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410 Study Matches

Describing your voice: Viewpoints from pre-professional voice users

The purpose of this study is to conduct semi-structured interviews with students at Penn State who are working towards degrees in fields that require a high vocal demand (e.g. teachers, lawyers, singers, actors, etc). The purpose is to learn more about what students think about their voice, what they know about protecting their voice, and what they would do if they had a voice disorder. This information can be used to design interventions and preventative outreach programs for these students.
Nicole Etter at oppal@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years and older
Working towards a degree in a field requiring high vocal demand (e.g. future teachers, lawyers, voice performers including singers and actors)
Exclusion Criteria:
Currently being treated for a voice disorder
Prevention, Education, Language & Linguistics
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Randomized trial of low nicotine cigarettes plus electronic cigarettes in smokers

This study will examine the health effects of lowering the nicotine content in cigarettes while having access to an electronic cigarette.
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04058717
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Inclusion Criteria:
Ages 21-70
Smoke 5 or more cigarettes per day
Must be willing to both switch to a different type of cigarette and try an electronic cigarette
No serious quit attempt or use of smoking cessation medication in the past 30 days
Meet diagnostic criteria for current or lifetime mental health condition
Exclusion Criteria:
Women who are pregnant, nursing, or trying to become pregnant
Any known allergy to propylene glycol or vegetable glycerin
History of difficulty providing blood samples
Other member of the household currently participating in the study
Unstable or significant medical condition in the past 3 months
Addiction & Substance Abuse, Lung Disease & Asthma, Mental & Behavioral Health
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Hershey, PA

Site for A Phase 2, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety and Efficacy of Risankizumab in Adult Subjects with Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa: Phase 2 Subject and Investigator Blinded, 68 week study with phone call 20 weeks after last dose. Hidradenitis Suppurativa (HS) is a chronic recurrent and debilitating skin condition that typically presents with deep and painful lesions. The most common areas affected are the armpits, the groin, and the anus and genitals area. The purpose of the study is to find out if risankizumab is beneficial and well tolerated in patients with HS. Each subject will be assigned to 1 of 3 treatment groups, reassigned to a different treatment at week 16, and then receive risankizumab at week 20.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03926169
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Inclusion Criteria:
Moderate to Severe HS for at least 1 year
HS lesions in at least 2 affected areas
Willing to follow all study instructions
Exclusion Criteria:
Certain treatments for HS are not allowed; coordinator will discuss specific treatments
unable or unwilling to return to the study site for all study visits and tests.
Known Hepatitis B, Hepatitis C, or HIV infections
Skin Conditions
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Location
Hershey, PA

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of BMS-986165 in Subjects with Moderate-to-Severe Crohn's Disease

This study is for patients with moderate to severely active Crohn's disease to measure how effective and safe an experimental medication is in treating this condition.
Laurie Peiffer at lpeiffer@pennstatehealth.psu.edu or 717-531-5226
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03599622
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Inclusion Criteria:
moderate to severe crohn's disease, 3 months
failed prior treatment
Exclusion Criteria:
severe or fulminant colitis requiring surgery
presence of stoma, gastric pouch
prior bowel resection, 6 months
bleeding disorders
cancer < 5 years
Digestive Systems & Liver Disease
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Hershey, PA

Assessing cognitive and psychosocial mechanisms of Useful Field of View cognitive training using ecological momentary assessment

We are interested in how brain games impact everyday life in healthy older adults. Participants will play 20 hours of brain games, and we will examine how the brain games impact everyday life. Some participants may also participate in 2 optional visits with brain MRI scans and at home sleep monitoring.
Michelle Huerbin at mlh5955@psu.edu or 814-865-4773
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT00000000
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Inclusion Criteria:
65 or older
no diagnosis of dementia
within 40 miles of State College
available for 9 months
Exclusion Criteria:
64 or younger
dementia or motor movement disorder diagnosis
cognitive training within past 2 years
Mental & Behavioral Health
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State College, PA

