A Phase I/II, Multicenter, Open Label, Multi Arm Study Evaluating The Safety, Tolerability, Pharmacokinetics, And Preliminary Activity Of Idasanutlin In Combination With Either Chemotherapy Or Venetoclax In The Treatment Of Pediatric And Young Adult Patients With Relapsed/Refractory Acute Leukemias Or Solid Tumors
A study of the safety of idasanutlin for children with solid tumors and leukemias that returned or did not respond to previous treatment.
Suzanne Treadway at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT04029688
Cancer
Defining the cellular and molecular signatures that are associated with the clinical heterogeneity of hidradenitis suppurativa
Patients with the clinical diagnosis of mild, moderate to severe Hidradenditis Suppurativa or normal healthy volunteers ages 18 and older to participate in a 1 time study visit. There is no treatment provided but we may gain information for the treatment of HS.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-1513
All
18 year(s) or older
N/A
Skin Conditions
An Observational, Non-Interventional Study of Patients with Hereditary Angioedema in the United States and Canada (EMPOWER study)
Evaluate real-world effectiveness of drug in patients with hereditary angioedema (HAE). Patient reported attack diaries and patient-reported outcomes (PROs) as well as physician assessments at visits will be used to describe HAE attack rates, treatment patterns, healthcare utilization and patient quality of life.
Joshua Adams at jadams4@pennstatehealth.psu.edu or 717-531-4513
All
All
NCT03845400
Infectious Diseases & Immune System
CLadribine tablets: Observational evaluation of effectIveness and patient-reported outcomes (PROs) in suboptimally Controlled patients previously taKing injectable disease-modifying drugs (DMDs) for relapsing forms of Multiple Sclerosis (RMS) (CLICK-MS)
The purpose of this study is to understand how well multiple sclerosis (MS) patients respond to a drug to help with relapsing MS (RMS), This is an oral drug called Cladribine. An observational study is research that aims to collect data over time on how a certain treatment is used and its effects, without any change to your normal care. This means that routine clinical practice is followed. Any treatment given follows your normal routine and is decided by you and your doctor. This study will not alter or interfere with the normal care you receive in any way.
All
18 year(s) or older
NCT03933215
Neurology
Associations of dietary preferences with management of HS symptoms
We will be examining the diets of people with hidradenitis suppurativa to see if they consume different amounts of foods like dairy, tomatoes, or gluten.
Melissa Butt at mbutt1@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Skin Conditions, Food & Nutrition
PSCI-18-052 A Phase II Study to Evaluate the Response and Tolerability of Verzenio (Abemaciclib) in Patients with Advanced Biliary Tract Carcinoma who have Failed Prior Chemotherapy
The prognosis of patients with recurrent, late-stage inoperable, or progressed biliary tract carcinoma (BTC) is generally poor. The goal of this clinical study is to determine the effectiveness and safety of abemaciclib in patients with late-stage or progressed BTC that has failed one line of chemotherapy.
Irina Geier at igeier@pennstatehealth.psu.edu or 717-531-4300
All
18 year(s) or older
NCT04003896
Cancer
Design and Evaluation of a Portable Test Bed to Measure Cognitive Workload
The purpose of the experiment is to examine the effectiveness of a portable mental workload monitor. Participants will be using a game-like computer program that tests the ability to perform multiple tasks simultaneously. The experimenter will be recording performance data as well as multiple physiological indices to include a desktop eye tracker, a simple electroencephalogram (EEG), a galvanic skin response monitor, and a heart-rate monitor. The recording devices are not intrusive and should not cause discomfort.
Snehal Dhengre at sud702@psu.edu
All
18 year(s) or older
N/A
Mental & Behavioral Health
A Phase III Randomized Open Label Study to Compare NKTR-214 Combined with Nivolumab to the Investigator's Choice of Sunitinib or Cabozantinib in Patients with Previously Untreated Advanced Renal Cell Carcinoma (PSCI 18-122)
The purpose of the study is to compare how well the drug called NKTR-214 works when combined with the other drugs: nivolumab, sunitinib, and cabozantinib in patients with renal cell carcinoma.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu
All
18 year(s) or older
NCT03729245
Cancer
Identity Fusion and "Vladimir's Choice": An Exploration of Costly Decision Making
This study will experimentally determine if individuals who identify more strongly with their political party are more likely to make decisions that cause discomfort and possible pain when faced with opposition and competition from individuals with opposing views. This goal will be accomplished in the laboratory via a game between individuals with opposing views that can be won by taking a shot of hot sauce.
