Sound symbolism is the idea that the sound of a word alone can convey its meaning. Aphasia is a language impairment, occurring most often as a result of a stroke. There is some evidence that sound-symbolic language is preserved in stroke patients. Studies in this protocol will investigate the extent to which this is so, and whether sound-symbolic language could be a rehabilitation strategy for aphasia.

We will ask you to listen to real words and non-words and make judgements about them. We may also ask you to complete some tests of language ability. The total time commitment may be up to four hours but will be split into two sessions.

Amount varies depending on the study

The purpose of this study is to better understand how human teams with non-human virtual agent team members operate and function.

If you agree to be in this study, you will be fitted to sensors that will measure your neurophysiological (i.e., brain, cardiac, and respiratory) signals while you complete group tasks in person or in virtual reality. This interaction will be recorded and coded. You will also be asked to complete several questionnaires about your demographics, behaviors, and emotions.

$38

The purpose of this research study is to learn about how humans provide corrections to robot movements when the robot makes mistakes while performing a task. Understanding the intent of humans can inform how we incorporate the information provided by that interaction into machine learning algorithms that improve the robot’s task performance in future.

Participants will observe the robot performing three different tasks. The robot will place a peg in a hole, pickup and pour a cup, and draw and erase an image on a whiteboard. The robot may or may not make mistakes while performing these tasks. Mistakes may be minor or may be significant such as colliding with an object or the work table. Participants will be asked to correct the robot’s mistake by moving the robot arm or stopping the task execution altogether by hitting a red stop button. After observing the robot perform each task several times, you will be asked to demonstrate a new task to the robot. The robot will then try to replicate your demonstration and you may choose to provide corrections to improve the robot’s execution of the task anytime you think it is making a mistake or not performing well enough.

20

Social network site (SNS) use has been very integrated into our daily practices. The distinctions between offline and online social relationship management become blurred with the mediation of SNSs. We are interested in how people perceive and use SNS and engage in social relationship management, such as self-disclosure or privacy management. Users may appropriate technological features to meet their own needs and such practices may be different from how others use the sites. The discrepancy of usage may in turn influence social relationship maintenance.

This study is designed to better understand how people complete complicated tasks, and the best ways in which to measure their performance. If you agree to the study, you will be asked to fill out questionnaires on your thoughts, feelings, and behaviors; take a short interview on the same; and complete brain teasers and computerized tests of attention and learning.

There are several steps to determining whether you are a good fit for the study. If you agree to be in the study, then we will send you a link to complete online questionnaires (~10 min) on your thoughts, feelings, and behaviors. If you are a good fit, then we will schedule a laboratory visit in Moore Building at the University Park campus (maximum length of time = 3 hours). During that visit you will complete an interview and more questionnaires, brain teasers, and computerized tests of attention and learning. The visit will be video recorded for quality assurance.

$50

The objective of this cross sectional survey study is to describe the social and psychological outcomes of cancer survivors and characterize the disparities between rural and non-rural cancer survivors. We will collaborate will members of the Big 10 Cancer Research Consortium's Population Science Working Group to invite cancer survivors in rural and non-rural communities to complete one online survey, with each site targeting cancer survivors in their catchment areas. At Penn State, we will target recruitment to cancer survivors living in Pennsylvania. We plan to enroll 150 participants. It will take participants 30-40 minutes to complete the study and they will receive a $15 Amazon gift card for their time and effort.

If eligible, study participants will be asked to complete one online survey about their experience as a cancer survivor. Potential participants will first complete a REDCap screening form, if eligible, they will view the consent form. If they provide consent, they can complete the survey. A member of the Penn State study team will call the participant to confirm eligibility and once confirmed, will issue a $15 Amazon e-gift card. The entire study should take between 30-40 minutes to complete.

$15

This is a study of the drug DFMO (difluoromethylornithine) for medulloblastoma that has returned or not responded to treatment. DFMO is an oral drug that inhibits a certain enzyme (protein) in blood which is associated with a bad outcome in neuroblastoma cases. Cancer cells have pathways that drive the cancer to grow and DFMO targets the specific pathway of this enzyme to turn these cells off.

