Identifying views of Military Veterans Regarding Contemporary War and Conflict Reporting
This study will involve surveying and interviewing US military veterans and non-veterans regarding their perceptions of the quality, accuracy, and themes of contemporary war and conflict reporting.
Hans Schmidt at hcs10@psu.edu or 610-892-1251
All
18 year(s) or older
N/A
Study of Antimalarials in Incomplete Lupus Erythematosus (SMILE)
This is a study to test whether a widely-used drug, hydroxychloroquine, might slow the progression of lupus like features in individuals who are at high risk for developing systemic lupus erythematosus. This will be measured by the accumulation of clinical and laboratory features of lupus. The study will randomize subjects to the active drug, hydroxychloroquine, or placebo, with an equal chance of receiving either treatment. The study treatment lasts approximately 2 years with visits approximately every 3 months.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-4921
All
All
NCT03030118
Arthritis & Rheumatic Diseases
Examining responses to rewards in the laboratory and during daily life in individuals who smoke cigarettes
The goal of this study is to learn more about how people who smoke
cigarettes respond to rewards, such as winning money, under different
conditions. The study uses a method called functional magnetic
resonance imaging, or fMRI, which is a research method for measuring
activity in the brain. In this study, we are using fMRI to measure how
brain activity changes in people who smoke when they receive rewards.
The fMRI measures are collected during two separate visits.
Participants are also asked to fill out questionnaires and complete
computer tasks while in the lab. In total, participants are required
to visit the research lab on the University Park campus a total of
five times. In addition, the study involves measuring thoughts and
behaviors in people who smoke in real life by asking them to fill out
surveys on a smartphone. Participants are asked to carry a smartphone
for a total of 10 days and answer several surveys throughout each day.
In order to be eligible for the study, individuals must be between 18
and 55 years old and you must smoke on a daily basis.
Julian Peck at jnp5021@psu.edu or 814-867-2333
All
18 year(s) or older
N/A
Men's Health, Addiction & Substance Abuse, Women's Health
An Examination of Student-Mentor Relationships
This is a self-report survey and questionnaire study that examines whether members of marginalized groups are more motivated than members of dominant groups to give referent power to high status others in attempts to belonging.
Maria Sanchez at mfs5350@psu.edu
All
18 year(s) or older
N/A
The Child Health Study
We want to understand how a child's environment affects biology in ways that impact child health
Megann Koegler at childhealthstudy@psu.edu or 888-924-4535
All
Younger than 18 years old
N/A
Children's Health, Food & Nutrition, Education
Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes
The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
All
N/A
Sports Medicine, Muscle & Bone
Development of Adolescent and Young Adult Social Health (DASH)
Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time (between $185-630) in the lab and for the neuroimaging session.
If you are a parent and want to begin the screening process for you child, please go here
https://pennstate.qualtrics.com/jfe/form/SV_51lN8sODiukYOON
If you are an adult, and want to begin the screening process please go here:
https://pennstate.qualtrics.com/jfe/form/SV_5cXMng6ybKe0WwJ
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-954-0112
All
All
N/A
Children's Health, Education, Mental & Behavioral Health
Second language speech perception and production
In this a behavioral study that will examine how second language learners perceive and produce second language speech - often in comparison to native speakers - and how these skills develop. Participants might be asked to read word lists or sentences, describe pictures or answer questions, listen to speech samples and make judgments about them (e.g. was this a real word in English? which sound did you hear?), complete a proficiency test, and fill out some background information including a language background questionnaire.
Katharina Schuhmann at kxs811@psu.edu or 814-863-7867
All
18 year(s) or older
N/A
Education, Language & Linguistics
Evaluating the Cough Reflex in Fibrotic and Healthy Lungs
Determining cough threshold in patients with fibrotic lung disease and in healthy controls by stimulating cough.
Timothy Sheehan at tsheehan@pennstatehealth.psu.edu or 717-531-2925
All
18 year(s) or older
N/A
Lung Disease & Asthma
The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging
Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sue Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
N/A
Heart & Vascular, Prevention, Sports Medicine
GLNE 010: Validation and Comparison of Biomarkers for the Early Detection of Colorectal Adenocarcinoma
The purpose of this study is to see if stool, urine or blood can be used to find colon cancer as early or earlier than colonoscopy can. The researchers want to use these samples to learn about specific proteins or genes (also called biomarkers) that may indicate if someone has colon polyps (pre-cancer), colon cancer, or an increased risk for developing colon cancer. The researchers are part of a National Cancer Institute program called the Early Detection Research Network (EDRN). We have some biomarkers that are very promising, so we are testing them (“validating them”) in this study.
