This study will aim to see if there is a difference in strength and balance changes among college students when comparing the Wii Fit Balance and whole-body vibration training.

The study duration will be six-weeks, in which study participants will be involved in either a gaming training group or a vibration platform training group. Participants will complete a baseline session and post-training assessment, each lasting two hours. During both of these visits measures of balance, strength, and walking ability will be acquired. In the six weeks of the study,18 individual vibration or gaming training sessions will be completed. The respective training sessions will take place three times a week for 6 weeks and will last 10-minutes each.

$20.00

The purpose of this research study is to determine if a healthy Mediterranean diet containing one medium potato/day has equivalent or non-different effects on risk factors for type 2 diabetes and heart disease as a healthy Mediterranean diet without potatoes. Participants will be randomly assigned to one of the test diets and be asked to consume this diet for 12 weeks (84 days). Testing will be conducted at the beginning and end of the study.

This study runs for about 3 months. During this time, you will be randomly assigned to one of the test diets and be asked to consume this diet for 12 weeks (84 days). We will provide you with all of the food you need to follow this diet. This will include 3 meals, snacks and some beverages prepared in the Penn State Research Kitchen, which will meet your energy and nutrient needs. During the study, we will ask you not to eat any foods outside of those provided by the study. You may have up to 5 days off the diet during the 12 week period. Testing will take place on two separate days at the beginning and end of the study (4 testing days total). For these visits, you will need to fast for 12 hours prior and avoid alcohol for 48 hours. At these visits, we will collect a blood sample, measure your weight, and perform non-invasive tests to assess your vascular health. You will also be asked to wear a continuous glucose monitor (CGM) for 14 days—7 days before the first testing visit and 7 days at the end of the study. The CGM is a small sensor worn on your arm that measures your blood sugar every 15 minutes. You will need to attend a visit to have the CGM fitted (2 visits total). Additionally, we will ask you to collect a stool sample twice during the study.

500

This study aims to support midlife adults by enhancing their emotional well-being and reducing psychological stress, which may affect cardiometabolic health. We are evaluating a novel 4-week program that integrates three components—emotional well-being–enhancing writing, chair-assisted squats, and slow-paced breathing—using a factorial design. Eighty adults aged 40–65 with a sedentary lifestyle will be randomly assigned to one of eight groups that include different combinations of these activities. Participants will engage in their assigned activities via Zoom five times per week over four weeks. Emotional well-being and stress will be assessed through self-report at multiple time points, and physiological health (e.g., blood pressure, heart rate, heart rate variability, inflammation) will be measured during in-person visits before and after the program. The study will also evaluate the feasibility, acceptability, and preliminary effects of each intervention component and their combinations.

Participants will engage in a four-week program involving three components: EWB-enhancing writing exercises, chair assisted squat, and slow-paced breathing. They will complete these activities five times per week, with each session lasting 30 minutes.Participants will undergo cardiovascular assessments at Penn State University’s Biobehavioral Health (BBH) Building at baseline and post-intervention. These assessments will include heart rate variability measured via a standard three-lead electrocardiogram (ECG) and continuous blood pressure measured non-invasively using a finger cuff device that captures beat-to-beat waveforms.

$300

This study is comparing using rilvegostomig or pembrolizumab with a platinum based chemotherapy. The doctor, subject and study team will not know if the subject is receiving rilvegostomig or pembrolizumab.

After signing consent to agree to join the study, the subject will have lab work and scans of their body to see if they are wll enough to participate. If they begin study treatment, they must come to all study visits. It is important that the subject tell the study team if there has been a change in their medications and how they are feeling. Subjects will continue treatment until the treatment no longer is working, they no longer want to participate of the study doctor feels it is not safe for them to participate any further. Once study treatment is finished, subjects will be followed to see how they are feeling and what new treatments for their cancer they are getting.

$75.00 for each visit completed for a minimum of $300. Compensation may be more if additional visits are completed.

