute to the rise in heart rate with exercise) are temporarily blocked through a medication infused into an arm vein. The findings will help us understand how aging affects the regulation of oxygen supply to working muscles is regulated with normal aging.

David Proctor
Matthew Studinski - at mxs1455@psu.edu or 715-498-8093
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT04181606
STUDY00010736
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Inclusion Criteria:
Premenopausal women (18-35 years)
Postmenopausal women (55-70 years)

Exclusion Criteria:
Users of any tobacco and/or nicotine products
Individuals taking hormone therapy
Pregnant or lactating
Individuals with any over cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disorders
Heart & Vascular
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State College, PA ,

Phase II Trial of Palbociclib with Fulvestrant in Individuals with Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer who have Progressed on Treatment with Palbociclib and an Aromatase Inhibitor

In this phase II trial, we will determine the progression-free survival (PFS) of the cyclin dependent kinase 4/6 inhibitor (CDK4/6i) palbociclib with fulvestrant in women and men with estrogen or progesterone receptor (ER/PR) positive, HER2-negative metastatic breast cancer (MBC) who progressed on treatment with palbociclib and an aromatase inhibitor (AI). We will also determine the prevalence rate of estrogen eceptor α (ESR1) and phosphatidylinositol-3-kinase (PI3K) mutations in the study population.

Participants will be required to come to the clinic every three weeks for evaluation and fulvestrant injections, take medication correctly, keep all appointments.

Cristina Truica
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02738866
STUDY00010878
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Inclusion Criteria:
Men and women, 18 years of age or older
Histologically or cytologically confirmed adenocarcinoma of the breast with evidence of metastatic disease (stage IV) or locally advanced disease,
ER-positive and/or PR-positive tumor (≥1% positive stained cells) • HER2-negative tumor
Progressed on and following at least 6 months of combined treatment with palbociclib and AI therapy for advanced/metastatic breast cancer, and be able and willing to receive additional palbociclib treatment
Eastern Cooperative Oncology Group (ECOG) performance status 0-2

Exclusion Criteria:
Women who are pregnant or breast-feeding
Concurrent use of any of the following medications during study participation: • Inhibitors or inducers of CYP3A4 that may affect serum concentrations of palbociclib
Major surgery, chemotherapy, radiotherapy, or other anti-cancer therapy within 2 weeks before registration.
Any other malignancy within 3 years prior to registration, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ of the cervix.
Prior hematopoietic stem cell or bone marrow transplantation.
Cancer
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Hershey, PA ,

Depressive Symptomatology and Inflammation

The purpose of this research is to investigate the associations between depressive symptoms and inflammation. The researchers are studying how specific symptoms of depression (such as fatigue, sadness, impaired concentration, and loss of pleasure) are related to markers of inflammation, which is a key component of our immune system. Volunteers with depressive symptoms, as well as volunteers without depressive symptoms are needed for this research study. This study includes an online survey to determine eligibility and one in-lab visit. Participants who are eligible will be scheduled for one in-lab visit (2.5-3h for participants with depressive symptoms & 1-2h for participants without depressive symptoms), where they will be asked to answer surveys with questions related to depressive symptoms and complete a number of tasks (using an iPad and a touch screen phone) that measure thinking skills including attention, memory and reaction time. Participants will also undergo a single blood draw to assess inflammatory markers.

Participation will require one in person visit at the CRC that takes from 1 to 1.5 hours total where they will have their blood drawn, fill out surveys about their mood, and complete cognitive tests.

30

Molly Wright
Molly Wright - at mpw5810@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011171
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Inclusion Criteria:
Fluent in English
No history of depression
Free of chronic inflammatory or autoimmune disorders
If female, not pregnant or nursing

Exclusion Criteria:
Personal or family history (first-degree relatives) of major depressive disorder or major psychiatric illness
Taking non-steroidal anti-inflammatory agents or statins everyday within the past month
Taking antipsychotics or mood stabilizers
If female, are post-menopausal or pregnancy/lactation
Infectious Diseases & Immune System, Mental & Behavioral Health
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State College, PA ,

Asymmetries in Cognitive Aspects of Motor Control and Learning

This study will improve our understanding of movement control and how strokes of different sides affect overall independence. Participants will complete the visit seated at a chair with sensors connected to the less-affected arm. They will then play a short virtual reality game and complete several questionnaires and assessments.

