Search Results
A Confirmatory Phase 3 Mutlicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy of Topical HyBryte (Hypericin Sodium) and Visible-Light Activation for the Treatment of Cutaneous T-Cell Lymphoma (CTCL).
The purpose of this trial is to evaluate the safety and efficacy of 18 weeks of HyBryte (topical gel) treatment in combination with visible light therapy in subjects with cutaneous T-cell lymphoma when compared to placebo (no active ingredient). Cutaneous T-cell lymphoma (CTCL), of which the most common early stages are also known as mycosis fungoides (MF), is the most common type of T cell lymphoma. Participants will be enrolled in this trial for 30 weeks and will follow up at the clinic site every 4 weeks following the last trial treatment for a total of 12 weeks.
Participants will attend in person visits over 30 weeks. At different timepoints throughout the study participants will have their skin evaluated and photographed, have blood drawn, have an ECG done, and apply the study medication as directed by the study team.
Participants must have a minimum of 3 evaluable, discrete lesions
Participants must be willing to follow the clinical protocol and voluntarily give their written informed consent
Participants with extensive skin disease may not be eligible to participate; investigator will discuss during skin evaluation
Certain medical conditions may not be eligible to participate; study coordinator will discuss further.
Using the Socio-ecological Model to Assess Correlates of Physical Activity Participation Among Sexual and Gender Minority Adults
The purpose of this research is to examine correlates of physical activity participation among self-identifying sexual and/or gender diverse (e.g., non-heterosexual, non-cisgender) adults, guided by the socio-ecological model for health behavior (i.e., individual, social, communal, environmental).
Eligible participants will be invited to complete an open-link online survey that should take approximately 10 - 15 minutes to complete. There will be no other research activities after this unless individuals indicate that they would like to participate in a follow-up interview by indicating their interest on a separate form at the end of the survey. Participants who agree to take part in the interview (from the survey) will be contacted via email and an interview day/time will be scheduled. Three days before the interview, there will be an email reminder sent. Interviews will take place via Zoom at a day and time to be chosen by the participant.
Participants will be eligible to enter a drawing for a $50 gift card once they complete the survey. If you opt in to participate in the follow-up interview portion of the study, you will receive a $25 gift card for your time.
Identify as a sexual and/or gender diverse identity (i.e., non-heterosexual and/or non-cisgender).
Be able to participate in physical activities (e.g., exercise, sport).
Be able to read and write English.
Identify as heterosexual (i.e., straight).
Unable to participate in physical activities (e.g., exercise, sport)
Unable to read and write English.
PSCI 24-018 Phase 1, open label clinical trial to treat Stage IV cancer patients with multiple patient-specific mutated cell surface proteins with chimeric antibodies
This study will examine if giving patients their cells that have been modified in the lab will help control their cancer.
Subjects will be required to come to all visits. Each treatment will take 2-5 hours and there will be a total of 10 treatments over a 14 week period.
Subjects who have refractory or progressive disease after at least 1 line of systemic treatment
Subjects must have measurable disease
Known human immunodeficiency virus infection.
Subjects who have received any cytotoxic treatment within 3 weeks of antibody treatment.
Subjects who have received any radiotreatment to the primary sample site within the last 14 days
NUTRI-Beta Study: A Pilot Clinical Trial for Children with New Diagnosis of Stage 3 Type 1 Diabetes
This will be a 12-week single blinded, randomized, nutrition clinical trial for children with new diagnosis of stage 3 type 1 diabetes (clinical diagnosis of T1D). Beta cell function will be measured after 3 and 6 months.
Study participants in the intervention group will be required to follow the intake of specific foods and adhere to specific nutrition guidelines in addition to follow with a registered dietitian for 12 weeks (4 in person visits and 3 virtual visits). All these visits will be compensated. All study visits will be seen for a screening visit, an enrollment visit, 12-week visit and a 24-week visit. During the study visits, participants will undergo the following: physical exam/ demographic/social evaluation, clinical nutrition evaluation, nutrition counseling, dietary intake assessment, blood test collection, 2-hour Mixed Meal Tolerance Test (MMTT) and anthropometry.