Connor Somgynari at cjs72@psu.edu or 224-637-5504
All
18 year(s) or older
N/A
Food & Nutrition, Education, Mental & Behavioral Health
The Role of Obesity on the Phenotype and Function of Human Monocytes and their Role in Atherosclerotic Risk
We are conducting a study that is comparing the distribution of monocyte subsets (i.e. classical, intermediate and non-classical monocyte) between adults aged 55-75 with obesity/metabolic syndrome and healthy controls. The participants will have one screening visit and one study visit, and both will involve a blood draw. Each visit should take an hour or less, and the compensation for this study is $10. Lab results from screening will also be provided to participants at no cost.
Ester Oh at sxo35@psu.edu or 814-867-3720
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Heart & Vascular, Prevention
Testing conflicting theories of semantics by constructing neuroinformatic networks of keywords using fMRI data
This is a brain imaging study that will examine how people mentally organize word meanings. Participants will perform a language task while in an MRI scanner, and their brain imaging data will be used to create networks of words that will be used to test conflicting theories of word meaning.
Dominick DiMercurio at dimercurio@psu.edu or 814-867-4341
All
18 year(s) or older
N/A
Language & Linguistics
AN OPEN-LABEL STUDY TO EVALUATE THE LONG-TERM SAFETY OF DAILY ORAL BCX7353 IN SUBJECTS WITH TYPE I AND II HEREDITARY ANGIOEDEMA
This is a clinical trial to determine the effectiveness of a daily oral medication in prevention of swelling attacks in patients with Hereditary Angioedema.
Kristina Richwine at krichwine@pennstatehealth.psu.edu or 717-531-4513
All
18 year(s) or older
NCT03472040
Infectious Diseases & Immune System, Allergies
Site for Phase III Randomized Trial of Concurrent Chemoradiotherapy with or without Atezolizumab in Localized Muscle Invasive Bladder Cancer (Study SWOG/NRG 1806) (PSCI#19-044)
The purpose of this study is to compare the effects, good and/or bad, of chemotherapy and radiation therapy with or without the use of atezolizumab, which is used to treat bladder cancer. The combination of chemotherapy, radiation therapy and the immunotherapy atezolizumab is considered experimental.
If you decide to take part in this study, you will receive combined chemotherapy and radiation therapy which is called “chemoradiotherapy” either with or without the study drug. The chemoradiotherapy you will receive is standard of care and what your doctor thinks is best. You will receive chemoradiotherapy for up to 7 weeks. If you are assigned to the group receiving study drug, you will take the drug for up to 6 months in addition the chemoradiotherapy.
Your doctor will continue to follow your condition for up to 5 years after you register to the study, even though you have finished treatment in the first year. Your doctor will watch you for side effects and to see how your cancer affects you. You will have clinic visits at 3 months from the time you stop taking treatment for the first two years and then twice a year for the third year and once a year thereafter until 5 years after you register to the study.
Kathleen Rizzo at krizzo@pennstatehealth.psu.edu or 717-531-0003, ext=289630
All
18 year(s) or older
NCT03775265
Cancer
A Phase 3, Multi-center, Open-label, Safety Study of Oral Edaravone Administered over 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)
The purpose of this study is to test if an experimental drug called edaravone is safe and well tolerated in patients with ALS. In this study, you will receive an oral form of edaravone (a liquid solution that you will swallow). This oral formulation is considered experimental, as it has not been approved to treat ALS. The IV (intravenous) form of edaravone has been approved as a treatment for ALS. The IV form was approved in 2017 by the U.S. Food and Drug Administration (“FDA”). It is known by its commercial-brand name, Radicava, and its generic name, edaravone.
