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442 Study Matches

Beneficial effects of moderate heating on cardiovascular control in heart failure

The purpose of this project, is to examine if moderate whole body heating will effect the resting muscle sympathetic nerve activity (MSNA) and the MSNA response to the stimulation of muscle mechanoreceptors in chronic heart failure patients.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
non-smoker
Heart failure patients
•may be on medications
Healthy subjects
•no blood pressure or cholesterol meds
Exclusion Criteria:
pregnant or nursing women
uncontrolled blood pressure
recent heart attack in past 6 months
on kidney dialysis
Heart & Vascular
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Hershey, PA

Perception of English sentences in context

This study tracks the eye movements of 30 adults to gather information on how they process sentences when presented in a context.
Frances Blanchette at fkb1@psu.edu or 814-863-7392
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
adult (18+)
native speaker of American English
grew up mainly in the US
Exclusion Criteria:
under 18 years of age
not a native speaker of American English
did not grow up mainly in the US
Language & Linguistics
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State College, PA

Dining with Diabetes in Pennsylvania

Penn State Extension's Dining with Diabetes program is an evidence-based community education program for people with or at risk for type 2 diabetes. The program teaches participants how to prevent or manage their disease by providing practical knowledge and strategies to make the necessary lifestyle changes that will lead to healthier living and reduction in the risk of complications. The overall goals and objectives of the program are as follows: Increasing knowledge of healthy food choices for families with or at risk for diabetes Promoting behavior changes by offering demonstrations and tasting of healthy food. Increasing knowledge of essential medical tests associated with diabetes management. Promoting physical activity as a component of diabetes control. Encouraging self-management and self-efficacy skill. Connecting participants to their healthcare providers for long-term follow-up. The program is designed to meet 4 consecutive weeks and then a 3 month follow-up. Classes consist of a nutrition lesson, physical activity, cooking demonstration and food tasting.
Mandel Smith at mjs52@psu.edu or 610-489-4315
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04080960
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Inclusion Criteria:
Individulas with type 2 diabetes
individuals with pre-diabetes
individuals at risk of developing type 2 diabetes
healthy family members/caretakers
healthy volunteers
Exclusion Criteria:
under the age of 18
Diabetes & Hormones
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Altoona, PA
DuBois, PA
Erie, PA
Greater Pittsburgh Area, PA
Hazleton, PA
Reading, PA
State College, PA
Wilkes-Barre/Scranton Area, PA

The peripheral vascular effects of sulfhydryl-containing antihypertensive pharmacotherapy on microvascular function and vessel remodeling in hypertensive humans

High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have poor results with medical treatment for hypertension. We examine the impact of different classes of drugs that doctors use to treat high blood pressure (hypertension) on blood vessel remodeling. Some drugs that doctors prescribe for their patients contain a “sulfhydryl group” (a sulfur atom bonded to a hydrogen atom). Drugs that have the sulfhydryl group may reduce blood vessel remodeling more that drugs that do not. For this study, participants who have high blood pressure perform the experiments, take a drug for 16-weeks to lower blood pressure, and repeat the experiments. We randomly assign one of three drugs to participants who have high blood pressure: a diuretic (“water pill”), a drug containing a sulfhydryl group, or a drug that does not contain a sulfhydryl group. Participants who do not have high blood pressure perform the experiments, but do not take any of the drugs. In some of our experiments, we use a technique called “microdialysis” (MD). With MD, we perfuse some research drugs into the skin on the forearm through tiny tubing that mimics capillaries. These MD drugs mimic or block substances the body naturally makes to control the small blood vessels in the skin. The drugs remain in nickel-sized areas around the tubing and do not go into the rest of the body. We also analyze very small skin samples (skin biopsy) obtained from the forearm. Lastly, we use a standard technique called “flow mediated dilation” (FMD) that uses blood pressure cuffs and ultrasound to look at the health of larger blood vessels in the body. FMD includes placing a small tablet of nitroglycerin under the tongue during part of the test.
Susan Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03179163
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Inclusion Criteria:
Women and men
40-65 years
May or may not have high blood pressure
Women who are post-menopausal are not taking hormone replacement therapy
· May or may not be taking a drug to lower blood pressure
Exclusion Criteria:
Current medications which could conceivably alter the cardiovascular or thermoregulatory control or responses (e.g. beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers)
Allergy to latex
Use of tobacco products
Use of illegal/recreational drugs
Pregnancy or breastfeeding
Heart & Vascular
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State College, PA

