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This study investigates whether persons with aphasia understand and process sentences with vernacular features in a manner similar to more typical populations. Participants will rate sentences on their naturalness and on whether they make sense, and they will also read sentences while we track their eye movements.

In an increasingly global environment, both within the US and abroad, the ability to rapidly gain native-like linguistic competence is a critical asset. The ability to use an L2 in a way that is both expected and recognized by its native speakers is important both to the broad public, and to specific sectors, such as military personnel, that must develop native-like competence in a foreign language in a limited amount of time. The studies conducted under this IRB protocol will examine how learners/speakers of a second language acquire and process multi-word units (e.g., carry a business; run a store) in their second language, and how knowledge from the first language might influence the learning and processing of multi-word units in a second language.

Participants will complete a number of simple tasks on a computer in English and/or in Spanish (depending on language background).

$12/hour (behavioral sessions); $18/hour (EEG sessions); $20 bonus at completion of study when at least 3 behavioral sessions or 2 EEG sessions are required.

This study seeks to verify the findings of the CHARM I pilot study by conducting a multi-center clinical trial. We hypothesize that: • Pancreatic cyst infusion with a specifically designed drug therapy cocktail following normal saline lavage will result in cyst destruction rates that do not significantly differ from those achieved by alcohol-based cyst treatment (ethanol lavage followed by infusion of the same chemotherapeutic cocktail). • The removal of alcohol from the procedure will decrease both serious and minor adverse event rates associated with pancreatic cyst treatment. • There may be molecular markers contained within the fluid of these cystic tumors which identify cysts that are favorable to or resistant to EUS-guided fine needle infusion using this drug combination. As such, we will test all treated cysts for 10 of the best known molecular markers for evaluation in post study analysis. We expect that administering a specifically designed chemotherapeutic cocktail without prior alcohol lavage will result in an equivalent rate of cyst resolution with fewer complications when compared to alcohol. The results of this study will provide important information about the most efficient and safest method for treating premalignant pancreatic cysts, an important step for treating these lesions with a minimally invasive technique and preventing their progression to cancer. Standard alternative treatment options for this patient group (if not taking part in this study) would be ongoing periodic radiographic monitoring with MR or CT imaging waiting for signs of cancer to develop or to consider surgical removal of the affected tissue.

Patients will have to sign the consent form to participate in the trial

We are asking you to take part in this voluntary research study because you have a brain tumor (glioblastoma) that has gotten worse despite first treatment. The purpose of this voluntary research study is to is to learn if the SonoCloud-9 (SC9) implantable device can be used in combination with Carboplatin chemotherapy to help control glioblastoma at recurrence. Neither Sonocloud-9 (SC9) in combination with Carboplatin chemotherapy is not FDA approved.

As part of your routine care, you will be asked to undergo surgery to remove the tumor that has come back. You will be randomized into one of the treatment groups. If you are in the study drug group the surgeon will insert the SonoCloud-9 device (SC9) implant into the skull bone at the end of the tumor resection surgery. If you are in the routine treatment group, the surgeon will close the wound without implanting the SC9 device. The treatment itself will start within 12 to 21 days after the randomization. - If you are in the study drug group you will receive up to 7 doses (every 3 weeks) of Carboplatin at the same time the SonoCloud-9 device is being activated. Further details on the procedures are described below. A brain MRI (Magnetic Resonance Imaging) scan will be performed after the first cycle as part of the research to evaluate opening of the BBB (blood-brain barrier). - If you are in the routine treatment group, you will receive up to 4 doses of Lomustine (every 6 weeks), or, if considered as best appropriate, up to 6 doses of Temozolomide (every 4 weeks). Additional in-person hospital visits or telehealth consultations by video or phone will be performed at regular intervals.

$350.00

Description: This research study is to assess energetic status, reproductive health, and bone health in a population of young exercising men. Secondarily, this study will also explore how diet, fitness, cardiovascular function, eating behaviors, stress, cognitive function, and sleep related to energy and reproductive outcomes in exercising men. Eligible young men (age 18-35) are those who are generally healthy and either a) exercising or b) not exercising.