Mobile phones in the bedroom: Impact on adolescent sleep

The purpose of this study is to explore the behaviors, sleep patterns, and sleep attitudes of adolescents who use mobile phones within the bedroom setting after lights out. Participants will complete a series of questionnaires at the beginning of the study. The participants will wear a wrist device for 7 days which measure sleep and wake patterns by activity, as well as complete short daily diary surveys in the morning and evening related to sleep patterns and behaviors, and their mobile phone use.
Cynthia Snyder at ckg2@psu.edu or 717-572-5771
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
13-17 years of age
own or regularly use a smartphone device
read and write English
Exclusion Criteria:
none
Children's Health
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Location
Hershey, PA

Cardio-metabolic effects of diets including pecans

The purpose of the study is to examine how the inclusion of 2 oz./day of pecans into a typical American diet and a healthy diet affect risk factors for heart disease and diabetes.
Philip Sapp at pzs5199@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 25-70 years
BMI 25-40 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Not willing to consume all meals and snacks provided for the study
Food & Nutrition
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Location
State College, PA

A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 2-Arm, Efficacy, and Safety Study in Prurigo Nodularis with Nalbuphine ER Tables for Pruritus Relief Through Itch Scratch Modulation (PRISM Study)

Prurigo Nodularis: Phase 2b/3 Subject and Investigator Blinded, 56 Week study. Oral medication taken twice daily, Males/Females 18 years and older with Prurigo Nodularis Prurigo Nodularis (PN) is a skin disease that causes hard, itchy lumps (nodules) to form on the skin. The itching (pruritus) can be intense, cause people to scratch themselves to the point of bleeding or pain. The goal of this study is to evaluate the change of itch with using Nalbuphine ER.
Amy Longenecker at alongenecker@pennstatehealth.psu.edu or 717-531-5136
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03497975
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Inclusion Criteria:
PN involving 2 affected areas
Willing to follow all study directions and attend appointments
Exclusion Criteria:
PN affecting only 1 part of the body
Certain diagnosis associated with PN are not allowed, coordinator will discuss specifics
Skin Conditions
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Location
Hershey, PA

Understanding the effect of drivers’ profile information on riders’ feedback in ride-sharing context

This study aims to understand ways to affect how riders perceive and provide feedback to drivers through technology intervention. Particularly, we investigate how presenting drivers’ personal profile under different trip conditions may lead to differences in the ways riders may provide feedback. We hypothesize that riders will provide positive feedback when provided drivers’ personal information when the trip goes well, and that riders will provide less negative feedback when provided drivers’ personal information when the trip goes bad due to uncontrollable reasons.
Ning Ma at nzm37@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Taken at least 10 Uber/Lyft ride in the last 12 months.
You are willing to share several of your past Uber/Lyft trip records in the app with us.
Exclusion Criteria:
You are a current or past employee with one of the ride-sharing corporations (Uber/Lyft)
Education
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Study Locations

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Location
State College, PA

A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit in Subjects with Hypertension

The purpose of this study is to evaluate the safety and effectiveness of renal denervation while still on blood pressure medications. Renal denervation is the destruction of nerve fibers that run along the kidney blood vessels. This causes an interruption of nerve signals that may cause high blood pressure. Therefore, the effectiveness of the study catheter and the alcohol (Peregrine Kit) will be assessed by how well the treatment reduces blood pressure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02910414
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Inclusion Criteria:
age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
Exclusion Criteria:
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder
Heart & Vascular
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Location
Hershey, PA

