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583 Study Matches

Lexical and sentence processing in novice L2 learners: Psycholinguistic and neurocognitive investigations

We are studying how children and adults learn second languages in the classroom. To do this, we ask children and adults to read words or sentences in English and in Spanish while we record brainwaves using noninvasive sensors. The participant wears a cap that looks like a swimmers cap with the sensors attached to it.

Yes
 

Adriana (Janet) van Hell
Katharine Donnelly Adams - at kda11@psu.edu
Psychology (UNIVERSITY PARK)
 

All
Younger than 18 years old
This study is also accepting healthy volunteers
PRAMS00041301
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Inclusion Criteria:
Adults enrolled in third semester (intermediate) Spanish
Middle school students enrolled in first year Spanish
Monolingual English speaker
Right-handed
Normal or corrected-to-normal vision

Exclusion Criteria:
Not fluent in any language other than English
History of neurological disorders
Uncorrected vision
Education, Language & Linguistics
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State College, PA ,

The Blended4Blues Study

An intervention using an internet-based platform for coping and mood difficulties. Participants will be able to use cognitive-behavioral therapy (CBT) based online self-help modules over the course of a 10-week program.

Participants will engage with online materials on a weekly basis for 10 weeks.

$25

No
 

Michelle Newman
Jeremy Schwob - at jts462@psu.edu or 314-458-7375
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT00000000
STUDY00018688
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Inclusion Criteria:
Have access to a computer and/or or mobile phone with an internet connection and data plan allowing 90 min spent on treatment per week.
U.S. resident currently residing in the United States
Fluent in the English language in terms of speaking, listening, reading, and writing.
Aged 18-19 years
Presence of depressive symptoms as measured by a score ≥ 10 on the QIDS-17-SR

Exclusion Criteria:
Not a U.S. resident currently residing in the United States
Unable to speak, read, listen, and write English fluently.
Do not meet inclusion criteria for clinical depression on the QIDS-17-SR, i.e., score ≥ 10
Does not fulfill DSM-5 Criteria for MDE on the MINI Clinical Interview.
Expressed suicidal ideation defined as score >1 on the suicide ideation item on the PHQ-9, and/or on the MINI.
Mental & Behavioral Health
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An Open-Label, Randomized, Controlled Multi-Center Study of The Efficacy of Daromun (L19IL2 + L19TNF) Neoadjuvant Intratumoral Treatment Followed by Surgery and Adjuvant Therapy Versus Surgery and Adjuvant Therapy in Clinical Stage IIIB/C Melanoma Patients

The purpose of this study is to test the efficacy of Daromun neoadjuvant treatment followed by surgery and adjuvant therapy to improve in a statistically significant manner the recurrence-free survival (RFS) of Stage IIIB/C melanoma patients with respect to the standard of care (surgery and adjuvant therapy)

•Blood collection for laboratory tests•CT/MRI/PET/CT scans•ECG•Take study drug•Tumor assessment

Yes
 

Joseph Drabick
Laurie ONeal - at loneal1@pennstatehealth.psu.edu or 717-531-0003, ext=343429
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03567889
SITE00001259
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Inclusion Criteria:
Diagnosis of clinical stage IIIB and IIIC (AJCC v7) metastatic melanoma, eligible for complete surgical resection of all metastases (surgically resectable).
Eligible subjects must have measurable disease and must be candidate for intralesional therapy with at least one injectable cutaneous, subcutaneous, or nodal melanoma lesion
Males or females, age ≥ 18 years
ECOG Performance Status/WHO Performance Status ≤ 1.
Life expectancy of > 24 months

Exclusion Criteria:
Uveal melanoma or mucosal melanoma
Evidence of distant metastases at screening
Previous or concurrent cancer that is distinct in primary site or histology from the cancer being evaluated in this study except cervical carcinoma in situ
Presence of active infections
History within the last year of acute or subacute coronary syndromes including myocardial infarction, unstable or severe stable angina pectoris
Cancer
Experimental drug compared to an approved drug
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Hershey, PA ,

Using Apple Watches to Assess Substance Co-use in Young Adults (Project SPARC Pre-Pilot): a Feasibility Study

In this study, we aim to investigate the feasibility and usability of using Apple Watches to collect substance co-use data, as well as contextual data that could potentially be associated with substance co-use data (location, social context, mood, health, etc.)

