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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C mutation (MRT849-001)

This study is to determine the maximum tolerated dose (MTD) of MRTX849 using one or more dosing regimens. The regimens includ using MRTX849 or in combination with Afatinib, Cetuximab, or Pembrolizumab. The study will also look at how it can be tolerated MRTX849 when its taken with food.

If you take part in this research, your major responsibilities will include: •Keep your study appointments and complete all study assessments. If you cannot keep anappointment, please contact study personnel (your study doctor or study staff) as soon aspossible to schedule a new appointment.•Inform your study personnel about any symptoms, changes in medications, doctor's or nurse'sappointments, or hospital admissions that you may have had.•Agree to not participate in any other clinical research study•Inform study personnel if you believe you or your partner might be pregnant•Inform study personnel if you change your mind about participating in the study.•Inform your other doctors that you are taking part in this study.•Avoid grapefruit and grapefruit juice.•Avoid herbal medications and preparations including but not limited to St. John’s wort, Kava,turmeric/curcumin, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA),yohimbe (yohimbine), saw palmetto, and ginseng.•Avoid medications that are processed by liver enzymes, your doctor will counsel you on these.•Avoid medications known to have risk of changing the electrical activity in the heart, your doctorwill council you on these.•For your safety, you must tell the study doctor or nurse about all the prescription drugs, herbalproducts, over-the-counter drugs (OTC), vitamins and other supplements you are taking.Check with the study doctor before starting any new medicines (including prescription, OTCdrugs, vitamins and herbal supplements) or changing doses of medications that you arealready taking.

Yes
 

Patrick Ma
Irina Geier - at igeier@pennstatehealth.psu.edu or 717-531-8678
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03785249
STUDY00014803
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Inclusion Criteria:
Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation.
Unresectable or metastatic disease.
Presence of tumor lesions to be evaluated per RECIST 1.1:
Life expectancy of at least 3 months.
Eastern Cooperative Oncology Group (ECOG) performance status in 0 or 1.

Exclusion Criteria:
Active brain metastases.
Patients with carcinomatous meningitis
History of significant hemoptysis or hemorrhage within 4 weeks of the first dose date
Undergone major surgery within 4 weeks of first dose date
History of intestinal disease or major gastric surgery likely to alter absorption of study treatment or inability to swallow oral medications
Cancer
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Hershey, PA ,

Campus Environments and Student Health

The purpose of this study is to learn about the relationship between the campus environment and students’ health. It involves a survey consisting questions about campus-related activities, COVID-19, physical activity and health, environmental perceptions, and demographic information.

There will be an online survey that will take about 20-30 minutes. No need to meet in-person.

No
 

Amaryllis Park
Amaryllis Park - at ahp5234@psu.edu or 281-628-6496
Landscape Architecture (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00022472
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Inclusion Criteria:
Currently enrolled as a student (part-time or full-time)
At least 18 years old or older

Exclusion Criteria:
Younger than 18 years old
Mental & Behavioral Health
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Dysgeusia and Anosmia in Head and Neck Cancer Patients: Long Term Outcomes

The primary aim of this study is to understand taste changes after head and neck cancer treatment, especially long term taste disturbance, using various methods including online surveys, Teams interviews, at home taste and smell tests, and MRIs.

The purpose of this voluntary research study is to identify taste changes in patients treated for head and neck cancer. We are recruiting healthy participants over the age of 40 as well as head and neck cancer survivors who were treated 3 or more years ago. The overall study consists of multiple parts, which are explained along the way. You can choose to participate in this portion, which is an online survey, and nothing else, or all of the invited components. •The survey will take approximately 10 minutes of your time. •Completion of this survey is voluntary and you are not required to complete it if you do not wish to do so.•At the end of the survey you will be asked about your willingness to participate in other portions of this study. These include at-home taste and smell tests over Teams and a Teams interview about your taste and smell function. Participating in these tasks is optional and not required. If you complete the smell and taste tests at home you may be invited to have an MRI scan.

Max of $75: No compensation for the survey, $15 giftcard for 1-hour interview (optional), $15 giftcard for at-home taste/smell tests (optional), $50 giftcard for MRI at Hershey Med Center (optional).

