The purpose of this study is to test the performance of a web-based system for automated review of MRI images across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Participants will attend two study visits that will include questionnaires, a physical exam and motor exams and an MRI (during one of the visits).

300

This study aims to understand peoples’ selfie-taking behavior and how, if at all, they relate to their driving behavior and gender difference. The participants will participate the study by completing an online survey.

This a collaborative multisite NIH funded project to develop smell tests as a rapid low cost way to screen for Covid19 infections. The lead institution is the University of Florida, and this project is being entered into CATS to create a Reliance Agreement under the NIH single IRB rules (sIRB).

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows:1)Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years.2)Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.

Saliva collection and surveys at baseline, 7 days, and 30 Days

$20

The purpose of this study is to gather information about what family mealtimes look like for families with children between the ages of 3 and 8. Families will be asked to video record their family mealtime, in addition to answer some questions and to complete some questionnaires, some about body image and dieting.

On one occasion, your family's mealtime will be recorded via Zoom. You and your family will be asked some questions and to complete some questionnaires online.

$20

We are interested in developing robots that can interact with humans. We hope that to develop robots that can interact with people and be used in a variety of different situations such as schools, offices, and homes. This study investigates human-robot interaction.

Hormones are molecules that deliver signals throughout the body. They influence behavior, sleep, hunger, stress, and virtually all other aspects of life. This study seeks to better understand several of these functions, specifically how hormones affect specific aspects of human behavior and psychology, as well as speech production. Following an initial lab visit, subjects will participate in the remainder of the study (~5 weeks) at home via the internet. On a daily basis, they will collect urine samples for hormone analysis, saliva samples for analysis of oral micro-organisms, and will submit voice samples for analysis of speech (e.g. measuring voice pitch and loudness). They will then complete an online survey designed to collect information about their behavior, and attitudes over the previous 24 hours. Subjects receive compensation for their participation.

- Compensation $330 at maximum- Pre-sampling lab visit to sign a consent form and receive training- A series of ~42 daily at-home sample (urine, saliva) collection & online surveys- Weekly lab visits for sample drop-off

$330

This trial is comparing radiation therapy with or without hormone therapy in men with prostate cancer.

Patients must come in for all radiation treatments. Patients must take their androgen therapy as prescribed.

This is a randomized trial whereby a study device will be used to remove tissue from the ovary via a transvaginal ultrasound procedure in order to promote/restore ovulation in women with infertility due to PCOS. Weekly serum blood draws will also be obtained to determine ovulation rates during the first 12 weeks of study enrollment. Those randomized to the control arm will have the option of crossing over to the device arm after 3 months.

Preliminary visit to assess eligibility followed by randomization into the Device or Control Arm. Device Arm requires May Health procedure (approximately 1 hour long, similar to ovarian drilling) followed by 12 weekly blood tests and 6 follow up clinic visits and follow up calls for up to 36 months after the procedur4e. Control Arm requires 12 weekly blood tests and the option to cross-over to the device arm after 3 months. If no cross-over occurs, the control arm will have one follow up visit at 3 months and can then exit the study. Both arms will complete questionnaires and log menstruation dates in an e-diary.

1220

This trial is comparing disease free survival using standard radiation versus higher doses of radiation to the prostate to prevent the cancer from spreading.

Participants will be chosen to enroll into one of two types of radiation to treat their prostate cancer. they must agree to keep all appointments over the 5 years period and agree to be contacted every year for follow up.

To examine women’s self-reported pregnancy hydration behaviors, especially during a global pandemic. This study will also examine other lifestyle behaviors (e.g., weight gain, exercise, eating behaviors, sleep, pain management). It is hypothesized that hydration behaviors will decrease due to lifestyle changes related to the pandemic. Secondary outcomes will also be influenced by hydration behaviors and pandemic lifestyle changes.

The study will test GS-1427 for treatment of ulcerative colitis (UC). Adults diagnosed with UC can participate if otherwise eligible.The study has two parts; the first part lasts 12 weeks. Participants will be randomly assigned to either a treatment or a placebo arm. At 12-week evaluation the participants can be further assigned to an active treatment lasting 40 weeks. The second part of the study is for new participants. Eligible participants will be randomized to the treatment with GS-1427, Stelara, or both drugs.The study procedures include blood tests, endoscopy with biopsies, vitals, and physical exam, EKG testing, providing urine and stool samples, and completion of symptom-related diary questionnaires.