The IRB proposal is to conduct research to enhance effectiveness of teaching and learning in college.

Consent for Exempt Research The Pennsylvania State University Title of Project: A Study of Effective Teaching Methods across College Courses Principal Investigator: Yi-An Burleson, Ph.D. Email: ylb5007@psu.edu You are invited to volunteer to participate in a research study. This summary explains information about this research. The study is to collect data to know ways to improve college teaching and learning. Participants will fill out online surveys in teaching and learning in addition to demographic information (e.g. gender, ethnicity, year of study, etc.). It may take 40-50 minutes to complete all of the questions in the surveys. You are strongly encouraged to take the surveys at the beginning of a semester/quarter/term and then at the end of a semester/quarter/term. You are welcome to take the surveys in more than one semester/quarter/term but no more than twice per semester/quarter/term. There may be mild discomfort in feelings, but no risk beyond mild discomfort is involved in the study. If you feel distressed after taking the surveys, you are encouraged to seek counseling resources at college counseling centers. A list of counseling resources is available on request. Other than your email, no other identifying information will be collected. All of the information you provided will be kept confidential by storing it on password protected devices and two-factor authenticated (2FA) online Drive. You can get access through the Sona system/Study Finder of Penn State University. If you are a student at Pennsylvania State University, you can earn 3 points per course by sending an email to indicate that you in the study (with the name of the study), signing up on the Sona system, and indicate that you consent to participate by, clicking “Yes, I consent to participate. My responses to the following questions indicate that I agree to participate” on top of the Google Form at https://forms.gle/H3p2SnErkhpWmYYm7 and then fill out the online surveys at the end of the consent form. You can fill out the survey in the beginning and end of the semester for multiple semesters. If you have questions, complaints, or concerns about the research, you should contact Yi-An Burleson, Ph.D. at ylb5007@psu.edu. If you have questions regarding your rights as a research subject or concerns regarding your privacy, you may contact the Human Research Protection Program at 814-865-1775. Your participation is voluntary and you may decide to stop at any time. You do not have to answer any questions that you do not want to answer.

This is a Phase 3, randomized, double-blind, placebo-controlled study evaluating the clinical benefit and safety of EFX in subjects with compensated cirrhosis due to NASH/MASH. The study will enroll in 2 cohorts. Cohort 1 will enroll approximately 750 subjects with biopsy-proven compensated cirrhosis due to NASH/MASH. Cohort 2 will enroll approximately 400 subjects with a clinical diagnosis of compensated cirrhosis due to NASH/MASH.

You will be required to visit the study clinic at specific times points. Laboratory and safety assessments will be completed at each visit. You will need to take the study drug as directed. Study procedures that will be performed include Liver Imaging scans, Liver Stiffness Exams, Electrocardiogram, Bloodwork, Liver Biopsy and an Endoscopy.

The purpose of this Phase 2 clinical trial is to study treating patients with non-muscle invasive bladder cancer (NMIBC) with an investigational drug, Cretostimogene and DDM. Participants will be assigned to either Cohort A or Cohort B depending on whether they have previously been treated with BCG (Bacillus Calmette-Guerin) for NMIBC.

Eligible participants will receive the study drug, Cretostimogene every week for 6 treatments, followed by a maintenance period as directed by the Investigator. For the first 2 years after treatment initiation, participants will be assessed for disease status every 3 months by urine cytology and cystoscopy, with directed TURBT/biopsy (if indicated). CT urogram or MRU will be performed every 6 months. Thereafter, efficacy assessments will be performed at 6-month intervals for up to an additional 2 years

This dissertation will look at the implementation process of current DV policies/strategies and how the process can be improved in Pennsylvania. The proposal will incorporate the voices of DV survivors and understand their experience with DV services. The goal of the study is to recommend ways to enhance the support structures available to survivors and victims.

Participants will be asked to take part in a one-on-one interview over PSU PSU-licensed Zoom video or audio. The interview will last about 45 to 60 minutes. They will be asked about your experiences with services, any challenges you faced, and your thoughts on what could improve.