No
 

Neerav Goyal
Hanel Eberly - at HNCtaste@pennstatehealth.psu.edu
Otolaryngology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019457
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Inclusion Criteria:
Able to give consent
Over the age of 40
English Speaking

Exclusion Criteria:
Under 40 years of age
have undergone a total glossectomy
currently have an upper respiratory infection, sinus infection, or ear infection
Cancer
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A 52-week, randomised, double-blind, double-dummy, parallel group, multi-centre, non-inferiority study assessing exacerbation rate, additional measures of asthma control and safety in adult and adolescent severe asthmatic participants with an eosinophilic phenotype treated with GSK3511294 compared with mepolizumab or benralizumab.

Non-inferiority study of GSK3511294 compared with mepolizumab or benralizumab in participants with severe asthma with an eosinophilic phenotype.

You will receive either study drug or placebo, undergo research-related tests and procedures, and questionnaires. You will need to visit the study center up to 18 times over a period of 15 months. You will have different tests and procedures throughout the study. The aim is to check on your health andsymptoms, check on your response to treatment and any side effects, and assess the study drug.This study will compare the study drug with either mepolizumab or benralizumab, known as the comparator medications. The effects of the drugs, both good and bad, will be compared. Study participants will be divided into 2 groups to receive:Study drug (once every 26 weeks) + placebo (once every 4 or 8 weeks) OR,Mepolizumab (once every 4 weeks) or benralizumab (once every 8 weeks) + placebo (once every 26 weeks).All participants will receive an active treatment. You will be assigned to receive either the study drug or comparator (mepolizumab or benralizumab) you were taking before the study. No participant previouslytaking mepolizumab will be assigned to benralizumab, and no participant previously taking benralizumab will be assigned to mepolizumab.

$183.00

Yes
 

Timothy Craig
Kristina Richwine - at krichwine@pennstatehealth.psu.edu or 717-531-4506
Medicine: Pulmonary, Allergy and Critical Care (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04718389
STUDY00017202
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Inclusion Criteria:
Adults 18 years or older at the time of signing the informed consent.
Have a documented diagnosis of asthma for 2 or more years.
Receiving either mepolizumab or benralizumab for 12 or more months prior to screening.
A well-documented requirement for regular treatment with medium to high dose inhaled corticosteroid in the 12 months prior to Visit 1 with or without maintenance oral corticosteroid.
Current treatment with at least one additional controller medication, besides an inhaled corticosteroids.

Exclusion Criteria:
Concurrent respiratory disease
Eosinophilic diseases
Pregnancy
Current or former smokers with a smoking history of 10 or more years.
Active COVID-19 infection
Lung Disease & Asthma
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Hershey, PA ,

Foot mechanics during gait with load carriage and toe elevation

This experimental study will investigate foot joint function during walking and running and/or hopping and performing heel raises. Participants will walk and run and/or complete heel raises with mass added to their body and will walk and run and/or hop with a plastic wedge secured to the underside of their toes.

Participants will walk and run and/or complete heel raises with mass added to their body and will walk and run and/or hop with a plastic wedge secured to the underside of their toes.

Yes
 

Ben Perrin
Ben Perrin - at bkp5431@psu.edu or 919-389-9898
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016164
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Inclusion Criteria:
Age 18-35
Run > 10 kilometers/week for past 6 months
If participant does not fit running criteria: Lifted weights of at least one bodyweight using barbell >= 2x/week for past 6 months

Exclusion Criteria:
Have had previous lower limb surgery
Experienced pain with walking, running, or (if applicable) weightlifting in past 6 months
Have had plantar fasciitis
Have osteoarthritis in lower limb
Have had diabetes 1 or 2
Sports Medicine, Muscle & Bone
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State College, PA ,

Comparing Mechanisms of Pattern Learning

The purpose of the proposed plan of research is to investigate the types of patterns that human adults with or without a history of language/ learning difficulties tap into as they learn.

Our study involves an initial testing session lasting between 1-2 hours, followed by up to two additional sessions for eligible participants. As part of our study, you will take part in some speaking, listening, learning, and visual processing tasks.

up to $75

No
 

Roger Beaty
jzp6211@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017229
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Inclusion Criteria:
Age 18-28
Only speaks English fluently
Normal or corrected-to-normal vision/ hearing
Minimum of high school education
May have a history of language/ learning difficulties

Exclusion Criteria:
History of neurological injury or disease
Speaks more than one language
Under age 18
Over age 28
Does not have minimum of high school education
Language & Linguistics
Not applicable
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A double-blind randomized placebo-controlled study on the analgesic properties of amiloride in exercise-induced skeletal muscle pain

To determine if the drug Amiloride will reduce exercise related muscle pain and improve exercise tolerance in healthy volunteers.