Amanda Taylor Gehman at ataylor6@pennstatehealth.psu.edu or 717-531-1283
All
18 year(s) or older
NCT01511653
Prevention, Digestive Systems & Liver Disease, Cancer
A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy, Safety, and Tolerability of JBT-101 in Systemic Lupus Erythematosus
This study is for patients with Systemic Lupus Erythematosus (SLE) to test the effect, safety, and tolerability of the experimental drug JBT-101 in people with SLE to see if JBT-101 stops inflammation and how well JBT-101 is tolerated. The study will evaluate whether JBT-101 will decrease the pain associated with active arthritis or tendonitis in SLE patients.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-0003, ext=283833
All
18 year(s) or older
NCT03093402
Arthritis & Rheumatic Diseases
Imaging and Depression with or without MS
A study looking at the neural and genetic correlates of depression. Presently, the current study is looking to recruit individuals for two separate groups:
1. MS but NO history of depression
2. Depression but NO history of MS or neurological disease.
The purpose of the study is to look at patterns of brain structure and function in individuals with depression and compare them to those with MS. We will explore how any differences we find contribute to more problems with depression in MS and see how such differences might lead to better treatment options for depression.
Cristina Roman at car342@psu.edu or 814-865-5578
All
18 year(s) or older
N/A
Mental & Behavioral Health
Gene-transfer, open-label, dose-escalation study of SPK-8011 [recombinant adeno-associated viral vector with B-domain deleted human factor VIII gene] in individuals with hemophilia A
Gene-transfer, open-label, dose-escalation study of SPK-8011 in individuals with hemophilia A. Primary Objective to evaluate the safety, tolerability and efficacy of SPK-8011 a recombinant adeno-associated viral vector with B-domain deleted human factor VIII gene.
Cynthia Campbell-Baird at cbaird@pennstatehealth.psu.edu or 717-531-5777
Male
18 year(s) or older
NCT03003533
Blood Disorders
SPIRIT 1: An International Phase 3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate Relugolix Administered with and without Low-Dose Estradiol and Norethindrone Acetate in Women with Endometriosis-Associated Pain
Endometriosis is a common chronic condition that can cause pain in the lower part of the stomach (pelvis) during the menstrual period and at other times and pain during sexual intercourse.
The purpose of this study is to test how effective and safe the investigational study drug, relugolix (rel-U-GO-lix), given with or without low-dose estradiol and norethindrone is in treating endometriosis-associated pain. Estradiol is a form of estrogen and norethindrone is form of progesterone. Both estrogen and progesterone are hormones normally made by women’s bodies. These hormones help control the menstrual cycle and menstrual periods and also support bone health. The study wants to know if endometriosis pain affects how women function, how they feel and if the study drug is effective and safe at treating the pain from endometriosis.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
NCT03204318
Pain Management, Women's Health
Neurophysiological Markers of Pediatric Irritability and its Response to Intervention
This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.
Vanessa Cao at vcao@pennstatehealth.psu.edu or 717-531-0003, ext=285966
All
Younger than 18 years old
NCT03279952
Children's Health, Mental & Behavioral Health
Analyzing Student Newspaper Political Coverage
This study involves a content analysis of student newspaper political articles, as well as a survey of student journalists regarding their views about how politics are reported in student media.
Hans Schmidt at hcs10@psu.edu or 610-892-1251
All
18 year(s) or older
N/A
Education
Attention and Emotional Development in Children
Children with attention problems often feel anxious or worried, and likewise, children who are anxious or worried often have problems with attention. We are looking for children aged 8-12 who may or may not have problems with attention or anxiety to help us understand what happens in the brain that could explain why. You will receive up to $100 gift card for your participation, and informal clinical feedback on your child.
Caitlin Givens at ChildAttention@psu.edu or 814-863-0250
All
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health
Long-Term Nicotine Treatment of Mild Cognitive Impairment
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in people experiencing mild memory problems (referred to in this study as “mild cognitive impairment” or MCI).
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our attention. In people with MCI (and Alzheimer’s disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer’s disease (AD). It has been known for many years that nicotine imitates many of the actions of acetylcholine.
By administering nicotine over a longer period of time to participants with MCI, we hope to better understand whether nicotine may act to improve memory loss symptoms over the longer term and whether it may help to delay the progression of memory loss symptoms.
The amount of nicotine in each patch used in this study is the same as patches that are FDA approved for use in people who are trying to quit smoking.
All
18 year(s) or older
NCT02720445
Neurology, Mental & Behavioral Health
An investigation of the daily experiences of cancer survivors preparing for follow-up appointments: An ecological momentary assessment study
Have you been diagnosed with cancer?
Have you completed cancer treatment(s)?
Have you scheduled or are you planning to schedule a follow-up appointment?
We are trying to understand how follow-up appointments impact the everyday health and wellbeing of cancer survivors. We are seeking men and women (age 30-75) who have completed treatments for cancer (stages 0-3), and have a scheduled or plan to schedule a follow-up cancer screening appointment in the next 30 days.
