Refine your search

Search Results

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

442 Study Matches

Functional and Mechanical Changes Following Total Ankle Arthroplasty

Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle. The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
No recent history (< 1 year) of injuries to Achilles tendon
No history of lower limb reconstruction or surgery
age 70 year or older
Exclusion Criteria:
History of any previous surgery to lower limb
History of rheumatoid arthritis or other degenerative joint disease
Non English speaking
Inability to provide consent
Men's Health, Muscle & Bone, Women's Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

The perception and experiences of newly diagnosed type 2 diabetes patients (T2D) on the impact of patient-provider communication on subsequent decision to engage in diabetes self-management education (DSME).

This study seeks to explore the perception and experiences of newly diagnosed type 2 diabetes patients about how their interaction with their provider at diagnosis led to their uptake of diabetes education.
Michelle Boakye at mdb521@psu.edu or 814-699-1783
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Age 18 or older
Any gender
Newly diagnosed type 2 diabetes patient within the past 12 months
Have attended at least one diabetes education after diagnosis
Able to provide consent in English
Exclusion Criteria:
Patients who are below 18 years
Patients who have a different type of diabetes either than type 2
Patients diagnosed with Type 2 diabetes more than 12 months
Newly diagnosed diabetes patients who have not attended diabetes self-management education
Diabetes & Hormones
  Email this study information to me
  Contact the study team

PhAse 1/2 StuDy of Modern ImmunotherApy in BCG-RelaPsing UroThelial Carcinoma of the BLADDER – (ADAPT-BLADDER) HCRN GU16-243 (PSCI 18-129)

This is a Phase II drug study which is designed to examine the effects of Durvalumab on individuals with bladder cancer that has not invaded muscle tissue. Study subjects will have already been treated with one or more surgical resections and Bacillus Calmette-Guerin or BCG, and the disease has now recurred.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03317158
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Histologically confirmed non-muscle invasive urothelial carcinoma of the bladder (Ta, T1, or Tis stage) on transurethral resection of bladder tumor (TURBT) obtained within 60 days of registration.
ECOG (WHO) performance status 0 or 1
Age ≥ 18 years old at time of consent
White blood cell count (WBC) > 3.0 K/mm3
Absolute neutrophil count (ANC) ≥ 1.5 K/mm3
Exclusion Criteria:
Subjects with muscle-invasive (i.e. T2, T3, T4), locally advanced unresectable, or metastatic urothelial carcinoma as assessed on baseline radiographic imaging obtained within 60 days prior to study registration.
Subjects with another active second malignancy other than non-melanoma skin cancers and biochemical relapsed prostate cancer.
Subjects that have completed all necessary therapy and are considered to be at less than 30% risk of relapse are not considered to have an active second malignancy and are eligible for enrollment.
Subjects who have received the last administration of an anti-cancer therapy including chemotherapy, immunotherapy, and monoclonal antibodies ≤ 4 weeks prior to starting study drug, or who have not recovered from the side effects of such therapy.
Subjects who have had any prior radiation to the prostate or pelvis.
Cancer
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Mechanisms of autonomic blood pressure control after acute exercise

This study may help to describe how blood pressure is controlled in healthy adults. Results from this study may be important for designing exercise programs for people who suffer from poor blood pressure control.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 21 years old
healthy
normal blood pressure
can perform 20 continuous min of cycling
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
blood pressure over 150/100
taking medications that affect the heart
unable to perform 20 continuous min of cycling
Heart & Vascular
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Ulcerative Colitis

This study is for patients with moderate to severely active ulcerative colitis to measure how effective and safe an experimental medication is in treating this condition.
Zvjezdana Sever Chroneos at zchroneos1@pennstatehealth.psu.edu or 717-531-0003, ext=322136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03934216
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
moderate to severe ulcerative colitis
failed prior treatment
Exclusion Criteria:
women breast feeding or pregnant
no cancer in past 5 years
no Crohns disease
Digestive Systems & Liver Disease
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Site for ATHN 10: Leveraging the ATHNdataset to Document the State of Rare Coagulation Disorders in the United States