There will be essentially 5 study visits - The first visit will include informed consent to take part in the study & completion of questionnaires and measurement of anthropometrics. Visit 2 will include tests of your metabolism, a blood draw, a saliva collection, and assessment of diet and physical activity. Visit 3 will be a short visit for a saliva collection. Visit 4 will include tests of stress (a hair sample), body composition, bone health, aerobic and anaerobic fitness, cognitive testing, and reproductive function. Visit 5 will consist of a results meeting and return of wearable devices and logs.

This trial will examine different doses of JANX007 to find the safest dose to treat metastatic castration resistant prostate cancer (mCRPC)

Participants will be required to come to all clinic visits, report any symptoms they are having and all medications they are taking, including over the counter medications.

To determine if chemotherapy added to ovarian suppression and endocrine therapy is better than endocrine therapy and ovarian supression alone.

Subjects will be required to keep all study appointments, take the medications as required, have an annual mammogram, inform the study of any over the counter medications they may be taking.

This study aims to measure child eating behavior at home. Parents will video record their child eat 3 meals at home using a smart phone device and then take pictures of food storage locations (e.g., fridge, pantry). Videos will be coded for child eating behaviors. Parents will complete baseline and follow-up questionnaires. Children will wear an activity watch (like a Fitbit) for 1 week. In addition to these study procedures, there is an optional urine sample collection for children in order to study urinary metabolites as a marker of diet.

You will be asked to video record your child eating 3 meals at home and to take photos of food storage locations in your home (e.g., fridge, pantry).

$75 and an optional $25 for completing the urine sample collection

In this study, we hope to better understand the neural mechanisms underlying risk for Borderline Personality Disorder (BPD) in adolescent girls. BPD is a condition that is usually found in adults. However, it may be possible to identify risk for the disorder before adulthood. Understanding who is at risk for BPD early in development is important in order to develop preventative interventions.

There will be a total of three visits - one main visit and two follow-ups. Participants will be completing questionnaires, participating in a parent-child observation task, and children will be doing an EEG assessment during the first visit. Participants will be asked to complete questionnaires and participate in a parent-child observation task during the follow-up visits.

$100

The purpose of the first part of this study is to compare the usual treatment of a standard-dose radiation given over 6 weeks with cisplatin chemotherapy to a reduced-dose radiation given over either 6 weeks with cisplatin or 5 weeks with the immunotherapy drug, nivolumab. A lower dose of radiation as compared to the usual radiation treatment dose could be as effective in lengthening the time without your cancer getting worse. Nivolumab with reduced-dose radiation may or may not be as effective in lengthening the time without your cancer getting worse. This study will help the study doctors find out if this different approach is the same or worse than the usual approach.

The purpose of the first part of this study is to compare the usual treatment of a standard-dose radiation given over 6 weeks with cisplatin chemotherapy to a reduced-dose radiation given over either 6 weeks with cisplatin or 5 weeks with the immunotherapy drug, nivolumab. A lower dose of radiation as compared to the usual radiation treatment dose could be as effective in lengthening the time without your cancer getting worse. Nivolumab with reduced-dose radiation may or may not be as effective in lengthening the time without your cancer getting worse. This study will help the study doctors find out if this different approach is the same or worse than the usual approach.

This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with H&Y stage 1 or 2 Parkinson’s disease compared to that of healthy volunteers.

In this study, you will receive a clinical evaluation and an MRI examination. After that, you will be followed every 12 months for up to 4 years.

up to a total of $250.00.

The purpose of the study is to determine the effects of amiloride on the blood pressure response during exercise, and exercise tolerance in patients with PAD and healthy controls.

There will be 3 in-person visits. You will take a capsule of amiloride or placebo before visits 2 and 3 and blood pressure, heart rate and other physiological measurements will be recorded.

You will receive $25 per hour for your participation in this research study

The purpose of this study is to see if stool or blood can be used to determine whether or not a patient has any colon polyps or colon cancer. This study will compare these biological samples (blood, urine, stool) to any colonoscopy or surgery a patient has to see if the outcome could be predicted.

Sound symbolism is the idea that the sound of a word alone can convey its meaning. Aphasia is a language impairment, occurring most often as a result of a stroke. There is some evidence that sound-symbolic language is preserved in stroke patients. Studies in this protocol will investigate the extent to which this is so, and whether sound-symbolic language could be a rehabilitation strategy for aphasia.

We will ask you to listen to real words and non-words, or look at pictures of objects, and make judgements about them. We may also ask you to complete some tests of language ability. The total time commitment may be up to four hours but will be split into two sessions.