No
 

Saeed Abdullah
Saeed Abdullah - at saeed@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00017735
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Inclusion Criteria:
Between 18-25 years of age
Currently owns and uses an iPhone with iOS version 15 or newer
Currently owns and uses an Apple Watch with watchOS version 8 or newer
Determined eligible through screener

Exclusion Criteria:
Eligibility determined using a screening survey
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PSCI 23-020: EA8212 A Randomized Phase III Trial of Intravesical BCG veRsus Intravesical Docetaxel and GEmcitabine Treatment in BCG Naïve High Grade Non-Muscle Invasive Bladder Cancer (BRIDGE)

If you decide to take part in this study, you will either get Gemcitabine and Docetaxel instilled through a catheter weekly in your bladder for up to 6 weeks, or you will get BCG instilled weekly in your bladder for up to 6 weeks. Your initial therapy may be followed with maintenance therapy.

If you decide to take part in this study, you will either get Gemcitabine and Docetaxel instilled through a catheter weekly in your bladder for up to 6 weeks, or you will get BCG instilled weekly in your bladder for up to 6 weeks. Your initial therapy may be followed with maintenance therapy.After you finish your treatment, your doctor will continue to follow your condition for 5 years with a combination of cystoscopies (inserting a telescope in your bladder) and CT scans (to take images of your body) in order to detect cancer recurrence.

Yes
 

Matthew Kaag
PSCI CTO Office at psci-cto@pennstatehealth.psu.edu or 717-531-5471
Urology (HERSHEY)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05538663
SITE00001374
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Inclusion Criteria:
Patient must be > 18 years of age.
Patient must have histologically confirmed high-grade non-muscle invasive urothelial carcinoma of the bladder (HgTa, HGT1, CIS, HgTa + CIS, or HGT1 + CIS stage)
Patient must have ECOG Performance Status 0-2.
Patient must have all visible papillary tumor resected by the treating urologist at the site registering the patient to this protocol prior to randomization.
Patient may have received prior systemic gemcitabine or docetaxel use if it was for a non-bladder malignancy

Exclusion Criteria:
Patients must not have prostatic urethral involvement
Patient must have not received prior intravesical therapy for bladder cancer, with the exception of perioperative chemotherapy at the time of TURBT.
Patient must not have pure squamous cell carcinoma or adenocarcinoma.
Patient must not have any component of neuroendocrine carcinoma (i.e., small cell or large cell).
Patient must not have any component of sarcomatoid, micropapillary, or plasmacytoid variant histology.
Kidney & Urinary System
Experimental drug compared to an approved drug
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Hershey, PA ,

Early Identification in Older Adults of Risks to Sleep Health, Movement, and Cognition Using Ecological Methods

This proposal is a prospective study in which we will collect both subjective and objective quantitative data from older adults residing in independent living retirement communities, microlongitudinally (~1wk). Comprehensive measures of sleep health, cognition, and movement will be collected at community residences. The first phase of this project will recruit local, State College area adults over 70 residing in independent living facilities (e.g., Foxdale Village and The Village at Penn State). A second phase of data collection will extend to community-based older adults in rural parts of Centre and nearby counties.With this prospective, microlongitudinal information we will evaluate the characteristics of sleep predictive of daytime cognitive and neurobehavioral function and use those conclusions to inform nonpharmacologic, preventative interventions for older adults.

After consent, there will be 6 study visits at either Penn State University Park campus or at the participant's personal residence. Study participation lasts about 1 week.Participants wear non-invasive ambulatory watch-like activity monitors throughout (both day and night) the week. Participants complete electronic surveys and cognitive tests 6 times daily, with additional surveys at study conclusion.Sleep and daytime brain and heart activity are recorded (without video) using non-invasive clinical-type wire sensors applied to the face, head, and chest. Wires are worn on the face, head, and chest throughout the first two study nights. Wires are worn on the head and chest throughout the first two study days. There is not a sleep intervention in this study. We are collecting data about the typical sleep health of older adults and its relation to cognitive health.

$350

Yes
 

Orfeu Buxton
Margeaux Gray - at ecosleep@psu.edu or 814-863-5800
Biobehavioral Health (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00011786
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Inclusion Criteria:
>=50 and <91 years of age
Resident of PA, Centre County region
Living without functional assistance
Able to walk unassisted for at least 5min

Exclusion Criteria:
Previous participants are not eligible
Evidence of cognitive impairment (will be tested)
Men's Health, Sleep Management, Women's Health
Not applicable
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State College, PA ,

Telehealth Navigation for Informed Prostate Cancer Screening in Black Men

This study is being conducted to determine whether patient navigation improves informed decision making for prostate cancer screening. Participants will be offered the opportunity to discuss and address issues related to PSA testing with a patient navigator over a one month period. Surveys at the beginning and end of this period will include health knowledge, opinions on telehealth, and barriers to health care. All sessions will be conducted virtually.

