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442 Study Matches

A Study Examining Biological Rhythms in Bipolar I Disorder

The research is being done to examine the relationships between chronobiological characteristics and clinical characteristics, physiological markers, cellular signatures, and genetic markers of the illness. The goal of conducting this research is to advance our knowledge of the biological rhythms (the internal body clock) in bipolar disorder. Rhythm disruption is a major characteristic of bipolar disorder, however, to date these relationships have been understudied. The researchers hope to learn more about chronobiology in bipolar disorder and healthy controls through investigating the associations between clinical and biological factors measured in this research study. It is hoped that this information will eventually help doctors understand what may lead to the development of bipolar disorder and to development of methods to monitor and treat the illness.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
English-speaking adults
Bipolar I Disorder OR Healthy Control
Willingness and ability to comply with all biological assessments, clinical assessments, and daily self-assessments per protocol
Able to provide informed consent
Exclusion Criteria:
Currently taking sleep medications to aid with sleep (e.g., Ambien, Lunesta, and melatonin)
Documented diagnosis of a primary sleep or circadian rhythm disorder
Uncontrolled medical condition that could result in psychiatric symptoms or chronobiological disturbances
Shift work (e.g., working second, third, or inconsistent shifts)
History of substance abuse in past month
Mental & Behavioral Health
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Study Locations

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Location
Hershey, PA

Inositol Supplementation to Treat Polycystic Ovary Syndrome: A Double Blind Dose Ranging RCT (INSUPP-PCOS)

Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in women in the U.S. and is characterized by both reproductive (anovulation and androgen excess) and metabolic dysfunction (insulin resistance). PCOS lacks a simple, safe and effective treatment for women of all ages and all weights. Recently a dietary supplement, inositol, has been used widely to treat women with PCOS. However there are no well designed trials to address the risk/benefit ratio and identify the mechanism of action. In this study we propose a 3 month double blind (of both patients and investigators) randomized controlled trial of inositol supplementation compared to placebo. We hypothesis that women with PCOS who receive inositol supplementation will have a significantly greater reduction in serum total testosterone than women on placebo as well has improvement in glucose tolerance and decrease in fasting insulin.
Amyee McMonagle at amcmonagle@pennstatehealth.psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Women 18-45 years old
Diagonosed with Polycystic Ovary Sydrome
Periods that last greater than or equal to 45 days OR a total of 8 or less per year
Exclusion Criteria:
High protactin levels
Uncorrected thyroid disease
Suspected adrenal or ovarian tumor screting androgens
Suspected Cushing's syndrome
Contraindications to the study drug or placebo
Women's Health
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Study Locations

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Location
Hershey, PA

Experimental determination of the neurogenic contribution to skin flowmotion

The purpose of this study is to use spectral analysis to measure blow flow changes in superficial vessels of the arm. This study will explore how skin blood flow changes in response to heat and nerve inhibition. We will be locally heating the skin and blocking nerves of the skin with a topical numbing cream and measuring the resulting skin blood flow. Skin blood flow is measured by a machine that shines a harmless laser light onto the skin. The machine produces a signal that looks like a wave moving up and down. There is a known, and previously used, algorithm that can identify the neurogenic input-wave from the total skin blood flow-wave.
Zachary Lichter at zzl5229@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-85
English speaking individuals
Exclusion Criteria:
individuals diagnosed cardiovascular, metabolic, or dermatological conditions
nicotine use (e.g. smoking, chewing tobacco, etc)
pregnancy or breastfeeding
illicit or recreational drug use
allergies to lidocaine or prilocaine
Heart & Vascular, Neurology
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Study Locations

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Location
State College, PA

Participation in Rural Settings to Engage in Communities (PARSEC): A program to increase community participation for adults with Autism Spectrum Disorder

This is a longitudinal study that will examine the effectiveness of a program to increase community participation for adults with autism living in rural communities in Pennsylvania.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Autism
Living in a rural community
English speaking
Able to self-report
High school graduate
Exclusion Criteria:
Inability to provide consent
Mental & Behavioral Health
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Angiotensin-(1-7) and Energy Expenditure in Human Obesity