Regional Brain Manganese Accumulation and Functional Consequences in Welders

Inhalation of welding fumes has been known to cause tremor, muscle rigidity and abnormal gait similar to what is seen in Parkinson's disease. Previous studies by the Translational Brain Research Center have used measures such as brain MRIs and tests for movement and function to investigate the effect of these welding fumes on brain health in active welders. The center is currently expanding its efforts to investigate brain health in retired welders. This is an independent study sponsored by the National Institute of Environmental Health Sciences, with no affiliation to any private entities such as law firms. In this study participants will be asked to undergo clinical tests (blood draw, motor examination, memory tests), complete lifestyle questionnaires, and undergo an MRI scan during a baseline and 18 month follow-up visit. Participants also will be mailed a welding exposure questionnaire to complete every three months between their baseline and follow-up visit.
Savannah Olimpo at TBRC@pennstatehealth.psu.edu or 717-531-5233
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Active or retired welder (e.g., boilermaker, pipefitter, etc.)
No obvious signs of parkinsonism (e.g., tremor, impaired speech)
Fluent in written and spoken English
No metal eye fragments
Able to tolerate a brain MRI
Exclusion Criteria:
Severe memory impairment or signs of dementia
Claustrophobia or unwillingness to undergo an MRI
Significant medical and neurological deficits (e.g., brain tumor, seizures, stroke, etc.)
Significant recreational drug use or alcohol abuse
History of chronic paint and solvent exposure
Neurology
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Hershey, PA

Understanding Practices on Social Network Sites and Social Relationships

Social network site (SNS) use has been very integrated into our daily practices. The distinctions between offline and online social relationship management become blurred with the mediation of SNSs. We are interested in how people perceive and use SNS and engage in social relationship management, such as self-disclosure or privacy management. Users may appropriate technological features to meet their own needs and such practices may be different from how others use the sites. The discrepancy of usage may in turn influence social relationship maintenance.
Tina Yuan at tuy11@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Social network site user (Facebook, Instagram, WeChat, etc.)
18 years and older
Exclusion Criteria:
Non-social network site users
Below 18 years old
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State College, PA

Early Childhood practitioner’s knowledge and attitudes regarding reporting child abuse/neglect: iLookOut- Phase II

Despite their daily interactions with young children, little research has been conducted into early childhood practitioners’ (ECPs’) knowledge of, and attitudes towards, reporting of child abuse/neglect. Researchers have developed an eLearning Module (iLook Out for Child Abuse) created to train and inform early childhood practitioners (ECPs). Study plans to recruit ECPs to take the learning program. The learner will be asked to answer questions before and after the learning program to help the study team evaluate the effectiveness, engagement, and usability of the program. This study is the second phase of a currently approved study- STUDY00000376.
Nicole Verdiglione at nverdiglione@pennstatehealth.psu.edu or 717-531-4552
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT02225301
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Inclusion Criteria:
Early Child Care Provider (i.e. working in a Child care center, child care home, or volunteer)
Over 18 Years of Age
Exclusion Criteria:
Under 18 years of age
Children's Health, Education
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Examining elderly traumatic brain injury and risk for neurodegeneration

The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI: 


Frank Hillary at fgh3@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
>54 years of age
sustained a traumatic brain injury
Exclusion Criteria:
<55 years of age
history of neurological disorder such as stroke, epilepsy, or multiple sclerosis
history of bipolar
Neurology
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State College, PA

IMpact of PRehabilitation in Oncology Via Exercise – Breast cancer

It is well known that breast cancer patients suffer from many cancer- and treatment-related side effects that all worsen overall quality of life. Besides dealing with existing treatment-related side-effects, there is the idea of prehabilitation a process on the cancer continuum of care that occurs between the time of cancer diagnosis and the beginning of acute treatment. IMPROVE-B will evaluate an exercise prehabilitation approach with regard to safety, feasibility, acceptability and effectivity in breast cancer patients (n=30) prior surgery.
Joachim Wiskemann at jwiskema@phs.psu.edu or 717-531-0003, ext=289736
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Scheduled for breast cancer surgery
Not metastatic (stage <4)
more than 2 weeks till surgery
Exclusion Criteria:
Receiving neoadjuvant chemotherapy or radiotherapy
Pregnant
• Engaging in systematic intense exercise training (at least 1h twice per week)
Cancer
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Hershey, PA

A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis (NASH)