The Daily Reflections Study

This 14-day daily diary study is being conducted to better understand how young adults' thoughts and feelings about their bodies influence their health behaviors, and how their daily experiences and characteristics contribute to their health behaviors. Participants will be asked to complete a 10-20 minute baseline survey and a brief (5-8 minutes) daily survey each day for 14 consecutive days. Surveys will include questions about participants' mental and physical health, emotions, relationships, health behaviors, thoughts, and experiences.
Anna Hochgraf at akh7@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Age 18-25 years
Enrolled in undergraduate degree program at Penn State
Access to internet between 8:00 AM and 12:00 PM
Proficient in English language
Exclusion Criteria:
Not between ages 18-25 years
Not enrolled in undergraduate degree program at Penn State
No access to internet between 8:00 AM and 12:00 PM
Not proficient in English language
Mental & Behavioral Health, Women's Health
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EXALT: EXercise Attenuates Liver Tumors Trial

Our goal is to better understand how exercise impacts patients with liver cancer in order to identify treatments that can improve outcomes and access to liver transplantation.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03979547
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Inclusion Criteria:
Adults age >=18 or <70 years
Liver cancer diagnosis (HCC)
absence of all detectable cancer after your treatment
Exclusion Criteria:
active heart problems
BMI <18 or >45 kg/m2
Severe medical or mental illness
Cancer
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Location
Hershey, PA

Zip-Stitch for Vaginal Cuff Closure in Laparoscopic Hysterectomy Safety &amp; Efficacy Study

This study will assess the safety and efficacy of the Zip-stitch System in maintaining vaginal cuff closure following laparoscopic hysterectomy. Participating subjects will be randomized and evaluated for implant passing, successful cuff closure, healing, adverse events and pain. Follow-up will involve in-person visits at approximately one week, six weeks, and six months. There will be an additional unblinded follow-up by telephone at 12 months post-operatively.
Heidi Watts at hwatts@pennstatehealth.psu.edu or 717-531-6272
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04081727
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Inclusion Criteria:
Women 18 years or older
Having a laparoscopic hysterectomy
Exclusion Criteria:
History of HIV, Hepatitis C, diabetes or known clotting defects or bleeding disorders
Active gynecological infection, sexually transmitted infection or pelvic inflamatory disease
Anemia
•Hemoglobin < 8g/dL
Pregnancy
Abnormal PAP results that have not been fully evaluated
Women's Health
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Location
Hershey, PA

Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Amanda Miller at aross1@pennstatehealth.psu.edu or 717-531-7676
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04137757
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Inclusion Criteria:
Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Exclusion Criteria:
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)
Heart & Vascular, Neurology
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Hershey, PA

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Ravulizumab in Complement-Inhibitor-Naïve Adult Patients With Generalized Myasthenia Gravis

The primary purpose of this phase 3 clinical trial is to evaluate the safety and efficacy of ravulizumab for the treatment of participants with generalized myasthenia gravis (gMG).
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03920293
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Inclusion Criteria:
Diagnosed with myasthenia gravis for at least 6 months
Myasthenia Gravis Foundation of America (MGFA) classification: Class II to IV
Weigh at least 40 kg (about 88 lbs)
Exclusion Criteria:
History of thymectomy (removal of the thymus gland) within 12 months
Active or untreated thymoma (tumor of the thymus gland)
History of meningococcal infection
HIV infection
Pregnancy
Neurology
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Hershey, PA

Collaborative Research: Measuring and Enhancing Scientific Creative Thinking for STEM Education and Research: Classroom-Aligned Assessment and Network Neuroscience-Based Mechanisms

The project is interested in understanding how the brain supports creative thinking in the context of solving scientific problems. During functional magnetic resonance imaging (fMRI) and behavioral experiments, participants will be presented with open-ended scientific questions and asked to produce responses.
James Lloyd-Cox at jll487@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Over 18 in age
English is first language
Right-handed
No history of neurological injury or disease
Under 300 lbs in weight
Exclusion Criteria:
Claustrophobic
Taking medication that affects brain or blood flow
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Location
State College, PA

S1612-A Randomized Phase II/III Trial of “Novel Therapeutics” versus Azacitidine in Newly Diagnosed Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS), Age 60 or Older