Robert Sainburg
Shanie Jayasinghe - at sjayasinghe@pennstatehealth.psu.edu or 717-531-0003, ext=283146
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00015871
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Inclusion Criteria:
Right handed (pre-stroke)
Neurological confirmation of unilateral stroke
Severe paresis on one side only
Adults over the age of 18
Chronic stage of stroke (>3 months post stroke)

Exclusion Criteria:
Left-handed (pre-stroke)
Neuro radiological confirmation of extensive periventricular white matter changes
History of neurological diseases other than stroke
Significant joint pain that is activity limiting
Neurology
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Hershey, PA ,

Personalized assessment of daily experiences

The purpose of this voluntary research study is to understand how experiences that might change moment-to-moment influence suicidal thoughts and behaviors for individual people. In other words, the purpose of this research is to understand how much the experiences that lead to suicidal thoughts and behaviors might differ from person to person. We are including people living in rural municipalities in this research because people living in rural areas are not often represented in suicide research, even though suicidal thoughts and behaviors are important issues for people in rural communities. We want to make sure that we understand how suicidal thoughts and behaviors might develop specifically for individual people living in rural areas.

First, you will complete surveys at a baseline assessment. Second, following the baseline assessment, you will be asked to complete short assessments of your mood, thoughts, and behaviors, 5 times per day for 21 days. Each assessment should take less than 2 minutes to complete. Third, at the end of the 21-day period, you will provide feedback on your experience rating your mood, thoughts, and behaviors. Fourth, you will complete 12 brief weekly assessments. Fifth, you will complete surveys four months after completing the baseline assessment.

$300

Lauren Forrest
Lauren Forrest - at lforrest@pennstatehealth.psu.edu
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00020173
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Inclusion Criteria:
age 18-64
own a smartphone with internet and email access
English language fluency
Lifetime suicide attempt with past-year suicidal ideation or a suicide plan or suicide intent within the last 12 months
Lives in a rural borough/township

Exclusion Criteria:
cognitive impairment
mania
psychosis
Mental & Behavioral Health
Not applicable
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The Use of Micro-Doppler Radar to Identify Service Members at Risk for Musculoskeletal Injury: A Gold Standard Comparison

The purpose of this research study is to see if we can use micro-doppler signal technology to determine if someone has had an ACL reconstruction in the past. We will do this by comparing a group of people who have had the surgery against a group who has never had this surgery to see if this technology can tell the difference.

If you join this study you would be asked to come to a one-hour appointment at the Lebanon Valley College campus and perform a variety of activities that are part of daily life, such as walking, jumping, and standing from a seated position.

50

Cayce Onks
Cayce Onks - at conks@pennstatehealth.psu.edu or 717-531-8187
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020118
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Inclusion Criteria:
Ages 18-40
ACL Group: ACL Reconstruction surgery 9-24 months prior and approved to return to normal activities
Control group: No history of lower extremity surgery
Able to provide consent and read/write in English
No current musculoskeletal injuries

Exclusion Criteria:
Prisoner
Pregnant person
any surgery within 6 months of the study visit
Unable to provide consent or read/write in English
Unable to perform movements consistent with daily activities such as walking, jumping, or moving from sit to stand
Prevention, Sports Medicine, Muscle & Bone
Not applicable
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Hershey, PA ,

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.

Lawrence Sinoway
Cheryl Blaha - at cblaha@pennstatehealth.psu.edu or 717-531-1605
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00005330
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Inclusion Criteria:
At least 21 years old
healthy - no major medical concerns
women and men of all races

Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
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Hershey, PA ,

Human Interaction with Information and Communication Technology

This study investigates users’ experience with Information and Communication Technology (ICTs). This study makes further implications for designing more user-friendly ICT for a better user experience. We aim to make such contributions by answering these questions: 1. How do users interact with ICTs? 2. What challenges do users face when using ICTs? 3. What strategies do users apply to adapt themselves to ICTs? 4. What service do ICT producers provide for users to get better user experience? 5. When does user experience break down when interacting with ICTs?

