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Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.

417 Study Matches

A volunteer study to determine the anatomical distribution of injectate, the extent of sensory block, and the pharmacokinetics of ropivacaine following Erector Spinae Plane (ESP) blocks.

This study will recruit healthy volunteers to determine the effect of a peripheral nerve block. The participants will get an injection in their back muscle after an intravenous line is placed in their hand or arm. After the injection they will have two MRI done at 30 and 90 minute time intervals. A half tablespoon of blood also will be taken through the IV line already placed 6 times during the study period starting just before to Peripheral nerve block placement up to four hours post injections. They will be discharged from the study after half an hour of the last blood sample. During this whole process they will be monitored for their blood pressure, oxygen saturation and other effects related to the procedure.
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03476642
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Inclusion Criteria:
Healthy adults ages 18 to 60
Weight between 55kgs (~120lbs) and 100kgs (~220lbs)
Height 160cms (~5ft 3in) to 190cms (~6ft 3in)
Exclusion Criteria:
Pregnant females, chronic medical condition requiring medication
History of previous major spinal, abdominal or thoracic surgery, 4. Congenital abnormalities of the spine, back, thorax or abdomen
History of major trauma to the thorax or abdomen; 6. Allergy to ropivacaine or other amide local anesthetics
The presence of any metallic implant in their body, 9. Allergy to Gadolinium radiological contrast agent
Any contraindication to magnetic resonance imaging as determined by completion of a standard questionnaire administered to all patients undergoing magnetic resonance imaging.
Prevention, Muscle & Bone, Pain Management
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Hershey, PA

A phase III, randomized, double blind, parallel group, placebo controlled, international, multicentre study to assess efficacy and safety of Cx601, adult allogeneic expanded adipose-derived stem cells (eASC), for the treatment of complex perianal fistula(s) in patients with Crohn’s disease over a period of 24 weeks and a follow-up period up to 52 weeks. ADMIRE-CD II study.

This study is for patients with Crohn's disease which involves an investigational new drug to treat perianal fistulas in patients with Crohn’s disease (CD). The purpose of this study is to find out: 1) How well the study drug works at a single dose compared to a placebo; 2) how safe and tolerable the study drug is in patients with fistulizing CD.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03279081
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Inclusion Criteria:
Diagnosis of Crohn's Disease for at least 6 months
Presence of complex perianal fistulas
Clinically controlled, non active or mildly active CD during the last 6 months
Patients whose perianal fistulas were previously treated and have shown an inadequate response
Exclusion Criteria:
Any major surgery of the GI tract within past 6 months
Patients without prior specific treatment for perianal complex fistulas
Patients with diverting stomas
Patients with active, uncontrolled infection requiring IV antibiotics
Patients with allergies or hypersensitivity to penicillin or aminoglycosides, local anesthetics or MRI contrast
Infectious Diseases & Immune System, Digestive Systems & Liver Disease
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Hershey, PA

The role of nuclear factor from activated T-cells (NFAT) in microvascular dysfunction

High blood pressure can lead to cardiovascular disease (CVD). CVD is a leading cause of illness and death in the United States. This research explores some of the ways high blood pressure impairs blood vessel function. This study uses minimum-risk procedures (flow meditated dilation, skin biopsy, and microdialysis) to explore the mechanisms underlying the impaired blood vessel function. We conduct experiments before and after 7-day treatment with FDA-approved drugs Telmisartan (prescribed to treat high blood pressure) and Tacrolimus (prescribed to treat eczema). The results of this study could suggest new ways to diagnose and treat high blood pressure. The expression of NFAT isoforms are altered in essential hypertensive vascular tissue and that short term telmisartan decreases NFAT-mediated cytokine production in hypertensive adults. We predict that 7 days of Telmisartan will alter the expression profiles of NFATc1 and NFATc3 and improve endothelial function and vascular smooth muscle cell responsiveness.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women, 40-70 years of age
Normal or high blood pressure
Non-obese, BMI ≤ 32
Normal HbA1C of <6.5%
Not pregnant or breastfeeding
Exclusion Criteria:
Rash, skin disease, disorders of pigmentation
Diabetes, kidney, liver disease
Taking heart and blood pressure drugs
Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
Low blood pressure, < 90/60 mmHg
Heart & Vascular
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State College, PA