We will investigate the effects of the hormone angiotensin-(1-7) on energy expenditure in patients with obesity.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03777215
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Inclusion Criteria:
Men and women of all races
Age 18-60 years
Body mass index between 30-40 kg/m2
Capable of giving informed consent
Exclusion Criteria:
Age less than 18 years or greater than 60 years
Pregnant or nursing women
Current smokers
Type I or type II diabetes
History of major cardiovascular or cerebrovascular disease, immune diseases, impaired kidney or liver function
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Caregiver's Perceptions of High-quality Early Education and Care

This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.
Hannah Mudrick at hxm99@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Adults age 18 and older
Adults who are fluent in English
Adults who are regular caregivers of children between birth and age 5
Individuals who can read and respond to written close- and open-ended survey questions electronically
Individuals who live in the United States
Exclusion Criteria:
Individuals under the age of 18
Individuals who are not fluent in English
Individuals who are not regular caregivers of children between birth and age 5
Individuals with poor reading comprehension and are otherwise limited in their ability to read and respond to survey questions
Individuals who do not currently live in the United States of America
Children's Health, Education, Mental & Behavioral Health
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Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
over the age of 18
Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
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Study Locations

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Location
Hershey, PA
State College, PA

Establishing the effect of flavor on the addictive potential of electronic cigarettes

For the current study, smokers will use an electronic cigarette in addition to their usual cigarettes for 4 weeks. The electronic cigarette will contain sweet or tobacco flavored liquid that may or may not contain nicotine. Participants will complete functional magnetic resonance imaging scans at the beginning and end of the study to measure how the brain responds to the electronic cigarette flavor.
Brianna Hoglen at abl@pennstatehealth.psu.edu or 717-531-5473
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03905928
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Inclusion Criteria:
21-60 years old
Smoke at least 5 cigarettes per day
Smoke regular tobacco flavored cigarettes
Not currently interested in quitting smoking
Exclusion Criteria:
Unstable or significant medical conditions
Pregnant or nursing
Regular use of flavored tobacco products
Regular use of electronic cigarettes
Implanted metal in the body
Addiction & Substance Abuse
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Location
Hershey, PA

A randomized, subject and investigator blinded, placebocontrolled and multi-center platform study, to assess efficacy and safety of different investigational drugs in patients with moderate to severe hidradenitis suppurativa

Hidradenitis Suppurativa: Phase 2 Subject and Investigator Blinded, 7 and a half month study. Platform Study: Injectable and Oral drug, Males/Females 18-65 years old with Hidradenitis Suppurativa. Hidradenitis Suppurativa (HS) is a chronic recurrent and debilitating skin condition that typically presents with deep and painful lesions. The most common areas affected are the armpits, the groin, and the anus and genitals area. The purpose of the study is to find out if the study drugs (iscalimab and LYS006) are beneficial and safe in patients with HS.
Samantha Gettle at sgettle2@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03827798
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Inclusion Criteria:
HS diagnosis for at least 1 year
HS lesions in at least 2 affected areas
Exclusion Criteria:
Prior treatment to certain medications
Skin Conditions
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Study Locations

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Location
Hershey, PA

A Phase 3, Randomized, 3-Part Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients with Eosinophilic Esophagitis

This study is for patients who have active eosinophilic esophagitis (EoE). This research is being done to evaluate the safety and effectiveness of an experimental medication on relieving EoE symptoms and reducing esophageal inflammation in adults. The information derived from this study will also help to better understand how the medication works in the body and side effects that may be experienced by people taking the medication.
Larisa Zifchak at lzifchak@pennstatehealth.psu.edu or 717-531-4506
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03633617
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Inclusion Criteria:
18 and older
Diagnosis of Eosinophilic Esophagitis
Exclusion Criteria:
History of achalasia, ulcerative colitis, Crohn's disease or celiac disease
Prior esophageal surgery
History of bleeding disorders or esophageal varices
Anticipated major surgery
Active (acute or chronic) infections
Digestive Systems & Liver Disease
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Study Locations

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Location
Hershey, PA

Decreasing Stress in Type 2 Diabetes: A Randomized Controlled Trial (DE-STRESS T2D)