In each visit, you will be asked to perform foot exercise with, and without a blood pressure cuff inflated on your leg. You will also be asked to take pills prior to visit 2 and 3. One of these pills will be a drug called amiloride (10mg), which was traditionally used to lower blood pressure. The other pill will be a placebo (no active medication). During each visit, we will collect the following measurements:•We will collect a nerve recording from the leg not performing exercise, which will require a small needle-like electrode to be inserted behind your knee, just under the skin (a procedure called microneurography).•We will collect blood pressure from cuffs placed on your finger and upper arm.•We will collect blood lactate by sticking your finger with a small pin-prick (similar to taking a blood sugar measurement).•We will place to light-sensing device over the skin of your leg(s) to measure the oxygen level in your muscle.•We will hold a doppler ultrasound probe over your hip/leg region to measure blood flow.•We will use sticky-gel electrodes to measure heart rate and muscle activity.

You will receive $25 per hour for your participation in this research study

Yes
 

Jian Cui
Aimee Cauffman - at acauffman@pennstatehealth.psu.edu or 717-531-1617
Heart and Vascular Institute (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015300
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Inclusion Criteria:
healthy males and females
between 21-40 years old
any race or ethnicity

Exclusion Criteria:
Females who are pregnant or lactating
Smoker
high blood pressure
opiod use
taking amiloride or similar medication
Heart & Vascular
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Hershey, PA ,

Emotion Regulation and Mother-Infant Synchrony

The aim of this study is to better understand emotion regulation in infants by measuring brain, behavior, and mother-infant relational mechanisms. We plan to collect simultaneous brain activation in mothers and infants while they engage in a face-to-face interaction. We will then test associations between individual brain activation, mother-infant brain synchrony, and infant emotion regulation behaviors.

Participants complete questionnaires online, then come in for 1 in-person visit. Mother and baby complete a play and a neutral task while fNIRS is collected from them simultaneously.

40

Yes
 

Berenice Anaya
Berenice Anaya - at bua25@psu.edu
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00018109
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Inclusion Criteria:
Infants who are 4 months and their mother.
Infants born 3 weeks within their due date.
Infants of a birth weight > 2500 g.
Infants with NO serious medical complications.
English-speaking families.

Exclusion Criteria:
Infants who were < 2500 g at birth.
Infants who experienced any serious medical complications.
Infants who were born > 3 weeks before the indicated gestational period.
Families who do not understand and do not speak English
Children's Health, Neurology
Not applicable
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State College, PA ,

SNAC Study

This is a multi center clinical trial to test the efficacy of N-acetylcysteine for treatment of patients with active systemic lupus Erythematosus. Healthy control subjects who do not receive treatment are also recruited to serve as controls for the laboratory assays.

This is a clinical trial to be carried out in patients who have systemic lupus erythematosus. Participants will be asked to attend seven study visits over a period of 13 months. After an initial period where it will be determined that the patient can tolerate the medication, N-acetyl cysteine, then there will be a three-month double blind phase where the participant receives either the active treatment or a placebo. At each visit the participant will be asked to complete several questionnaires and blood and urine samples will be obtained. Healthy control individuals will be also enrolled for blood samples only; not for any treatment intervention.

$20 per visit completed

Yes
 

Nancy Olsen
Jamie Carter - at jcarter3@pennstatehealth.psu.edu or 717-531-4921
Medicine: Rheumatology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00775476
SITE00001115
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Inclusion Criteria:
Diagnosis of Systemic Lupus Erythematosus
Age 18 years or older
On stable medications
Experiencing flare of disease

Exclusion Criteria:
pregnant or lactating
regular daily use of Tylenol (acetaminophen)
active chronic infections
current treatment with cyclophosphamide or rituximab
current use of anti-oxidants
Arthritis & Rheumatic Diseases
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

AIDP

The purpose of this study is to test the performance of a web-based system for automated review of MRI images across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Participants will attend two study visits that will include questionnaires, a physical exam and motor exams and an MRI (during one of the visits).

300

Yes
 

Sol De Jesus
Autumn Collier - at acollier3@pennstatehealth.psu.edu or 717-531-5233
Neurology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
SITE00001044
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Inclusion Criteria:
40-80 years old at baseline
Diagnosed with a Parkinsonism (PD, MSA or PSP)

Exclusion Criteria:
Unable to undergo an MRI
Neurology
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Hershey, PA ,

A Survey of the Sex Differences in Taking Selfies while Driving

This study aims to understand peoples’ selfie-taking behavior and how, if at all, they relate to their driving behavior and gender difference. The participants will participate the study by completing an online survey.

