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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

410 Study Matches

Characterization of Agrin/LRP4 Antibody Positive Myasthenia Gravis

This study will evaluate new autoantibodies that might explain symptoms in patients with double negative myasthenia gravis (DNMG). If these newly identified autoantibodies are associated with different subtypes of MG, being able to test for them will allow clinicians to have a biomarker that will identify patients with these subsets of MG.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with myasthenia gravis AND negative for myasthenia gravis-related antibodies OR
Diagnosed with another neuromuscular disorder that is not myasthenia gravis OR
Not diagnosed with any neuromuscular disorder
At least 21 years old
Exclusion Criteria:
Received IVIG treatments within the last 6 weeks
Received plasma exchange withing the last 6 weeks
Received treatment with rituximab within the last 24 weeks
Neurology
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Location
Hershey, PA

Real-world Older Driving Study (ROADS)

ROADS will examine the relationships between driving, health, psychosocial and cognition in healthy older adults. This study will involve the placement of a video recording device in participants’ vehicles for 3 months. These devices will record driving habits and conditions such as speed and braking. Participants will also be asked to complete daily surveys on a study provided phone throughout the 3 month study. ROADS participants will be asked to visit the Penn State University for 3 in person visits to complete questionnaires, cognitive and health assessments, and to learn how to use the study provided phone. These visits may last up to 3 hours and on a rare occasion slightly longer.
Michelle Huerbin at mlh5955@psu.edu or 814-865-4773
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 70-95 years
Have a valid US driver's license
Drive on average 3 days a week
Willing to have camera installed in vehicle for 3 months
Exclusion Criteria:
Alzheimers or dementia
Any reason for driving restrictions
Neurology, Mental & Behavioral Health
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Study Locations

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Location
State College, PA

Parents’ Perceptions of the Coparenting Relationship: an interview study

This research study is being done to gather information from parents to figure out strategies and difficulties in their coparenting relationship for an intervention program which helps them to navigate the transition to parenthood process more comfortably and build up supportive relationships between parents.
Livia Guerra at llg5223@psu.edu or 814-206-4410
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Parent of child 6 years old or younger
Exclusion Criteria:
none
Prevention, Education
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Using Serious Game Technology to Improve Social Skills in Autism

The goal of this study is to help ASD adolescents improve social skills during face-to-face interactions. We have designed an immersive computer game to help them learn these skills in a fun way. Adolescents play the game at home 3 times a week for 3 months on a computer that we give you. In order to see how well the game is working to teach them, we have to test it against another game that is similar but teaches other skills. We measure your adolescent’s attention in the lab through computer games and by measuring their eye movements. We invite you to answer questions about their social behavior. We are flexible in how we work with families to accommodate busy schedules (e.g., weekend appointments). Families come to Penn State for three visits. We pay for all travel expenses (mileage, toll, hotel). Families are also compensated up to $450 for their time.
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-204-2272
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03690661
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Inclusion Criteria:
10-18 years old
autism spectrum disorder
corrected vision and hearing at normal levels
can speak in full sentences
stable internet connection in the home
Exclusion Criteria:
active seizure disorder in last 2 years
non-native English speaker
Children's Health, Mental & Behavioral Health
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Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA

Site for Therapy in Amyotrophic Lateral Sclerosis (TAME)

This is a phase IIB multi-centered, double blind, placebo controlled study to assess the safety and efficacy of a medication called memantine in people with ALS. This study is designed to validate the preliminary data that suggests memantine can slow down the course of ALS and also to determine if memantine can improve ALS patients who have characteristics of frontotemporal dementia.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02118727
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Inclusion Criteria:
Age 18-85
Diagnosed with amyotrophic lateral sclerosis (ALS)
ALS Functional Rating Scale (ALSFRS-R) score > 25
Has a caregiver willing to help with study activities
Exclusion Criteria:
Forced vital capacity (FVC) ≤ 60% predicted
ALS-related weakness for more than 3 years
History of liver disease
Kidney failure
Neurology
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Location
Hershey, PA