You will have exams, tests, and procedures while on the study to evaluate whether you can participate in the study and how you are doing while on the study. These include physical exams, blood tests, urine tests, bone marrow aspirate and biopsies, heart tests, hearing tests, and imaging evaluations such as MRI of your brain and spine. You will receive treatment on this study for a total of about 2 years. After treatment, you will have follow-up examinations and medical tests. We would like to continue to find out about your health for about 5 years after you complete the study.

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.

There will be three in person visits for this study. At the screening visit, participants will undergo a detailed medical history and physical examination and then will complete a mental test while lying down and standing. If eligible based on the results of the mental test, participants will undergo a pregnancy test if female and of childbearing potential, measurements of blood pressure and heart rate and blood draws while lying down and standing up, and a test to determine if they can tolerate being in a lower body negative pressure (LBNP) device that distributes more blood to the legs to mimic standing. If eligible based on the results of the screening visit, participants will be asked to complete an online questionnaire and two study visits that are separated by at least one week. At these study visits, they will perform a mental test in a magnetic resonance imaging (MRI) scanner. The LBNP device will also be used while in the MRI scanner to distribute more blood to the legs to mimic standing.

$25 per hour; additional $25 for completion of online questionnaire

This study will examine neural reactivity to stress in young adults who use alcohol and cannabis and link these responses to behaviors in everyday life.

You will be asked to complete the following:1) An in-lab intake appointment for interviews and questionnaires, and a smartphone-based training session2) A 14-day burst of smartphone-based reporting in daily life3) An in-lab neuroimaging training session and scan, and bloods draws4) Two additional 14-day bursts (total of 28 days) of smartphone-based reporting in daily life, one at 6 months post-MRI and one at 12 months post-MRI5) 6-month follow-up appointment for interviews and questionnaires6) 12-month follow-up appointment for interviews and questionnaires

717

This study will examine how international spouses improve their English ability and form connections with the local community. Participants will be interviewed to learn about their experiences. Social events that are found to be positive will be recorded so that the interactions in that space can be analyzed to determine how they help international spouses.

This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.

The purpose of this study is to understand parents' experiences of emotion regulation in parenting and coparenting contexts and how individual differences in parents' emotion regulation are associated with well-being and relationship functioning.

Coparents will be asked to fill out questionnaires and engage in interviews with the researchers during three online sessions across the transition to parenthood.

110

This research study investigates the neural processes underlying how people process, store, and remember visual or auditory information.

Participants ages 18-30 will participate for one 2-hour session involving 1 hour inside the MRI scanner. Participants ages 60-85 will participate for five sessions total, two of them being MRI scans. All five sessions will occur between 7-10 days of each other and scheduling is very flexible.

$15.00/hour for behavioral tasks, $20.00/hour for fMRI scanner tasks.

The study's primary objective is to see how people react to the influences of performance expectancy in Initial Coin Offering (ICO) projects. As a participant in this study, you will be asked to answer 28 questions about your experiences with ICO projects. Then, at the end of the survey, participants will be briefed on the potential correlations between performance expectancy and how this phenomenon influences participants' behaviors toward ICO projects.

The participant will be asked to complete a questionnaire composed of 28 questions about ICO projects during the study. Then, at the end of the survey, participants will be debriefed on the potential correlations between performance expectancy and ICO projects.

This is a phase 2 pharmaceutical sponsored clinical trial looking to evaluate the safety, tolerability, and efficacy of experimental drug TTI-101 in patients with Idiopathic Pulmonary Fibrosis (IPF).

Participants will attend 7 visits over 18-20 weeks at the Penn State Hershey Medical Center. Participants will receive study treatment for 12 weeks and the study doctor will continue to monitor you for 4 weeks. The study visits will involve completing some procedures and tests such as taking some blood and urine samples, taking vitals signs, physical exams, electrocardiograms (ECGs), questionnaires, breathing and walking tests, and a high-resolution computed tomography (HRCT) scan.