The purpose of this study is to find out how two different stress reduction programs affect blood sugar levels in people with type 2 diabetes. Participants will attend fourteen study sessions online via videoconferencing (Zoom) where they will take part in one or more of the following activities: breathing exercises, meditation, stretching exercises or health education activities. Participants will undergo questionnaires, blood tests, and a brief physical exam at baseline, two months, and six months. Compensation is provided.
Larisa Zifchak at lzifchak@pennstatehealth.psu.edu or 717-531-8395
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04016415
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Inclusion Criteria:
Age 18 years or older
Type 2 diabetes diagnosed for one year or more
Hemoglobin A1c 8% or greater
Have a device with internet connection, camera and microphone for participation in online stress reduction classes
Able to attend 14 online stress reduction classes
Exclusion Criteria:
Current suicidality, history of significant psychopathology such as bipolar disorder or psychosis
History of an inpatient admission for psychiatric disorder within the past two years
Active alcohol or drug abuse
Inability to read, write or speak English
Current enrollment in a stress reduction program, or in any other investigative study
Mental & Behavioral Health, Diabetes & Hormones
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Location
Hershey, PA

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 2 Study to Evaluate the Safety and Efficacy of Avacopan in Subjects with Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa: Phase 2 Double-Blind, 12 week placebo controlled period followed by 24 week active treatment period. Oral Medication, Males/Females 18 years and older with Hidradenitis Suppurativa. Hidradenitis Suppurativa (HS) is a chronic recurrent and debilitating skin condition that typically presents with deep and painful lesions. The most common areas affected are the armpits, the groin, and the anus and genitals area. The purpose of this study is to see if Avacopan is safe and effective for the treatment of HS.
Samantha Gettle at sgettle2@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03852472
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Inclusion Criteria:
HS diagnosis for at least 6 months
HS lesions in at least 2 affected areas
Willing to follow all study instructions
Exclusion Criteria:
Certain treatments for HS are not allowed; coordinator will discuss specific treatments
Positive test result for HIV, Hep C or Hep B
Skin Conditions
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Study Locations

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Location
Hershey, PA

Management Of Pain After Cesarean Trial

This is a double blinded, placebo-controlled randomized controlled trial to test the efficacy of a combination of acetaminophen and ibuprofen administered to patients on schedule compared to ibuprofen and placebo on the patient's reported pain score on the second post-operative day after Cesarean delivery. We will also record opiate consumption and pain scores throughout the hospitalization of participants, and will survey patients at one and two weeks after surgery regarding opiate consumption and quality of life.
Female
All
This study is also accepting healthy volunteers
NCT03929640
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Inclusion Criteria:
Pregnant woman
Planned delivery via C-section
Pfannenstiel ("bikini line") skin incision
Able to read and speak English fluently
Exclusion Criteria:
Major intra-operative or post-operative complication such that clinical recommends patient should not receive non-steroidal anti-inflammatory drugs
Unplanned surgery (hysterectomy, bowel/bladder repair, cystoscopy)
Allergy or contraindication to study medication
History of opioid or other substance use disorder either before or during pregnancy
History of kidney or liver disease
Pregnancy & Infertility, Women's Health
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Study Locations

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Location
Hershey, PA

Assessing the Feasibility of Implementing a Storytelling Intervention among African Americans with Hypertension: A Pilot Study

Personal narratives or storytelling is an approach that has been used to promote healthy behaviors among people with diabetes, breast cancer, and high blood pressure. There is a need for low-cost, culturally-tailored interventions that promote healthy behaviors and improve health outcomes in the African American community. The objective of this project is to develop a storytelling intervention for African Americans with high blood pressure. Participants will be filmed sharing their experiences living with high blood pressure, and the videos will be shared with other African Americans with high blood pressure. We are recruiting 6-8 African American adults with high blood pressure, age 18-80, that have been diagnosed with high blood pressure and are taking medications to manage high blood pressure.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-7178
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Diagnosis of hypertension
Prescribed anti-hypertensive medication
Age greater than or equal to 18 years
African American
Exclusion Criteria:
Pregnancy
Unable to speak or read English
Mental status precluding ability to provide informed consent
Heart & Vascular
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Study Locations

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Location
Harrisburg, PA
Hershey, PA