No
 

Yiqi Zhang
Josh Avalos - at jqa5409@psu.edu or 610-716-7976
Industrial and Manufacturing Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016045
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Inclusion Criteria:
Subjects who are 18 years of age or older
Subjects have a valid U.S. driver license or are allowed to drive in the US

Exclusion Criteria:
Subjects who under 18 years of age
Subjects who do not have a valid U.S. driver license or are not allowed to drive in the US
Education, Language & Linguistics
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Olfactory tools for COVID-19 screening and surveillance

This a collaborative multisite NIH funded project to develop smell tests as a rapid low cost way to screen for Covid19 infections. The lead institution is the University of Florida, and this project is being entered into CATS to create a Reliance Agreement under the NIH single IRB rules (sIRB).

No
 

John Hayes
Elisabeth Weir - at efw5195@psu.edu
Food Science (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
SITE00000951
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Inclusion Criteria:
Aged 18 to 99
COVID19 negative
COVID19 positive
Able to Consent in English

Exclusion Criteria:
Inability to provide consent
History of known pre-existing olfactory or taste disorder
History of head trauma with loss of consciousness
History of neurodegenerative disease
COVID-19
I'm interested
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A Phase 1b/2 Single and Multiple Dose Study to Assess the Safety, Tolerability, Clinical Activity, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of STAR-0215 in Participants with Hereditary Angioedema (The ALPHA-STAR Trial)

The main purpose of the study is to evaluate the safety and tolerability of an injection of the study drug in participants with Hereditary Angioedema. This study is open-label, which means that everyone in the study will receive the study drug and no participant will receive a placebo.

The study will last approximately for one year, with a total of approximately 11-16 study site visits. You will have your blood drawn at every study site visit, urine collected, pregnancy test if applicable, and receive study drug. You will also complete questionnaires and be contact weekly by the study site.

Yes
 

Timothy Craig
Kristina Richwine - at krichwine@pennstatehealth.psu.edu or 717-531-4506
Medicine: Pulmonary, Allergy and Critical Care (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05695248
STUDY00022131
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Inclusion Criteria:
At least 18 years of age.
Documented diagnosis of HAE type I or II.
Experienced at least 4 HAE attacks within the 12 months prior to screening.
Negative pregnancy test at screening visit
Experience at least 2 HAE attacks during the Run-In period.

Exclusion Criteria:
Any use of androgens
Active liver disease
History of drug or alcohol abuse in the 12 months prior to screening
Pregnant or breastfeeding
Use of medications prescribed for the prevention of HAE attacks prior to screening: lanadelumab within 90 days, berotralstat within 21 days, all other prophylactice therapies within 7 days.
Infectious Diseases & Immune System
Not applicable
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Hershey, PA ,

Predicting Concussion Outcomes with Salivary miRNA

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows:1)Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years.2)Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.

Saliva collection and surveys at baseline, 7 days, and 30 Days

$20

Yes
 

Jayson Loeffert
Brennen Harding - at bharding@pennstatehealth.psu.edu or 717-531-5656
Family and Community Medicine (HERSHEY)
 

All
All
This study is also accepting healthy volunteers
NCT02901821
STUDY00003729
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Inclusion Criteria:
5 to 23 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion

Exclusion Criteria:
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI
Children's Health, Neurology, Sports Medicine
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Hershey, PA ,

Creative Thinking and Problem Solving

This is a behavioral study that will examine cognitive processes relevant for creative thinking. Participants will be asked to complete a series of cognitive tasks and self-report measures on a computer.

Yes
 

Roger Beaty
James Lloyd-Cox - at jll487@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00010475
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Inclusion Criteria:
18 years or older
They must consent to participate in research
Healthy volunteers

Native English Speakers

Exclusion Criteria:
Cannot be non-native English speakers
I'm interested
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State College, PA ,

Observations of Family Mealtime Routines

The purpose of this study is to gather information about what family mealtimes look like for families with children between the ages of 3 and 8. Families will be asked to video record their family mealtime, in addition to answer some questions and to complete some questionnaires, some about body image and dieting.

On one occasion, your family's mealtime will be recorded via Zoom. You and your family will be asked some questions and to complete some questionnaires online.