Complete short on-line questionnairesComplete at least one telehealth session with the Patient Navigator

100

No
 

Joshua Muscat
Chrispin Bandakulu - at ckayembebandakulu@pennstatehealth.psu.edu or 717-531-5274
Public Health Sciences (HERSHEY)
 

Male
18 year(s) or older
This study is also accepting healthy volunteers
NCT00000000
STUDY00019025
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Inclusion Criteria:
black men
ages 45 to 70
spoken english language

Exclusion Criteria:
history of prostate cancer
Men's Health, Prevention, Cancer
Not applicable
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A qualitative exploration of rurality, physical activity, and intervention preferences among older residents in Pennsylvania

This study will use interviews to explore to explore perceptions of rurality, physical activity behaviors and physical activity intervention preferences among rural older adults who live in Pennsylvania

No
 

Nishat Bhuiyan
Nishat Bhuiyan - at nxb49@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00014534
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Inclusion Criteria:
At least 50 years old
Currently residing in Pennsylvania
Able to speak, read, and write in English

Exclusion Criteria:
Below age 50
Not currently residing in Pennsylvania
Not able to speak, read, and write in English
Prevention, Mental & Behavioral Health
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Identification of Critical Thermal Environments for Aged Adults

The earth’s climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely exercise in warm and/or humid conditions. It is important to learn about safe limits of heat and humidity for older adults to exercise. Also, nearly 40% of adults over age 50 take aspirin to lower their risk for heart disease. Our lab has shown that aspirin lowers the control of body heat.In this study, we will determine critical temperature and humidity environments above which normal body temperature cannot be maintained in young and older adults. We will also look at how aspirin may change critical temperature and humidity thresholds in older adults.

There will be 4 in person visits and sit, walk, or cycle at a low intensity in an environmental chamber.

360

Yes
 

William Kenney, Jr.
Susan Slimak - at sks31@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04284397
STUDY00014062
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Inclusion Criteria:
Healthy subjects 18 and older
Asymptomatic and no signs/symptoms of disease

Exclusion Criteria:
Have any conditions to advise against low-intensity physical activity
History of Crohn's disease, diverticulitis, or other similar gastrointestinal disease
Medications that could alter cardiovascular responses or body temperature regulation during exercise (blood pressure reducers, fever reducers, anti-depressants, etc.)
Tobacco or recreational drug use
Post-menopausal women taking hormone replacement therapy
Heart & Vascular, Sports Medicine
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State College, PA ,

ATHN 10: Rare Coagulation Disorders Project

This is a multi-center project in which the American Thrombosis &amp; Hemostasis Network (ATHN) will offer free genotyping to individuals with Rare Coagulation Disorders (RCD).

One tube of blood will be collected during a routine clinic visit.

Yes
 

M. Elaine Eyster
Bree Kelly - at jhawthorne@pennstatehealth.psu.edu or 717-531-0003, ext=281498
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
All
This study is NOT accepting healthy volunteers
SITE00000669
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Inclusion Criteria:
Subject must have an established Rare Coagulation Disorder diagnosis (
Must currently receive or have received care at and ATHN affiliated HTC
Subject must have opted into the ATHNdataset

Exclusion Criteria:
Subject is unwilling to sign informed consent form
Blood Disorders
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Hershey, PA ,

Understanding experiences of international students with healthcare and antibiotics

This study examines the experiences of international students with regard to upper respiratory illnesses, healthcare, and use of antibiotics in their home countries and in the United States. The findings of the study will inform the development of training to improve healthcare providers’ communication skills for discussing antibiotics with international students.

Complete one online survey, which takes approximately 20 minutes.

10.00

No
 

Erina Farrell
Erina Farrell - at elm26@psu.edu
Communication Arts and Sciences (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00021922
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Inclusion Criteria:
18 years of age or older
College/university undergraduate or graduate student at a U.S. university
born and raised in and is currently a citizen of China, India, or South Korea
English speaking
lived in the United States for less than 7 years

Exclusion Criteria:
Less than 18 years of age
Not a college or university student at a U.S. university
Not born or raised in and currently citizen of China, India, or South Korea
Not English speaking
Lived in the United States more than 7 years
Infectious Diseases & Immune System
Not applicable
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Modifiable Prevention and Early Intervention Targets for Unhealthy Eating Behaviors: A Study in First Year Undergraduates

This is a research study investigating the prevalence and manifestation of unhealthy eating behaviors and the relationships of energetic status, cognitive function, and reproductive health in a population of first year college students.

