The purpose of this study is to improve understanding of direct-care nursing home (NH) staff risk perceptions and experiences associated with NH operations and culture of care defined as restricted activities (communal dining, social engagement, walking in hallway, visitors during illness).

The goal of this research is to confirm the relationships between virtual self-discrepancy, character attachment, view of self, attachment styles, and the potential for a moderating variable within the relationships as a starting point for future research tying in player/character relationship and gaming addiction.

This study is to determine the recommended Phase 3 dose of venetoclax in combination with azacitidine in Acute Myeloid Leukemia patients when given as maintenance therapy following allogeneic stem cell transplantation. It also is to determine if venetoclax can be effective in combination with azacitidine to improve Relapse Free Survival in Acute Myeloid Leukemia patients compared to Best Supportive Care (BSC) when given as maintenance therapy following allogeneic stem cell transplantation.

There are different phases of this study. The first phase is Screening, then there is the Treatment phase as well as a Follow up phase. Each phase will have testing and procedures that will require you to come to the study center.

50.00 Travel expenses

The purpose of this study is to compare the usual treatment of chemotherapy and radiation to adding MEDI4736 (durvalumab) immunotherapy to the usual treatment. The addition of MEDI4736 (durvalumab) immunotherapy to the usual treatment may help shrink your cancer better than the current standard of care or usual approach for bladder cancer. But, it could also cause side effects, which are described in the risks section. This study will help determine if this different approach is better than the usual approach. To decide if it is better, the study doctors will be looking to see if the study approach increases the life of patients by 6 months or more compared to the usual approach.

If you decide to take part in this study, you will either get chemotherapy and radiation for 6-8 weeks, or you will get durvalumab immunotherapy in addition to chemotherapy and radiation for 6.5-8 weeks. After you finish your study treatment, your doctor will continue to follow you for up to 3 years. The follow-up will consist of visits to his or her office and CT scans of the bladder.

Through in-depth interviews, we examine how the Covid-19 pandemic has impacted the daily lives and mental well-being of essential workers, as well as their use of social media.

The purpose of this research study is 1.) to determine if Parkinson’s Disease (PD) causes changes in the way that people sense the movements of and forces produced by their bodies, and to connect any of these changes in sensation to changes in the brain, and 2.) to identify how changes in movement might come from different parts of the nervous system. This study will use a combination of electromyography, via electrodes placed on the skin, and finger force recordings to infer how PD effects patients' sense of force production, and the neural mechanisms underlying this change.

This study requires a single in-person visit and will use adhesive skin sensors on the forearms to measure muscle activity while subjects press on sensors which record force levels. Subjects will be asked to match force levels between hands and to move an on-screen cursor into a target.

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The purpose of this study is to find genetic causes of recurrent pregnancy loss (RPL). RPL is defined by two or more miscarriages under 20 weeks gestation and affects approximately 5% of women. The causes of RPL are not well understood. After all the currently recommended testing for RPL has been done, about half of women with RPL will still have no identifiable cause. This lack of knowledge makes it difficult to provide effective medical care for couples with RPL. This study will compare reading about 20000 genes in the entire human genetic library by whole genome sequencing in the miscarriage material and also your and your partner’s DNA from blood samples. The DNA in a person is a combination of the DNA from each of their biological parents. If you have healthy children we may ask your consent for them to give a blood sample for DNA extraction and testing. Similarly, we may ask the same for other family members such as grandparents if necessary. We may also request your permission to use stored DNA or miscarriage material from previous pregnancy loss if available. Testing of family members or previous miscarriage materials may help to understand DNA sequence variants or changes identified in the miscarriage sample.

There will be a one time collection of blood samples.

This is a voice perception study that asks participants to listen to voices and rate on various attributes such as attractiveness, social status, health, and others.

This research is being conducted to determine how oxygen extraction within exercising muscles is altered in younger and older women when beta-1 receptors (receptors that contribute to the rise in heart rate with exercise) are temporarily blocked through a medication infused into an arm vein. The findings will help us understand how aging affects the regulation of oxygen supply to working muscles is regulated with normal aging.