This is a multi-center project in which the American Thrombosis &amp; Hemostasis Network (ATHN) will offer free genotyping to individuals with Rare Coagulation Disorders (RCD).
Lisa Baker at lbaker@pennstatehealth.psu.edu or 717-531-7468
All
All
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Subject must have an established Rare Coagulation Disorder diagnosis (
Must currently receive or have received care at and ATHN affiliated HTC
Subject must have opted into the ATHNdataset
Exclusion Criteria:
Subject is unwilling to sign informed consent form
Blood Disorders
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Livestreaming, Content Creation, and Playing and Learning Online

This study surveys how different viewers, livestreamers and content creators learn and engage online. We are recruiting people who view or create content on livestreaming platforms such as Twitch, YouTube or Mixer (past or present). This study involves filling out a survey which should take 15-20 minutes to complete. Participants will be entered into a drawing to win one of 20 $75 e-gift cards for their participation.
G. Richard at gamingstudy@psu.edu
All
All
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
people who livestream
people who watch livestreams
aged 13 or older (if not yet legally adults, with parental/guardian permission)
online content creators
gamers or esports viewers
Exclusion Criteria:
under 13 years of age
cannot read, communicate or provide consent in English
does not livestream or watch livestreams or create content online
if a minor, does not have parental/legal guardian permission
Education
  Email this study information to me
  Contact the study team

A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled, 16-Week Study Evaluating the Safety and Efficacy of PF-06650833, PF-06700841, and PF-06826647 in Adults with Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa: Phase 2a Double-Blinded Study, 26 weeks long. Injection under the skin, Males/Females 18-75 years old with Hidradenitis Suppurativa (HS) Hidradenitis Suppurativa (HS), is a recurrent inflammatory skin condition. HS is characterized by lesions that can be found most commonly in the groin, armpits, and buttocks. These lesions are very painful and can drain and cause scarring. The purpose of this study is to find out if the study medicines, PF-06650833, PF-06700841, and PF-06826647 can help with the treatment of HS.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04092452
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
HS diagnosis for at least 1 year
HS lesions in at least 2 different areas
Willing to follow all study guidelines
Exclusion Criteria:
Certain treatments for HS are not allowed; coordinator will discuss specific treatments
Positive test results for HIV, hepatitis B, or hepatitis C
Skin Conditions
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Sympathetic Response

The purpose of this study is to examine if nervous system and blood pressure responses to exercise will be less with heat exposure in patients with peripheral artery disease (PAD) and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 21 years old
free of acute medical conditions
any race or ethnicity
women or men
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
age < 21 years old
Heart & Vascular
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Data4Action: Phase 2

This study is being done by researchers at The Pennsylvania State University. The goal of this research is to measure the level of Coronavirus Disease-19 (COVID-19) exposure and the social, economic, and behavioral implications of the pandemic in the Centre County and PSU student community. Approximately 2000 residents of Centre County and approximately 1000 PSU students (up to a maximum of 1500) will take part in this research study. We will measure the level of Coronavirus exposure in the region and its changes over time through collection of small blood, saliva, and hair samples 4 times over one year from participants. We will also measure changes in employment, education, social relationships, and well-being over time (as the pandemic evolves) using participant surveys. Participants receive results that indicate whether they may have had Coronavirus in the past, but results will not indicate whether they have a current, active infection.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 18 years of age.
Currently living in Centre County, PA.
Expecting to continue living in Centre County, PA through at least April (students) or June (community) of 2021.
Capable of providing your own Informed Consent.
Fluent in the English language.
Exclusion Criteria:
If you have any symptoms of acute infection, you will be excluded from in-person visits until 14 days after presenting symptoms but may still be eligible for the survey portion of the research.
Individuals unable to tolerate wearing a mask (up to 60mins) may only be eligible for the survey portion of the research.
Pregnant, lactating, or planning to become pregnant in the next 12mos may only be eligible for the survey portion of the research.
Not at least 18 years of age.
Not living in Centre County, PA.
Infectious Diseases & Immune System, Prevention, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