Watch and Human Observers (who!): Switched System Models of Physical Activity

This is a behavioral/engineering study that will examine whether the behavioral feedback derived from data generated by a wearable sensor has equivalent effects as the feedback derived from self-monitoring prompts. A change in the step counts as measured by the Fitbit Versa following prompt receipt is the primary endpoint.
Deborah Reese at dlb43@psu.edu or 814-865-7935
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Participants capable of reading, speaking and understanding English and of giving informed consent.
Participants between the ages of 18-29 years.
Participants must be free of visual impairment that would interfere with the use of a Fitbit Versa to receive behavioral prompts.
Participants must be willing to wear a Fitbit Versa almost continually (23.5 hours/day) for a 3 month period of time.
Exclusion Criteria:
Participants engaging in 150 or more minutes of moderate- or greater intensity physical activity each week.
Participation in an organized program with mandated physical activity (ROTC, sport)
Participants who require an assistive device for mobility or have any other condition that may limit or prevent participation in moderate-intensity physical activity
Participants with contraindications to normal physical activity on the Physical Activity Readiness Questionnaire.
Participants with a prior diagnosis of cancer, cardiovascular disease, diabetes or metabolic syndrome.
Mental & Behavioral Health
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Location
State College, PA

A qualitative exploration of rurality, physical activity, and intervention preferences among older residents in Pennsylvania

This study will use interviews to explore to explore perceptions of rurality, physical activity behaviors and physical activity intervention preferences among rural older adults who live in Pennsylvania
Nishat Bhuiyan at nxb49@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 50 years old
Currently residing in Pennsylvania
Able to speak, read, and write in English
Exclusion Criteria:
Below age 50
Not currently residing in Pennsylvania
Not able to speak, read, and write in English
Prevention, Mental & Behavioral Health
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The Effects of Aircraft Seat Width on Passenger Comfort

The objective of this research is to determine the relationship between aircraft seat width and passenger comfort. Airlines are reducing the sizes of seats and improving their ability to fly planes at or near capacity. The combined effect is to decrease the quality of the experience of passengers. This work will help us to understand the degree to which comfort has been reduced.
Ritwik Biswas at AirplaneResearch@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
We are particularly interested in small and large participants.
You must be a healthy adult aged 18 years or older.
Exclusion Criteria:
Individuals under 18 years of age are not eligible.
Muscle & Bone, Mental & Behavioral Health
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Study Locations

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Location
State College, PA

Functional and Mechanical Changes Following Total Ankle Arthroplasty

Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle. The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
No recent history (< 1 year) of injuries to Achilles tendon
No history of lower limb reconstruction or surgery
age 70 year or older
Exclusion Criteria:
History of any previous surgery to lower limb
History of rheumatoid arthritis or other degenerative joint disease
Non English speaking
Inability to provide consent
Men's Health, Muscle & Bone, Women's Health
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Location
State College, PA

The perception and experiences of newly diagnosed type 2 diabetes patients (T2D) on the impact of patient-provider communication on subsequent decision to engage in diabetes self-management education (DSME).

This study seeks to explore the perception and experiences of newly diagnosed type 2 diabetes patients about how their interaction with their provider at diagnosis led to their uptake of diabetes education.
Michelle Boakye at mdb521@psu.edu or 814-699-1783
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 18 or older
Any gender
Newly diagnosed type 2 diabetes patient within the past 12 months
Have attended at least one diabetes education after diagnosis
Able to provide consent in English
Exclusion Criteria:
Patients who are below 18 years
Patients who have a different type of diabetes either than type 2
Patients diagnosed with Type 2 diabetes more than 12 months
Newly diagnosed diabetes patients who have not attended diabetes self-management education
Diabetes & Hormones
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PhAse 1/2 StuDy of Modern ImmunotherApy in BCG-RelaPsing UroThelial Carcinoma of the BLADDER – (ADAPT-BLADDER) HCRN GU16-243 (PSCI 18-129)