20

The study will investigate the role of standard medications for IBD on pregnancy outcomes. The subjects will be pregnant IBD patients receiving standard therapies. This study will also test whether the IBD medication transferred across placenta predicts the risk of infection. As many women receive these drugs during their reproductive years this information will guide future therapies for women with IBD and their children.

The participants will sign the informed consent. They will complete the questionnaires. There are four to five in the first year of pregnancy. After that, the questionnaires are annual, up to eighteen years after the birth of the child. The participants will have a blood sample done in the second trimester. They will send the sample to the sponsor.

The purpose of this study is to compare accuracy and repeatability of biomechanical metrics between technologies during golf swings. This study also aims to identify differences in swing characteristics between various skill levels and environments.

You will be screened with a Health History Questionnaire via email, online survey, or in-person. You will come to either the Suzy and Jim Broadhurst Golf Teaching and Research Center (GTRC) or the Penn State Golf Courses with your golf clubs to provide consent, collect blood pressure and heart rate, answer golf-related questions, and perform golf-related tasks (full swing shots with various clubs). Various technologies will be used to measure the biomechanics of your swing. The total time of participation is expected to be about 60-90 minutes.

When you have finished the golf-related activites, you will be provided with a brief piece of instruction from one of the Center’s two Class-A PGA Professionals.

This study aims to understand how well current methods for evaluating Counterfactual recourse recommendations match human preferences. Participants will review different Machine learning model generated Counterfactual options and provide feedback on which options they find more practical and feasible. The goal is to improve Counterfactual generation systems so that they can offer recommendations that better align with what people actually want or need.

The participants will attend two Zoom sessions. During each session, they will compare loan profile options and indicate their preferences and acceptable change limits. A researcher will record their responses in the survey form. Each session will last approximately 30–45 minutes. Participants will receive $10 for completing the first session and $15 for completing the second session.

25

This research is being done to investigate the effect of human-machine interface design on promoting driver situation awareness restoration and effective human-AI collaboration under varied takeover situations.

You will complete a set of questionnaires and evaluate the design of the automated driving system by driving on a driving simulator. During the drive, you will be asked to drive in automated mode and focus on tasks unrelated to driving until the system issues a takeover request. The form of the takeover request will change in the experiment. You will be wearing eye tracking glasses while performing the driving task. After the driving tasks, you will complete questionnaires about your perception of the system.

$10/hour

The objective of this study is to pilot test a text-message and electronic delivered educational intervention, Ready, Set Recharge focused on the mental health benefits of physical activity ( PA) in undergraduate students at Penn State University.

Participants interested in participating in this study will be directed to complete a pre-program survey that will take less than 30 minutes to complete. After completion of the survey, participants will be enrolled in the program which is 8 weeks in duration. The program is entirely online and participants will be sent weekly text messages with links to content to read about physical activity and mental health. Participants will also be taught strategies they can try to increase their physical activity behavior in their own life. Participants will compete weekly surveys that take less than 5 minutes to complete. At the end of the 8-weeks, participants will complete a post-program survey that will take less than 30 minutes to complete.

$25

This trial is looking at the progression free survival and overall survival in patients treated with docetaxel alone and those treated with docetaxel and RAS G12X-C

This study has 4 periods: 1. Pre-screening period (to provide your tumor genetic information) 2. Screening period (before you begin the study to see if you qualify for the study). This is when you will have all the testing done to make sure it is safe for you to join the study. it may require several trips to the hospital. 3. Study Treatment period (when you will receive the study treatment; this occurs in 21-day cycles). this is when you will be taking the study medication. For the first cycle of treatment you will need to come to the clinic about 3 times to make sure you are ok while taking the study drug. From cycle 2 onward you will need to come to the clinic twice. 4. Follow-up period (to check on you after your study treatment is finished) and then we will check to see how you are doing every three months. It is important that you come to all of your visits.