Influence of Diet on Body Odor and Social Judgments

We are interested in a broader assessment of how changes in body odor influence social judgments outside of the mating context. The main question this project seeks to answer is whether we are able to change body odor through diet (e.g., aromatic foods) and how these changes affect group identity and social judgments.
Jessica Gaby at jessica.gaby@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Non-smoker
English fluency
Willing to return to the testing facility for multiple visits
Normal sense of smell
Willing to smell t-shirts of other humans
Exclusion Criteria:
Current smoker
Pregnant or breastfeeding
Reported deficiency in smell function
Taking medication that might interact with body odor production
Allergy to rice or curry spices
Food & Nutrition
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Study Locations

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Location
State College, PA

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Efficacy of GS-9674 in Non-Cirrhotic Subjects with Primary Sclerosing Cholangitis

This study is for patients with Primary Sclerosing Cholangitis which is a chronic disease which causes scarring of the bile ducts. This can lead to damage of the liver over time. The purpose of this study is to see if an experimental medication slows the scarring process.
Laurie Peiffer at lpeiffer@pennstatehealth.psu.edu or 717-531-5226
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03890120
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Inclusion Criteria:
18-70 years old
Diagnosis of Primary Sclerosing Cholangitisi
Exclusion Criteria:
Liver cirrhosis
Received a liver transplant
Liver cancer
HIV or Hepatitis B or C diagnosis
Alcohol use exceeding limits
Digestive Systems & Liver Disease
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Location
Hershey, PA

GLNE 007 Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

The purpose of this study is to see if stool or blood can be used to determine whether or not a patient has any colon polyps or colon cancer. This study will compare these biological samples (blood, urine, stool) to any colonoscopy or surgery a patient has to see if the outcome could be predicted.
Amanda Taylor Gehman at ataylor6@pennstatehealth.psu.edu or 717-531-1283
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00843375
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Inclusion Criteria:
Adult 18+
Subjects with Colon Cancer or Adenoma
OR subjects undergoing colonoscopy screening
Exclusion Criteria:
Inflammatory Bowel Disease
HIV/Hepatitis
Have had or are receiving chemotherapy or radiation
Have had surgery for your colon cancer
Cognitive Impairment
Prevention, Cancer
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Investigation of pulse starch impact on the gut microbiome

We are investigating how the starch from pulse crops (chickpeas, lentils and dry peas) affects the gut microbiome, particularly with regards to the production of butyrate, a microbial metabolite with a number of known health benefits. We are recruiting people from two groups, those that consume a lot of these pulses and those who rarely consume them. These participants will then track their food intake for 48 hours before collecting a fecal sample which they will return to the lab. We will then use these fecal samples to conduct laboratory fermentations with pulse starches processed in a number of different ways to see what factors are important for determining the amount of butyrate that is produced. This will serve as pilot data for designing future human clinical trials.
Darrell Cockburn at dwc30@psu.edu or 814-863-2950
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-65 years of age
Either consume pulses twice or more per week or consume them once a month or less. Pulses are dry legumes such as chickpeas(Garbanzo beans), lentils or other dry peas and beans
Exclusion Criteria:
Currently or in the past month taking antibiotics
Taking a fiber supplement
Bowel problems such as IBD, IBS, chronic diarrhea or constipation
Pregnancy
Food & Nutrition
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Study Locations

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Location
State College, PA

Stakeholders' perspectives of collecting patient-level data on social determinants of health to identify patient needs and barriers to cancer care across the PSCI catchment area

This study will conduct one-on-one interviews with cancer patients, survivors, medical providers, and patient navigators to better understand individuals' experiences and opinions on the use of social information to improve cancer care. Social information includes one's current living situation, income, transportation needs, medical insurance coverage, social support system, and other related factors.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
English or Spanish Speaking
Provides care for cancer patient(s)/survivor(s)
A cancer patient/survivor
Current role is a cancer patient care navigator
Exclusion Criteria:
Unable to speak English or Spanish
Under 18 years of age
Unwilling to be audio recorded
Cancer
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Collective Punishment and Identity Fusion: An Examination

This study, part of a broader dissertation on terrorism and radicalization, aims to experimentally determine how collective punishment fuses individual identities to that of an ingroup, expanding extant knowledge of identity fusion theory.
Connor Somgynari at cjs72@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Over age 18
Identification as Republican or Democratic
English Speaker
Exclusion Criteria:
Under age 18
Political identification as independent (not republican or democrat)
Non-English Speakers
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Study Locations