1050

An online survey about emojis for text feedback on a short story or design. You categorize emojis for this task, write a critique with emojis, and then answer a survey for an Amazon gift card.

This trial will compare the use of elacestrant versus standard endocrine therapy in those who are node positive, ER +, Her2 - with high risk of the cancer coming back

Participants will be expected to come to all visits, take all study medication as instructed by the study doctor, report any new medications, prescription or over the counter, report all side effects.

This is a survey and interview study recruiting patients with sickle cell disease (SCD). Participants will answer questionnaires and complete a remote interview about health care experiences, pain, and discrimination. Natural language processing of interview transcripts will be used to quantify linguistic features indicative of subjective associations between individual experiences of racial discrimination and sickle cell pain.

Participants will be asked to fill out questionnaires and answer questions during an interview.

$50

The primary objective of this protocol, Mechanisms of Cardiovascular Disease (MCD) is to collect biological specimens and data from patients with cardiovascular disease (CVD) to study the mechanisms that contribute to cardiovascular dysfunction and disease.

If you decide to participate in this study, you will be asked to provide a blood sample and possibly additional optional samples, either immediately or later. Additional samples may include saliva, cheek swab, urine, waste tissue or nasal swabs. You will decide whether you are willing to provide these other samples. Clinical data will be included in the dataset along with your sample.

This research seeks to better understand functioning in children who differ in symptoms of Attention-Deficit Hyperactivity Disorder (ADHD), conduct problems (CP), and callous-unemotional (CU) traits, ages 6 - 13. Specifically, this research is being done to find out how these different types of behaviors impact cognitive skills (like attention, impulsivity, working memory, emotion identification) and social functioning to help inform future treatment with these children.

The purpose of this study is to better understand how civilian stereotypes about veterans impact veterans' feelings about themselves and others, and how that influences veteran behavior in the workplace.

This study will examine via ethnographic observation the Story feature on social media. Participants will be asked to provide their Snapchat or Instagram username and must be willing to let the researcher observe the Stories that they post. The primary aims are to illuminate how and why people are using the Story feature on social media, and to analyze how this feature is changing how we relate to and understand the world around us.

Menthol, capsaicin, and camphor are active ingredients often found in over-the-counter pain relief creams and gels. These ingredients typically work by interacting with certain receptors in the skin that are sensitive to temperature changes. There is limited information on how combining menthol with other substances that target similar receptors affects the body. These naturally occurring substances found in plants can widen small blood vessels in the skin through specific processes controlled by nerves in the skin. This study aims to understand how menthol, camphor, and capsaicin individually and together affect sensory function and blood flow in the skin. Additionally, as people age, their skin's nerve and blood vessel function tends to decrease. The study also seeks to explore how aging impacts the effects of these substances on sensory perception and how nerves and blood vessels work together in the skin.

There will be a screening visit and then 6 experiment visits where different topical analgesics will be applied to the forearm skin. We will measure skin blood flow.

240

The purpose of this study is to find out if parents and children 6-10 years old are willing and able to follow a protocol to be used to study the effects of short and/or variable sleep in children. During each of three, one-week long periods, we are asking parents to follow one of the following bedtime schedules: 1) habitual bedtime; 2) 1 hour later bedtime; or 3) variable bedtime (+/- 1 hour of habitual bedtime each day). Children will wear a sleep tracker and parents will complete daily diaries. We will also ask participants questions about their experiences completing the protocol.

Participants will attend an enrollment visit at the Noll Laboratory at Penn State's campus where we will go over the study and give participants a sleep monitor. We will then ask parents to put their child to bed at different, specified times over the course of three weeks - normal bedtime in one week; 1 hour later than their usual bedtime in another week; and at a different assigned time each day that will be +/- 1 hour of their normal bedtime during the third week. During all three weeks, children will wear a sleep monitor on their wrist (similar to a Fitbit), and parents will answer a short survey each evening on their smartphone or other device. At the end of the study, participants will attend a final visit (either in-person or by Zoom depending on preference) to answer questions about their experience with the protocol.