Participants will be required to sign the informed consent and show that they understand the study requirements. They will be required to complete in-person clinic visits. During the visits, the participants will have their vitals checked, and we will ask them about any problems they may have or adverse events. During the screening periods, participants will undergo endoscopy with biopsies and provide stool and urine samples. Blood draws will also be done, and we will teach them to complete the questionnaires about the disease symptoms. If eligible for the study, screened subjects will be randomized for either tone of the three drug dose or placebo treatment (blinded). They will attend at least five clinic visits over the twelve-week treatment period. At that time, the endoscopy evaluation will be done again, and the participants will be eligible to enter the next study phase. They will again be randomized to one of the four possible treatment arms using different drug doses. In the part 2, investigational drug, standard of care biologic Stelara, or concomitant treatment of both medicines. During part 2 of the study, subjects are required to attend at least ten clinic visits every four weeks. When the treatment is completed, the participants will be followed for four weeks and attend the end of the therapy visit. The final endoscopy will be done at week 52 of treatment. Participants will have an ECG done at selected study visits and a pregnancy check for WOCBA at every visit. Blood draws and a review the study diary will be done at every visit.

Part 1 total $1765 ($75 per visit, $20 meal cards v2 and v12); Part 2 TBD

This study aims to understand ways to affect how riders perceive and provide feedback to drivers through technology intervention. Particularly, we investigate how presenting drivers’ personal profile under different trip conditions may lead to differences in the ways riders may provide feedback. We hypothesize that riders will provide positive feedback when provided drivers’ personal information when the trip goes well, and that riders will provide less negative feedback when provided drivers’ personal information when the trip goes bad due to uncontrollable reasons.

This study establishes the reliability and convergent validity of the PACED rating scale. 15 undergraduate nursing students and registered nurses will be recruited to complete 2 clinical scenarios related to nursing home residents with dementia experiencing pain and symptoms of distress. Participants will use their clinical judgment to conduct assessments and provide interventions and treatments.

Participants (nurses and nursing students) will be asked to complete a demographic survey, a pain management knowledge survey (POAKS), and complete 2 clinical scenarios followed by pain management notes related to persons with dementia experiencing symptoms of distress. It may take about an hour to complete the study procedure mentioned above. You can choose to complete the 2 clinical scenarios in one setting or at different times.

$25 gift card for Registered Nurses (RN) and nursing students.

Emerging technologies, particularly in the semiconductor industry, are advancing at an extraordinary pace in the United States, creating an urgent demand for a highly skilled workforce. In 1990, the U.S. held 37% of the global semiconductor manufacturing market; today, that share has sharply declined to just 12% (MASH, 2024). Meanwhile, most semiconductor production has moved overseas, with Taiwan alone accounting for nearly 60% of global output. This concentration of manufacturing capacity in East Asia is increasingly concerning, especially given China’s strategic goal to secure Taiwan by 2030. As such, the U.S. semiconductor supply chain has become a critical national security issue, further emphasizing the immediate need to rebuild a robust domestic manufacturing workforce. To reverse this trend, it is estimated that the U.S. will need an additional 230,000 skilled workers to double its semiconductor market share and regain competitiveness on the global stage (Lightcast, 2023). Achieving this goal requires a significant investment in education and training programs. The HI-TECH (High-Impact Technology Experiential Career Hub) program directly addresses this challenge by offering 75 recent graduates from Career and Technical Education (CTE) programs summer internships in the semiconductor industry over the next three years. These internships will provide invaluable hands-on experience, positioning participants for lucrative, high-demand careers in this vital and rapidly expanding sector. Through this initiative, HI-TECH aims to play a key role in strengthening the U.S. workforce, enhancing national security, and securing America’s future competitiveness in the global semiconductor market.

Participants will be asked to complete an online survey (15-20 minutes) about their experiences with CTE programs, employment in the semiconductor industry, and workforce readiness. Some participants may also be invited to participate in a 30-45 minute interview (conducted via Zoom) to provide further insights.

The main purpose of the study is to find out if patients treated with remibrutinib may experience fewer MS relapses (also called clinical attacks, exacerbations or flare ups) than patients treated with teriflunomide (also known as Aubagio®). Teriflunomide is an approved medication for the treatment of relapsing MS

This study requires you to take a medication. This study consists of a core part (21 in person visits over 2.5 years) and an extension part (18 in person visits over 5 years). Study activities consist of blood draws for labs every 3 months, vitals (blood pressure readings, heart rate, height and weight), physical exam, electrocardiogram (ECG), clinical outcome assessments, a participant diary that will be filled out during treatment, and an optional magnetic resonance imaging (MRI) sub-study. All study activities will be done at the Penn State Health Hershey Medical Center in the neurology clinic at 30 Hope Drive and clinical research center (CRC) in the main hospital.

