Functional and Mechanical Changes Following Total Ankle Arthroplasty
Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle.
The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
N/A
Men's Health, Muscle & Bone, Women's Health
The perception and experiences of newly diagnosed type 2 diabetes patients (T2D) on the impact of patient-provider communication on subsequent decision to engage in diabetes self-management education (DSME).
This study seeks to explore the perception and experiences of newly diagnosed type 2 diabetes patients about how their interaction with their provider at diagnosis led to their uptake of diabetes education.
Michelle Boakye at mdb521@psu.edu or 814-699-1783
All
18 year(s) or older
N/A
Diabetes & Hormones
PhAse 1/2 StuDy of Modern ImmunotherApy in BCG-RelaPsing UroThelial Carcinoma of the BLADDER – (ADAPT-BLADDER) HCRN GU16-243 (PSCI 18-129)
This is a Phase II drug study which is designed to examine the effects of Durvalumab on individuals with bladder cancer that has not invaded muscle tissue. Study subjects will have already been treated with one or more surgical resections and Bacillus Calmette-Guerin or BCG, and the disease has now recurred.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu
All
18 year(s) or older
NCT03317158
Cancer
Mechanisms of autonomic blood pressure control after acute exercise
This study may help to describe how blood pressure is controlled in healthy adults. Results from this study may be important for designing exercise programs for people who suffer from poor blood pressure control.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
N/A
Heart & Vascular
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Ulcerative Colitis
This study is for patients with moderate to severely active ulcerative colitis to measure how effective and safe an experimental medication is in treating this condition.
Zvjezdana Sever Chroneos at zchroneos1@pennstatehealth.psu.edu or 717-531-0003, ext=322136
All
18 year(s) or older
NCT03934216
Digestive Systems & Liver Disease
Site for ATHN 10: Leveraging the ATHNdataset to Document the State of Rare Coagulation Disorders in the United States
This is a multi-center project in which the American Thrombosis & Hemostasis Network (ATHN) will offer free genotyping to individuals with Rare Coagulation Disorders (RCD).
Lisa Baker at lbaker@pennstatehealth.psu.edu or 717-531-7468
All
All
N/A
Blood Disorders
The Muscle Reflex: Limb blood flow
We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
N/A
Heart & Vascular
Livestreaming, Content Creation, and Playing and Learning Online
This study surveys how different viewers, livestreamers and content creators learn and engage online. We are recruiting people who view or create content on livestreaming platforms such as Twitch, YouTube or Mixer (past or present). This study involves filling out a survey which should take 15-20 minutes to complete. Participants will be entered into a drawing to win one of 20 $75 e-gift cards for their participation.
G. Richard at gamingstudy@psu.edu
All
All
N/A
Education
A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled, 16-Week Study Evaluating the Safety and Efficacy of PF-06650833, PF-06700841, and PF-06826647 in Adults with Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa: Phase 2a Double-Blinded Study, 26 weeks long. Injection under the skin, Males/Females 18-75 years old with Hidradenitis Suppurativa (HS)
Hidradenitis Suppurativa (HS), is a recurrent inflammatory skin condition. HS is characterized by lesions that can be found most commonly in the groin, armpits, and buttocks. These lesions are very painful and can drain and cause scarring.
The purpose of this study is to find out if the study medicines, PF-06650833, PF-06700841, and PF-06826647 can help with the treatment of HS.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
NCT04092452
Skin Conditions
Effects of heating on exercise pressor reflex in peripheral artery disease: Sympathetic Response
The purpose of this study is to examine if nervous system and blood pressure responses to exercise will be less with heat exposure in patients with peripheral artery disease (PAD) and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
N/A
Heart & Vascular
Data4Action: Phase 2
This study is being done by researchers at The Pennsylvania State University. The goal of this research is to measure the level of Coronavirus Disease-19 (COVID-19) exposure and the social, economic, and behavioral implications of the pandemic in the Centre County and PSU student community. Approximately 2000 residents of Centre County and approximately 1000 PSU students (up to a maximum of 1500) will take part in this research study.
We will measure the level of Coronavirus exposure in the region and its changes over time through collection of small blood, saliva, and hair samples 4 times over one year from participants. We will also measure changes in employment, education, social relationships, and well-being over time (as the pandemic evolves) using participant surveys. Participants receive results that indicate whether they may have had Coronavirus in the past, but results will not indicate whether they have a current, active infection.