The present study will examine the role of different input conditions on the learning of words and morphosyntactic units in a new language. We specifically aim to examine the effects of variables researched in the field: type of knowledge (explicitly stated via pre-training, or incidental; Pellicer-Sánchez et al., 2021), salience (manipulated via input properties; Ellis & Sagarra, 2010) and modality (visual or auditory; Borro, 2021) play on learning outcomes. Our goal is to examine how cognitive processes underlying learning are affected by our manipulations, and the impact on learning outcomes. We hypothesize that pre-training will enhance speakers' ability to detect target vocabulary and structures to be learned. While the literature is mixed on the role of salience, across the experiments described below, we will explore the impact of low-level salience (e.g., text enhanced visually) and psychological salience (the amount of repetition / expectedness of a target items. We will also investigate the less investigated effect of modality.

This is a language learning study. There will be up to two visits to the research lab. Sessions will consist of simple tasks consisting of readings sentences, remembering words, and completing memory tasks. EEG data will be collected via a wearable EEG cap; eye-tracking data will be collected while reading and completing some of the tasks are on a computer.

18 / hour

SR604 is a monoclonal antibody that blocks anticoagulant activity, which improves clotting in patients with the clotting disorders of Hemophilia A & B. This study is looking at treatment options for Hemophilia A & B. There will be 4 cohorts (1B, 2B, 3B & 4B). Our site will be starting study drug SR604 dose escalation with 0.1mg/kg (2B), then 0.2mg/kg (3B) with the final dose 0.4mg/kg (4B). Lower doses will start in the first cohort & dose escalation will continue in subsequent cohorts after a 3-month monitoring period in each cohort. See page 44 of the protocol for patient numbers in each cohort.

Participants will receive subcutaneous SR604 every 4 weeks for 3 months. Total visits to site will be 15. Blood draws will be obtained at each of these 15 visits.

75.00 per visit travel reimbursement

This study aims to examine differences in physiological variables (inflammation and heart rate variability) at different menopausal stages and whether these differences influence depression symptomatology. There will be one 3.5-4 hour in person study visit that includes completion of questionnaires, cognitive tests, electrocardiogram (ECG) recordings, and one blood draw.

There will be one 3.5-4 hour in person study visit that includes completion of questionnaires, cognitive tests, electrocardiogram (ECG) recordings, and one blood draw. If you are still having menstrual periods, you will be asked to record menstrual bleeding on a menstrual calendar for 3 cycles.

75

Bilinguals frequently mix languages, even mid-sentence, when communicating with other bilinguals, a practice known as code-switching. This study aims to understand how bilinguals weave together different ways of producing the same sounds, corresponding to the languages they use, when code-switching. Participants will read aloud a list of sentences in Spanish, or in Spanish with switches to English partway through. They will also complete English and Spanish proficiency tasks and a questionnaire about their language background.

Participants will participate in a single session in our lab, lasting about an hour. During this time participants will: Produce words and sentences in Spanish and English. These will be audio recorded. Read and make decisions about words in Spanish and English. Name pictures in Spanish and English. These will be audio recorded. Complete a questionnaire about your language background.

$15

The purpose of this study is to find out if an implant of ACT is safe and effective in reducing urinary incontinence. The study will involve about 132 women that have urinary incontinence. This system is investigational. After placement of the devices, participants will be followed for 12 months on a regular visit schedule. Annual visits may continue for up to 5 year. ACT® is an implantable device for treating stress urinary incontinence. One end of the device is a balloon that is attached by a tube to a port at the other end of the device.

Participants will attend a screening visit, the implantation visit, post-op assessment, 6 week, 3 month, 6 month, 12 month, and annual follow up visits for necessary device adjustments.