A Phase 3, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Larazotide for Relief of Persistent Symptoms in Patients with Celiac Disease on a Gluten Free Diet

This study is for patients with Celiac disease. We are studying whether an investigational drug will reduce symptoms associated with Celiac disease when taken while on a gluten free diet.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03569007
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
BMI between 16 and 45
Celiac diagnosis for at least 6 months
Follows a gluten free diet
Exclusion Criteria:
Open abdominal surgery in the last 6 months
Chronic GI disease other than celiac
Received antibiotics in past 4 weeks
Diagnosis of cancer in past 5 years
Uncontrolled Type 2 diabetes
Digestive Systems & Liver Disease
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Perception of Eating Specific Food and Liquid Textures

The purpose of this qualitative/quality of life (QOL) research study is to learn more about people's thoughts and opinions regarding eating specific food and drinking specific liquid textures. We are interested in learning how people's food and drink preferences change with age.
Nicole Etter at oppal@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
40 years and older
Hearing proficiency enough to complete a semi-structured interview
English proficiency enough to complete a semi-structured interview
Exclusion Criteria:
History of dysphagia (swallowing disorders)
Currently on a modified dysphagia diet
Currently receiving treatment for dysphagia (swallowing problem)
Participant reports diagnosed dementia or related cognitive disorder
Participant reports any progressive neurologic diagnosis (e.g. Parkinson’s disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), etc)
Food & Nutrition, Digestive Systems & Liver Disease, Diabetes & Hormones
  Email this study information to me
  Contact the study team

Phase 1/2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

This Phase 1 and 2 study is to determine the safety of APL-101 in subjects with NSCLC with specific mutations. It is also to determine the dose that is tolerable for oral administration of APL-101. And to see if there is a clinical benefit to subjects for the amount of time to progression, or progression free survival and overall survival.
Irina Geier at igeier@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03175224
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Phase 1, histologically and / or cytological confirmed unresectable or metastatic solid malignancy, refractory to standard therapies with no more than three prior lines of therapy
Women of child-bearing potential (WOCBP) must have a negative serum or β-human chorionic gonadotropin (β-hCG) at screening or evidence of surgical sterility or evidence of postmenopausal status.
Abnormal c-Met dysregulation, by tissue and/or plasma, defined as the following from local/archival molecular pre-screening evaluations.
Measurable disease according to RECIST v1.1
Eastern Cooperative Oncology Group (ECOG) performance status of 0–1
Exclusion Criteria:
Hypersensitivity to APL-101, excipients of the drug product, or other components of the study treatment regimen.
Known mutation/gene rearrangement of EGFR (except for Cohort C), ALK, ROS1, RET, NTRK, KRAS, and BRAF.
Active uncontrolled systemic bacterial, viral, or fungal infection or clinically significant, active disease process
History of, or currently, or at risk for, cardiac disease (e.g., long QT syndrome [> 450 msec QTcF or concurrent treatment with any medication that prolongs QT interval).
Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter drug absorption (e.g., Crohn’s, ulcerative colitis, active inflammatory bowel disease, uncontrolled nausea, vomiting, diarrhea, or malabsorption sydrome).
Cancer
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

A Phase 3, Randomized, Double Blinded, Placebo Controlled Trial to Evaluate the Efficacy and Safety of a Respiratory Syncytial Virus (RSV) Prefusion F Subunit Vaccine in Infants Born to Women Vaccinated During Pregnancy

This study is designed to evaluate the efficacy and safety of maternal immunization with RSVpreF against medically attended lower respiratory tract illness in infants.
Erin Hammett at ehammett@pennstatehealth.psu.edu
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT04424316
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Healthy pregnant women between the ages of 18 and 49
No significant fetal anomalies noted on ultrasound at at least 18 weeks gestation
HIV, syphilis, and hepatitis b negative
Planning to deliver at Hershey Medical Center
Willing to consent for infant to participate in study
Exclusion Criteria:
Pre-pregnancy BMI >40
History of severe adverse/allergic reaction to vaccination
Current pregnancy resulting from in vitro fertilization
Current or past pregnancy complications or abnormalities
Children's Health, Prevention, Pregnancy & Infertility
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Effects of antibiotic use on fecal microbiome and resistome