This is a Phase II drug study which is designed to examine the effects of Durvalumab on individuals with bladder cancer that has not invaded muscle tissue. Study subjects will have already been treated with one or more surgical resections and Bacillus Calmette-Guerin or BCG, and the disease has now recurred.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03317158
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Inclusion Criteria:
Histologically confirmed non-muscle invasive urothelial carcinoma of the bladder (Ta, T1, or Tis stage) on transurethral resection of bladder tumor (TURBT) obtained within 60 days of registration.
ECOG (WHO) performance status 0 or 1
Age ≥ 18 years old at time of consent
White blood cell count (WBC) > 3.0 K/mm3
Absolute neutrophil count (ANC) ≥ 1.5 K/mm3
Exclusion Criteria:
Subjects with muscle-invasive (i.e. T2, T3, T4), locally advanced unresectable, or metastatic urothelial carcinoma as assessed on baseline radiographic imaging obtained within 60 days prior to study registration.
Subjects with another active second malignancy other than non-melanoma skin cancers and biochemical relapsed prostate cancer.
Subjects that have completed all necessary therapy and are considered to be at less than 30% risk of relapse are not considered to have an active second malignancy and are eligible for enrollment.
Subjects who have received the last administration of an anti-cancer therapy including chemotherapy, immunotherapy, and monoclonal antibodies ≤ 4 weeks prior to starting study drug, or who have not recovered from the side effects of such therapy.
Subjects who have had any prior radiation to the prostate or pelvis.
Cancer
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Location
Hershey, PA

Mechanisms of autonomic blood pressure control after acute exercise

This study may help to describe how blood pressure is controlled in healthy adults. Results from this study may be important for designing exercise programs for people who suffer from poor blood pressure control.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
At least 21 years old
healthy
normal blood pressure
can perform 20 continuous min of cycling
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
blood pressure over 150/100
taking medications that affect the heart
unable to perform 20 continuous min of cycling
Heart & Vascular
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Location
Hershey, PA

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate to Severe Ulcerative Colitis

This study is for patients with moderate to severely active ulcerative colitis to measure how effective and safe an experimental medication is in treating this condition.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03934216
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Inclusion Criteria:
moderate to severe ulcerative colitis
failed prior treatment
Exclusion Criteria:
women breast feeding or pregnant
no cancer in past 5 years
no Crohns disease
Digestive Systems & Liver Disease
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Location
Hershey, PA

Site for ATHN 10: Leveraging the ATHNdataset to Document the State of Rare Coagulation Disorders in the United States

This is a multi-center project in which the American Thrombosis &amp; Hemostasis Network (ATHN) will offer free genotyping to individuals with Rare Coagulation Disorders (RCD).
Lisa Baker at lbaker@pennstatehealth.psu.edu or 717-531-7468
All
All
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Subject must have an established Rare Coagulation Disorder diagnosis (
Must currently receive or have received care at and ATHN affiliated HTC
Subject must have opted into the ATHNdataset
Exclusion Criteria:
Subject is unwilling to sign informed consent form
Blood Disorders
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Location
Hershey, PA

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
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Study Locations

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Location
Hershey, PA

Brain Mechanisms of Overeating in Children

Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kara Hickok at kih5334@psu.edu or 814-865-5169
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03341247
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Inclusion Criteria:
The child must be age 7-8 when the first study visit is completed
The child must not have any food allergies to foods used in the study, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia.
The child must not be taking any medications known to influence cognitive function, taste, appetite or blood flow
The child's BMI must be below the 90th percentile at the first visit
The biological mother and father must have a BMI between 18.5-25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers and greater than or equal to 25 kg/m2 for fathers (high-risk group) and 1 parent must attend all visits.
Exclusion Criteria:
Children will be excluded if they are not within the age requirements (< than 7 years old or > than 8 years-old at the first visit).
Children will be excluded if they have any food allergies, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia
Children will be excluded if they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow
Children will be excluded if their BMI is above the 90th percentile at the first visit
Families will be excluded if the biological mother or father do not fit the BMI requirements
Food & Nutrition, Prevention, Neurology
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State College, PA

How urban infrastructure fosters romantic relationships

The primary endpoint of this study is to identify the contributing factors in development of romantic relationships through an analysis of the real-life experiences of Penn state couples that we collect in our surveys. Our focus is to identify the spatial factors in different scales as they relate to two-person relationships. The results of this study informs architects, planners, and administrators of practical strategies to generate friendly spaces in college towns.
sohrab rahimi at sur216@psu.edu or 814-206-4341
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Be in a romantic relationship
Live in State College area
Has visited at least 5 places with their romantic partner(s) in State College
Exclusion Criteria:
Have never lived in State College area
have never engaged in a romantic relationship
Education
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Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial

This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Brian Allen at ballen1@pennstatehealth.psu.edu or 717-531-4100
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
NCT03135119
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Inclusion Criteria:
Child between the ages of 6 and 17
Child has a history of physical abuse, sexual abuse, or other type of maltreatment
Child displays posttraumatic stress symptoms
Primary caregiver willing to participate in treatment
Exclusion Criteria:
Child has a developmental or intellectual delay.
Uncontrolled allergy to or fear of dogs on part of either the child or caregiver.
CHild or caregiver has a history of aggression toward animals
Children's Health, Mental & Behavioral Health
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Study Locations

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Location
Harrisburg, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT02822378
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Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
Food & Nutrition, Muscle & Bone, Women's Health
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Location
State College, PA

Identifying views of Military Veterans Regarding Contemporary War and Conflict Reporting

This study will involve surveying and interviewing US military veterans and non-veterans regarding their perceptions of the quality, accuracy, and themes of contemporary war and conflict reporting.
Hans Schmidt at hcs10@psu.edu or 610-892-1251
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
College Student
Military Veteran
Current Member of the Military
Non-Military Civilians
Exclusion Criteria:
Under age 18
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Study of Antimalarials in Incomplete Lupus Erythematosus (SMILE)

This is a study to test whether a widely-used drug, hydroxychloroquine, might slow the progression of lupus like features in individuals who are at high risk for developing systemic lupus erythematosus. This will be measured by the accumulation of clinical and laboratory features of lupus. The study will randomize subjects to the active drug, hydroxychloroquine, or placebo, with an equal chance of receiving either treatment. The study treatment lasts approximately 2 years with visits approximately every 3 months.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-4921
All
All
This study is NOT accepting healthy volunteers
NCT03030118
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Inclusion Criteria:
Positive for ANA (antinuclear antibodies)
Age 18 to 45 years, inclusive
Have never taken hydroxychloroquine
Exclusion Criteria:
Previous use of immunosuppressive drugs
Diagnosis of systemic lupus erythematosus
Arthritis & Rheumatic Diseases
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Study Locations

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Location
Hershey, PA

Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes

The goal of this study is to learn more about how people who smoke cigarettes respond to rewards, such as winning money, under different conditions. The study uses a method called functional magnetic resonance imaging, or fMRI, which is a research method for measuring activity in the brain. In this study, we are using fMRI to measure how brain activity changes in people who smoke when they receive rewards. The fMRI measures are collected during two separate visits. Participants are also asked to fill out questionnaires and complete computer tasks while in the lab. In total, participants are required to visit the research lab on the University Park campus a total of five times. In addition, the study involves measuring thoughts and behaviors in people who smoke in real life by asking them to fill out surveys on a smartphone. Participants are asked to carry a smartphone for a total of 10 days and answer several surveys throughout each day. In order to be eligible for the study, individuals must be between 18 and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 814-867-2333
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18-55 years of age
Right Handed
Smokes cigarettes
Exclusion Criteria:
under 18 years of age or over 55 years of age
Left Handed
non-smokers
Men's Health, Addiction & Substance Abuse, Women's Health
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Study Locations

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Location
Altoona, PA
State College, PA

An Examination of Student-Mentor Relationships

This is a self-report survey and questionnaire study that examines whether members of marginalized groups are more motivated than members of dominant groups to give referent power to high status others in attempts to belonging.
Maria Sanchez at mfs5350@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
All Genders
All races/ethincities
Participants between 18 and 25
Exclusion Criteria:
Participants YOUNGER than 18
Participants OLDER than 25
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The Child Health Study

We want to understand how a child's environment affects biology in ways that impact child health
Megann Koegler at childhealthstudy@psu.edu or 888-924-4535
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Children 8-13 years of age
Speak and understand English
Participation of a legal guardian
Exclusion Criteria:
Intellectual or learning disability
Children's Health, Food & Nutrition, Education
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Location
State College, PA

Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes

The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy throwing athletes (baseball, javelin, football)
Athletes with Ulnar Collateral Ligament Injury
Ulnar Collateral Ligament Surgery
Tommy John's Surgery
Exclusion Criteria:
Sensibility to Ultrasound Gels
Sports Medicine, Muscle & Bone
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Location
State College, PA