There will be 3 in person visits. Visit 1) Subjects will undergo a physical and one blood draw in the Clinical Research Center and then perform two recumbent cycling exercise trials on a stationary bike. Visit 2) Subjects will undergo a DXA scan and then perform two recumbent cycling exercise trials. Visit 3) Subjects will have an IV catheter inserted into an arm vein. They will then perform two recumbent cycling exercise trials. During one trial the will receive esmolol via the IV catheter and during the other they will receive saline via the IV catheter (random order).

$150

In this phase II trial, we will determine the progression-free survival (PFS) of the cyclin dependent kinase 4/6 inhibitor (CDK4/6i) palbociclib with fulvestrant in women and men with estrogen or progesterone receptor (ER/PR) positive, HER2-negative metastatic breast cancer (MBC) who progressed on treatment with palbociclib and an aromatase inhibitor (AI). We will also determine the prevalence rate of estrogen eceptor α (ESR1) and phosphatidylinositol-3-kinase (PI3K) mutations in the study population.

Participants will be required to come to the clinic every three weeks for evaluation and fulvestrant injections, take medication correctly, keep all appointments.

The purpose of this research is to investigate the associations between depressive symptoms and inflammation. The researchers are studying how specific symptoms of depression (such as fatigue, sadness, impaired concentration, and loss of pleasure) are related to markers of inflammation, which is a key component of our immune system. Volunteers with depressive symptoms, as well as volunteers without depressive symptoms are needed for this research study. This study includes an online survey to determine eligibility and one in-lab visit. Participants who are eligible will be scheduled for one in-lab visit (2.5-3h for participants with depressive symptoms & 1-2h for participants without depressive symptoms), where they will be asked to answer surveys with questions related to depressive symptoms and complete a number of tasks (using an iPad and a touch screen phone) that measure thinking skills including attention, memory and reaction time. Participants will also undergo a single blood draw to assess inflammatory markers.

Participation will require one in person visit at the CRC that takes from 1 to 1.5 hours total where they will have their blood drawn, fill out surveys about their mood, and complete cognitive tests.

30

This study will improve our understanding of movement control and how strokes of different sides affect overall independence. Participants will complete the visit seated at a chair with sensors connected to the less-affected arm. They will then play a short virtual reality game and complete several questionnaires and assessments.

The purpose of this voluntary research study is to understand how experiences that might change moment-to-moment influence suicidal thoughts and behaviors for individual people. In other words, the purpose of this research is to understand how much the experiences that lead to suicidal thoughts and behaviors might differ from person to person. We are including people living in rural municipalities in this research because people living in rural areas are not often represented in suicide research, even though suicidal thoughts and behaviors are important issues for people in rural communities. We want to make sure that we understand how suicidal thoughts and behaviors might develop specifically for individual people living in rural areas. We also want to understand how suicidal thoughts and behaviors develop specifically for people in the LGBTQIA+ community who live in rural areas.

First, you will complete surveys at a baseline assessment. Second, following the baseline assessment, you will be asked to complete short assessments of your mood, thoughts, and behaviors, 5 times per day for 21 days. Each assessment should take less than 2 minutes to complete. Third, at the end of the 21-day period, you will provide feedback on your experience rating your mood, thoughts, and behaviors. Fourth, you will complete 12 brief weekly assessments. Fifth, you will complete surveys four months after completing the baseline assessment.

$300

The purpose of this research study is to see if we can use micro-doppler signal technology to determine if someone has had an ACL reconstruction in the past. We will do this by comparing a group of people who have had the surgery against a group who has never had this surgery to see if this technology can tell the difference.

If you join this study you would be asked to come to a one-hour appointment at the Lebanon Valley College campus in Annville, PA and perform a variety of activities that are part of daily life, such as walking, jumping, and standing from a seated position. We'll ask you to complete a questionnaire on any musculoskeletal pain you're experiencing and report your demographic information.