600

This study is testing whether a lower dose of a medicine called cyclophosphamide (25 mg per kg), given after an allogeneic stem cell transplant, can reduce serious side effects and improve outcomes. We are enrolling people who are receiving a reduced-intensity or non-myeloablative (less intensive) stem cell transplant. We will follow participants for one year after their transplant to see if they stay free from severe graft-versus-host disease (GVHD), cancer relapse, or death. We will also look at overall survival, rates of GVHD, infections, donor cell recovery, and other side effects.

You must attend all scheduled study visits, tell the study doctor about all medications you are taking (including over-the-counter medicines), and let the study team know how you are feeling. Before joining the study, you will have routine health checks. These include breathing tests (called pulmonary function tests, or PFTs) to see how well your lungs work, and a heart scan (MUGA scan or echocardiogram) to see how well your heart is pumping. As part of this study, you will be given a low dose of cyclophosphamide (25 mg/kg) on day +3 and +4 after your stem cell transplant. You will be carefully monitored for any side effects, and the study team will evaluate your risk for graft-versus-host disease (GVHD) and disease relapse.

This project will be an 18-month dietary intervention of prune consumption during the late perimenopausal period of the menopause transition investigating if prune intake can slow down the rapid period of bone loss (bone mineral density) that occurs in the late transmenopause. The study will also investigate the effects of prune intake on inflammation, gut permeability, gut microbiome, and bone strength and geometry. Women transitioning into menopause will be randomized to either a group that will consume 6 prunes/day or to a no-prune group that will avoid prunes for the entire duration of the 18-month intervention. Both groups will consume calcium and vitamin D supplements daily. Study procedures will include collection of blood, urine, and stool samples, bone and body composition scans, completion of health-related questionnaires, exercise records, and daily compliance logs.

Participants will be asked to consume calcium and vitamin D supplements daily for 18 months and will be randomized into either a group that will be asked to consume 6 prunes daily for 18 months, or a control group that will be asked to avoid prunes and similar fruits (for example, blueberries, blackberries, pomegranates) for 18 months. There will be 10 in-person visits and 13 virtual visits (Zoom calls). In-person visits include questionnaires, blood draws, and bone and body composition scans. The study also involves urine and stool sampling.

$300

This study examines whether night-shift healthcare workers who experience greater differences in their sleep timing between days off and after night shifts also report poorer sleep quality. Participants will complete a brief anonymous online survey about their typical sleep patterns and overall sleep quality.

Complete a one-time anonymous online survey (5-10 minutes) about sleep patterns and sleep quality. Survey includes questions about typical sleep times on days off and after night shifts, plus brief demographics and work information.

This study is to see if patients with clinical stage I-III HER2+ breast cancer who achieve a pCR after neoadjuvant chemotherapy with HER2 blockade and receive a total of 6 months of HER2 blockade in the combined neoadjuvant + adjuvant (neo/adjuvant) setting will NOT have inferior (RFS) compared to patients who receive the standard total of 1 year of HER2 blockade.

Participants will get the HER2-targeted medication trastuzumab (with or without pertuzumab) for up to 51 weeks (approximately 12 months), or they will get the HER2-targeted medication trastuzumab (with or without pertuzumab) for up to 27 weeks (approximately 6 months). After participant finishes study treatment, your doctor will continue to follow your condition every 6 months for 5 years and watch for side effects or cancer coming back. Participants will see your doctor for 5 years after treatment. After that, every year for a total of 10 years after being enrolled on the study.

This is a usability study that will evaluate how allied health, education and technology professionals perceive a new virtual therapy environment designed for children with autism spectrum disorder. Participants will experience a guided session using a virtual reality headset and then complete questionnaires about usability, immersion, and any discomfort. The goal is to improve the tool before it is used in clinical settings.

There will be only one on-site meeting with one hour of duration. Participants will take part in an 25 minutes immersive experience in a virtual environment and complete one questionnaire before, and four questionnaires after the experience.

$30 Amazon gift card

The purpose of this voluntary research study is to test the effectiveness of the Positive Affect Intervention Program in reducing mental health symptoms for families experiencing financial hardship.