Amount varies depending on the study

The purpose of this study is to better understand how human teams with non-human virtual agent team members operate and function.

If you agree to be in this study, you will be fitted to sensors that will measure your neurophysiological (i.e., brain, cardiac, and respiratory) signals while you complete group tasks in person or in virtual reality. This interaction will be recorded and coded. You will also be asked to complete several questionnaires about your demographics, behaviors, and emotions.

$40

The purpose of this research study is to learn about how humans provide corrections to robot movements when the robot makes mistakes while performing a task. Understanding the intent of humans can inform how we incorporate the information provided by that interaction into machine learning algorithms that improve the robot’s task performance in future.

Participants will observe the robot performing three different tasks. The robot will place a peg in a hole, pickup and pour a cup, and draw and erase an image on a whiteboard. The robot may or may not make mistakes while performing these tasks. Mistakes may be minor or may be significant such as colliding with an object or the work table. Participants will be asked to correct the robot’s mistake by moving the robot arm or stopping the task execution altogether by hitting a red stop button. After observing the robot perform each task several times, you will be asked to demonstrate a new task to the robot. The robot will then try to replicate your demonstration and you may choose to provide corrections to improve the robot’s execution of the task anytime you think it is making a mistake or not performing well enough.

20

This study is designed to better understand how people complete complicated tasks, and the best ways in which to measure their performance. If you agree to the study, you will be asked to fill out questionnaires on your thoughts, feelings, and behaviors; take a short interview on the same; and complete brain teasers and computerized tests of attention and learning.

There are several steps to determining whether you are a good fit for the study. If you agree to be in the study, then we will send you a link to complete online questionnaires (~10 min) on your thoughts, feelings, and behaviors. If you are a good fit, then we will schedule a laboratory visit in Moore Building at the University Park campus (maximum length of time = 3 hours). During that visit you will complete an interview and more questionnaires, brain teasers, and computerized tests of attention and learning. The visit will be video recorded for quality assurance.

$50

The objective of this cross sectional survey study is to describe the social and psychological outcomes of cancer survivors and characterize the disparities between rural and non-rural cancer survivors. We will collaborate will members of the Big 10 Cancer Research Consortium's Population Science Working Group to invite cancer survivors in rural and non-rural communities to complete one online survey, with each site targeting cancer survivors in their catchment areas. At Penn State, we will target recruitment to cancer survivors living in Pennsylvania. We plan to enroll 150 participants. It will take participants 30-40 minutes to complete the study and they will receive a $15 Amazon gift card for their time and effort.

Study participants will be asked to complete one online survey about their experience as a cancer survivor. A member of the Penn State study team will call the participant to confirm eligibility before sending a $15 Amazon e-gift card. The entire study should take between 30-40 minutes to complete.

$15

This is a study of the drug DFMO (difluoromethylornithine) for medulloblastoma that has returned or not responded to treatment. DFMO is an oral drug that inhibits a certain enzyme (protein) in blood which is associated with a bad outcome in neuroblastoma cases. Cancer cells have pathways that drive the cancer to grow and DFMO targets the specific pathway of this enzyme to turn these cells off.

You will have exams, tests, and procedures while on the study to evaluate whether you can participate in the study and how you are doing while on the study. These include physical exams, blood tests, urine tests, bone marrow aspirate and biopsies, heart tests, hearing tests, and imaging evaluations such as MRI of your brain and spine. You will receive treatment on this study for a total of about 2 years. After treatment, you will have follow-up examinations and medical tests. We would like to continue to find out about your health for about 5 years after you complete the study.

The purpose of the Vivistim Registry for Paired VNS Therapy (GRASP) is to gather real-world information on patients with arm and hand deficits post- stroke who are considering Vivistim System treatment. Before and after Vivistim System implant, patient data will be collected and reported throughout the therapy process.

The purpose of this study is to follow individuals that plan to be implanted with the MicroTransponder Vivistim® System. We will be collecting data at various time points over 3 years. Data collection includes questionnaires about arm movement, quality of life, productivity, and use of healthcare services. This study lasts for 3 years, with 6 total visits. One visit is prior to being implanted and 5 are post-implant. Visits can be done via telephone or in person. Questionnaires and Therapy data will be collected at each visit.

$600.00

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.