Yao Lyu
Yao Lyu - at yml5549@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016978
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Inclusion Criteria:
18 years or elder
all genders included
have prior experience with ICT
speak Madarin or English

Exclusion Criteria:
younger than 18 years old
vulnerable populations like cognitive impaired adults, prisoners.
no prior experience with ICT
speak neither Madarin nor English
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Watch Over: Using Apple Watches to Assess and Predict Substance Co-use in Young Adults

This study seeks to understand substance use and other health behaviors in young adults' daily lives. Interested participants can email the study team to complete a brief screener to see determine their eligibility. If eligible, participants will be asked to complete a short online survey and follow-up surveys for up to four weeks via a mobile device. Financial compensation will be provided.

This study involves three parts. First, potential participants will complete an online screener survey. If they are eligible, they will be immediately enrolled in the study and will proceed to the baseline survey. Second, participants who have completed the baseline portion of the study will schedule an in-person visit with the research team for the next portion of the study. At the start of the in-person visit, participants will be oriented about the study design which involves completing daily surveys about various health behaviors. Third, participants will come back in-person for a brief final visit and receive payment.

76

Ashley Linden-Carmichael
Sahiti Kunchay - at sahiti@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013672
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Inclusion Criteria:
Between 18-25 years of age
Current Penn State student
Currently owns and uses an iPhone with iOS version 15 or newer
Determined eligible through screener

Exclusion Criteria:
Eligibility determined using a screening survey
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State College, PA ,

Site for EA8183 A Phase III Study of Early Intervention after RADICAl ProstaTEctomy with Androgen Deprivation Therapy with Darolutamide vs. Placebo in Men at Highest Risk of Prostate Cancer Metastasis by Genomic Stratification (ERADICATE) (PSCI# 21-122)

This study is being done to answer the following question: Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

This study is being done to answer the following question: Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

Bryan Traughber
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
 

Male
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04484818
SITE00001026
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Inclusion Criteria:
Patient must be = 18 years of age.
Patient must have undergone a radical prostatectomy (RP) and must be preregistered to Step 0 of this study at least 6 weeks after but not more than 12 weeks after their radical prostatectomy.
Patient must not have any previous treatment with androgen deprivation therapy (ADT), chemotherapy, or other physician prescribed systemic therapy for treatment of their prostate cancer.
Patient must have an ECOG performance status of 0-2.

Exclusion Criteria:
Patient must not have pathologic evidence of pelvic lymph node involvement.
Patient must not have an uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association Class III and IV heart failure).
Cancer
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Hershey, PA ,

Biologic and Environmental Impacts on Neurodevelopment and Growth (BEING)

Examine associations between biologic factors (genetic, epigenetic, transcriptomic, metabolomic) and environmental factors (family psychosocial dynamics, environmental allergens, diet, microbiome) in developing children, and their relationship with health and disease over the lifespan.

Depending on the age your child is when they are enrolled into the study will determine their designated enrollment group (Cohort 1, Cohort 2, Cohort 3, or Cohort 4) to determine how many study visits are required to complete participation in the study. For Cohort 1 participants (for infants enrolled at age 5-50 days): -9 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes at minimum a saliva swab sample **Infants will be asked to collect a stool sample for 3 study visits -Optional mother participant for breast-feeding mothers who will agree to provide a small breast milk sample for 3 study visits. For Cohort 2 participants (for children enrolled at age ~24 months): -6 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample **Children will be asked to collect a stool sample for 1 study visit For Cohort 3 participants (for children enrolled at age 5-7 years): -4 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample For Cohort 4 participants (for children enrolled at age 12-14 years): -2 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample

20-100

Steven Hicks
Alexandra Confair - at aconfair1@pennstatehealth.psu.edu or 717-531-0003, ext=323206
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
STUDY00014022
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Inclusion Criteria:
Child participant under 18 years old
Fluent in spoken/written English
Parent or legal guardian 18+ years old
Child ages: 5-50 days old, 2 years old, 5-7 years old, and 12-14 years old

Exclusion Criteria:
Wards of the state
Non-english speaking
Parent or legal guardian with decisional impairment
Children's Health
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Parent-to-child anxiety transmission in early childhood: Capturing in-the-moment mechanisms through emotion modeling and biological synchrony

Anxiety can emerge as early as pre-school age (4-7) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.

Participation requires three steps; a remote video session with the primary parent, an in-lab visit scheduled with the primary parent and child, and then an additional set of questionnaires given to the secondary caregiver. The remote session consists of obtaining consent, 2 questionnaires, and a clinical interview. The in-lab visit typically lasts about 2-3 hours, consisting of two parent-child activities and several child-only activities. Participants will be asked to wear mobile eye-tracking glasses and special caps used to measures brain activity during some of the tasks.