This Phase 3, double-blind, randomized, long-term, placebo-controlled, multicenter international study will evaluate the effect of OCA on histological improvements in NASH, all-cause mortality, and liver-related clinical outcomes. Primary Objective Assessed at 18 Months • To evaluate the effect of OCA compared to placebo on histological improvement in NASH by assessing the following as co-primary endpoints using NASH CRN scoring criteria: − Improvement in fibrosis by at least 1 stage with no worsening of NASH defined as no increase in hepatocellular ballooning or lobular inflammation Page 33 of 261 Protocol 747-303 Version 4: 14 Apr 2016 Page 34 Confidential and Proprietary − Resolution of NASH as defined by overall histopathological interpretation with no worsening of fibrosis 6.2. Secondary Objectives Assessed at 18 Months • To evaluate the effect of OCA compared to placebo on histological improvement in NASH by assessing the following using NASH CRN scoring criteria: − Improvement of fibrosis and NASH as a composite endpoint and as defined by improvement in fibrosis by at least 1 stage and improvement in NAFLD activity score (NAS) by at least 2 points with at least 1 point improvement each for hepatocellular ballooning and lobular inflammation − Resolution of fibrosis − Improvement in NAS by at least 2 points with no worsening of fibrosis − Improvement in each key histological feature of NASH by at least 1 point (steatosis, lobular inflammation, and hepatocellular ballooning)
laurie peiffer at lpeiffer@pennstatehealth.psu.edu or 717-531-5226
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02548351
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Inclusion Criteria:
NASH
fibrosis stage 2 or 3
stable body weight
Exclusion Criteria:
cirrhosis
prior cancer
heptocellular cancer
hiv, hcv, hbv
hba1c>9.5
Digestive Systems & Liver Disease
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Hershey, PA

Risk-based, response-adapted, Phase II open-label trial of nivolumab + brentuximab vedotin (N + Bv) for children, adolescents, and young adults with relapsed/refractory (R/R) CD30 + classic Hodgkin lymphoma (cHL) after failure of first-line therapy, followed by brentuximab + bendamustine (Bv + B) for participants with a suboptimal response. CheckMate 744: CHECKpoint pathway and nivolumab clinical Trial Evaluation

This is is a Phase 2, open-label study of nivolumab and brentuximab for children and young adults with relapsed/refractory classic Hodgkin lymphoma.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
This study is NOT accepting healthy volunteers
NCT02927769
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Inclusion Criteria:
Must be 5-30 Years of Age
A confirmed diagnosis of Classic Hodgkin Disease
Failed or did not respond to initial treatment
Exclusion Criteria:
A previous allogeneic stem cell transplant
Received certain antibody therapies in the past
Cancer
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Hershey, PA

Measuring the impact of three types of resistant starch on fecal butyrate levels and the gut microbiome in healthy and obese individuals

This is dietary intervention trial that will examine the impact of consuming three different types of resistant starch on the gut microbiome and butyrate levels in normal weight and obese individuals. Participants will consume starch samples daily for 24 weeks, collecting weekly fecal samples that will be returned to the lab. Researchers will analyze the bacterial fermentation products in these samples, particularly butyrate and analyze the microbiome composition. This will allow identification of differences in resistant starch (a dietary fiber) processing between normal weight and obese individuals and will also determine if the three resistant starches tested have differing impacts on the microbiome and butyrate levels.
Darrell Cockburn at dwc30@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
BMI greater than 30
Exclusion Criteria:
Diagnosis of Inflammatory Bowel Disease
Diagnosis of Diabetes
Pregnant
Taking antibiotics
Food & Nutrition
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State College, PA

Lexical and sentence processing in novice L2 learners: Psycholinguistic and neurocognitive investigations

We are studying how children and adults learn second languages in the classroom. To do this, we ask children and adults to read words or sentences in English and in Spanish while we record brainwaves using noninvasive sensors. The participant wears a cap that looks like a swimmers cap with the sensors attached to it.
Katharine Donnelly Adams at kda11@psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Adults enrolled in third semester (intermediate) Spanish
Middle school students enrolled in first year Spanish
Monolingual English speaker
Right-handed
Normal or corrected-to-normal vision
Exclusion Criteria:
Not fluent in any language other than English
History of neurological disorders
Uncorrected vision
Education, Language & Linguistics
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State College, PA