This study will investigate the changes in the human fecal microbiomes and resistomes in response to antibiotic treatment.
Jasna Kovac at jzk303@psu.edu or 814-699-1680
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
over age 18
English speaking/reading
Books a medical appointment for upper respiratory tract infection
Exclusion Criteria:
Patient took antibiotics in the past week
Patient participated in STUDY00012891 previously
Reason for medical visit is not upper respiratory tract infection
Patient is pregnant
Patient has a medical history that includes diagnosis of any intestinal related disease
Infectious Diseases & Immune System, Lung Disease & Asthma
  Email this study information to me
  Contact the study team

Online Investigation of Spoken Language Processes

This online study aims to examine whether factors like language history and visual information influence spoken language processes in typical listening environments.
Navin Viswanathan at splacolab@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
English Speakers
Between 18 and 65 years of age
Exclusion Criteria:
Those with diagnosed speech, hearing or language issues
Language & Linguistics
  Email this study information to me
  Contact the study team

Business as Usual? A Study of Online Content Creators as Sex Workers

The purpose of this study is to understand what motivates online content creators who sell sexualized products and content and how they view their work. We also explore the ways in which emotional labor plays out within this industry and how the online forum allows for autonomy for workers in ways that differ from traditional forms of sex work where there is direct physical contact between worker and customer.
Beth Montemurro at eam15@psu.edu
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Cisgender women
18 and older
Selling sexual content online for a period of at least 3 months
Exclusion Criteria:
Men
Under 18
  Email this study information to me
  Contact the study team

A Survey of the Sex Differences in Taking Selfies while Driving

This study aims to understand peoples’ selfie-taking behavior and how, if at all, they relate to their driving behavior and gender difference. The participants will participate the study by completing an online survey.
Josh Avalos at jqa5409@psu.edu or 610-716-7976
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Subjects who are 18 years of age or older
Subjects have a valid U.S. driver license or are allowed to drive in the US
Exclusion Criteria:
Subjects who under 18 years of age
Subjects who do not have a valid U.S. driver license or are not allowed to drive in the US
Education, Language & Linguistics
  Email this study information to me
  Contact the study team

Social Processing in Girls with and without Attention-Deficit/Hyperactivity Disorder (ADHD)

This study examines social peer functioning in adolescent girls, with a specific focus in identifying underlying neural mechanisms.
Female
All
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Must be female
May or may not have ADHD
Has a mobile device and capable of downloading applications
Exclusion Criteria:
Male
Not fluent in English
Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

My Character is...Myself? Exploring Attachment Styles, View of Self, Virtual Self-Discrepancy, &amp; Character Attachment

The goal of this research is to confirm the relationships between virtual self-discrepancy, character attachment, view of self, attachment styles, and the potential for a moderating variable within the relationships as a starting point for future research tying in player/character relationship and gaming addiction.
Jessica Cornelius Smith at jjc6618@psu.edu or 870-403-7817
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Must be 18 years of age or older.
Players that engage in role-play gaming using a character they have spent a significant amount of time creating.
Participants that can understand English
Exclusion Criteria:
Participants younger than 18 years of age.
Players that do not engage in role-play gaming using a character they have spent a significant amount of time creating.
People who do not speak and read English.
Mental & Behavioral Health
  Email this study information to me
  Contact the study team

Comparing Interactions Between Heterogeneous and Homogeneous Pairs of Building Designers

This study considers how building designers work together on a design task. During the 1-hour long study, participants will be assigned a design partner and given a design task with specific goals to address. The entire study will take place over a computer and the design process will be recorded through the computer's video and audio.
Stephanie Bunt at s.bunt@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Architecture Students
Architectural Engineering Students
4th or 5th year undergrads with internship experience
Graduate students
Exclusion Criteria:
First, Second, or Third year students
  Email this study information to me
  Contact the study team

Site for A study of enfortumab vedotin (ASG-22CE) as monotherapy or in combination with other anticancer therapies for the treatment of urothelial cancer