$150

The purpose of this study is to test how social decisions are affected by possible risk of infection. We aim to examine the neural and behavioral mechanisms underlying how choices in a risky social decision-making situation can be influenced by viewing images of infection threat (e.g., person with runny nose) vs. images of neutral scenes or other threatening scenes.

Participants will come to the research site for a one-time visit. They will complete brief questionnaires, followed by playing a social decision-making game while undergoing fMRI scanning.

$35.42

This protocol is comparing two types of surgery, one with the removal of the ovaries, fallopian tubes and uterus against removal of the fallopian tubes and uterus in subjects how are between 35 and 50 with the BRCA1 mutation..

Participants must be carriers of the BRCA1 gene mutation. This trial involves going to the operating room to have either their fallopian tubes removed or their ovaries and fallopian tubes removed. A vaginal ultrasound will be done. you will have blood drawn and a pregnancy test done. This will happen before surgery.

This research study is to provide expanded access to a new investigational drug DFMO (difluoromethylornithine) for patients with neuroblastoma, medulloblastoma, and certain rare tumors that have no other curative options. DFMO is an oral drug that inhibits a certain enzyme (protein) in blood which is associated with a bad outcome in neuroblastoma cases. Cancer cells have pathways that drive the cancer to grow and DFMO targets the specific pathway of this enzyme to turn these cells off.

If you are enrolled on this study, DFMO will be started in clinic on Day 1. After this first day you will be seen in clinic approximately once every 30 days for the first 6 months of study and once every 90 days for the last 18 months of study. These visits will last about 2 hours, and involve a physical exam, blood tests, and other testing.

This study is recruiting only medical trainees, specifically first- and last-year medical students and nursing students. The study examines how these trainees assess pain during simulated patient interactions. Participants will watch videos of patients experiencing different levels of pain while undergoing functional Magnetic Resonance Imaging (fMRI) to monitor brain activity. The goal is to explore the neurological and behavioral processes involved in clinical decision-making

Participants will complete pre-visit questionnaires at home, engage in simulated clinical interactions during a single fMRI session, and fill out post-visit questionnaires immediately after the MRI task. This study is designed to assess their clinical decision-making in response to pain scenarios.

250-400

The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS. The trial is designed as a perpetual platform trial. This means that there is a single Master Protocol dictating the conduct of the trial. The Master Protocol describes the overall framework of the platform trial, including the target population, inclusion and exclusion criteria, randomization scheme, study endpoints, schedule of assessments, trial design, the mechanism for adding and removing interventions, and the statistical methodology and recommended statistical methods for evaluating interventions.

The HEALEY ALS Platform Trial is a research trial that tests the safety and effectiveness of multiple treatments in ALS. A regimen is a specific course of treatment, each with a different study drug.The following things will happen in this research study: Blood and urine sample collection; Completion of questionnaires; Physical and neurological exams; Vital signs, current and historical review of medical information about general health and medication use review; Muscle strength testing; Measurement of the electrical activity of the heart with an electrocardiogram (ECG); and Measurement of respiratory (breathing) function.Participants will also take either the study drug, or placebo, according to the study schedule

This study will examine whether patients who have insomnia with different sleep characteristics demonstrate a differential response to two common insomnia treatments, Cognitive Behavioral Therapy for Insomnia (CBT-I) and trazodone. All participants will complete a trial of CBT-I, followed by a medication trial in some participants. Participants will be evaluated with structured interviews; self-report questionnaires; in lab sleep recording; activity monitoring; saliva, blood, & urine collection for routine clinical measures; blood pressure monitoring and an EKG. All outcomes will be assessed again following the end of treatment.

Study involvement is 9-12 monthsPhone Screen to determine basic eligibility.There are 5-6 in person visits (first is consent/screening visit)3-4 of the in person visits are overnight visits to the sleep labUp to 18 other visits for treatment may be done in person or by video conference.Data is collected at home for 6-8 weeks during the 12 month period (activity monitor & blood pressure)Online self-completed surveys & structured interviews are required.A single blood sample and saliva samples will be collectedPregnancy Test, 12-Lead EKG, Medication may need to be taken in addition to the CBT-I Sessions

$465.00