$20

No
 

Hannah Mudrick
Hannah Mudrick - at hxm99@psu.edu or 717-948-6404
Behavioral Sciences and Education (HARRISBURG)
 

All
All
This study is also accepting healthy volunteers
STUDY00015339
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Inclusion Criteria:
At least one adult who is the caregiver of at least one child between age 3 and 8 (e.g., at least one parent-child dyad)
Adults age 18 and older
Children, ages 3-8
Individuals fluent in English

Exclusion Criteria:
Non-family members, as defined individually by each family
Caregivers who are under the age of 18
Individuals who are not fluent in English
Families without at least one child age 3 to 8
Children's Health, Food & Nutrition
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Human-robot interaction study

We are interested in developing robots that can interact with humans. We hope that to develop robots that can interact with people and be used in a variety of different situations such as schools, offices, and homes. This study investigates human-robot interaction.

Yes
 

Alan Wagner
Alan Wagner - at alan.r.wagner@psu.edu or 814-865-3136
Aerospace Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00010270
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Inclusion Criteria:
Ability to read and see

Exclusion Criteria:
Under 18
Education
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State College, PA ,

Behavior, Voice, and Sex Hormones Study

Hormones are molecules that deliver signals throughout the body. They influence behavior, sleep, hunger, stress, and virtually all other aspects of life. This study seeks to better understand several of these functions, specifically how hormones affect specific aspects of human behavior and psychology, as well as speech production. Following an initial lab visit, subjects will participate in the remainder of the study (~5 weeks) at home via the internet. On a daily basis, they will collect urine samples for hormone analysis, saliva samples for analysis of oral micro-organisms, and will submit voice samples for analysis of speech (e.g. measuring voice pitch and loudness). They will then complete an online survey designed to collect information about their behavior, and attitudes over the previous 24 hours. Subjects receive compensation for their participation.

- Compensation $330 at maximum- Pre-sampling lab visit to sign a consent form and receive training- A series of ~42 daily at-home sample (urine, saliva) collection &amp; online surveys- Weekly lab visits for sample drop-off

$330

Yes
 

David Puts
Sojung Baek - at research1871@psu.edu or 814-321-5541
Anthropology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013693
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Inclusion Criteria:
Between 18 and 30 years of age
Normal menstrual cycles
Available for daily at-home session for approximately 5 weeks
Female/Identifying as a woman
Predominantly or exclusively heterosexual sexual orientation

Exclusion Criteria:
On hormonal birth control
Uncorrected severe defects of hearing, speech, or vision
Bisexual or predominantly homosexual sexual orientation
Very heavy smoking or alchohol consumption
Medications that affect levels of ovarian hormones (e.g. anti-depressants, anti-psychotics)
Language & Linguistics, Diabetes & Hormones, Women's Health
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State College, PA ,

PSCI-22-063: NRG-GU011 NRG Promethean

This trial is comparing radiation therapy with or without hormone therapy in men with prostate cancer.

Patients must come in for all radiation treatments. Patients must take their androgen therapy as prescribed.

Yes
 

Joseph Miccio
psci-cto@pennstatehealth.psu.edu 717-531-5471
Radiation Oncology (HERSHEY)
 

Male
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05053152
SITE00001224
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Inclusion Criteria:
Pathologically (histologically or cytologically) proven diagnosis of prostate adenocarcinoma at any anatomical location (for example, prostate, metastatic site), including intraductal or ductal carcinoma, at any time before registration.
Age ≥ 18 years.
ECOG Performance Status 0-2 within 120 days prior to registration.
External beam and/or brachytherapy to: Prostate alone, prostate and seminal vesicles, prostate and pelvic nodes, or radiation to all three sites.
Radical prostatectomy alone, radical prostatectomy plus postoperative radiotherapy to the prostate bed, or radical prostatectomy plus postoperative radiotherapy to the pelvic nodes.

Exclusion Criteria:
Evidence of local tumor recurrence in the prostate and/or periprostatic/seminal vesicle region after radiotherapy, or in the prostate bed after prostatectomy.
Currently on androgen deprivation or anti-androgen therapy.
Osseous metastasis on 99mTc radionuclide bone scan
Extra pelvic nodal/soft tissue disease (> 1.5cm in short axis) on CT or MRI pelvis +/- abdomen
Spinal cord compression, or spinal intramedullary, brain, and/or visceral (for example liver, lung, etc.) metastasis
Cancer
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

Understanding Prenatal Hydration Behaviors

To examine women’s self-reported pregnancy hydration behaviors, especially during a global pandemic. This study will also examine other lifestyle behaviors (e.g., weight gain, exercise, eating behaviors, sleep, pain management). It is hypothesized that hydration behaviors will decrease due to lifestyle changes related to the pandemic. Secondary outcomes will also be influenced by hydration behaviors and pandemic lifestyle changes.

