Search Results
5
Study Matches
Predicting Ipsilesional Motor Deficits in Stroke with Dynamic Dominance Model
This study will test the hypothesize that the combination of low-moderate to severe paresis and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the less-impaired arm should improve functional independence.
Candice Maenza at CMaenza@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
N/A
Neurology
Asymmetries in Cognitive Aspects of Motor Control and Learning
This study will improve our understanding of movement control and how strokes of different sides affect overall independence. Participants will complete the visit seated at a chair with sensors connected to the less-affected arm. They will then play a short virtual reality game and complete several questionnaires and assessments.
Alison Celigoi at aceligoi@pennstatehealth.psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
N/A
Neurology
Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis.
To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up
To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim.
To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
Deborah Hoffman at dhoffman1@pennstatehealth.psu.edu or 717-531-0003, ext=283063
All
18 year(s) or older
NCT02089217
Heart & Vascular, Neurology
Assessing Concreteness Rating Data from Older Adults
This project is looking to collect psycholinguistic ratings from older adults (i.e., 50 years or older), using online surveys. The quality adults will be rating is word concreteness, a measurement of how perceivably physical/tangible a concept is (e.g., a word like "apple" should rate high in concreteness whereas a word like "sympathy" should have a minimal rating). Previous research has collected these ratings from large, but predominantly young adult samples. Therefore, the present study aims to adress this bias and gather normative ratings from older adults specifically. This study can improve speech therapies provided to largely older adult populations (e.g., patients with language impairments after stroke).
Jacquelyn Stochel at jfs6039@psu.edu or 914-703-9887
All
18 year(s) or older
N/A
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction
This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number of people with large hemispheric infarction (LHI). These studies suggested that the study drug was safe, did not cause serious side effects or discomfort, and may reduce brain swelling, disability, and death in subjects with LHI. In this study, we want to investigate the study drug in a larger number of subjects (hundreds) to know more about it.
LHI is a type of stroke. An ischemic stroke occurs when blood flow to parts of the brain is blocked, such as by a blood clot. This can cause damage to the brain. In LHI a large portion of the brain is damaged. People who have LHI can develop swelling of the brain called cerebral edema, which can worsen the symptoms and outcomes of LHI.
Currently, there are no medications available to specifically reduce brain swelling caused by LHI. In this study, we want to investigate how well the study drug works to improve functional outcomes (the ability to do normal daily activities, such as walking and getting dressed) in subjects with LHI. This study will also look at the long-term effects of the study drug over time and see how safe the study drug is.
All
18 year(s) or older
NCT02864953
Neurology