This study is to determine the recommended Phase 3 dose of venetoclax in combination with azacitidine in AML patients when given as maintenance therapy following allogeneic stem cell transplantation. It also is to determine if venetoclax can be effective in combination with azacitidine to improve RFS in AML patients compared to Best Supportive Care (BSC) when given as maintenance therapy following allogeneic stem cell transplantation.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03288545
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Patients must have histologically documented locally advanced or metastatic urothelial (previously known as transitional cell) cancer (i.e., cancer of the bladder, renal pelvis, ureter, or urethra).
Patients in dose-escalation cohorts, Cohort A, Optional Cohort B, Cohort G, and Cohort K must be eligible for CPI therapy.
Minimum age of 18 years
Patients must have measurable disease according to RECIST Version 1.1
An ECOG performance status of 0, 1, or 2
Exclusion Criteria:
Received any prior treatment with a CPI. A CPI is defined as a PD-1 inhibitor, PD-L1 inhibitor, or PD-L2 inhibitor (including, but not limited to, atezolizumab, pembrolizumab, nivolumab, durvalumab, or avelumab).
Ongoing sensory or motor neuropathy Grade 2 or higher.
Active central nervous system (CNS) metastases.
Ongoing clinically significant toxicity (Grade 2 or greater) associated with prior treatment (including radiotherapy or surgery).
Patients with conditions requiring high doses of steroids (>10 mg/day of prednisone or equivalent) or other immunosuppressive medications are excluded.
Cancer
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Site for RANDOMIZED PHASE II/III TRIAL OF SENTINEL LYMPH NODE BIOPSY VERSUS ELECTIVE NECK DISSECTION FOR EARLY-STAGE ORAL CAVITY CANCER (NRG-HN006) (PSCI# 20-085)

The purpose of this study is to see if neck and shoulder function and pain are better after SLN biopsy surgery compared to the usual approach and to see if SLN biopsy surgery is as good as the usual approach in extending your time without cancer. SLN biopsy surgery is potentially less invasive compared to the usual approach, but it requires a radioactive imaging agent to see the lymph nodes and it could also cause side effects. These side effects are described in the risks section below. Your study doctor will choose the appropriate imaging agent, Lymphoseek or sulfur colloid, for use in your surgery. This study will help the study doctors find out if this different approach is better than the usual approach at improving neck and shoulder function. To decide if it is better, in the first part of the study, doctors will be looking to see if shoulder and neck function and quality of life are better after SLN biopsy surgery compared to the END surgery.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04333537
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Pathologically (histologically or cytologically) proven diagnosis of squamous cell carcinoma of the oral cavity
Age ≥ 18
Zubrod Performance Status 0-2 within 42 days prior to registration
Only English speaking patients (able to read and understand English) are eligible to participate as the mandatory patient reported NDII tool is only available in this language
For women of child bearing potential, negative serum or urine pregnancy test within 42 days prior to registration
Exclusion Criteria:
Definitive clinical or radiologic evidence of regional (cervical) and/or distant metastatic disease
Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable
Patient with severe, active co-morbidity that would preclude an elective or completion neck dissection
Incomplete resection of oral cavity lesion with a positive margin; however, an excision biopsy is permitted
Actively receiving systemic cytotoxic chemotherapy, immunosuppressive, anti-monocyte or immunomodulatory therapy.
Cancer
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Site for Strong Foundations: Intervening to Promote Co-Parenting and Reduce Father Hazardous Drinking in Expectant Parents.