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This study investigates users’ experience with Information and Communication Technology (ICTs). This study makes further implications for designing more user-friendly ICT for a better user experience. We aim to make such contributions by answering these questions: 1. How do users interact with ICTs? 2. What challenges do users face when using ICTs? 3. What strategies do users apply to adapt themselves to ICTs? 4. What service do ICT producers provide for users to get better user experience? 5. When does user experience break down when interacting with ICTs?

This study seeks to understand substance use and other health behaviors in young adults' daily lives. Interested participants can email the study team to complete a brief screener to see determine their eligibility. If eligible, participants will be asked to complete a short online survey and follow-up surveys for up to four weeks via a mobile device. Financial compensation will be provided.

This study involves three parts. First, potential participants will complete an online screener survey. If they are eligible, they will be immediately enrolled in the study and will proceed to the baseline survey. Second, participants who have completed the baseline portion of the study will schedule an in-person visit with the research team for the next portion of the study. At the start of the in-person visit, participants will be oriented about the study design which involves completing daily surveys about various health behaviors. Third, participants will come back in-person for a brief final visit and receive payment.

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This study is being done to answer the following question: Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

This study is being done to answer the following question: Will the addition of a new drug, darolutamide, to standard Androgen Deprivation Therapy (ADT) (a hormonal therapy that is a usual approach to treatment) after surgery cure more men with prostate cancer than using Androgen Deprivation Therapy alone? We are doing this study because we want to find out if this approach is better or worse than the usual approach for your prostate cancer. The usual approach is defined as care most people get for prostate cancer.

Examine associations between biologic factors (genetic, epigenetic, transcriptomic, metabolomic) and environmental factors (family psychosocial dynamics, environmental allergens, diet, microbiome) in developing children, and their relationship with health and disease over the lifespan.

Depending on the age your child is when they are enrolled into the study will determine their designated enrollment group (Cohort 1, Cohort 2, Cohort 3, or Cohort 4) to determine how many study visits are required to complete participation in the study. For Cohort 1 participants (for infants enrolled at age 5-50 days): -9 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes at minimum a saliva swab sample **Infants will be asked to collect a stool sample for 3 study visits -Optional mother participant for breast-feeding mothers who will agree to provide a small breast milk sample for 3 study visits. For Cohort 2 participants (for children enrolled at age ~24 months): -6 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample **Children will be asked to collect a stool sample for 1 study visit For Cohort 3 participants (for children enrolled at age 5-7 years): -4 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample For Cohort 4 participants (for children enrolled at age 12-14 years): -2 study visits total -Each study visit includes surveys that assess your child's growth and development that you can complete via your email -Each study visit includes a saliva swab sample

20-100

Anxiety can emerge as early as pre-school age (4-7) and is often linked to anxiety in the parent. This study will examine patterns of brain and behavioral synchrony in parent-child pairs as they complete puzzles together and other social activities.

Participation requires three steps; a remote video session with the primary parent, an in-lab visit scheduled with the primary parent and child, and then an additional set of questionnaires given to the secondary caregiver. The remote session consists of obtaining consent, 2 questionnaires, and a clinical interview. The in-lab visit typically lasts about 2-3 hours, consisting of two parent-child activities and several child-only activities. Participants will be asked to wear mobile eye-tracking glasses and special caps used to measures brain activity during some of the tasks.

$125, $100 for the primary parent/or child and $25 for secondary parent

Participants may receive the medication Durvalumab in addition to standard of care medications or standard of care medications alone for treatment of Mesothelioma.

This is a randomized study. We do not know which treatment is best for participants. Randomization means that participants will be put into two different groups for treatment. One group is the Experimental Group (standard chemotherapy with durvalumab). The other group is the Control Group (either standard chemotherapy, or immunotherapy with ipilimumab and nivolumab). Before you are randomized your Study Doctor will choose if you will receive standard chemotherapy or immunotherapy with ipilimumab and nivolumab if you are randomized to the Control Group. The results of each group are compared to see if one is better.