Assessing hair care practices in pediatric patients

Examining the differences/trends in hair care maintenance for all ethic type in the treatment of seborrheic dermatitis.
Melissa Butt at mbutt1@pennstatehealth.psu.edu or 717-531-6117
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Must be 18 years of age or older
Parent of at least 1 child under the age of 18
Access to the Internet
Exclusion Criteria:
All children are over the age of 18
Skin Conditions
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Site for LungMAP: A MASTER PROTOCOL TO EVALUATE BIOMARKER-DRIVEN THERAPIES AND IMMUNOTHERAPIES IN PREVIOUSLY-TREATED NON-SMALL CELL LUNG CANCER

This is a screening study and there is no treatment. The purpose of this study is to collect blood samples to determine if you are able to participate in other LUNGMAP studies.
Irina Geier at iug29@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
pathologically proven non-small cell lung cancer
at least one line of systemic therapy for any stage of disease
Patients with known EGFR sensitizing mutations, EGFR T790M mutation, ALK gene fusion, ROS 1 gene rearrangement, or BRAF V600E
Patients must have Zubrod performance status 0-1
Patients must be ≥ 18 years of age.
Exclusion Criteria:
Patients must be willing to provide prior smoking history as required on the LungMAP Onstudy Form.
Patients under age of 18
Criteria documentation within 28 days
n/a
n/a
Cancer
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Hershey, PA
Reading, PA

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF)

This is a registry based clinical trial to assess whether the initiation of spironolactone plus standard of care compared to standard care alone improves outcomes in patients with heart failure with preserved ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02901184
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Inclusion Criteria:
Diagnosed with heart failure by a physician
Ejection fraction 40% or higher
Exclusion Criteria:
Currently taking the medication Spironolactone
Pregnant or able to become pregnant
Using home oxygen
Currently on dialysis
Known significant heart valve disease
Heart & Vascular
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Hershey, PA

Eye-tracking of Aging and Language

We are interested in how adults understand language, and how this changes across the lifespan. Participants will complete paper and pencil tasks, computer-based tasks, and we will monitor how they move their eyes.
Victoria Gertel at vhg2@psu.edu or 814-865-2912
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Native English Speaker
Right Handed
Monolingual
Minimum High School Education or GED
Normal or corrected to normal vision (20/20, not color blind)
Exclusion Criteria:
History of Neurological or Psychological Disease
Left Handed
<18 years old
speaking more than 1 language
less than 12 years education and no GED
Language & Linguistics
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State College, PA

The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-40 years
Exclusion Criteria:
• Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
• Individuals that use nicotine-containing products
Illicit or recreational drug-use
• Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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Location
State College, PA

The effect of pistachios on blood sugar control, heart and gut health

The purpose of the study is to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk factors for heart disease. This study will also investigate how pistachios affects gut health.
Terry Riley at tmr359@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 30-75 years
BMI 25-45 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Night shift-workers and and those who cannot consume a snack in the evening
Food & Nutrition, Heart & Vascular
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Location
State College, PA

Examining Cortical Lateralization of Motor Learning through High Definition Transcranial Direct Current Stimulation

The aim of this study is to understand how brain stimulation affects learning of a novel task on a virtual reality system. Participation involves playing virtual reality games during non-invasive brain stimulation.
Brooke Fosaaen at brooke.fosaaen@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
right-handed
18-40 years old
Exclusion Criteria:
left handed or ambidextrous
neurological disease
movement disorder
major psychiatric diagnosis
orthopedic damage to the arms
Neurology, Mental & Behavioral Health
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Hershey, PA
State College, PA