$125, $100 for the primary parent/or child and $25 for secondary parent

Koraly Perez-Edgar
Dakota Reis - at drr5484@psu.edu or 814-867-2322
 

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All
This study is also accepting healthy volunteers
STUDY00017857
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Inclusion Criteria:
Parents/Caregivers over 18
Children ages 4 to 6

Exclusion Criteria:
major medical illness
Children less than age 4 or over age 6
Children's Health, Mental & Behavioral Health
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State College, PA ,

DuRvalumab MEDI4730 with chEmotherapy as first line treAtment in advanced pleural Mesothelioma A phase 3 Randomised trial (DREAM3R) (PrE0506)(PSCI#20-123)

Participants may receive the medication Durvalumab in addition to standard of care medications or standard of care medications alone for treatment of Mesothelioma.

Patrick Ma
psci-cto@pennstatehealth.psu.edu 717-531-5471
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04334759
STUDY00017746
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Inclusion Criteria:
unable to surgically remove pleural mesothelioma
post menopausal or negative pregnancy test
greater than 66 pounds in weight
life expectancy of at least 12 weeks

Exclusion Criteria:
prior chemotherapy
autoimmune disease
metastasized to the brain
Cancer
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Hershey, PA ,

Childhood Adverse Experiences: Impacts in Young Adulthood

The purpose of the study is to examine how individuals change over time and what impacts their development. In particular, we are interested in mental health outcomes in young adulthood. Participants will be required to complete a survey one time that will take about 10-15 minutes to complete. Participants will be eligible to win a $10.00 amazon gift card.

Aubrey Daniels
Aubrey Daniels - at aubreyd@psu.edu
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011332
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Inclusion Criteria:
Between the age of 18-35

Exclusion Criteria:
Not between the age of 18-35
Prevention, Mental & Behavioral Health
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Assessing cognitive and psychosocial mechanisms of Useful Field of View cognitive training using ecological momentary assessment

We are interested in how brain games impact everyday life in healthy older adults. Participants will play 20 hours of brain games on a study-provided laptop, and we will examine how the brain games impact everyday life. This study will be performed remotely in participants homes using study-provided laptops. Some participants may also participate in 2 optional visits with brain MRI scans at Penn State University and at home sleep monitoring.

Alyssa Gamaldo
Courtney Fine - at cjf5860@psu.edu or 814-865-4773
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04651582
STUDY00010155
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Inclusion Criteria:
65 or older
no diagnosis of dementia
available for 6 months

Exclusion Criteria:
64 or younger
dementia or motor movement disorder diagnosis
cognitive training within past 2 years
Mental & Behavioral Health
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Interoception, the 8th Sensory System, Is it measurable?

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.

Cheryl Tierney
Cheryl Tierney - at ctierney@pennstatehealth.psu.edu or 717-531-8414
 

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All
This study is also accepting healthy volunteers
STUDY00004312
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Inclusion Criteria:
Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism

Exclusion Criteria:
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English
Children's Health, Mental & Behavioral Health
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A Phase III, Randomized, Open-Label Active Comparator-Controlled Multicenter Study to Evaluate Efficacy and Safety of Obinutuzumab in Patients with Primary Membranous Nephropathy

To evaluate the effectiveness and safety of obinutuzumab compared to tacrolimus in patients with primary membranous nephropathy

Agree to participate in one of two treatment groups, attend scheduled study visits and have blood drawn for samples. will have visits approximately every 2 to 14 weeks during the first two years of the study, every 12-16 weeks in the third and fourth years of the study, and then every 26 weeks until you finish the study. Visits will usually last 1-3 hours, but visits that require an obinutuzumab infusion may last 6 hours. Your total time in the study will be a minimum of about 4 years, but could be up to about 9 years, depending on how the treatment affects your disease.

$100.00 per visit

Umar Farooq
Kim Hitz - at khitz1@pennstatehealth.psu.edu or 717-531-4924
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04629248
STUDY00016316
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Inclusion Criteria:
diagnosis of primary membranous nephropathy
age 18-75
ability to comply with requried study procedures
stable blood pressure

Exclusion Criteria:
secondary cause of membranous nephropathy
uncontrolled blood pressure
kidney transplant or dialysis
Type 1 or type 2 diabetes
Kidney & Urinary System
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Hershey, PA ,

Site for Strong Foundations: Intervening to Promote Co-Parenting in Expectant Parents and Healthy Child Development.

Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.

Couples will be asked to participate in online parenting classes and family assessments during and after pregnancy. There are 3-5 prenatal and 1-4 postnatal classes that take place over Zoom. Family are also asked tp participate in 3 family assessments: 1 during pregnancy, 1 at 6 months of infant age, and one at 12 months of infant age. Families will be asked to complete inline surveys before each assessment. Additionally, families are asked to submit hair and saliva samples.

425.00

Rina Eiden
Jenna Sassaman - at jnk5173@psu.edu or 814-865-6902
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04441307
SITE00000607
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Inclusion Criteria:
Pregnant/Expecting Couples
First time parents
18 years of age or above
English speaking
Both parents living together

Exclusion Criteria:
Below 18 years of age
Not pregnant with first child
Parents not living together
Children's Health, Pregnancy & Infertility, Women's Health
Survey(s)
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Examining views associated with physical exercise and its connection to diet, social connectivity, and stress reduction: Online Focus Groups

The primary objective of this study is to examine, via online focus groups, the perceptions that are held by potentially-eligible subjects in the PSH DPP program in regard to the importance of physical exercise, particularly within the context of diet, social connectivity, and stress reduction. These perspectives will then be used to help develop, test, and refine additional motivational text messages that can be used in a text messaging intervention. Participants will receive a $25.00 gift card.

Selena Ortiz
Selena Ortiz - at suo13@psu.edu or 814-863-8041
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00014288
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Inclusion Criteria:
Be at least 18 years old and under age 65
Body Mass Index ≥25 kg/m2 (≥23 kg/m2 if Asian)
Have no previous diagnosis of type 1 or type 2 diabetes
Fluent in English

Exclusion Criteria:
Under 18 years old and over age 65
Body Mass Index <25 kg/m2 (<23 kg/m2if Asian)
Previous diagnosis of type 1 or type 2 diabetes
Not fluent in English
Prevention, Education, Diabetes & Hormones
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Health Apps to Mitigate COVID-19 Risk Survey

With the COVID-19 pandemic affecting everyone’s daily routine, our lives have changed drastically. The health of ourselves, families, friends, and communities is our biggest concern and finding a cure to this problem is still underway The purpose of this survey is to analyze how people are taking control of their health using various health applications forms.

Rafay Ahmad
Rafay Ahmad - at rqa5302@psu.edu or 814-933-2861
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016969
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Inclusion Criteria:
At least 18 years old or old

Exclusion Criteria:
Younger than 18 years old
COVID-19, Education, Mental & Behavioral Health
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iVR for the Geosciences

Fieldwork is a core activity in the geosciences. Immersive technologies, such as virtual reality (VR), allow for embodied experiences while not physically present at a field site or create experiences not possible in physical reality. Immersive VR (short: iVR) refers to systems using head-mounted displays to deliver 360-degree experiences. It can deliver remote and large-scale geological entities to the laboratory, allowing geoscientists to apply real-world skills and methods to explore and interact with 3D geological models. We describe a project in which we developed an iVR workbench and experience for Iceland’s Thrihnukar volcano combining satellite imagery with terrain elevation data to create a basic reconstruction of the real world, using terrain elevation terrestrial LiDAR data to provide a point cloud model of the entire magmatic-volcanic system and intensity values for the identification of rock types, and Structure from Motion (SfM) mapping to construct a photorealistic point cloud of the volcano. To reproduce fieldwork activities, this project digs deeply into the scientific workflow of geosciences research, evaluates the priorities of the major phases of geosciences fieldwork, and develops a prototype immersive workbench for direct manipulation, information retrieval, geometric measurement, and the integration of multimedia resources. This workbench offers analytic functions currently not available in the field and is expected to help making fieldwork experiences accessible, shareable, and available any time. Future developments will also allow for collaborating remotely as well as designing repositories for comparative studies.

Jiayan Zhao
Jiayan Zhao - at juz64@psu.edu or 814-321-6982
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011002
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Inclusion Criteria:
Graduate Students
Major in disciplines related to Earth Sciences (e.g., Geosciences, Geography, and Environmental Science)

Exclusion Criteria:
Younger than 18 years old
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State College, PA ,