Anne Haulman at ahaulman@pennstatehealth.psu.edu or 717-531-0003, ext=289123
All
18 year(s) or older
NCT04165824
Neurology
Investigating the impact of food form on children’s ability to compensate for energy
This study is looking at how different apple products (apple juice, apple sauce, and apple slices) might affect children's hunger and fullness. During 5 visits to our laboratory at Penn State, children will participate in a variety of games and tasks, and will eat meals and snacks with a research assistant. Children must be between the ages of 4.5-6 years old to participate in this study.
Nicole Reigh at nar5235@psu.edu
All
Younger than 18 years old
N/A
Children's Health, Food & Nutrition
Centre County COVID-19 Data 4 Action Study
The purpose of this research is to evaluate the extent of COVID-19 risk and perceived risk among Centre County residents and students, and how those risks evolve from the time isolation guidelines were implemented through a return to normal functioning.
Participants in this research will complete an electronic survey with questions about their demographic, about their exposure to COVID-19, and about how COVID-19 has affected their health and work/education.
Data from this research will be used to inform Centre County planning authorities and the Pennsylvania State University about the needs of communities, including needs for information dissemination and for potentially actionable, local interventions in response to the COVID-19 pandemic.
Susan McHale at src-ssri@psu.edu
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Men's Health, Women's Health
PSCI-17-085 Effect of Omega-3 Fatty Acid (EPA) and its Metabolites in Combination with Tyrosine Kinase Inhibitors (TKIs) in Chronic Myeloid Leukemia (CML) in Stable Chronic Phase
The purpose of this Phase I/II study is to evaluate the safety and efficacy of the combination of tyrosine kinase inhibitors (TKIs) and an omega-3 fatty acid (like fish oil) in patients with Chronic Myeloid Leukemia (CML).
Seema Naik at snaik@pennstatehealth.psu.edu
All
18 year(s) or older
NCT04006847
Cancer
COVID-19: Implications for Family Meals
The purpose of this study is to gather information about family meals, what they look like, and how they have changed over time since the COVID-19 pandemic. Participants will complete a confidential online survey last approximately 10-15 minutes.
Hannah Mudrick at hxm99@psu.edu or 717-948-6404
All
18 year(s) or older
N/A
Food & Nutrition
Neurophysiological patterns of sentence processing
Spoken language can affect the brain in numerous ways. Monolingual (speaking one language) and bilingual (speaking more than one language) volunteers will complete language tasks remotely via the internet. Participants may be invited back later for an in-person study in which their brainwaves are measured by an electroencephalogram (EEG). Language tasks include listening to words and sentences, repeating words and sentences, and answering questions. Two sessions are required for the online study: a questionnaire and a Zoom meeting with a researcher.
So Yeon Chun at sfc5538@psu.edu
All
18 year(s) or older
N/A
Language & Linguistics
Using Social Media to Perform Parasocial Relationships with Celebrities
This research is being conducted to create a better understanding of how parasocial relationships are developed by young adults with actors, artists/musicians, and fictional characters. This research aims to understand the extent of how Tumblr users interact and follow celebrities or fictional characters and the attachment they form to them. The participants will fill out an online survey asking questions about their emotional intensity and dedication to a celebrity or fictional character as well as whether you share about them and what technology they use. Participants may skip any questions that she/he would prefer not to answer.
Courtney Smith at ces92@psu.edu
All
18 year(s) or older
N/A
Men's Health, Education, Women's Health
Randomized Trial of Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia (AML) (PrE0905)
The purpose of this study is to compare the effectiveness of gilteritinib to midostaurin in patients receiving standard combination chemotherapy for a particular change in AML of their leukemia cells (called a mutation) in a gene called FLT3.
Lea Russell at lrussell@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
NCT03836209
Cancer
A Multicenter Phase 2, Open-Label Study of Intratumoral Tavokinogene Telseplasmid (tavo, pIL-12) plus Electroporation in Combination with Intravenous Pembrolizumab in Patients with Stage III/IV Melanoma who are Progressing on either Pembrolizumab or Nivolumab Treatment (PISCES)
The purpose of this voluntary research study is to find out what effects, good and/or bad, the combination of a type of gene therapy treatment called plasmid electroporation and pembrolizumab has on your cancer.