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Prevention, Mental & Behavioral Health
A Phase 3, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Larazotide for Relief of Persistent Symptoms in Patients with Celiac Disease on a Gluten Free Diet
This study is for patients with Celiac disease. We are studying whether an investigational drug will reduce symptoms associated with Celiac disease when taken while on a gluten free diet.
Zvjezdana Sever at zchroneos1@pennstatehealth.psu.edu or 717-531-0003, ext=322136
All
18 year(s) or older
NCT03569007
Digestive Systems & Liver Disease
Perception of Eating Specific Food and Liquid Textures
The purpose of this qualitative/quality of life (QOL) research study is to learn more about people's thoughts and opinions regarding eating specific food and drinking specific liquid textures. We are interested in learning how people's food and drink preferences change with age.
Nicole Etter at oppal@psu.edu or 814-863-2021
All
18 year(s) or older
N/A
Food & Nutrition, Digestive Systems & Liver Disease, Diabetes & Hormones
Phase 1/2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
This Phase 1 and 2 study is to determine the safety of APL-101 in subjects with NSCLC with specific mutations. It is also to determine the dose that is tolerable for oral administration of APL-101. And to see if there is a clinical benefit to subjects for the amount of time to progression, or progression free survival and overall survival.
Irina Geier at igeier@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
NCT03175224
Cancer
A Phase 3, Randomized, Double Blinded, Placebo Controlled Trial to Evaluate the Efficacy and Safety of a Respiratory Syncytial Virus (RSV) Prefusion F Subunit Vaccine in Infants Born to Women Vaccinated During Pregnancy
This study is designed to evaluate the efficacy and safety of maternal immunization with RSVpreF against medically attended lower respiratory tract illness in infants.
Erin Hammett at ehammett@pennstatehealth.psu.edu
Female
18 year(s) or older
NCT04424316
Children's Health, Prevention, Pregnancy & Infertility
Effects of antibiotic use on fecal microbiome and resistome
This study will investigate the changes in the human fecal microbiomes and resistomes in response to antibiotic treatment.
Jasna Kovac at jzk303@psu.edu or 814-699-1680
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Lung Disease & Asthma
Online Investigation of Spoken Language Processes
This online study aims to examine whether factors like language history and visual information influence spoken language processes in typical listening environments.
Navin Viswanathan at splacolab@psu.edu
All
18 year(s) or older
N/A
Language & Linguistics
Business as Usual? A Study of Online Content Creators as Sex Workers
The purpose of this study is to understand what motivates online content creators who sell sexualized products and content and how they view their work. We also explore the ways in which emotional labor plays out within this industry and how the online forum allows for autonomy for workers in ways that differ from traditional forms of sex work where there is direct physical contact between worker and customer.
Beth Montemurro at eam15@psu.edu
Female
18 year(s) or older
N/A
A Survey of the Sex Differences in Taking Selfies while Driving
This study aims to understand peoples’ selfie-taking behavior and how, if at all, they relate to their driving behavior and gender difference. The participants will participate the study by completing an online survey.
Josh Avalos at jqa5409@psu.edu or 610-716-7976
All
18 year(s) or older
N/A
Education, Language & Linguistics
Social Processing in Girls with and without Attention-Deficit/Hyperactivity Disorder (ADHD)
This study examines social peer functioning in adolescent girls, with a specific focus in identifying underlying neural mechanisms.
Michael West at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285968
Female
All
N/A
Mental & Behavioral Health
My Character is...Myself? Exploring Attachment Styles, View of Self, Virtual Self-Discrepancy, & Character Attachment
The goal of this research is to confirm the relationships between virtual self-discrepancy, character attachment, view of self, attachment styles, and the potential for a moderating variable within the relationships as a starting point for future research tying in player/character relationship and gaming addiction.
Jessica Cornelius Smith at jjc6618@psu.edu or 870-403-7817
All
18 year(s) or older
N/A
Mental & Behavioral Health
Comparing Interactions Between Heterogeneous and Homogeneous Pairs of Building Designers
This study considers how building designers work together on a design task. During the 1-hour long study, participants will be assigned a design partner and given a design task with specific goals to address. The entire study will take place over a computer and the design process will be recorded through the computer's video and audio.