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State College, PA

Pennsylvania Adoptees Longitudinal Study (PALS)

This study will examine various factors within the home of children adopted from the child welfare system between the ages of 4 and 10 that may impact their development. At the current time, there are two planned home visits, each 1-year apart. The children and parents will not be required to travel for sessions as all visits will occur in the home. This research will help understand the factors that impact the development of children adopted from the child welfare system and how we may better serve these children and their families.
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Child age between 4 and 10
Child legally adopted by the caregiver
The same caregiver will participate in each of 2 in-home assessment sessions
Exclusion Criteria:
Child diagnosed with intellectual disability
A legally adoptive caregiver is a biological relative of the child
Children's Health, Mental & Behavioral Health
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Study Locations

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Location
Altoona, PA
Carlisle, PA
DuBois, PA
Erie, PA
Greater Philadelphia Area, PA
Greater Pittsburgh Area, PA
Harrisburg, PA
Hazleton, PA
Hershey, PA
Mont Alto, PA
Reading, PA
Schuylkill Haven, PA
Sharon, PA
State College, PA
Wilkes-Barre/Scranton Area, PA
Williamsport, PA
York, PA

Testing the Risk Preferences of Engineering Students under Conditions of Limited Information, Sleep, Optimism, and Time Constraints

This is a study that will examine how engineers make decisions under certain conditions and the factors that drive these decisions. The game will be used to simulate different engineering scenarios. All you need to do is play an online game with 3 different scenarios and choose what you feel is the better design based on the available information.
Uzoezi Isaac-Onwah at uji5002@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Undergraduate engineering students
Over 18 years old
Speaks English
Exclusion Criteria:
Under 18
Graduate Students
Non-Engineering Majors
Education, Sleep Management
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Introducing Humor to Content of Prompts for Prolonged Sedentary Behavior

This is a mixed design study that will examine the effects of introducing humor to the content of prompts on nudging sedentary behavior change of stressful graduate students.
Shan Wang at sxw820@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Fully conversant in English
Stressful Graduate student
With iPhone and willing to change their Password to the assigned unique one by researcher
Three weeks commitment for the study
Those who work/study for more than 6 hours a day on workday and are Interested in developing healthy sedentary behavior and reduce stress
Exclusion Criteria:
those who cannot fully understand survey questions or express their ideas in English
Those who are not graduate student or not feel stressed at all
Those who do not have a iPhone
Those who do not sit a lot during work and have no motivation to have behavior changes
Those who can't commit three weeks
Mental & Behavioral Health
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Study Locations

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Location
State College, PA

Real-world Older Driving Study (ROADS)

ROADS will examine the relationships between driving, health, psychosocial and cognition in healthy older adults. This study will involve the placement of a video recording device in participants’ vehicles for 3 months. These devices will record driving habits and conditions such as speed and braking. Participants will also be asked to complete daily surveys on a study provided phone throughout the 3 month study. ROADS participants will be asked to visit the Penn State University for 3 in person visits to complete questionnaires, cognitive and health assessments, and to learn how to use the study provided phone. These visits may last up to 3 hours and on a rare occasion slightly longer.
Michelle Huerbin at mlh5955@psu.edu or 814-865-4773
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 70-95 years
Have a valid US driver's license
Drive on average 3 days a week
Willing to have camera installed in vehicle for 3 months
Exclusion Criteria:
Alzheimers or dementia
Any reason for driving restrictions
Neurology, Mental & Behavioral Health
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Study Locations

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Location
State College, PA

Parents’ Perceptions of the Coparenting Relationship: an interview study

This research study is being done to gather information from parents to figure out strategies and difficulties in their coparenting relationship for an intervention program which helps them to navigate the transition to parenthood process more comfortably and build up supportive relationships between parents.
Livia Guerra at llg5223@psu.edu or 814-206-4410
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Parent of child 6 years old or younger
Exclusion Criteria:
none
Prevention, Education
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Using Serious Game Technology to Improve Social Skills in Autism