$3960

The purpose of the Vivistim Registry for Paired VNS Therapy (GRASP) isto gather real-world information on patients with arm and hand deficits post-stroke who are considering Vivistim System treatment. Before and afterVivistim System implant, patient data will be collected and reportedthroughout the therapy process.

The purpose of this study is to follow individuals that plan to be implanted with the MicroTransponder Vivistim® System. We will be collecting data at various time points over 3 years. Data collection includes questionnaires about arm movement, quality of life, productivity, and use of healthcare services. This study lasts for 3 years, with 6 total visits. One visit is prior to being implanted and 5 are post-implant. Visits can be done via telephone or in person. Questionnaires and Therapy data will be collected at each visit.

$600.00

Comparing runners' perceptions of their running gait biomechanics to actual mechanics using RunScribe wearable technology validated drone video capture and subsequent kinematic analysis in a natural outdoor running environment.

You will complete a survey and be asked to run a short distance on a track at your typical long distance pace while being filmed by a drone and while wearing a wearable RunScribe device on your shoe.

$50

This is a drug study for children between 7-12 years old with ADHD that will examine how central nervous system (CNS) stimulants improve anger and irritability in children. It uses only meds that are already FDA approved for ADHD. After intake, families will meet with study doctors to determine an ideal stimulant dose (no placebos in this phase) over 6 visits spaced 1-2 weeks apart. All youth showing improved ADHD and stable or reduced levels of irritability/aggression will advance to a 2 week blinded crossover trial. Participants will complete computer tasks while hooked up to EEG to measure how CNS stimulants impact processing of reward and loss. Participants will complete two EEG visits one week apart - one visit will occur while the child is on the optimal active dose of CNS stimulant from the prior phase, and the other will occur while the child is on a placebo pill. Parents will complete 3 cell phone surveys per day of their child's behavior over these 14 days. This study is expected to take an average of 10 visits over 3 months.

Parent and child will first complete an intake up two hours (30 minutes for child) to verify that child has ADHD and issues with temper problems at home. Then over 6 visits spaced 1-2 weeks apart study doctors will find the best dose of ADHD medication for the child that also helps their anger, with parents filling out weekly ratings of child behavior. All medicines used in the study are already approved to treat ADHD in children and commercially available. At least half of these visits need to occur at the study site at 22 NE Drive in Hershey, PA. For the last two weeks, there will be one in office visit per week at the Hershey office. Children will complete 3 computer games while undergoing EEG testing to measure their brain wave activity. For each of these 14 days, parents will fill out 3 cell phone surveys per day about their child’s behavior. During one of these two weeks, children will take the dose of ADHD medication that worked the best for them. For the other week, it will be replaced with placebo (fake pill). Neither parent or child will know which week is real and which week is fake medication. The total study takes between 10 to 12 visits over an average of 3 months.

child is $100 parent is $105

Patients who are undergoing monitoring with scalp or intracortical EEG can be followed in the epilepsy monitoring unit for more than a week. This clinical resource provides an opportunity to conduct a comparison of imagery-based brain-computer interface control between scalp and intracranial recordings. The outcomes will be the information density of the signal of intent using the two recording methods, as well as the accuracy in controlling a single- and multi-dimensional computer task. A control group of neurologically-healthy control participants will be compared.

There will be two in-person visits lasting one hour each. Participants will complete a set of questionnaires and have an electroencephalography (EEG) recording performed while completing computer tasks.

$40

The purpose of this voluntary research study is to examine how individual differences in emotion regulation patterns are implicated in risk for depression in children and adolescents.

In this study, you will complete some interviews and surveys about you and your child’s mental health history, moods and emotions. We will also have your child complete two brain assessments (EEG and fMRI) at the start of the study, and at 12 and 24 months. You will complete follow-up surveys and interview assessments at 6, 12, 18, and 24 months.

$455

A study that looks at the efficacy of Frexalimab compared to standard of care drug, Teriflunomide, for adults with relapsing forms of MS.

The purpose of this clinical trial is to compare the efficacy and safety of investigational products in adult participants with relapsing forms of multiple sclerosis. There will be about 22 in person visits over 3.5 years that consist of monthly IV medication administration, monthly oral tablet medication dispensation, Magnetic resonance imaging (MRI) roughly every 6 months, monthly blood draws for lab work, vitals, ECG, and clinical outcome assessments. 13 of these visits are within the first 12 months of the study. All study activities will be done at the Penn State Health Hershey Medical Center in the Neurology Clinic at 30 Hope Drive and the Clinical Research Center (CRC) in the main hospital.

Up to $4300