Negotiating Narrowing Paths and Lateral Maneuvers in Older Adults

This study will identify how low fall-risk and moderate/high fall-risk older adults negotiate complex, real-world-like walking tasks where they have to make decisions related to avoiding risk of falling. Participants will walk in a virtual reality environment where they will have to navigate various narrowing paths and make lateral maneuvers to switch paths etc. We will quantify how older adults with different levels of fall risk exhibit differences in their performance in these tasks. This work is important in the context of better understanding how and why older adults fall.
Meghan Kazanski at LoCoLab@psu.edu or 814-863-0354
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 18-35 Years or Age over 65 Years
Able to walk at least 5 minutes unassisted
Exclusion Criteria:
History of serious health problems (physical or neurological) that may interfere with walking
Prevention
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Location
State College, PA

Remediation of the Non-Paretic Arm to Improve Functional Independence in Chronic Stroke Survivors

This study will test the hypothesize that the combination of low-moderate to severe paresis (Upper Extremity Fugl-Meyer Score ≤35) and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the non-paretic arm should improve functional independence. We propose a randomized study design with two tracts, two periods and four assessments.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
> 3 months post unilateral stroke
Age 21-85
Demonstrates cognitive abilities
Exclusion Criteria:
hospitalization for substance abuse and/or psychiatric diagnosis
non-stroke neurological diseases
certain peripheral movement restrictions
brainstem/cerebellar damage
Neurology, Mental & Behavioral Health
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Hershey, PA

Comparing barriers to cancer screening across PSCI catchment area county types: Implications for a self-sampling intervention – Patient Focus Groups

In this study, we will conduct focus groups with women, ages 45-65 years, who are patients in the Penn State Cancer Institute (PSCI) catchment area which includes rural/urban and segregated/not segregated counties in Pennsylvania to learn more about their barriers to cancer screening
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Female residing within the PSCI catchment area
45-65 years of age
Able to speak, read, and communicate well in English
May also participate in the "Comparing barriers to cancer screening across PSCI catchment area county types: Implications for a self-sampling intervention – Patient surveys" study
Exclusion Criteria:
Children
Cognitively impaired
Imprisoned
Complete hysterectomy
History of cervical or colorectal cancer
Cancer, Women's Health
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Hershey, PA
York, PA

Improving Self-Regulation Among Adopted Children

This is a clinical trial designed to understand the effectiveness of two different treatment programs for adopted children with behavioral and emotional concerns, and their parents.
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
NCT04061031
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Inclusion Criteria:
Child age between 4 and 10
Child legally adopted by the caregiver
The same caregiver will participate in each of 2 assessment sessions and 12 treatment sessions
Exclusion Criteria:
Child diagnosed with severe developmental delay and psychiatric concern that necessitates a higher level of care than outpatient treatment.
Mental & Behavioral Health
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Harrisburg, PA

Inflammatory, Behavioral and Neural Markers of Anhedonia in Major Depressive Disorder

The purpose of this study is to investigate the underlying biological causes of the loss of pleasure in individuals diagnosed with depression. This study will examine brain, behavioral, and inflammatory markers of depression. Participants will answer questions, give blood and saliva, undergo fMRI and perform computer tasks. The study is a 1 time appointment lasting 3hrs and participants will be compensated $130. The study is also recruiting healthy controls with no history of major mental illnesses.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Major Depressive Disorder
Failed two lines of anti depressant treatment
Between 18-65 years of age
Exclusion Criteria:
Any metallic implant
Bipolar Disorder or Psychotic Disorder
Heavy alcohol or recreational drug use
Inflammatory disease like Lupus, Rheumatoid Arthritis
Infectious Diseases & Immune System, Prevention, Mental & Behavioral Health
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Hershey, PA

Understanding the user experience of using consumer-facing digital symptom checkers