Phase 1 will involve a minimum of 1-2 visits, and completion of surveys about your general health, exercise and nutrition history, eating behaviors and attitudes, stress, and reproductive health, as well as cognitive testing and hair sampling. For those who qualify, Phase 2 will involve approximately 4 additional visits. Each visit will be about 2 hours. The visits include completion of surveys about general health, exercise and nutrition history, eating behaviors and attitudes, stress, and reproductive health, as well as cognitive testing and physiological measurements including blood and hair sampling, and tests of metabolism. Study participation will last at minimum about 1 week, and at maximum completion of Phase 1 and Phase 2 will occur over the course of a full academic year.

$25 per visit, up to $75

Yes
 

Nancy Williams
Jaime Rodden - at whel@psu.edu
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00022878
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Inclusion Criteria:
First Year College Student
Age 18-25 Years
BMI 16.5-30 kg/m2
No apparent metabolic, endocrine, or musculoskeletal disease.

Exclusion Criteria:
Pregnancy or intention to become pregnant in the next 9 months
Serious or chronic health condition (including thyroid illness, metabolic disease)
Unwilling to adhere to study protocol
Lactating
Does not speak English or are unable to give consent
Men's Health, Mental & Behavioral Health, Women's Health
Not applicable
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State College, PA ,

Penn State SELF - Student Engagement, Learning and Flourishing

Substance misuse is a leading national problem, with young adults at high risk. We aim to develop a university resource that elucidates biobehavioral underpinnings of problematic student substance use at University Park campus. This initiative would inform services needed, provide engaged learning opportunities, connect with faculty, and catalyze high-impact, interdisciplinary research. In addition to this primary rationale, this study will allow us to capture detailed information about other critical student experiences such as food and housing insecurity, experiences of discrimination, and daily health practices to prevent the transmission of COVID-19. Participants will be asked to take a baseline survey followed by a 21- daily diary protocol (brief 5 minute survey each day for 21 days. For more information or to register interest in participating please see: https://projectself.psu.edu/register-your-interest/

No
 

Stephanie Lanza
Courtney Whetzel - at projectSELF@psu.edu
Methodology Center (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00015710
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Inclusion Criteria:
Undergraduate at PSU
Enrolled at UP
18-24 years old

Exclusion Criteria:
Non-students
Part-time students
Students located in the EEA
Older than 24
No graduate students
Smoking, Vaping, Nicotine and Tobacco, COVID-19, Mental & Behavioral Health
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Understanding University Students' Daily Interaction with ChatGPT through the Lens of Self-Determination Theory

This study aims to learn about how university students interact with ChatGPT and how ChatGPT's support of autonomy, competence, and relatedness could either help or hinder students' ability to learn. We will interview students to understand how ChatGPT supports student learning and identify any challenges that may arise.

There will be a 60-minute interview.

$10

No
 

Jiyoon Kim
jxk6167@psu.edu
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024072
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Inclusion Criteria:
Students
Use ChatGPT for their daily lives
Over 18 years old
Speak English
Students from non-EU countries

Exclusion Criteria:
Non-students
Under 18 years old
Do not use ChatGPT for their daily lives
Non-english speaker
Students from EU countries
Education
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Driver Training on the Advanced Driving Assistant System

This research aims to study the training knowledge that is essential for drivers to use Advanced Driving Assistant Systems safely and properly and identify the optimal training approaches.

If you participate in the first experiment, you will receive training of the in-vehicle system via videos and manuals, complete a driving task on the driving simulator, and answer questions from questionnaires. If you participate in the second experiment, there will be two visits. In the first visit, you will receive training via watching and interacting with online videos, watching an experimenter operating ADAS at the test track, or practicing the functions of ADAS in a vehicle at the test track. The functions in the training include adaptive cruise control, lane-keeping assistance, and Highway Driving Assist. In the second visit, you will complete a driving task on the driving simulator and answer questions from questionnaires.