There will be three in person visits for this study. At the screening visit, participants will undergo a detailed medical history and physical examination and then will complete a mental test while lying down and standing. If eligible based on the results of the mental test, participants will undergo a pregnancy test if female and of childbearing potential, measurements of blood pressure and heart rate and blood draws while lying down and standing up, and a test to determine if they can tolerate being in a lower body negative pressure (LBNP) device that distributes more blood to the legs to mimic standing. If eligible based on the results of the screening visit, participants will be asked to complete an online questionnaire and two study visits that are separated by at least one week. At these study visits, they will perform a mental test in a magnetic resonance imaging (MRI) scanner. The LBNP device will also be used while in the MRI scanner to distribute more blood to the legs to mimic standing.

$25 per hour; additional $25 for completion of online questionnaire

This study will examine neural reactivity to stress in young adults who use alcohol and cannabis and link these responses to behaviors in everyday life.

You will be asked to complete the following: 1) An in-lab intake appointment for interviews and questionnaires, and a smartphone-based training session 2) A 14-day burst of smartphone-based reporting in daily life 3) An in-lab neuroimaging training session and scan, and bloods draws 4) Two additional 14-day bursts (total of 28 days) of smartphone-based reporting in daily life, one at 6 months post-MRI and one at 12 months post-MRI 5) 6-month follow-up appointment for interviews and questionnaires 6) 12-month follow-up appointment for interviews and questionnaires

717

This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.

This trial will compare the use of elacestrant versus standard endocrine therapy in those who are node positive, ER +, Her2 - with high risk of the cancer coming back

Participants will be expected to come to all visits, take all study medication as instructed by the study doctor, report any new medications, prescription or over the counter, report all side effects.

This is a survey and interview study recruiting patients with sickle cell disease (SCD). Participants will answer questionnaires and complete a remote interview about health care experiences, pain, and discrimination. Natural language processing of interview transcripts will be used to quantify linguistic features indicative of subjective associations between individual experiences of racial discrimination and sickle cell pain.

Participants will be asked to fill out questionnaires and answer questions during an interview.

$50

The primary objective of this protocol, Mechanisms of Cardiovascular Disease (MCD) is to collect biological specimens and data from patients with cardiovascular disease (CVD) to study the mechanisms that contribute to cardiovascular dysfunction and disease.

If you decide to participate in this study, you will be asked to provide a blood sample and possibly additional optional samples, either immediately or later. Additional samples may include saliva, cheek swab, urine, waste tissue or nasal swabs. You will decide whether you are willing to provide these other samples. Clinical data will be included in the dataset along with your sample.

The purpose of this study is to better understand how civilian stereotypes about veterans impact veterans' feelings about themselves and others, and how that influences veteran behavior in the workplace.

Menthol, capsaicin, and camphor are active ingredients often found in over-the-counter pain relief creams and gels. These ingredients typically work by interacting with certain receptors in the skin that are sensitive to temperature changes. There is limited information on how combining menthol with other substances that target similar receptors affects the body. These naturally occurring substances found in plants can widen small blood vessels in the skin through specific processes controlled by nerves in the skin. This study aims to understand how menthol, camphor, and capsaicin individually and together affect sensory function and blood flow in the skin. Additionally, as people age, their skin's nerve and blood vessel function tends to decrease. The study also seeks to explore how aging impacts the effects of these substances on sensory perception and how nerves and blood vessels work together in the skin.

There will be a screening visit and then 6 experiment visits where different topical analgesics will be applied to the forearm skin. We will measure skin blood flow.

240

The purpose of this study is to test how social decisions are affected by possible risk of infection. We aim to examine the neural and behavioral mechanisms underlying how choices in a risky social decision-making situation can be influenced by viewing images of infection threat (e.g., person with runny nose) vs. images of neutral scenes or other threatening scenes.

Participants will come to the research site for a one-time visit. They will complete brief questionnaires, followed by playing a social decision-making game while undergoing fMRI scanning.

$35.42

This protocol is comparing two types of surgery, one with the removal of the ovaries, fallopian tubes and uterus against removal of the fallopian tubes and uterus in subjects how are between 35 and 50 with the BRCA1 mutation..

Participants must be carriers of the BRCA1 gene mutation. This trial involves going to the operating room to have either their fallopian tubes removed or their ovaries and fallopian tubes removed. A vaginal ultrasound will be done. you will have blood drawn and a pregnancy test done. This will happen before surgery.