This is an interview study that examines how people use online symptom checker platforms or apps (e.g., WebMD, Ada, K health app, Your.MD) to self-diagnose or support the decision of whether and when to do a medical visit. The research procedure involves: 1) a short screening survey which helps us determine who are eligible to participate; 2) an audio‐taped interview with each eligible participant that will last approximately 30‐60 minutes online or offline near Penn State University Park. Each participant will be compensated with a $20 Amazon gift card for completing the interview.
yxy340@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Live in US
Speak English or Chinese
At least 18 years of age
Have used online symptom checker platforms or apps
Exclusion Criteria:
Less than 18 years old
Have never used any symptom checker
Vulnerable populations such as children, pregnant women, cognitively impaired adults, and prisoners
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Altoona, PA
Hershey, PA
State College, PA

Food and Mood: Ecological Momentary Assessment of Eating Behaviors in Preadolescent Children

The goal of this study is to determine the feasibility of 8-10 year old children using a smartphone-based survey to measure appetite, mood, and eating behavior "in the moment".
Emily Hohman at foodandmood@psu.edu or 814-865-8078
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Child age 8-10 years old with a parent/guardian
Exclusion Criteria:
Not able to read and answer questions in English
Child has a medical condition impacting eating (e.g. eating disorder, diabetes, extreme food allergy or dietary restriction)
Child does not live with participating parent/guardian
Children's Health, Food & Nutrition, Mental & Behavioral Health
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Location
State College, PA

Site for An Open-label Multiple Dose Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Upadaticinib in Pediatric Subjects with Severe Atopic Dermatitis

Phase 1, multiple-dose, open-label study consisting of two parts, male and female subjects aged 2 to 12 years with severe atopic dermatitis (eczema).
Samantha Gettle at sgettle2@pennstatehealth.psu.edu or 717-531-5136
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
NCT03646604
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Inclusion Criteria:
must weight 22 pounds or more
Have a diagnosis of Atopic Dermatitis for at least 6 months
Exclusion Criteria:
Certain treatments are not allowed; coordinator will discuss specific treatments
No active Hep A, Hep C or Hep B
Current participation in another clinical trial
Skin Conditions
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Hershey, PA

Efficacy and Safety of Concizumab prophylaxis in patients with haemophilia A or B without inhibitors

To establish the effect and investigate safety of daily subcutaneous treatment with concizumab prophylaxis when given to adult and adolescent haemophilia patients without inhibitors.
Male
All
This study is NOT accepting healthy volunteers
NCT04082429
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Inclusion Criteria:
Male aged ≥12 years
Body weight >25 kg at screening
Congenital severe haemophilia A (FVIII < 1%) or moderate/severe B (FIX ≤ 2%)
Documented treatment with coagulation factor containing product in the last 24 weeks
Exclusion Criteria:
Treatment with emicizumab within 180 days before screening
Participation in any clinical trial of an approved or non-approved investigational product within 5 half-lives or 30 days from screening
Known or suspected hypersensitivity to monoclonal antibodies
History of thromboembolic disease
inhibitors ≥0.6 BU in the last 5 years
Blood Disorders
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Location
Hershey, PA

Site for Tomosynthesis Mammographic Imaging Screening Trial (TMIST)_EA1151_PSCI 19-080

This study is being done to answer the following question: Can tomosynthesis mammography, three-dimensional x-ray imaging of the breast, lower your chance of developing life-threatening breast cancer through routine screening compared with digital mammography, two-dimensional x-ray imaging of the breast? We are doing this study because we want to find out which of the two usual approaches to breast cancer screening are better in the early detection of life-threatening breast cancers.
Swati Shah at sshah@pennstatehealth.psu.edu
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03233191
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Inclusion Criteria:
Women age 45 or older and under age 75 at the time of study entry
Patients must be scheduled for, or have intent to schedule, a screening mammogram.
Patients must be able to tolerate digital breast tomosynthesis and fullfield digital mammographic imaging required by protocol.
Patients must be willing and able to provide a written informed consent.
Exclusion Criteria:
Women of childbearing potential must not be known to be pregnant or lactating.
Patients must not have new symptoms or signs of benign or malignant breast disease
Patients must not have had a screening mammogram within the last 11 months prior to date of randomization.
Patients must not have previous personal history of breast cancer including ductal carcinoma in situ
Patients must not currently have breast enhancements (e.g., implants or injections).
Prevention, Cancer, Women's Health
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Hershey, PA

eLLiPSIS—A Longitudinal, Observational Study to Examine the Measurement Characteristics of the Pompe Disease Symptom Scale and the Pompe Disease Impact Scale