The goal of this study is to help ASD adolescents improve social skills during face-to-face interactions. We have designed an immersive computer game to help them learn these skills in a fun way. Adolescents play the game at home 3 times a week for 3 months on a computer that we give you. In order to see how well the game is working to teach them, we have to test it against another game that is similar but teaches other skills. We measure your adolescent’s attention in the lab through computer games and by measuring their eye movements. We invite you to answer questions about their social behavior. We are flexible in how we work with families to accommodate busy schedules (e.g., weekend appointments). Families come to Penn State for three visits. We pay for all travel expenses (mileage, toll, hotel). Families are also compensated up to $450 for their time.
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-204-2272
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03690661
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Inclusion Criteria:
10-18 years old
autism spectrum disorder
corrected vision and hearing at normal levels
can speak in full sentences
stable internet connection in the home
Exclusion Criteria:
active seizure disorder in last 2 years
non-native English speaker
Children's Health, Mental & Behavioral Health
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Location
Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA

Site for Therapy in Amyotrophic Lateral Sclerosis (TAME)

This is a phase IIB multi-centered, double blind, placebo controlled study to assess the safety and efficacy of a medication called memantine in people with ALS. This study is designed to validate the preliminary data that suggests memantine can slow down the course of ALS and also to determine if memantine can improve ALS patients who have characteristics of frontotemporal dementia.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02118727
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Inclusion Criteria:
Age 18-85
Diagnosed with amyotrophic lateral sclerosis (ALS)
ALS Functional Rating Scale (ALSFRS-R) score > 25
Has a caregiver willing to help with study activities
Exclusion Criteria:
Forced vital capacity (FVC) ≤ 60% predicted
ALS-related weakness for more than 3 years
History of liver disease
Kidney failure
Neurology
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Study Locations

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Location
Hershey, PA

Watch and Human Observers (who!): Switched System Models of Physical Activity

This is a behavioral/engineering study that will examine whether the behavioral feedback derived from data generated by a wearable sensor has equivalent effects as the feedback derived from self-monitoring prompts. A change in the step counts as measured by the Fitbit Versa following prompt receipt is the primary endpoint.
Deborah Reese at dlb43@psu.edu or 814-865-7935
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Participants capable of reading, speaking and understanding English and of giving informed consent.
Participants between the ages of 18-29 years.
Participants must be free of visual impairment that would interfere with the use of a Fitbit Versa to receive behavioral prompts.
Participants must be willing to wear a Fitbit Versa almost continually (23.5 hours/day) for a 3 month period of time.
Participants must be residing within the state of Pennsylvania
Exclusion Criteria:
Participants engaging in 150 or more minutes of moderate- or greater intensity physical activity each week.
Participation in an organized program with mandated physical activity (ROTC, sport)
Participants who require an assistive device for mobility or have any other condition that may limit or prevent participation in moderate-intensity physical activity
Participants with contraindications to normal physical activity on the Physical Activity Readiness Questionnaire.
Participants with a prior diagnosis of cancer, cardiovascular disease, diabetes or metabolic syndrome.
Mental & Behavioral Health
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A qualitative exploration of rurality, physical activity, and intervention preferences among older residents in Pennsylvania

This study will use interviews to explore to explore perceptions of rurality, physical activity behaviors and physical activity intervention preferences among rural older adults who live in Pennsylvania
Nishat Bhuiyan at nxb49@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 50 years old
Currently residing in Pennsylvania
Able to speak, read, and write in English
Exclusion Criteria:
Below age 50
Not currently residing in Pennsylvania
Not able to speak, read, and write in English
Prevention, Mental & Behavioral Health
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The Effects of Aircraft Seat Width on Passenger Comfort

The objective of this research is to determine the relationship between aircraft seat width and passenger comfort. Airlines are reducing the sizes of seats and improving their ability to fly planes at or near capacity. The combined effect is to decrease the quality of the experience of passengers. This work will help us to understand the degree to which comfort has been reduced.
Ritwik Biswas at AirplaneResearch@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
We are particularly interested in small and large participants.
You must be a healthy adult aged 18 years or older.
Exclusion Criteria:
Individuals under 18 years of age are not eligible.
Muscle & Bone, Mental & Behavioral Health
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Study Locations

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Location
State College, PA