Stephanie Bunt at s.bunt@psu.edu
All
18 year(s) or older
N/A
Site for A study of enfortumab vedotin (ASG-22CE) as monotherapy or in combination with other anticancer therapies for the treatment of urothelial cancer
This study is to determine the recommended Phase 3 dose of venetoclax in combination with azacitidine in AML patients when given as maintenance therapy following allogeneic stem cell transplantation. It also is to determine if venetoclax can be effective in combination with azacitidine to improve RFS in AML patients compared to Best Supportive Care (BSC) when given as maintenance therapy following allogeneic stem cell transplantation.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
NCT03288545
Cancer
Site for RANDOMIZED PHASE II/III TRIAL OF SENTINEL LYMPH NODE BIOPSY VERSUS ELECTIVE NECK DISSECTION FOR EARLY-STAGE ORAL CAVITY CANCER (NRG-HN006) (PSCI# 20-085)
The purpose of this study is to see if neck and shoulder function and pain are better after SLN biopsy surgery compared to the usual approach and to see if SLN biopsy surgery is as good as the usual approach in extending your time without cancer. SLN biopsy surgery is potentially less invasive compared to the usual approach, but it requires a radioactive imaging agent to see the lymph nodes and it could also cause side effects. These side effects are described in the risks section below. Your study doctor will choose the appropriate imaging agent, Lymphoseek or sulfur colloid, for use in your surgery.
This study will help the study doctors find out if this different approach is better than the usual approach at improving neck and shoulder function. To decide if it is better, in the first part of the study, doctors will be looking to see if shoulder and neck function and quality of life are better after SLN biopsy surgery compared to the END surgery.
Tricia Morrison at tmorrison2@pennstatehealth.psu.edu or 717-531-0003, ext=310131
All
18 year(s) or older
NCT04333537
Cancer
Site for Strong Foundations: Intervening to Promote Co-Parenting and Reduce Father Hazardous Drinking in Expectant Parents.
Our goal is to examine the efficacy of this modified intervention, mFF+, in reducing fathers’ drinking and couple conflict while promoting co-parenting quality, parental sensitivity, and child outcomes among families with heavy drinking fathers. There are two major aims: 1) to conduct a RCT of mFF+ with 220 couples (110 in each condition) with heavy drinking men and light drinking/abstaining women recruited in the first trimester of pregnancy. Parent reports and observational assessments of family functioning will be conducted at baseline (pretest), 6 months postpartum (posttest), and 12 months postpartum (follow-up); 2) to examine whether these impacts on drinking, co-parenting, adjustment, and couple dyadic functioning mediate the impact of mFF+ on parenting, and infant outcomes. We will also examine if there are child sex differences in intervention outcome, or sex specific mediational pathways.
Jenna Sassaman at jnk5173@psu.edu or 814-865-6902
All
18 year(s) or older
N/A
Addiction & Substance Abuse, Prevention, Women's Health
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Bimekizumab in Study Participants with Moderate to Severe Hidradenitis Suppurativa
Hidradenitis Suppurativa: Phase 3 Double-Blind Study. Participation will last approximately 71 weeks. Injection under the skin, Males/Females at least 18 years old with Hidradenitis Suppurativa (HS)
Hidradenitis Suppurativa (HS), is an inflammatory skin condition that can come and go. It is characterized by painful spots, called lesions, that are found most commonly in the groin, armpits, and buttocks. These lesions are very painful and can drain and cause scarring.
The purpose of this study is to find out if the study medicine, bimekizumab, can help with the treatment of HS.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
NCT04242446
Skin Conditions
Brain Mechanisms of Overeating in Children
Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kara Hickok at kih5334@psu.edu or 814-865-5169
All
Younger than 18 years old
NCT03341247
Food & Nutrition, Prevention, Neurology
How urban infrastructure fosters romantic relationships
The primary endpoint of this study is to identify the contributing factors in development of romantic relationships through an analysis of the real-life experiences of Penn state couples that we collect in our surveys. Our focus is to identify the spatial factors in different scales as they relate to two-person relationships. The results of this study informs architects, planners, and administrators of practical strategies to generate friendly spaces in college towns.
sohrab rahimi at sur216@psu.edu or 814-206-4341
All
18 year(s) or older
N/A
Education
Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial
This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Brian Allen at ballen1@pennstatehealth.psu.edu or 717-531-4100
All
Younger than 18 years old
NCT03135119
Children's Health, Mental & Behavioral Health
Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women
This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
NCT02822378
Food & Nutrition, Muscle & Bone, Women's Health