The purpose of this non-interventional study is to measure the performance of the Pompe Disease Symptom Scale (PDSS) and the Pompe Disease Impact Scale (PDIS), which are disease-specific patient reported outcome (PRO) instruments exclusively for Pompe disease.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with late-onset Pompe disease
Enzyme Replacement Therapy Infusions occur no more frequently than every two weeks
Exclusion Criteria:
Patients who are wheelchair dependent OR unable to ambulate 50 meters (approximately 160 feet) without stopping and without an assistive device
Patients who require invasive-ventilation (non-invasive ventilation is allowed)
Patients currently on investigational drug/clinical trials
Neurology
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Hershey, PA

Phase 2, Multicenter, Double-blind (Sponsor-unblinded), Randomized, Placebo-Controlled Study of the Safety and Efficacy of Elagolix in Women with Polycystic Ovary Syndrome

The objective of the study is to see if elagolix can help with the symptoms experienced by women with a diagnosis of PCOS
Barbara Scheetz at bscheetz@pennstatehealth.psu.edu or 717-531-4483
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03951077
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Inclusion Criteria:
women aged 18-35
diagnosis of PCOS
Current or history of irregular periods defined as 8 or fewer periods per year
BMI between 18 and 38 kg/m2
Exclusion Criteria:
currently pregnant or less than 6 months post partum
planning a pregnancy within the next 12 months
diabetic
surgical history of tubal ligation, tubal occlusion or salpingectomy
osteoperosis or other bone disease
Women's Health
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Hershey, PA

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects with Heart Failure with Reduced Ejection Fraction and Decreased Exercise Tolerance (METEORIC-HF)

The study will evaluate the effect of treatment with omecamtiv mecarbil compared with placebo on exercise capacity as determined by cardiopulmonary exercise testing following 20 weeks of treatment with omecamtiv mecarbil or placebo.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03759392
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Inclusion Criteria:
age 18 to 85
taking medications for heart failure for at least 3 months
Exclusion Criteria:
severe heart valve disease
organ transplant
ongoing or planned cardiac rehab
pregnant, planning to be pregnant, or breast feeding
Heart & Vascular
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Hershey, PA

Brain potential reveals the effect of language immersion on L2 learning

In this project, we aim to understand how the environment influence language learning. Research in bilingualism and second language acquisition has demonstrated the high adaptability of the human brain in response to environmental input and behavioral experience. However, in the previous studies on second language (L2) learning, environmental factors that may lead to structural and functional changes in the brain have rarely been systematically investigated. The length of residence in an L2 environment (LoR), which strongly relates to the amount of language experience, is one environmental factor that can impact neural mechanisms underlying L2 processing. Thus, this project will examine the effect of LoR on the neural processing of English by native speakers of Mandarin.
Haoyun Zhang at hxz153@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-years of age or older

Right handed
Normal or corrected-to-normal vision
Either Native Monolingual English Speakers or Mandarin learners of English who do not know a third language
Exclusion Criteria:
A history of neurological disorders or language disorders
< 12 years of education
illiteracy
Language & Linguistics
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Location
State College, PA