Effects of Office Noise on Annoyance and Task Performance

There are two objectives of this study: (1) to determine the characteristics of a “good” quiet workspace and (2) to investigate the effects of typical office noise on task performance. The tests will include Ambisonic presentation (aural reproduction) of recorded office soundscapes to subjects in an anechoic chamber to determine subject preference for annoyance and effects on task performance due to noises that commonly occur in open-office environments.
Zhi Zhou at zmz5181@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years or older
Must have a hearing threshold of 25 dB HL (assessed during test session)
Exclusion Criteria:
Not meeting the inclusion criteria.
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State College, PA

Application of graph theory to both resting-state and task-based fMRI data to uncover brain-behavior relationships related to therapy outcomes in aphasia

This project will use fMRI to examine changes in the brain related to behavioral therapy outcomes in persons with aphasia. We aim to recruit twenty persons with aphasia. Each participant will receive 4 MRI scans. Between scan 1 and scan 2, no therapy will be provided (10 week break). Between scan 2 and scan 3, ten weeks of word finding therapy will be provided. Between scan 3 and scan 4, no therapy will be provided (10 week break). The therapy used is abstract word retrieval training. The results of this project will help inform rehabilitation practices in aphasia.
Chaleece Sandberg at cws18@psu.edu or 814-863-2006
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosis of aphasia
Sustained stroke at least 6 months ago
Right-handed
Native English speaker
Completed at least a high school education
Exclusion Criteria:
History of neurodegenerative disease (e.g., Alzheimer's)
History of other acquired neurological disorder (e.g., TBI)
History of developmental disorder (e.g., autism)
History of psychological disorder (e.g., schizophrenia)
Unsafe to receive MRI (e.g., pacemaker)
Neurology, Language & Linguistics
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Hershey, PA

NASH Fitness Intervention for Thrombosis (NASHFit) Trial

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States. The most advanced forms of NAFLD are associated with increased liver-related mortality and lower overall survival. The current standard of care for NAFLD is lifestyle changes through diet and exercise. The human genome and regulation of gene expression is influenced by physical activity. NAFLD is a prothrombotic state with derangements in all three phases of hemostasis leading to clinically important clotting events. Exercise can improve coagulation in healthy persons. In this proposal, we seek to begin a line of work to answer the question “Can lifestyle changes effectively mitigate the increased risk of clotting in patients with NAFLD?” focusing initially on the at-risk population genetically susceptible to advanced disease.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03518294
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Inclusion Criteria:
Nonalcoholic fatty liver disease (NAFLD)
Evidence of hepatic steatosis by imaging
Exclusion Criteria:
>90 minutes/week of at least moderate intensity exercise over the previous three months
Pregnancy
Active cardiac symptoms
Uncontrolled diabetes (changes in medication dosing over the previous three months or hemoglobin A1c >9%)
Blood Disorders, Digestive Systems & Liver Disease, Sports Medicine
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Hershey, PA

Micromanagement strategies in pump users with type 1 diabetes: What happens in day-to-day insulin use?

Because we know relatively little about the day-to-day process of insulin therapy in type 1 diabetes, we will systematically study insulin pumpers' experiences with daily micro-management. Many studies of insulin therapy implementation simply assess the degree to which people with diabetes report following the recommendations of their healthcare providers, or the frequency with which people with diabetes skip an insulin dose or give themselves less insulin than prescribed. We will assess the process through which people on insulin pumps self-manage their insulin therapy and the aspects of living that affect glycemic control. We will have participants report their daily glucose values, different treatment decisions that they have made, and overall management of their daily glucose. The success of diabetes self-management is dependent on the way these decisions are made and implemented. At the conclusion of this study, we will have developed a new conceptualization, or theory, of insulin treatment in type 1 diabetes that can be used in educational interventions to improve both self-management of blood glucose (SMBG) and A1c outcomes.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Type 1 diabetes (self-reported)
Insulin pump for one year or more
Age =>25
Participant interested in diabetes research studies
Able to communicate in English
Exclusion Criteria:
No access to technology (i.e. computer, tablet, smartphone)
Diabetes & Hormones
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Perceptional evaluation of concert halls with different properties

The overall goal of the project is to better understand how people subjectively perceive differences in concert hall acoustics. Subjects will listening to musical passages, side-by-side, in aural simulations of being in different concert halls or rooms. Subjects will then be asked to provide perceptual ratings on reverberance about the different rooms in which they are listening to. The results from this research will help to better understand how concert-goers perceive different room, and will help acoustic consultants to better design concert hall in the future to produce more pleasing acoustic environments.
Fernando del Solar Dorrego at fmd117@psu.edu or 814-441-7154
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years of age
5 years of formal musical training
Hearing thresholds below 15 dB (will be checked during testing)
Exclusion Criteria:
Less than 18 years of age
No musical training or less than 5 years
Hearing thresholds above 15 dB
Mental & Behavioral Health
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State College, PA