No
 

Danielle Downs
Abigail Pauley - at amp34@psu.edu
Kinesiology (UNIVERSITY PARK)
 

Female
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00016174
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Inclusion Criteria:
Pregnant
Women
18-45
English speaking

Exclusion Criteria:
Non-pregnant
Men
Younger than 18
Non-English speaking
Food & Nutrition, Mental & Behavioral Health, Women's Health
I'm interested
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AYA-CONNECT: A qualitative study to inform creation of a social network-based peer intervention for adolescent/young adult cancer survivors

In this study, in Aim 1 we will conduct focus groups of adolescent/young adult cancer survivors (AYACS) (at least 15 total AYACS) 15-25 years old to understand their perspectives on the importance of peer connection and social connectedness during and after cancer treatment, the role of an intervention to foster peer connections, and suggestions/feedback on designing AYA-CONNECT (an AYACS-peer network intervention) including delivery format, structure, and content to promote life goals and health-related behaviors. In Aim 2 we will further explore ways to design AYA-CONNECT through interviews of pairs of AYACS and a nominated peer.

You will participate in one focus group and/or interview that will last about 1 hour.

$40

No
 

Pooja Rao
Pooja Rao - at prao2@pennstatehealth.psu.edu
Pediatrics: Hematology/Oncology (HERSHEY)
 

All
All
This study is NOT accepting healthy volunteers
STUDY00024174
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Inclusion Criteria:
Participant age 15-25 years old at time of cancer diagnosis and within 5 years of initial cancer diagnosis
Participant is receiving or has received any oncologic care at Penn State Health Children’s Hospital or Penn State Cancer Institute
Participant fluency in written and spoken English for participants > 18 years old

Parent and participant fluency in written and spoken English for participants < 18 years old
Access to computer or smartphone

Exclusion Criteria:
Non-English speaking
Participants with cognitive or physical inability to participate in study
Cancer
Not applicable
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Assessing the impact of post-inflammatory hyperpigmentation on quality of life in people of color

This survey study is looking to see how post-inflammatory hyperpigmentation (PIH) affects quality of life in people with skin of color.

Participants will complete a one-time survey that will ask about post-inflammatory hyperpigmentation.

No
 

Lauren Hollins
Tierney Wallace - at twallace3@pennstatehealth.psu.edu or 717-531-6117
Dermatology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00021979
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Inclusion Criteria:
Ages 18-89
Experienced/experiencing post-inflammatory hyperpigmentation

Exclusion Criteria:
Individuals with acanthosis nigricans
Individuals who are not able to understand English
Skin Conditions
Survey(s)
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Imaging and Depression with or without MS

A study looking at the neural and genetic correlates of depression. Presently, the current study is looking to recruit individuals for two separate groups: 1. MS but NO history of depression2. Depression but NO history of MS or neurological disease. The purpose of the study is to look at patterns of brain structure and function in individuals with depression and compare them to those with MS. We will explore how any differences we find contribute to more problems with depression in MS and see how such differences might lead to better treatment options for depression.

Yes
 

Peter Arnett
Cristina Roman - at car342@psu.edu or 814-865-5578
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00006711
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Inclusion Criteria:
Between the ages of 30-65
Able and willing to undergo an MRI
Able to travel to State College for the Study

Exclusion Criteria:
Current psychotherapy treatment for depression
Started anti-depressant medication in the last 2 months
Diagnosis of bipolar disorder, schizophrenia, or significant neurocognitive impairment
Very severe depression that would interfere with the ability to participate or suicidal ideations
Unable to undergo an MRI (metal in your body)
Mental & Behavioral Health
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State College, PA ,

Understanding the effect of drivers’ profile information on riders’ feedback in ride-sharing context

This study aims to understand ways to affect how riders perceive and provide feedback to drivers through technology intervention. Particularly, we investigate how presenting drivers’ personal profile under different trip conditions may lead to differences in the ways riders may provide feedback. We hypothesize that riders will provide positive feedback when provided drivers’ personal information when the trip goes well, and that riders will provide less negative feedback when provided drivers’ personal information when the trip goes bad due to uncontrollable reasons.