$30 for experiment1 and $60 for experiment 2

Yes
 

Yiqi Zhang
Ruby Kim - at rubykim@psu.edu
Industrial and Manufacturing Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020300
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Inclusion Criteria:
Being over 18 years old
Being fluent in English
Have a valid driver license for at least one year
have normal vision or corrected vision only wearing contact lenses

Exclusion Criteria:
NA
Education, Mental & Behavioral Health, Women's Health
Not applicable
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State College, PA ,

Evaluation of calf muscle size and structure after an Achilles tendon rupture

The objective of this study is to compare to different methods of measuring the size of calf muscles: magnetic resonance (MRI) and ultrasound imaging. Participant will undergo a MRI scan (about 1 hour) and an ultrasound imaging session (about 1 hour). Images obtained from patients with Achilles tendon rupture will also be used to determine the feasibility of quantifying damage to the soleus muscle.

After you accept participating demographic questions will be asked. You will also be asked standard MRI safety/screening questions. These questions are used to determine that it is safe for you to participate in MRI research. You will be asked to leave metal objects and personal belongings and to remove any articles of clothing with metal before entering the MRI room. Please ask the experimenter if you are unsure about any items. If it is safe, an MRI will be performed on your leg. Additionally, several images will be taken from your leg using ultrasound. The ultrasound and MRI sessions can be performed the same day or in different days depending on your preference. Depending on scheduling constraints at the MRI facility, you may be scheduled for the ultrasound session first.

You will receive $25 after completing the MRI and $25 after completing the ultrasound imaging sessions.

Yes
 

Daniel Cortes Correales
Daniel Cortes - at dhc13@psu.edu or 814-863-3103
Mechanical and Nuclear Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04727047
STUDY00019121
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Inclusion Criteria:
Healthy individuals

Exclusion Criteria:
Contraindications to MRI
Previous Achilles injury (only for healthy individuals)
Muscle & Bone
Not applicable
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State College, PA ,

Defining the role of slow eye movements on limb motor control in younger and older adults

The purpose of this study is to define how eye movements contribute to eye-hand coordination in individuals of the age group 18-50 (young adults) and 65-80 (older adults). Specifically, the aim of the study is to understand how slow eye movements affect arm and hand movements. All procedures to be used in our study will be non-invasive. The task during the study will be performed with a robotic handle that participants will grasp with their right hand. They will interact with visual stimuli by moving the robotic handle. The robotic environmentwill attempt to simulate real-world mechanical interactions, such as those experienced during catching a ball.

During this study, we will ask you to come to our laboratory located in 23 Recreation Building,Pennsylvania State University, on two days separated by a maximum of 48 hours. Both sessions will last approximately 90-120 minutes. During the first session, we will review the procedures with you and if you agree to participate, you will sign this form and then proceed to perform the study. You will perform about 20-25 blocks of hand movements. Each block will consist of 24-30 trials and each trial will last between 3-5 seconds.The second day will be identical to the first day but the order of trials within a block will be changed.

$10/hour

Yes
 

Tarkeshwar Singh
Tarkesh Singh - at tsingh@psu.edu or 814-865-7851
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00024035
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Inclusion Criteria:
Participants should be between 18-80 years old.
Participants will be right-hand dominant individuals.
They will have normal or corrected-to-normal vision.
Participants should be able to sit upright in a chair for long periods (up to 2 and a half hours) with rest.
Participants should be able to grasp and move objects with both hands.

Exclusion Criteria:
Any history of neurological disorders.
Any history of musculoskeletal disorders
Eye or vision problems (e.g., cataracts, glaucoma, a detached retina or macular degeneration).
Cognitive impairment
Medication that could make the participant drowsy or tired during the experiment.
Neurology, Muscle & Bone, Vision & Eyes
Not applicable
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State College, PA ,

Respect and Satisfaction in Same-Sex Romantic Relationships

The purpose of this study is to expand on previous research looking at respect and relationship satisfaction among heterosexual relationships and compare it to that of same-sex relationships to find where they are similar or different. Participants will complete self-report measures regarding their romantic relationships, including respect toward partner, satisfaction, and attitudes toward love. 30 minutes will be required for the study.

No
 

Michelle Yarwood
Michelle Yarwood - at mxg925@psu.edu or 814-867-4851
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00014276
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Inclusion Criteria:
age 18 years or older

Exclusion Criteria:
younger than 18 years of age
Men's Health, Mental & Behavioral Health, Women's Health
I'm interested
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Identifying views of Military Veterans Regarding Contemporary War and Conflict Reporting

This study will involve surveying and interviewing US military veterans and non-veterans regarding their perceptions of the quality, accuracy, and themes of contemporary war and conflict reporting.