In this study, you will be asked to:
- Attend two remote sessions with a Penn State researcher via Zoom or phone call
- Complete two online surveys
- Carry around a study smartphone for 2 weeks to answer brief surveys throughout the day
Participants in this study can receive up to $160 compensation for their time.
If you are interested in learning more about this study or would like to find out if you are eligible, please contact our study team at (814) 424-5601 or email jaj53@psu.edu
Jillian Johnson at jaj53@psu.edu or 814-424-5601
All
18 year(s) or older
N/A
Cancer
A Phase 3 Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Two Dose Levels of BCX7353 as an Oral Treatment for the Prevention of Attacks in Subjects with Hereditary Angioedema
This study is for patients diagnosed with Type 1 or Type 2 Hereditary Angioedema (HAE) and have suffered HAE attacks (episodes of swelling), and are either not using HAE medications to prevent HAE attacks or for medical or personal choice reasons have decided to discontinue using these medications.
This research is being done to compare the effects of two different doses of BCX7353 compared to placebo. Placebo-containing capsules look exactly like BCX7353 capsules, but do not contain BCX7353 or any other drug. The Sponsor will test two different doses of BCX7353 to see if BCX7353 is able to prevent or reduce the number of swelling episodes or attacks in people with HAE when taken every day by mouth, compared to placebo. This research study will also assess the safety of the new drug BCX7353.
Terri Smith at tjs97@psu.edu or 717-531-4513
All
All
NCT03485911
Infectious Diseases & Immune System, Allergies
Human Robot Trust in a Belay Experiment
Studying the factors affecting trust or lack there of when a human is belayed by a robot
Vidullan Surendran at vus133@psu.edu
All
18 year(s) or older
N/A
Temperament, Evolving Emotions, Neuroscience Study (T.E.E.N.S.)
We are conducting a study examining factors associated with anxiety development in adolescence. We do this through questionnaires and observations of behavior in our laboratory. In this study, we will examine adolescent's emotional development through encountering novel social situations, measuring heart rate and brain activity, and using eye tracking during computer tasks.
All
Younger than 18 years old
N/A
Mental & Behavioral Health
Identification of Emotion in Music in Autism Spectrum Disorders
The purpose of the project is to learn more about reactions to music by adults with and without autism spectrum disorders. Participants will listen to short pieces of music and answer some questions on a computer. They will also complete some formal testing and answer some interview questions.
Diane Williams at dlw81@psu.edu or 814-865-3177
All
18 year(s) or older
N/A
Mental & Behavioral Health, Language & Linguistics
Investigating the emotional and behavioral response in humans playing games against a humanoid robot
We would like to study the emotional and behavioral response of a human playing games against a robot. Games such as Connect Four and card games will be used.
Vidullan Surendran at vus133@psu.edu
All
18 year(s) or older
N/A
Exploring Facilitators and Barriers to Self-Initiated Sexually Transmitted Infection Testing among College Student
The purpose of this study is to identify modifiable facilitators and barriers to self-initiated sexually transmitted infection (STI) testing among college students aged 18 – 24 years. This study will entail filling out a demographic and sexual history questionnaire, and a private face-to-face interview.
Oluwamuyiwa Adebayo at DAresearch@psu.edu or 814-867-4656
All
18 year(s) or older
N/A
Infectious Diseases & Immune System, Men's Health, Women's Health
Cardiovascular Effects of Angiotensin 1-7 in Obesity Hypertension
The purpose of this study is to see if the hormone angiotensin-(1-7) improves the function of blood vessels and lowers blood pressure in obese subjects with hypertension.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
NCT03604289
Heart & Vascular
Examining Maternal Reward Responsiveness and the Intergenerational Risk for Depression
Children of depressed mothers are at high risk for developing depression, particularly as youth age into adolescence, yet relatively little is known about the mechanism underlying risk for depression in youth with depressed mothers. The present study examines maternal reward responsiveness, measured across neurophysiological, behavioral, and self-report measures as a marker of depression in mothers of adolescents. Associations between maternal reward responsiveness and parenting difficulties often associated with maternal depression, as well as adolescent functioning will be examined, to explore the clinical impact of maternal reward responsiveness on the intergenerational transmission of depression.
Sarah Shahriar at sshahriar1@pennstatehealth.psu.edu or 717-531-0003, ext=285189
All
All
N/A
Children's Health, Mental & Behavioral Health, Women's Health
Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?
Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development.
The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women. Participants will drink beetroot juice and a placebo juice and blood pressure and blood vessel function will be measured.
Jocelyn Delgado at jmd956@psu.edu or 408-679-8390
Female
18 year(s) or older
NCT03644472
Food & Nutrition, Heart & Vascular, Women's Health
Site For CLOVERS
Site For CLOVERS
Nancy Campbell RN at ncampbell1@pennstatehealth.psu.edu or 717-531-1707, ext=3
All
18 year(s) or older
NCT00343402
Infectious Diseases & Immune System, Heart & Vascular