Study of Angelica gigas dietary supplements (Cogni.Q) and potential effects on human immune cells

This human study will test the impact of dietary supplement vegicaps containing Korean Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and other germs and natural killer (NK) cells that kill virus-infected cells and cancers. We had done an earlier study with Korean Angelica supplement and discovered even a single dose of it increased blood neutrophils and NK cells within 24 h. In the new study, Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo) capsules. This is to make sure the immune boosting actions are really from the Korean Angelica supplement. Approximately 40 men will take part in this research study at Hershey Medical Center.
Male
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Male subjects 21 to 65 years of age
Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in the range of 19=< BMI >=30
Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR).
Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg)
Exclusion Criteria:
Subjects positive for HIV, HBV and HCV (self-reported)
Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded.
Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study.
Non-English-speaking subjects
Infectious Diseases & Immune System, Blood Disorders, Food & Nutrition
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Hershey, PA

Human-robot interaction study

We are interested in developing robots that can interact with humans. We hope that to develop robots that can interact with people and be used in a variety of different situations such as schools, offices, and homes. This study investigates human-robot interaction.
Alan Wagner at alan.r.wagner@psu.edu or 814-865-3136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Ability to read and see
Exclusion Criteria:
Under 18
Education
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State College, PA

Pictorial Influence on Sentence Comprehension

This behavioral study will examine the influence of pictorial primes on general knowledge questions. A participant will be shown a cartoon-type picture prior to the presentation of a question. They will be asked to answer the question verbally. This study aims to determine the influence of pictorial primes on memory recall and retrieval.
Marissa Scotto at mxs2620@psu.edu or 814-867-3033
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Must be over the age of 18
Must be a native English speaker
Exclusion Criteria:
Under the age of 18
Not a native English speaker
Education, Language & Linguistics
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State College, PA

REducing Lung congestion symptoms using the V-wavE shunt in advanced heart failure (RELIEVE-HF)

The objective of the study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System to improve clinical outcomes in a certain high-risk group of symptomatic patients suffering from heart failure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03499236
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Inclusion Criteria:
18 years of age or older
Diagnosed by a physician and told that I have Heart Failure
Currently on medications for the treatment of HF
Have symptoms of HF such as shortness of breath, fatigue, inability to lie flat or reduced ability to exert myself
Have been hospitalized or treated in an emergency department within the past year for my HF
Exclusion Criteria:
Presently on kidney dialysis
Presently enrolled in another clinical research study for an investigational drug or device
Have had a heart transplant or am presently on a waiting list for a transplant
Have an implanted mechanical heart assist device (pump)
Heart & Vascular
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Hershey, PA

Site For ENDOmarker

Site For ENDOmarker
Patsy Rawa at prawa@pennstatehealth.psu.edu or 717-531-3692
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03161704
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Inclusion Criteria:
Scheduled to undergo gynecologic surgery
Exclusion Criteria:
Currently pregnant
Current or past diagnosis of any malignancy (exception melanoma skin cancer)
Known to be HIV-positive
Clinical evidence of active cervical infection
Clinical evidence of pelvic inflammatory disease (PID)
Women's Health
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Hershey, PA

Tolerization Reduces Intolerance to Pegloticase and Prolongs the Urate Lowering Effect (TRIPLE)

This study is for people who have chronic gout and their signs and symptoms of gout are not well controlled by their current medications. This study has two arms of treatment: one is using an approved medication for treatment of gout and the other uses the same approved medication in conjunction with an oral medication (immunosuppressant drug) which is commonly used to prevent rejection from kidney transplant and to treat patients with signs and symptoms of rheumatoid arthritis. The use of the immunosuppressant drug in this study is considered experimental. This research is being done to see whether a new dosing regimen of the approved medication helps to improve gout symptoms and reduces side effects due to the infusions.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02598596
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Inclusion Criteria:
Chronic Gout with symptoms that are not well controlled
Taking gout flare prophylaxis
Exclusion Criteria:
Have CHF, uncontrolled heart rhythms, treatment for chest pain/ heart attack/ unstable chest pain syndrome
Hospitalized for CHF in the past 3 months
Uncontrolled blood pressure or blood sugars
Solid organ transplant recipient
Currently on dialysis
Arthritis & Rheumatic Diseases
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Hershey, PA

Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Reduced Ejection Fraction (ANTHEM-HFrEF)

To assess the safety and efficacy of the VITARIA System when added to stable, guideline directed medical therapy for patients with heart failure and reduced left ventricular ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03425422
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Inclusion Criteria:
Have an Ejection Fraction (EF) ≤ 35%
Exclusion Criteria:
Chronic (permanent) atrial fibrillation, or previous ablation for atrial fibrillation
Pregnant, planning on getting pregnant, or breastfeeding during the study
Previous or current implanted system or lead for vagus or other nerve stimulation
Heart failure due to congenital heart disease, hypertrophic obstructive cardiomyopathy, or infiltrative cardiomyopathy (e.g. amyloidosis, sarcoidosis)
Heart & Vascular
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Hershey, PA

The Investigation of Human Response to Robot-Controlled Punishment

This study examines how people respond to interaction with robots.
Himavath Jois at hxj5142@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
The person must be an adult.
Must be able to see, hear, and talk.
Must be willing to complete the surveys.
Must be able to complete the consent form.
Must be able to perform small physical tasks, such as sorting items on a table.
Exclusion Criteria:
Anyone under the age of 18.
Individuals that have uncorrected seeing or hearing difficulties.
Adults unable to consent.
Individuals unable to perform minor physical tasks.
Individuals unable to fit comfortably into the experimental equipment.
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State College, PA

Pilot Study to Assess Medication Adherence, Health Literacy, and Technological Literacy among African Americans and Latinos with Hypertension

This pilot study aims explore the health literacy and medication adherence found among African Americans and Latinos with hypertension receiving care at Hamilton Health Center in Harrisburg PA. We also aim to determine the feasibility of the iPad or smartphone as a tool for accessing health related information among African American and Latino patients with hypertension receiving care at clinics at Hamilton Health Center in Harrisburg PA. The expected outcomes of this project are to obtain a better understand of the literacy levels and adherence behaviors of African Americans and Latinos in Harrisburg, Pennsylvania. The findings from this study will provide valuable insights into the health management behaviors of this community and determine if there is a need to develop a mobile health application for the management of hypertension.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-2044
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with high blood pressure
Prescribed medication for high blood pressure
African American/Black (Hispanic or Non-Hispanic) or White (Hispanic)
21 years and older
Able to speak and read English
Exclusion Criteria:
Unable to provide consent to participate in the study
Heart & Vascular, Diabetes & Hormones
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Hershey, PA

Student Housing Assessment

The primary objectives are to identify why students choose where they live; what is their perception of value for housing; is this value based on their home city/state/country; how are they paying for housing costs; if their parents are paying for the housing, what perception of value do the parents have, what is their economic status, what is their home owning status, etc.
Mallory Meehan at mmm446@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Undergraduate Student
Graduate Student
Enrolled and living at University Park
Exclusion Criteria:
Non-student
Education
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CUFF Study: Characterization of Upper Limb Function following Mastectomy and Reconstruction for Breast Cancer

This is an observational study that will provide information describing the relationships between type of breast reconstruction and shoulder/upper extremity function and perceived health-related quality of life (HRQOL) for breast cancer survivors. This study will obtain measurements of arm strength and mobility and use self-report questionnaires to evaluate patient quality of life and satisfaction with treatment. Outcomes across three patient groups will be compared, including patients who undergo mastectomy with: 1) no reconstruction; 2) reconstruction with implants; and 3) reconstruction with autologous flaps.
Meghan Vidt at mzv130@psu.edu or 814-865-6885
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Women aged 18-79 years old
Plan to undergo mastectomy as a part of breast cancer treatment
Mastectomy with or without secondary reconstruction
Exclusion Criteria:
Men
Women who do not plan to have mastectomy as a part of their breast cancer treatment
History of a stroke or neuromuscular disorder (e.g. Parkinson's disease, tremor)
Severe arthritis that affects how you move
Any condition that affects memory (e.g. Alzheimer's disease, dementia)
Cancer
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Hershey, PA

Childhood Adverse Experiences: Impacts in Young Adulthood

The purpose of the study is to examine how individuals change over time and what impacts their development. In particular, we are interested in mental health outcomes in young adulthood. Participants will be required to complete a survey one time that will take about 10-15 minutes to complete. Participants will be eligible to win a $10.00 amazon gift card.
Aubrey Daniels at aubreyd@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Between the age of 18-35
Exclusion Criteria:
Not between the age of 18-35
Prevention, Mental & Behavioral Health
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