No
 

Hans Schmidt
Hans Schmidt - at hcs10@psu.edu or 610-892-1251
Academic Affairs (BRANDYWINE)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00007749
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Inclusion Criteria:
College Student
Military Veteran
Current Member of the Military
Non-Military Civilians

Exclusion Criteria:
Under age 18
I'm interested
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Daily Thought Monitoring Study for Anxiety and Depression

This study aims to assess the relations among our daily thought patterns, positive emotions, everyday experiences, and cognitive functioning abilities. Eligible participants will complete a series of online questionnaires, a short 15- to 25-minute psychological interview, and brief cognitive functioning tests at Day 1 and Day 16. All visits will occur via Zoom. In between study visits on Day 1 and Day 16, they will be prompted to complete smartphone-delivered assessments of cognitive functioning, symptoms, and experiences for 14 days, 5 times a day. This is important to inform clinicians and researchers on how best to develop effective digital mental health therapies.

During Day 1, participants will undergo a brief 15- to 25-minute clinical interview over Zoom. After the clinical interview, if participants meet the study eligibility criteria, we will continue with the procedures outlined below. Otherwise, if they are ineligible for the study, we will mention that this study is not suitable for them and provide the contact of mental health treatment services. Eligible participants will then conduct a series of self-report questionnaires and performance-based cognitive functioning tests for the next 35 minutes. Participants will then complete a series of 14-day brief ecological momentary assessments administered on their smartphone five times a day, for 14 days. Last, participants will return for a 35- to 45-minute visit on Day 15 to complete a series of self-report questionnaires and performance-based cognitive functioning tests.

15

No
 

Michelle Newman
Nur Hani Zainal - at nvz5057@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00018534
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Inclusion Criteria:
Over 18 years of age
Owns an Android or iPhone
Fluent in the English language
Scores on self-report questionnaires suggest person does or does not struggle with depression and/or anxiety
Pregnant women will be allowed to participate

Exclusion Criteria:
Owns a Life’s Good Android phone brand that does not support the app
Unable to consent
Younger than 18 years of age
Reports struggling with suicidal thoughts
Judged to have alcohol, substance use, and/or eating disorder
Men's Health, Mental & Behavioral Health, Women's Health
I'm interested
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Understanding Information Needs and Challenges faced by International Spouses during Adjustment

The study examines ways in which technology can be designed to provide support and services to international spouses during their adjustment to a new host environment. In particular, we would like to investigate the needs of spouse’s communities, the challenges faced by this population during adjustment, and propose design implications for developing systems and services to improve their access to social services and to promote community development and civic engagement.

Yes
 

Jomara Sandbulte
Jomara Binda - at jmb89@psu.edu
Information Sciences and Technology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00007486
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Inclusion Criteria:
Individuals who understand English
Individuals who hold a dependent (F-2/J-2) visa status

Exclusion Criteria:
Non-English speakers
Age under 18
Non-dependents (F-2/J-2) visa status
Anyone who cannot consent to participate in this study
I'm interested
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State College, PA ,

Attention and Emotional Development in Children

Children with attention problems often feel anxious or worried, and likewise, children who are anxious or worried often have problems with attention. We are looking for children aged 8-12 who may or may not have problems with attention or anxiety to help us understand what happens in the brain that could explain why. You will receive up to $100 gift card for your participation, and informal clinical feedback on your child.

Two in person visits of 2 hours each to the University Park campus, scheduled at the participant(s) convenience

$100

Yes
 

Cynthia Huang-Pollock
Christina Hlutkowsky - at ChildAttention@psu.edu or 814-863-0250
Psychology (UNIVERSITY PARK)
 

All
All
This study is also accepting healthy volunteers
STUDY00005954
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Inclusion Criteria:
Children aged 8-12

Exclusion Criteria:
Children outside of the 8-12 age range
History of seizures or photosensitive epilepsy
Children's Health, Mental & Behavioral Health
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Altoona, PA ,
State College, PA ,

PSCI# 18-049 A PHASE II, DOUBLE-BLINDED, PLACEBO-CONTROLLED RANDOMIZED TRIAL OF SALVAGE RADIOTHERAPY WITH OR WITHOUT ENHANCED ANTI-ANDROGEN THERAPY WITH APALUTAMIDE IN RECURRENT PROSTATE CANCER

To determine whether, in men with post-prostatectomy PSA recurrences, salvage radiation (SRT) with enhanced anti-androgen therapy with apalutamide will improve biochemical progression-free survival (bPFS) compared to SRT alone.

To determine whether, in men with post-prostatectomy PSA recurrences, salvage radiation (SRT) with enhanced anti-androgen therapy with apalutamide will improve biochemical progression-free survival (bPFS) compared to SRT alone.