Purpose of this study is to compare any good and bad effects of using different new treatment options to one of the current standard treatment options given for patients with AML or MDS who cannot tolerate or do not want to get intensive chemotherapy.
Daniel Ward at dward1@pennstatehealth.psu.edu or 610-378-2336
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03092674
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Inclusion Criteria:
Untreated AML or MDS-EB-2
Patients must be ≥ 60 years of age
Patients must have disease present in the blood or bone marrow
Exclusion Criteria:
Patients with acute promyelocytic leukemia (APL), biphenotypic leukemia, blastic
Patients must not be known to have AML in the CNS.
Cancer
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Location
Reading, PA

Characterization and Exploration of Cognitive Assistants in the Space of Knowledge and Social Demands

The objective of this study is to investigate the effects of artificial intelligence on ideation in groups (specifically the process of brainstorming). Facilitation and facilitator/participant perceptions will also be analyzed. This study collects qualitative data through surveys, interviews, and audio/video recording.
Torsten Maier at torstennamaier@psu.edu or 812-781-0014
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Individuals must be 18 years of age or older
Individuals must be an undergraduate OR graduate student at Penn State
Exclusion Criteria:
Individuals under the age of 18
Individuals who are not an undergraduate OR graduate student at Penn State
Education, Language & Linguistics
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State College, PA

Using Exercise to Relieve Arthralgia (Joint Pain) and Improve AI Adherence in Older Survivors (REJOIN): A Pilot Study

Briefly, the purpose of this study is to use a self-management approach (combining education and exercise) to help older breast cancer survivors manage joint pain, a common side effect of aromatase inhibitors (AIs), a medication used to reduce hormones that might increase risk of recurrence and mortality following primary cancer treatment. We believe that reducing joint pain might help survivors take their medication longer and thus improve survival outcomes, compared to standard care.
Shirley Bluethmann at szb332@psu.edu
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03955627
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Inclusion Criteria:
Age 65 and older
Female
Breast Cancer Survivor
Preparing to Start AI medication
ER+ diagnosis
Exclusion Criteria:
Already taking AI medication (greater than 2 weeks)
Gross Cognitive Impairment
Recent Joint Surgery
Cardiac event/Stroke within last 6 months
Not willing to come to HMC for Exercise Sessions
Cancer
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Location
Hershey, PA

Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub Protocol

The Muscular Dystrophy Association (MDA) wants to collect information about individuals with neuromuscular disease to better understand the disease progression and ultimately improve the medical care, quality of life, and survival of those with neuromuscular disease. To collect this information, MDA has created a data registry called the Neuromuscular Observational Research Data Hub (referred to as the “MOVR Data Hub”). The MOVR Data Hub is a kind of database — a way of collecting and storing information.
All
All
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with a neuromuscular condition
Exclusion Criteria:
Unwilling to provide informed consent
Neurology
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Hershey, PA

Evaluating perceptions of teledermatology for people with Hidradenitis Suppurativa.

We would like to assess patient perceptions regarding willingness to use teledermatology services for people with hidradenitis suppurativa (HS).
Melissa Butt at mbutt1@pennstatehealth.psu.edu or 717-531-6117
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
18 years of age or older
Diagnosed with Hidradenitis Suppurativa
Can read and write in English
Access to the internet
Exclusion Criteria:
Less than 18 years old
No diagnosis of HS
No access to internet
Skin Conditions
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Understanding the Well-being of Advanced Counseling Students of Color

The primary objective of this study is to increase our understanding of the ways in which perceived discrimination, coping strategies, competence, stress, social support, and self-efficacy in counselor education programs relate to overall well-being for advanced counseling students of color.
Kyesha Isadore at kmi5@psu.edu or 337-326-3788
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Currently enrolled as a master’s or doctoral student in a counseling education program
18 years of age or older
Capable of providing informed consent without the assistance of a legal guardian
Identify as a racial or ethnic minority
Able to understand written and spoken English at the time of the survey
Exclusion Criteria:
Adults unable to consent
Individuals who are not yet adults (infants, children, teenagers)
Education, Mental & Behavioral Health
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The Influence of Estrogen-Status and Cardiorespiratory Fitness on Endothelial Signaling Pathways