$345
Age 6-17 years old, any gender
Attendance to the Pediatric diabetes clinic at Penn State Health in Hershey, PA
Positive antibodies for type 1 diabetes
History of seafood allergies and/or milk/dairy related allergies
Type 2 diabetes
Food sensory disorders
Pubertal children
Research on Survivorship Experiences: Disparities in cancer-related outcomes between rural and non-rural cancer survivors in the catchment areas of the Big 10 Cancer Research Consortium's Population Science Working Group
The objective of this cross sectional survey study is to describe the social and psychological outcomes of cancer survivors and characterize the disparities between rural and non-rural cancer survivors. We will collaborate will members of the Big 10 Cancer Research Consortium's Population Science Working Group to invite cancer survivors in rural and non-rural communities to complete one online survey, with each site targeting cancer survivors in their catchment areas. At Penn State, we will target recruitment to cancer survivors living in Pennsylvania. We plan to enroll 150 participants. It will take participants 30-40 minutes to complete the study and they will receive a $15 Amazon gift card for their time and effort.
If eligible, study participants will be asked to complete one online survey about their experience as a cancer survivor. Potential participants will first complete a REDCap screening form, if eligible, they will view the consent form. If they provide consent, they can complete the survey. A member of the Penn State study team will call the participant to confirm eligibility and once confirmed, will issue a $15 Amazon e-gift card. The entire study should take between 30-40 minutes to complete.
$15
non-metastatic cancer
1-5 years post completion of active treatment
no current evidence of cancer
living in certain counties in south central Pennsylvania
cannot speak or read English
unable to provide informed consent
less than 18 years old at time of cancer diagnosis
Dining Out in NYC: Using VR to investigate the influence of multisensory urban design factors on eating behavior in emerging adults
This study uses virtual reality to investigate how sensory aspects of an environment influence eating behavior. Specifically, subjects will be immersed in a virtual outdoor café environment and consume a standardized meal while being exposed to either a pleasant or unpleasant smell. Total food intake and mood will be measured following each visit.
Answer initial screening and demographics questionnaires. Two in-person visits to the lab to experience a VR setting and consume a provided meal. One visit will include a small hair sample. Answer questionnaires following the VR experience.
$20 in Amazon gift cards
Fluent in English
Not color blind or nose blind
No food allergies/sensitivities
No diagnosis of mental or physical disabilities that may affect appetite, eating behavior, or body awareness and balance (such as eating disorders, Major Depressive Disorder, epilepsy, and vertigo)
Not fluent in English
Color blind or nose blind
Self-reported food allergies/sensitivities
Have diagnosis of mental or physical disabilities that may affect appetite, eating behavior, or body awareness and balance (such as eating disorders, Major Depressive Disorder, epilepsy, and vertigo)
The Use of Micro-Doppler Radar for Fall Risk Assessment: A feasibility pilot
The purpose of this research is the understand the feasibility of using radar to identify older adults at high-risk for falls. We will enroll two groups of participants 65 and older: one group who self-report at least one fall in the past year and a control group that has no reported falls. Participants will move in front of the radar tool while we measure their movements. We will use machine learning algorithms to determine if there are differences in the movement patterns of those who have fallen versus those who have not. We hope that using the radar tool will be an effective method of identifying older adults at high risk for falls, thus enabling fall risk prevention interventions.
Participants 65 and older will come to one, 30-minute in-person visit at the Lebanon Valley College in Annville, PA and will perform a variety of movements that mimic activities of daily living. You will be asked to stand still, to get up and down from a chair, and to walk a short distance. You will be asked to repeat each of these movements several times while study team measures these movements with a radar device.
$20
able to walk 20 feet without stopping
able to walk without assistive devices
Fall Group: at least 1 fall in the past year
can read and write in English
self-reported chest pain or shortness of breath when walking less than 20 feet
any surgeries in the past 3 months
history of lower extremity surgery that would alter normal gait mechanics (e.g. amputation))
chronic neurodegenerative disease or cognitive impairment
Children's appetite regulation study
The purpose of this study is to determine whether girls and boys regulate their appetites differently. Children will attend 1, 3 hour session in the laboratory, complete some surveys and health measures, donate saliva, and eat pizza.
Children will come to the lab for a 3.5 hour session where they will wear a heart rate monitor, conduct some surveys, have their veggie intake measured, provide some saliva, and eat some pizza. Parents will attend the lab visit with the child and complete questionnaires about feeding and the home environment.
$50 plus travel costs for > 20 miles from lab
Healthy without food allergies
Parent in charge of feeding able to attend with child
Children with medical problems or taking a prescription medication that may affect appetite
Children who are not willing to eat pizza in the laboratory
The parent in charge of feeding decisions cannot attend with the child