Yes
 

Joseph Miccio
Kathleen Rizzo - at kar23@psu.edu
Radiation Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03371719
SITE00000428
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Inclusion Criteria:
Pathologically (histologically) proven diagnosis of prostate adenocarcinoma.
Post-prostatectomy patients with a detectable serum PSA (≥0.1, but ≤1.0 ng/mL) at study entry (within 90 days of Step 1 registration) a
pN0 or pNx
History/physical examination within 90 days prior to Step 1 registration
Karnofsky performance status of 70-100 within 90 days prior to Step 1 registration

Exclusion Criteria:
Definitive clinical, radiologic, or pathologic evidence of metastatic disease (M1) or lymph node involvement (N1)
Prior invasive malignancy (except non-melanomatous skin cancer, carcinoma in situ of the male breast, penis, oral cavity, or stage Ta of the bladder, or stage I completely resected melanoma) unless disease free for a minimum of 2 years
Prior systemic chemotherapy for the study cancer
Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields;
Prior whole gland ablative therapy
Cancer
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Hershey, PA ,

Study Driver Characteristics in Mixed Traffic with a Driving Simulator

This is a driving simulator behavioral study. This study aims to investigate drivers' subjective feelings and driving performance in mixed traffic shared by automated vehicles and human-driven vehicles.

This study aims to investigate the effects of drivers’ driving style and automated vehicle penetration rate on drivers’ subjective feelings and driving performance in mixed traffic shared by automated vehicles and human-driven vehicles. There will be one in-person visit for the experiment. This experiment involves driving on a driving simulator and filling out several questionnaires.

$15/hour

Yes
 

Yiqi Zhang
Book Chen - at hbc5417@psu.edu
Industrial and Manufacturing Engineering (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00020200
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Inclusion Criteria:
Being fluent in English
Have a valid US driver license for at least one year
Have normal vision or corrected vision only wearing contact lenses

Exclusion Criteria:
NA
Education, Mental & Behavioral Health, Language & Linguistics
Not applicable
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State College, PA ,

Second Language Learners’ Language Development in Different Modes: Focusing on Complexity, Accuracy, and Fluency

The current study aims to investigate the development of English as a Second Language (ESL) learners' language skills over time, focusing on the interplay between the mode of production (i.e., speech versus written mode) and linguistic features related to complexity, accuracy, and fluency. To address this question, the study will collect spoken and written data from ESL learners in the U.S. at five measurement points throughout an academic year (FA23 to SP24), analyzing their production data using various complexity, accuracy, and fluency measures. The objective is to contribute to the existing body of second language (L2) development research by examining whether the interaction among time, production mode, and proficiency, as well as the varying relationships among the measures, significantly influence the observed outcomes.

Over the course of an academic year (FA23 to SP24), participants will attend five in-person visits, spaced at 7-week intervals. During each visit, they will be asked to write an essay for 20 minutes and deliver a 5-minute spoken monologue in response to prompts similar to those found in the TOEFL speaking section.

$75 ($15 per visit)

Yes
 

Minjin Kim
Minjin Kim - at mmk6337@psu.edu
Division of Graduate Studies (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00022713
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Inclusion Criteria:
18 or older
non-native English speakers
first-year undergraduate students or students in Intensive English Communication Program

Exclusion Criteria:
younger than 18
native English speakers
not living in the US
Education, Language & Linguistics
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State College, PA ,

Attention for Neoteny Among Distractors

This is a reaction time study where participants need to detect a stimuli among distractor stimuli. This study will examine whether physical immaturity (also called neoteny) has preferential attentional mechanisms by asking participants to detect neotenous stimuli among other neotenous stimuli and non-neotenous stimuli as distractors.

Yes
 

Karin Machluf
Karin Machluf - at kxm5600@psu.edu
Social Sciences and Education (SCRANTON)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
STUDY00006614
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Inclusion Criteria:
Any adult over the age of 18 years
Opens to males and females

Exclusion Criteria:
Anyone under the age of 18 years old
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Wilkes-Barre/Scranton Area, PA ,

Asymmetries in Cognitive Aspects of Motor Control and Learning

This study will improve our understanding of movement control and how strokes of different sides affect overall independence. Participants will complete the visit seated at a chair with sensors connected to the less-affected arm. They will then play a short virtual reality game and complete several questionnaires and assessments.