Cardiovascular disease is the leading cause of death in women. Aerobic fitness is generally considered protective of vascular (blood vessel) health, but it is unclear whether this is true in postmenopausal women. The goal of this study is to understand whether aerobic fitness is beneficial for vascular health after menopause by evaluating signaling pathways that may be influenced by both menopause and fitness. Participants in this study will be healthy postmenopausal women who are either non-exercisers or regular exercisers. For the study, we will ask participants to complete 4 study visits at Penn State University. This will include health screenings, an exercise test, as well as measures of vascular health before and after 1 week of estrogen treatment.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Postmenopausal women (1-5 years postmenopausal)
50-60 years old
Regular Exerciser
Non-Exerciser
Healthy
Exclusion Criteria:
Cardiovascular Disease
Hormone Therapy Use or Long-term Menstrual Irregularities
High Blood Pressure or High Cholesterol
Smoker
Cardiovascular-related medications (blood pressure, cholesterol)
Heart & Vascular, Women's Health
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Location
State College, PA

The Effect of Resistance Exercise on Craving and Cannabis Use in Individuals with Cannabis Use Disorder

Cannabis is the most widely used illicit drug and rates of hazardous use, and cannabis use disorders (CUDs), have continued to rise in recent years. Increased exposure produces higher risk for detrimental psychological and behavioral effects of cannabis use. Given this increased prevalence of problematic cannabis use, identifying effective behavioral strategies for individuals experiencing problems with addiction would offer significant benefits. Exercise, particularly resistance exercise, is a behavioral intervention with considerable potential as an adjunctive treatment for CUD. No prior study has investigated the effects of an acute bout of resistance exercise on cannabis craving and consumption, nor has prior research identified what psychobiological mechanisms may underlie these exercise potentiated effects. The aims of this proposal seek to address these issues by implementing an acute resistance exercise protocol in men and women who have severe cannabis use disorder. This proposal will examine the acute effects of resistance exercise on craving, mood, anxiety, and markers of reward and stress regulation. In addition, this proposal will examine the trajectory of these effects in the subsequent days.
Gwendolyn Thomas at gat112@psu.edu or 814-863-3172
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Cannabis Use
Between 18-30 years old
Recreationally trained
Able to read write English and complete study evaluations
Provide negative toxicology screenings for nicotine or alcohol at intake
Exclusion Criteria:
Women who are pregnant or lactating
Known endocrine disorder
Blood clotting disorders
Any psychiatric disorder or current psychiatric symptoms
Inability to give informed consent
Addiction & Substance Abuse
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Study Locations

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Location
State College, PA

Examining contextual factors associated with food-related reward and eating restraint

Rates of obesity have risen sharply throughout the world over the past several decades. The increase in the availability of highly palatable, high-calorie foods may be one factor that has contributed to this trend. That is, the availability of such foods may lead to their over-consumption and corresponding weight gain. Currently, relatively little is known about how the availability of foods, per se, affects things such as the motivation to eat and the ability to resist doing so. The current study is designed to help address this knowledge gap by examining the effects of food availability in people with high levels of dietary restraint. Dietary restraint, which refers to the intention to restrict food intake deliberately in order to prevent weight gain or to promote weight, is linked to problematic patterns of eating. This project uses laboratory tasks and brain imaging to study the effects of food availability on various outcomes, including food choices, food craving, and responses in brain areas linked to motivation.
Josie Huang at suh438@psu.edu or 814-867-2333
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Participants must be between the ages of 18 and 45.
Participants must be right handed.
Participants must be fluent English speakers.
Participants must have a body mass index (BMI) >= 25.
Participants must have experienced food eating/weight issues.
Exclusion Criteria:
If participants are currently engaging in active dieting behaviors (e.g., a weight loss program) or they are taking medications that could alter appetite or body weight.
If participant have a lifetime history of diagnosed eating disorders, diabetes, hyperglycemia, high levels of triglycerides, or high cholesterol or other related medical conditions.
If participants have any known risk from exposure to high-field strength magnetic fields (e.g., pace makers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments.
If participants report that they are vegetarian/vegan.
If participants are not willing to refrain from using alcohol for 24 hours or from using nicotine products/recreational drugs for 3 weeks, or unwilling to fast from food for 5 hours prior to two of three lab visits.
Food & Nutrition, Mental & Behavioral Health
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State College, PA