Our goal is to examine the efficacy of this modified intervention, mFF+, in reducing fathers’ drinking and couple conflict while promoting co-parenting quality, parental sensitivity, and child outcomes among families with heavy drinking fathers. There are two major aims: 1) to conduct a RCT of mFF+ with 220 couples (110 in each condition) with heavy drinking men and light drinking/abstaining women recruited in the first trimester of pregnancy. Parent reports and observational assessments of family functioning will be conducted at baseline (pretest), 6 months postpartum (posttest), and 12 months postpartum (follow-up); 2) to examine whether these impacts on drinking, co-parenting, adjustment, and couple dyadic functioning mediate the impact of mFF+ on parenting, and infant outcomes. We will also examine if there are child sex differences in intervention outcome, or sex specific mediational pathways.
Jenna Sassaman at jnk5173@psu.edu or 814-865-6902
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Pregnant/Expecting Couples
First time parents
18 years of age or above
English speaking
Both parents cohabiting
Exclusion Criteria:
Below 18 years of age
Not pregnant with first child
Parents not living together
Addiction & Substance Abuse, Prevention, Women's Health
  Email this study information to me
  Contact the study team

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Bimekizumab in Study Participants with Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa: Phase 3 Double-Blind Study. Participation will last approximately 71 weeks. Injection under the skin, Males/Females at least 18 years old with Hidradenitis Suppurativa (HS) Hidradenitis Suppurativa (HS), is an inflammatory skin condition that can come and go. It is characterized by painful spots, called lesions, that are found most commonly in the groin, armpits, and buttocks. These lesions are very painful and can drain and cause scarring. The purpose of this study is to find out if the study medicine, bimekizumab, can help with the treatment of HS.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04242446
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
HS lesions present in at least 2 locations (armpits, under breast, abdomen, groin, buttock),
Diagnosed with HS for at least 6 months
failed antibiotic treatment for HS
Exclusion Criteria:
certain medication are not allowed; study coordinator will provide more information
Diagnosis of sarcoidosis, Systemic lupus erythematosus, or active IBD
Have had a splenectomy
Positive test result for Hepatitis B or Hepatitis C
Have had major surgery in the past 3 months
Skin Conditions
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Hershey, PA

Brain Mechanisms of Overeating in Children

Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kara Hickok at kih5334@psu.edu or 814-865-5169
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03341247
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
The child must be age 7-8 when the first study visit is completed
The child must not have any food allergies to foods used in the study, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia.
The child must not be taking any medications known to influence cognitive function, taste, appetite or blood flow
The child's BMI must be below the 90th percentile at the first visit
The biological mother and father must have a BMI between 18.5-25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers and greater than or equal to 25 kg/m2 for fathers (high-risk group) and 1 parent must attend all visits.
Exclusion Criteria:
Children will be excluded if they are not within the age requirements (< than 7 years old or > than 8 years-old at the first visit).
Children will be excluded if they have any food allergies, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia
Children will be excluded if they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow
Children will be excluded if their BMI is above the 90th percentile at the first visit
Families will be excluded if the biological mother or father do not fit the BMI requirements
Food & Nutrition, Prevention, Neurology
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA

How urban infrastructure fosters romantic relationships

The primary endpoint of this study is to identify the contributing factors in development of romantic relationships through an analysis of the real-life experiences of Penn state couples that we collect in our surveys. Our focus is to identify the spatial factors in different scales as they relate to two-person relationships. The results of this study informs architects, planners, and administrators of practical strategies to generate friendly spaces in college towns.
sohrab rahimi at sur216@psu.edu or 814-206-4341
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Be in a romantic relationship
Live in State College area
Has visited at least 5 places with their romantic partner(s) in State College
Exclusion Criteria:
Have never lived in State College area
have never engaged in a romantic relationship
Education
  Email this study information to me
  Contact the study team

Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial

This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Brian Allen at ballen1@pennstatehealth.psu.edu or 717-531-4100
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
NCT03135119
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Child between the ages of 6 and 17
Child has a history of physical abuse, sexual abuse, or other type of maltreatment
Child displays posttraumatic stress symptoms
Primary caregiver willing to participate in treatment
Exclusion Criteria:
Child has a developmental or intellectual delay.
Uncontrolled allergy to or fear of dogs on part of either the child or caregiver.
CHild or caregiver has a history of aggression toward animals
Children's Health, Mental & Behavioral Health
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
Harrisburg, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT02822378
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
Food & Nutrition, Muscle & Bone, Women's Health
  Email this study information to me
  Contact the study team
  See more information
  Show all 1 locations

Study Locations

Hide all locations
Location
State College, PA