Yes
 

Benjamin Hanrahan
Ning Ma - at nzm37@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00013808
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Inclusion Criteria:
Taken at least 10 Uber/Lyft ride in the last 12 months.
You are willing to share several of your past Uber/Lyft trip records in the app with us.

Exclusion Criteria:
You are a current or past employee with one of the ride-sharing corporations (Uber/Lyft)
Education
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State College, PA ,

Collecting Data for Human Confusion When Following Simulated Robot’s Instructions

We seek to try to try to create robots that recognize when people are confused. To do that, we need to collect data related to confusion. We are thus going to present confusing stimuli to people and record their facial expression.

No
 

Alan Wagner
Caroline Anderson - at cga5102@psu.edu
Aerospace Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00019469
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Inclusion Criteria:
Adult over 18
US resident

Exclusion Criteria:
Under 18 years of age
Non-US resident
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Skin pathophysiology of Hidradenitis Suppurativa

The purpose of this research study is to collect skin samples from volunteers with HS and volunteers with healthy skin. The collected skin samples will be processed and compared to each other to see if there are specific differences in the skin between the HS volunteer group and the healthy skin volunteer group.

Participants will need to come to a one-time, in-person visit where biopsies (small skin samples) will be collected.- For participants with HS: Up to 4 biopsies will be collected - For participants with healthy skin: Up to 2 biopsies will be collected

Yes
 

Amanda Nelson
Samantha Gettle - at sgettle2@pennstatehealth.psu.edu or 717-531-5136
Dermatology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020589
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Inclusion Criteria:
Diagnosis of hidradenitis suppurativa (HS)
HS lesions present in the armpits and/or groin

Exclusion Criteria:
Participants who are pregnant or are planning to become pregnant
Certain medications are not allowed in this study- the study team will provide details
Skin Conditions
Not applicable
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Hershey, PA ,

Evaluation of the reliability and convergent validity of the Pain Competency Evaluation in Dementia (PACED) Rating Scale

This study establishes the reliability and convergent validity of the PACED rating scale. 15 undergraduate nursing students and registered nurses will be recruited to complete 2 clinical scenarios related to nursing home residents with dementia experiencing pain and symptoms of distress. Participants will use their clinical judgment to conduct assessments and provide interventions and treatments.

Participants (nurses and nursing students) will be asked to complete a demographic survey, a pain management knowledge survey (POAKS), and complete 2 clinical scenarios followed by pain management notes related to persons with dementia experiencing symptoms of distress. It may take about an hour to complete the study procedure mentioned above. You can choose to complete the 2 clinical scenarios in one setting or at different times.

$25 gift card for Registered Nurses (RN) and nursing students.

No
 

Yo-Jen Liao
Yo-Jen Liao - at yzl541@psu.edu or 814-826-8603
Nursing (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00022937
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Inclusion Criteria:
English Speaking
18-years old or older
Undergraduate nursing students or Registered Nurses (RN)

Exclusion Criteria:
None
Pain Management
Not applicable
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Metabolic Alterations of the Semitendinosus Muscle After Tendon Harvest for Anterior Cruciate Ligament Reconstruction

This is a cohort study examining the changes in the muscle that occur following ACL injury and reconstruction. This study aims to determine if significant changes to the muscles properties occur as a result of the graft taken for ACL reconstruction, and whether or not these changes serve as a risk factor for further injuries. This study will examine the muscles ability to use oxygen non-invasively, an important determinant of muscle endurance and allow for comparisons of this between individuals with ACL-reconstruction surgery and healthy, non-injured adults.

Participants will have their leg muscle strength and endurance measured using common clinical techniques used in physical medicine and rehabilitation sciences. They will also have their mitochondrial capacity assessed through the skin using a non-invasive procedure.