Yes
 

Robert Sainburg
Shanie Jayasinghe - at sjayasinghe@pennstatehealth.psu.edu or 717-531-0003, ext=283146
Kinesiology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
STUDY00015871
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Inclusion Criteria:
Right handed (pre-stroke)
Neurological confirmation of unilateral stroke
Severe paresis on one side only
Adults over the age of 18
Chronic stage of stroke (>3 months post stroke)

Exclusion Criteria:
Left-handed (pre-stroke)
Neuro radiological confirmation of extensive periventricular white matter changes
History of neurological diseases other than stroke
Significant joint pain that is activity limiting
Neurology
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Hershey, PA ,

PSCI# 24-014 OPTIMICE-PCR: DE-ESCALATION OF THERAPY IN EARLY-STAGE TNBC PATIENTS WHO ACHIEVE PCR AFTER NEOADJUVANT CHEMOTHERAPY WITH CHECKPOINT INHIBITOR THERAPY

this trial is examining what happens if a less toxic therapy is given to triple negative breast cancer subjects who's tumor is completely gone after receiving pre surgery chemotherapy.

Participants will need to come to all research visits, reports any side effects of medication, if they are taking any over the counter medications.

Yes
 

Cristina Truica
PSCI-CTO@pennstatehealth.psu.edu 717-531-5471
Medicine: Hematology and Medical Oncology (HERSHEY)
 

All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05812807
STUDY00024629
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Inclusion Criteria:
Age ≥ 18 years
ECOG Performance Status 0-2
Triple Negative Breast Cancer
Patients must have received neoadjuvant chemotherapy in combination with pembrolizumab for a minimum of 6 cycles. All systemic chemotherapy must have been completed preoperatively.
An interval of no more than 12 weeks between the completion date of the final surgery and the date of randomization.

Exclusion Criteria:
No stage IV (metastatic) breast cancer
No history of any prior (ipsi- or contralateral) invasive breast cancer. Prior DCIS is allowed.
No evidence of recurrent disease following preoperative therapy and surgery.
No known active liver disease, e.g. due to HBV, HCV, autoimmune hepatic disorders, or sclerosing cholangitis
Cancer
Approved drug(s)
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Hershey, PA ,

Advanced fMRI Study on the Functional Abnormality of BNST in Anorexia Nervosa Restricting-type

This research is being done to better understand how certain parts of the brain may react differently in people who have a particular eating disorder, anorexia nervosa, which may help us understand why they respond to food in the way they do. This may help us design more effective treatments for people with anorexia nervosa.

You will complete a package of surveys for personality, psychopathology, an evaluation of taste functions, and an MRI/fMRI examination.

Up to a total of $100.

Yes
 

Jian-Li Wang
Nicholas Corbett - at ncorbett@pennstatehealth.psu.edu or 717-531-0003, ext=323023
Radiology (HERSHEY)
 

Female
All
This study is also accepting healthy volunteers
STUDY00021467
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Inclusion Criteria:
Age 10 to 24 years-old female
Anorexia nervosa restricting type patients
Healthy volunteer with normal body weight
Right-handed
Fluent in written and spoken English

Exclusion Criteria:
Left-handed
Pregnancy or breastfeeding
History of diabetes, substance abuse, head trauma
Allergy to milk and milk products
Cannot have MRI due to claustrophobia or specific implants
Children's Health, Mental & Behavioral Health
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Hershey, PA ,

Audio-based mental health intervention study

This study tests the effect of an audio-based mental health intervention for symptoms of depression. Participants will be asked to listen to an audio program and perform exercises to support their mental health as suggested by the program. Participants will be asked to complete questionnaires about their depression and related mental health symptoms at pre-intervention, mid-intervention, post-intervention, and follow-up.

The study takes place over five total weeks, with four survey sessions (the first two of which are live on Zoom), and two weeks of brief daily surveys. Detailed information is below.For the first day, participants would be asked to complete Visit 1, which involves an interview, listening to a mental health audio program, and completing surveys. One week later, participants would be asked to complete Visit 2, which involves listening to another mental health audio program and completing surveys. One week after that, participants would be asked to complete Visit 3, which involves completing surveys. Three weeks after that, participants would be asked to complete Visit 4, which involves completing surveys. For the week following Visits 1 and 2, participants would also be asked to complete daily surveys.

Up to $40

No
 

Gavin Rackoff
Gavin Rackoff - at gnr18@psu.edu
Psychology (UNIVERSITY PARK)
 

All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05555745
STUDY00020667
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Inclusion Criteria:
Age 18 or older
Moderate or higher depression symptoms as indicated by survey and interview

Exclusion Criteria:
Below 18 years of age
Score below moderate depression symptom range in survey and/or interview
Mental & Behavioral Health
Not applicable
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