The purpose of the study is to examine how individuals change over time and what impacts their development. In particular, we are interested in mental health outcomes in young adulthood. Participants will be required to complete a survey one time that will take about 10-15 minutes to complete. Participants will be eligible to win a $10.00 amazon gift card.

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.

To evaluate the effectiveness and safety of obinutuzumab compared to tacrolimus in patients with primary membranous nephropathy

Agree to participate in one of two treatment groups, attend scheduled study visits and have blood drawn for samples. will have visits approximately every 2 to 14 weeks during the first two years of the study, every 12-16 weeks in the third and fourth years of the study, and then every 26 weeks until you finish the study. Visits will usually last 1-3 hours, but visits that require an obinutuzumab infusion may last 6 hours. Your total time in the study will be a minimum of about 4 years, but could be up to about 9 years, depending on how the treatment affects your disease.

$100.00 per visit

Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.

Couples will be asked to participate in online parenting classes and family assessments during and after pregnancy. There are 3-5 prenatal and 1-4 postnatal classes that take place over Zoom. Family are also asked tp participate in 3 family assessments: 1 during pregnancy, 1 at 6 months of infant age, and one at 12 months of infant age. Families will be asked to complete inline surveys before each assessment. Additionally, families are asked to submit hair and saliva samples.

425.00

The primary objective of this study is to examine, via online focus groups, the perceptions that are held by potentially-eligible subjects in the PSH DPP program in regard to the importance of physical exercise, particularly within the context of diet, social connectivity, and stress reduction. These perspectives will then be used to help develop, test, and refine additional motivational text messages that can be used in a text messaging intervention. Participants will receive a $25.00 gift card.

With the COVID-19 pandemic affecting everyone’s daily routine, our lives have changed drastically. The health of ourselves, families, friends, and communities is our biggest concern and finding a cure to this problem is still underway The purpose of this survey is to analyze how people are taking control of their health using various health applications forms.

Fieldwork is a core activity in the geosciences. Immersive technologies, such as virtual reality (VR), allow for embodied experiences while not physically present at a field site or create experiences not possible in physical reality. Immersive VR (short: iVR) refers to systems using head-mounted displays to deliver 360-degree experiences. It can deliver remote and large-scale geological entities to the laboratory, allowing geoscientists to apply real-world skills and methods to explore and interact with 3D geological models. We describe a project in which we developed an iVR workbench and experience for Iceland’s Thrihnukar volcano combining satellite imagery with terrain elevation data to create a basic reconstruction of the real world, using terrain elevation terrestrial LiDAR data to provide a point cloud model of the entire magmatic-volcanic system and intensity values for the identification of rock types, and Structure from Motion (SfM) mapping to construct a photorealistic point cloud of the volcano. To reproduce fieldwork activities, this project digs deeply into the scientific workflow of geosciences research, evaluates the priorities of the major phases of geosciences fieldwork, and develops a prototype immersive workbench for direct manipulation, information retrieval, geometric measurement, and the integration of multimedia resources. This workbench offers analytic functions currently not available in the field and is expected to help making fieldwork experiences accessible, shareable, and available any time. Future developments will also allow for collaborating remotely as well as designing repositories for comparative studies.

Mild to Severe Acne: Women ages 16-40 years. Assigned to either spironolactone of doxycycline; oral medication taken once daily. The duration of the study will last 16 weeks. During that time participants will attend 3 in person study visits (study start, week 8 and week 16). In addition participants will completion questions outside of study visits at Week 4 and Week 12. The goal of this trial is to compare the effectiveness of spironolactone and doxycycline hyclate in the treatment of acne in women.

The duration of the study will last 16 weeks. During that time participants will attend 3 in person study visits (study start, week 8 and week 16). In addition participants will completion questions outside of study visits at Week 4 and Week 12.

A study of DFMO for patients with neuroblastoma in remission.

Prediction of a subject's goal in a task based on patterns in their body language, speech, facial expressions, reaction to outcome, in short any observable measure.