Irina Geier at igeier@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
NCT03132675
Cancer
A Randomized Controlled Pilot Study of the Use of Cannabidiol in the Management of Endometriosis Pain
We are looking to conduct a study looking at the effects of cannabidiol (CBD) in patients with endometriosis. We believe that CBD will improve both pain and quality of life.
The study will last a total of 12 weeks and involve several onsite visits in addition to daily pain assessments.
Amanda Chu at achu@pennstatehealth.psu.edu
Female
18 year(s) or older
NCT04527003
Pain Management, Women's Health
A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012)
This is a study that will compare a study drug pembrolizumab plus a study drug lenvatinib in combination with the therapy called TACE (transarterial chemoembolization) which is a way to deliver chemotherapy locally through a procedure called embolization and how that works versus placebo (or no study medications) plus TACE and how it could lead to progression-free survival (PFS).
Irina Geier at igeier@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
NCT04246177
Cancer
A double-blind randomized placebo-controlled study on the analgesic properties of amiloride in exercise-induced skeletal muscle pain
To determine if the drug Amiloride will reduce exercise related muscle pain and improve exercise tolerance in healthy volunteers.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
N/A
Heart & Vascular
Remote testing for psychophysical studies of sensory perception and cognition
The purpose of this study is (1) to understand how the brain processes sensory information and (2) how this is affected by factors like blindness or synesthesia.
Michelle Douthitt at mdouthitt@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Neurology, Language & Linguistics, Vision & Eyes
The changes in insulin resistance and metabolic health among young, middle aged, and older adults meeting the current aerobic exercise training recommendations.
The overall purpose of this research is to evaluate the difference the national cardiorespiratory exercise recommendations have on metabolic and cardiovascular health over 6 weeks in previously sedentary young, middle aged, and older adults matched for obesity. The participants will complete moderate intensity exercise for 30 minutes per day, 5 days per week for 6 weeks. Pre- and post-intervention testing will be completed to evaluate changes in metabolic and cardiovascular health.
Nicole Gilbertson at nmg46@psu.edu or 814-949-5016
All
18 year(s) or older
N/A
Heart & Vascular, Sports Medicine, Diabetes & Hormones
Self-Help for Stress Related to COVID-19
This is a study on internet-based self-help for stress related to the COVID-19 pandemic. College and university students who screen high on perceived stress or measures of risk for anxiety, depression, or eating disorders during the COVID-19 pandemic will be invited to participate in this study. Participants will be randomly assigned to receive access to an internet-based self-help program for stress resilience and coping with the COVID-19 pandemic or care as usual. Symptoms of stress, anxiety, depression, and eating disorders, as well as secondary outcomes, will be assessed via questionnaire at baseline (pre-randomization), one month post-randomization, and three months post-randomization.
Gavin Rackoff at gnr18@psu.edu
All
18 year(s) or older
N/A
Mental & Behavioral Health
Measuring motivation for alcohol use
In this study we are interested in measuring motivation for alcohol use within the context of the level of autonomy or control a person experiences for their drinking behavior. We are also interested in examining the relationship between motivation for alcohol use and physical activity, and motivation relates to alcohol use and physical activity behaviors.
If your are interested in participating, please follow the link to the screening survey to determine if you are eligible: https://redcap.ctsi.psu.edu/surveys/?s=KKLWFRHEKL (if the link does not work, please copy and paste it into your browser).
Jimikaye Courtney at jimikaye@psu.edu or 814-867-2297
All
18 year(s) or older
N/A
Addiction & Substance Abuse, Food & Nutrition, Prevention
Portion Size Training in the Immersive Virtual Reality Environment
This study aims to understand how we interact with different portion sizes of food in our environment. Participants will complete a series of tasks in an Oculus virtual reality headset and complete a number of pre-and post-questionnaires.
Caitlyn Edwards at cke5143@psu.edu
All
18 year(s) or older
N/A
Food & Nutrition, Education