Development of Adolescent and Young Adult Social Health (DASH)

Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time (between $185-630) in the lab and for the neuroimaging session. If you are a parent and want to begin the screening process for you child, please go here https://pennstate.qualtrics.com/jfe/form/SV_51lN8sODiukYOON If you are an adult, and want to begin the screening process please go here: https://pennstate.qualtrics.com/jfe/form/SV_5cXMng6ybKe0WwJ
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-954-0112
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Native English speaker
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
Exclusion Criteria:
Family history of autism spectrum disorders (in parents or full siblings)
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces
Children's Health, Education, Mental & Behavioral Health
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Study Locations

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Location
State College, PA

Second language speech perception and production

In this a behavioral study that will examine how second language learners perceive and produce second language speech - often in comparison to native speakers - and how these skills develop. Participants might be asked to read word lists or sentences, describe pictures or answer questions, listen to speech samples and make judgments about them (e.g. was this a real word in English? which sound did you hear?), complete a proficiency test, and fill out some background information including a language background questionnaire.
Katharina Schuhmann at kxs811@psu.edu or 814-863-7867
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18-50 years old
No known hearing impairment
No known speaking impairment
Subjects will need to be bilingual (with varying proficiency in the second language
•beginner to advanced) or monolingual
Exclusion Criteria:
Known hearing impairment (past or present)
Known speech impairment (past or present)
Under 18 or over 50
Education, Language & Linguistics
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State College, PA

Evaluating the Cough Reflex in Fibrotic and Healthy Lungs

Determining cough threshold in patients with fibrotic lung disease and in healthy controls by stimulating cough.
Timothy Sheehan at tsheehan@pennstatehealth.psu.edu or 717-531-2925
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
40 years of age or older
Patient Group: Fibrotic lung disease with chronic cough symptoms or Idiopathic cough syndrome
Healthy Control Group: no cough (either chronic or acute)
Exclusion Criteria:
Recent history of smoking (former smokers must be tobacco-free for at least 1 year)
History of (other) lung diseases
History of uncontrolled gastroesophageal reflux disease (GERD)
Use of exclusionary medications (i.e. steroids, ACE inhibitors, narcotics, cough suppressants)
History of uncontrolled post nasal drip
Lung Disease & Asthma
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Location
Hershey, PA

The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging

Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sue Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and Women aged 18-30 and 60-80 years old
Healthy weight
Not taking high cholesterol/high blood pressure medication
Non-diabetic
Exclusion Criteria:
Tobacco use
Illegal/recreational drug use
Pregnant or breastfeeding
Allergy to latex
Heart & Vascular, Prevention, Sports Medicine
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Location
State College, PA

GLNE 010: Validation and Comparison of Biomarkers for the Early Detection of Colorectal Adenocarcinoma

The purpose of this study is to see if stool, urine or blood can be used to find colon cancer as early or earlier than colonoscopy can. The researchers want to use these samples to learn about specific proteins or genes (also called biomarkers) that may indicate if someone has colon polyps (pre-cancer), colon cancer, or an increased risk for developing colon cancer. The researchers are part of a National Cancer Institute program called the Early Detection Research Network (EDRN). We have some biomarkers that are very promising, so we are testing them (“validating them”) in this study.
Amanda Taylor Gehman at ataylor6@pennstatehealth.psu.edu or 717-531-1283
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT01511653
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Inclusion Criteria:
Scheduled for colonoscopy in the next 4 months
age 50 and older who are undergoing their first ever screening colonoscopy
adults age 70 and older with colonoscopy more than 9.5 years ago
willing to provide blood, urine and stool samples
able to tolerate removal of 5 tubes (3.5 tablespoons) of blood
Exclusion Criteria:
positive stool blood test (FIT/FOBT) in the past year
ever had colon or rectal cancer
history of inflammatory bowel disease
confirmed hereditary non-polyposis colorectal cancer, familial adenomatous polyposis, HIV or chronic viral hepatitis
cancer diagnosis or treatment in past year
Prevention, Digestive Systems & Liver Disease, Cancer
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Location
Hershey, PA