Distance learning perception and experience investigation

In the study, we are trying to understand the relationship between the level of usage of the Zoom affordances and student’s class perceptions and experience in the remote class meeting. The survey method will be used to collect the data, and the statistical method will be used to analyze the data.
Yanting Wu at yxw514@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
at least 18 years old
is taking at least one remote class this time
is living in the U.S.
can read in English
Exclusion Criteria:
under 18 years old
is not living in the U.S.
Cannot read English
is not taking any remote class this time
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Vernacular Feature Comprehension and Perception in Persons with Aphasia

This study investigates whether persons with aphasia understand and process sentences with vernacular features in a manner similar to more typical populations. Participants will rate sentences on their naturalness and on whether they make sense, and they will also read sentences while we track their eye movements.
Frances Blanchette at fkb1@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
1. Diagnosis of aphasia
2. Sustained stroke more than 6 months prior to consent
3. Native speakers of English
4. Completed at least a high school education
5. Normal or corrected-to-normal vision and hearing
Exclusion Criteria:
1. History of degenerative neurological disorders (e.g., Alzheimer’s disease), acquired neurological disorders other than aphasia from stroke (e.g., traumatic brain injury), developmental neurological disorders (e.g., autism), or psychiatric disorders
2. An active medical condition that could compromise participation (e.g., cancer undergoing acute treatment)
3. Taking medications that are known to exert significant effects on cognitive processes
4. Do not meet the above inclusionary criteria
Language & Linguistics
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Location
Hershey, PA
State College, PA

Phones, Apps, and Sedentary Time

This study is examining the relationship between physical activity and smartphone use. Over a 10-day period, activity monitoring, questionnaires, and Apple Screentime software are used to track behaviors.
Abigail Faust at avf5371@psu.edu or 814-865-7935
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Between 13 to 29 years of age
Able to read, speak, and understand English
Must own or be the sole user of an iPhone smartphone
The iPhone owned or used by the participant must be version 5S or later
Exclusion Criteria:
Currently limiting smartphone use
Children's Health, Mental & Behavioral Health
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Location
State College, PA

Phase II Study of Bendamustine and Rituximab plus Venetoclax in Untreated Mantle Cell Lymphoma over 60 Years of Age

This study is to see if venetoclax in combination with bendamustine and rituximab chemotherapy is effective in treating people who have mantle cell lymphoma and to examine the side effects, good and bad, associated with this combination .
Jennifer Petrask at jpetrask@pennstatehealth.psu.edu or 717-531-8678
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03834688
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Inclusion Criteria:
Must have histologically confirmed (biopsy-proven) diagnosis of mantle cell lymphoma (MCL)
Must have measurable or evaluable disease as defined as a lymph node measuring >1.5 cm in any dimension or splenomegaly with spleen >15 cm in craniocaudal dimension
ECOG performance status of 0-2
Adequate organ function as measured by the criteria
Total Bilirubin ≤ 1.5x upper limit of normal (ULN) or ≤ 3x ULN with documented Gilbert’s syndrome
Exclusion Criteria:
Should not have known evidence of central nervous system (CNS) lymphoma
Should not have prior chemotherapy, radiotherapy or immunotherapy for lymphoma
Must not have received a prior allogeneic stem cell transplant or solid organ transplant (except for cornea) for any indication
Must have no active, uncontrolled infections
Must not have active hepatitis B or be chronic carriers of hepatitis B.
Cancer
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Study Locations

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Location
Hershey, PA