In this study, you and your child will attend some virtual study visits over 8 months. At each visit, you will complete some interviews, questionnaires, and discussion tasks with your child. You will be randomly assigned to either an 8-session prevention program or to receive weekly educational materials to read. You and your child will also be asked to complete some short daily phone surveys.

320 dollars

This study will see if participants who have the addition of saruparib to their treatment will have a longer time period before/if their cancer spreads.

Before participating in the trial, p[otential; participants will need to sign a consent form to have their tumor tested for the BRCA mutation. If the participants have this mutation in their tumor, they will be invited to participate in this trial. While you are receiving treatment you will need to come to the clinic on certain days for treatment, getting safety assessments, collection of blood samples and to see how you are feeling. You will come to the clinic every four weeks. The treatment will last for 24 months

This study is looking at how Mim8 works in people with hemophilia A, who either have inhibitors or do not have inhibitors. Mim8 is a new medicine that will be used to avoid bleeding episodes. Mim8 will be injected under the skin with a thin needle for up to 262 injections; the number of injections depends on how often injections are given.

Mim8 will be injected under the skin with a thin needle either once a week, once every two weeks or once a month. The study will last for up to 2.5 years. There will be fourteen in person visits and up to 2 phone visits. Completion of diary and PRO questionnaire.

$75 per visit up to $1050 (14 visits) to cover travel expenses

This study is comparing Pembrolizumab in combination with Sacituzumab Govitecan vs. standard treatment for individuals who have drug resistant advanced urolethial cancer

Participants will need to come to the clinic to meet with the study team and to sign a consent form. Once it has been determined that it is safe for you to participate, you will come into the clinic for treatment every 21 days, or depending upon the treatment arm you are assigned. You will continue to come into the clinic for treatment until the medication stops working, you no longer want to participate in the study or the document feels it is not safe for you to continue. You will be followed for up to five years to see how you are doing.

As more people around the world are getting older, there’s a growing need for homes that help seniors live independently while staying healthy, safe, and comfortable. This project explores how smart home technologies—like non-intrusive health monitors and privacy-respecting systems—can support aging in place. Instead of building these homes, the study gathers insights through surveys of older adults living independently to understand their needs, preferences, and concerns. Digital design tools (known as Building Information Modeling, or BIM) and Virtual Reality (VR) will be used to create simulated smart home environments based on the survey responses. These simulations allow researchers and participants to visualize and interact with potential home designs, helping older adults get familiar with future living spaces and stay socially connected through virtual activities that may reduce loneliness and support cognitive health. Artificial Intelligence (AI) is explored as a potential tool for enhancing smart home systems—such as monitoring health, detecting early signs of concern, and supporting memory and social interaction. While the homes are not being built, the project evaluates how these technologies might impact well-being, healthcare costs, and home durability. Findings will be shared through research papers, workshops, and online events to support the development of smarter, more supportive living environments for older adults.

Participants will be involved by taking a survey. We are still in the process of either choosing StudyFinder or Cloud Research. This study is designed to learn how older adults feel about smart home technologies that are meant to help them live safely and independently. Participants will be asked to complete a survey that includes questions about their comfort, safety, privacy, and interest in using devices like motion sensors, voice assistants, and virtual reality tools in their homes.

The purpose of this study is to evaluate the effect of lifetime self-report physical activity behavior on current cognitive and mental health status in populations of different ages through the lifespan. We will use a digital survey to obtain physical activity behavior reports, including intensity, duration, and physical activity type during several periods of each participant's life, and utilize online cognitive tests and mental health questionnaires to obtain current mental health and cognitive capacity.

Participants will complete an anonymous online survey that asks about their physical activity trends across their lifetime and their current mental health status. The survey will also direct the participants to several brief online cognitive tests. The survey will take approximately 20 minutes to complete. Participants who complete the survey will have the opportunity to fill out a separate form to be entered (via email address) into a drawing to win a $100 prize.

$100 compensation drawing entry