Respect and Satisfaction in Same-Sex Romantic Relationships

The purpose of this study is to expand on previous research looking at respect and relationship satisfaction among heterosexual relationships and compare it to that of same-sex relationships to find where they are similar or different. Participants will complete self-report measures regarding their romantic relationships, including respect toward partner, satisfaction, and attitudes toward love. 30 minutes will be required for the study.
Michelle Yarwood at mxg925@psu.edu or 814-867-4851
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
age 18 years or older
Exclusion Criteria:
younger than 18 years of age
Men's Health, Mental & Behavioral Health, Women's Health
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Watch Over: Using Apple Watches to Assess and Predict Substance Co-use in Young Adults

This study seeks to understand substance use and other health behaviors in young adults' daily lives. Interested participants can email the study team to complete a brief screener to see determine their eligibility. If eligible, participants will be asked to complete a short online survey and follow-up surveys for up to four weeks via a mobile device. Financial compensation will be provided.
Ashley Linden-Carmichael at ALindenCarmichael@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Between 18-25 years of age
Current Penn State student
Currently owns and uses an iPhone with iOS version 13 or newer
Determined eligible through screener
Exclusion Criteria:
Eligibility determined using a screening survey
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Location
State College, PA

Lunch Meal Study for Men and Women

The purpose of this study is to gain a better understanding of how food labels can change perceptions about how filling a meal is, and what influence this has on food consumption.
Cara Meehan at cmt5070@psu.edu or 814-863-8482
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Adult 18
•70 years old
BMI between 18.0 and 35.0 kg/m^2
Exclusion Criteria:
< 18 years old
BMI < 18.0 kg/m^2
BMI > 35.0 kg/m^2
> 70 years old
Food & Nutrition
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Location
State College, PA

A randomized, double-blind, placebo-controlled, phase 2a study to assess the clinical efficacy of ISIS721744, a second-generation ligand-conjugated antisense inhibitor of prekallikrein, in patients with hereditary angioedema

This is a study to test whether an investigational drug given by injection every four weeks will reduce swelling episodes in patients with hereditary angioedema (HAE).
Joshua Adams at jadams4@pennstatehealth.psu.edu or 717-531-4513
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT04030598
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Inclusion Criteria:
Hereditary angioedema
18 years of age and above
able to use 1 acute medication to treat angioedema attacks
females non-pregnant and not planning to get pregnant
males must be using contraceptive method
Exclusion Criteria:
use of short-term prophylaxis for angioedema attacks
concurrent diagnosis of any othe type of recurrent angioedema
abnormalities in screening lab values
active infection
known history positive for HIV, hep C or B
Allergies
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Study Locations

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Location
Hershey, PA

How Immigration Looks to America: Perspectives of the Photographic Portrayals of Immigrants in News Photographs

This study will involve surveying college students regarding their perceptions about how immigrants are portrayed in news media.
Hans Schmidt at hcs10@psu.edu or 610-892-1251, ext=6108921251
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Student at Penn State
Exclusion Criteria:
Below age 18
Education
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Families Being Supportive Together

This project studies the different ways that caregivers respond to their teens when teens ask for support. The study focuses on youth with and without a risk of developing depression and anxiety. We study how youth ask for help from their caregivers and how caregivers respond in their daily lives by observing family interactions at home. The ultimate goal of this study is to reveal how modern families support their teens and how communication among immediate family members can impact stress, mood, and mental health.
Sunny Bai at sub1164@psu.edu or 814-867-6488
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Family has youth between ages 12-15 yo
Parent and youth live together at least 5 days/week
Parent has an active driver's license
Family has car that they use regularly
Primary language spoken at home is English
Exclusion Criteria:
Youth or parent has current diagnosis of severe mental illness (ex: Bipolar, OCD, Alcohol/Substance use disorder, Eating disorder, Psychotic disorder)
Youth has developmental disability (Autism spectrum disorders)
Youth or parent has had a suicide attempt, or intensive care (inpatient, partial hospitalization, daily outpatient) care for emotional or behavior problems in the past 12-months
Other social (ex: homelessness) or medical conditions that make participation difficult
Children's Health, Prevention, Mental & Behavioral Health
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Study Locations

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Location
Harrisburg, PA
State College, PA