$60.00

Yes
 

Giampietro Vairo
Jigar Gosalia - at jzg691@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00010623
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Inclusion Criteria:
ACL tear within last 12-36 months
Full rehabilitation
autograft taken from hamstring tendon
other autografts may be considered
Recreationally active

Exclusion Criteria:
Other major knee injury (i.e. MCL tear)
Muscle & Bone
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State College, PA ,

ABTECT-2 Induction-A randomized, double-blind, placebo-controlled, multicenter phase III study to evaluate the efficacy and safety of ABX464 once daily for induction treatment in subjects with moderately to severely active ulcerative colitis

This is a multicenter, randomized, placebo-controlled Induction study to evaluate the efficacy and safety of oral ABX464 given daily in inducing clinical remission in subjects with moderately to severely active ulcerative colitis (UC) who have inadequate response, no response, a loss of response, or an intolerance to either conventional or advanced therapies.The screening period is 28 days long, and a 28-day follow-up follows 8 weeks of induction treatment. Approximately 612 subjects (only adults at our site) will be randomized in this study. On Day 1, subjects will be randomized to one of the three arms. On Day 56, subjects can either continue participation in the maintenance study (ABX464-107) or end the study by entering four-week safety follow-up. Colonoscopy procedures will include biopsies of the most severely affected areas. The subjects will complete daily electronic Diaries. Blood samples will be collected at some visits. A cardiac safety sub-study is optional for eligible subjects.

Participants will be asked to sign the informed consent. There are at least five in-person visits, approximately every four weeks. There are two colonoscopy procedures with biopsies: first during the screening period and second evaluation at week 56 at the end of the study. Physical examination and vital signs will be taken at every visit. Stool sample for pathogens will be collected at screening. Blood tests will be taken to test for infectious diseases and other tests. There is an optional cardiac safety study. Pregnancy testing is required for eligible female subjects at every visit. Subjects will complete e-Diary questionnaires. There will be two eye exam visits. Participation in the study is voluntary.

Subjects will receive a flat amount per completed visit, up to maximum of $425.

Yes
 

Kofi Clarke
Zvjezdana (Stella) Chroneos - at zchroneos1@pennstatehealth.psu.edu or 717-531-8259
Medicine: Gastroenterology and Hepatology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05507216
STUDY00023472
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Inclusion Criteria:
Age ≥ 18 years and weight ≥ 40 kg
must understand, sign and date the written voluntary informed consent.
Documented diagnosis of UC confirmed by endoscopy and histology
Inadequate response to immunosuppressants or treatment with biologics
Male partners and women WOCBP must agree to use highly effective contraception methods.

Exclusion Criteria:
Subjects with ulcerative colitis limited to an isolated proctitis.
Subjects with CD or subjects with heart disease, or history of malignancy
History or current evidence of toxic megacolon, fulminant colitis, bowel perforation.
Recent or planned bowel surgery.
Subjects on antidiarrheals and probiotics.
Digestive Systems & Liver Disease
Experimental drug compared to a placebo/”sugar pill”
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Hershey, PA ,

The Ketogenic Diet, Blood Lipids, and Heart Health in Healthy Adults with Differing BMI

The purpose of this feeding study is to examine if there is a difference in the effect of feeding a very low carbohydrate diet to people with normal weight and people with obesity. Participants will be asked to eat a very low carbohydrate diet, also known as a ketogenic diet, for 28 days. This diet will be provided to participants and includes 3 meals, some snacks, and beverages daily. Measurements of blood markers (fats, sugar, insulin, cholesterol), blood pressure, heart health, and body composition will be done at the start and end of the study.

In this study, you will be asked to consume a ketogenic diet for 28 days. This diet will be provided to you and includes 3 meals, some snacks, and beverages daily. This diet will meet your energy and nutrient needs. You will be asked to not eat any foods outside of what is provided by the study and consume no alcohol. Testing will be conducted on two consecutive days at the start of the study and the end of the study (a total of 4 testing days). For these visits, you will need to fast for 12 hours prior and avoid alcohol for 48 hours prior. At these visits, we will take a blood draw, measure your body weight, body composition, and preform non-invasive tests to assess your heart health.

$150

Yes
 

Kristina Petersen
Zachary DiMattia - at dchlab@psu.edu or 866-778-3438
Nutritional Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00000000
STUDY00024970
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Inclusion Criteria:
Age: 25 to 45 years
BMI: 18.5-22 or 30-35 kg/m^2
LDL cholesterol: <100 mg/dL
Blood glucose: <126 mg/dL
Triglycerides: <350 mg/dL

Exclusion Criteria:
Diagnosis of heart disease, stroke, kidney or liver disease
Current use of tobacco-containing products or (≤6 months) cessation
Pregnant or nursing individuals
Allergy or unwilling to eat study foods
Previously consumed a ketogenic diet for > 1 week
Food & Nutrition, Heart & Vascular, Prevention
Not applicable
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State College, PA ,