Search Results

The GAME-ONc Study aims to explore how video games can support teens and young adults going through cancer treatment. We will talk with adolescents and young adults with cancer, their parents, and healthcare providers to better understand what emotional, social, and practical challenges young people face during treatment, and how a video game intervention might help. The study will also ask participants what kinds of game features they’d like to see, such as whether the game should be single-player or involve someone else, what topics it should include (like coping strategies, health behaviors, or ways to connect with others), and how to make it easy and enjoyable to use. Ultimately, the feedback from this project will guide the design of a video game prototype tailored for teenagers and young adults with cancer, setting the stage for future testing and development.

Participants will complete a brief demographic and gameplay preferences questionnaire and then take part in a one-time focus group session (approximately 1-1.5 hours) conducted via Microsoft Teams or in person. During the focus group, participants will discuss psychosocial needs of adolescents and young adults with cancer and share their opinions on desired features, content, and usability of a proposed video game intervention. The session will be audio and video recorded for research purposes.

100

The overall goal of this study is to determine the effects, good and/or bad, of a new treatment regimen that combines dasatinib or imatinib to chemotherapy with blinatumomab in patients with Ph+ and ABL-class Ph-like B-ALL. In this study, you will receive blinatumomab with chemotherapy and dasatinib or imatinib.

The overall goal of this study is to determine the effects, good and/or bad, of a new treatment regimen that combines dasatinib or imatinib to chemotherapy with blinatumomab in patients with Ph+ and ABL-class Ph-like B-ALL. In this study, you will receive blinatumomab with chemotherapy and dasatinib or imatinib. All patients on this study will receive the immunotherapy medicine blinatumomab in addition to chemotherapy plus dasatinib or imatinib. The treatment on this study takes about 2 years. It is divided into 7-8 phases of therapy. Participants will be asked to do some optional tests that will help to learn more about their immune system. To do these tests, we would like to take about 2 teaspoons (6-10 ml) of peripheral blood and about 1 teaspoon (3-5 ml) of bone marrow (at the time of standard procedures) at different time points. These tests will not require additional needle sticks or additional procedures. There will also be optional collection of bone marrow and/or blood for banking for future research.

Current concussion testing tracks physical symptoms like headaches but often misses psychological factors that can slow down healing. This study asks patients to respond to prompts regarding their injury in three timepoints: acute, sub-acute, and post-acute phases of injury. We will use artificial intelligence to look for specific patterns in their language that might predict a longer recovery. The goal is to create a simple screening tool that helps doctors identify patients who need extra support earlier."

There will be three surveys over the course of one month. Each survey will take around 10-15 minutes.

This is a dietary treatment study that looks into the effects of the consumption of yogurt on child brain activity, behavioral control, memory, and gut health. This knowledge may help us better understand the health benefits of fermented dairy like yogurt. 60 children, ages 8-10 years-old, will complete 2 in-lab sessions that include problem-solving games, learning tasks, and IQ tests. This study also uses child-friendly brain scanning technology that uses light to record brain activity. Between the two sessions, children will consume either 1-2 yogurt or juice beverages per day for 4-weeks and also collect a stool sample before each session. Throughout the study, parents and children will complete a series of surveys that assess child behaviors, behavioral control, sleep habits, and more.

We are looking for children to help us learn about how different beverages can affect brain and gut health. The study consists of 2 visits to our facility in Chandlee Lab, located on the University Park Campus. In both visits, your child will play problem-solving games, take an IQ test, and wear a functional near-infrared spectroscopy (fNIRS) cap which uses light to measure your child's brain activity while playing a computer game. You and your child will also fill out questionnaires. We will provide you with supplies of a beverage to take home that your child will drink each day between the 2 visits (about 4 weeks). We also ask that you collect two stool samples from your child using our provided stool sample collection kits.

$300.00-380.00

This study examines how children plan and correct their speech while describing pictures. Children between the ages of 6 and 8 will complete several language and thinking tasks and then describe pictures in different situations. Researchers will listen for natural speech behaviors such as pauses, repetitions, and self-corrections. The goal is to understand whether these speech patterns are related to children’s language abilities. The findings may help researchers and clinicians better understand how children produce sentences and may eventually support improved methods for identifying children who may need help with language development.

There will be one session (60-75 minutes including breaks) in person or via Zoom. Parent completes a 5-10 minute questionnaire. Child completes language tasks (TONI and TILLS subtests) and a picture description task with audio recordings. A second 45-minute session may be scheduled if the child needs a longer break in the first session or could not finish it.

$50

The purpose of this study is to find out if gene expression signatures are different in people with cancer associated dermatomyositis (CAM) and CAM negative (CAM-) patients. Dermatomyositis (DM) participants will provide up to 3 blood samples and 2 skin samples for testing, including testing that has to do with genes. Control participants (those who do not have a skin condition) will provide up to 2 skin samples for testing, including testing that has to do with genes.

Only control subjects are being recruited through StudyFinder. There will be one in-person visit where up to 2 skin samples will be collected using a punch biopsy.

$50.00 per skin sample

We are developing a tool to help parents of young children practice communication, relationship building, and listening skills.

This is an online study where parents will be asked how they might verbally respond to common situations that come up in everyday life. Participants will also complete questionnaires on their and their child's thoughts, feelings, and behaviors.

$100 maximum

Ewing sarcoma (EWS) and osteosarcoma primarily affect adolescents and young adults. Common treatments include chemotherapy, surgery and radiation, however, there have been few recent advancements in the standard of care. By incorporating eflornithine (DFMO) as an additional therapy and/or maintenance therapy we hope to safely observe improved event-free survival and overall survival. There are 5 cohorts covered under this master protocol.

Patients will come in for screening and at the start of the study, and then approximately once a month during chemotherapy (if applicable). Patients may need to be seen more often for standard of care. During the DFMO alone phase, patients will come in once a month for the first 3 months, and then once every 3 months until the end of study treatment. During these visits patients will have tests done which may include a physical exam, blood tests, cardiac tests, hearing tests, or tumor evaluations.

We will utilize natural language processing using artificial intelligence to analyze text responses to open-ended survey questions. The population will be people who have experienced persistent symptoms following a concussion (more than three months), at any time in their life. We will also collect symptom data. The goal is to compare the symptom data between participants with cognitive distortions in their language compared to those with healthy language patterns.

Participants will complete one online survey using Qualtrics. If they choose to, they can be redirected to a gift card drawing after completing the survey.

In this project, we will study how elementary school aged children engage with our AI-integrated STEM learning materials. AI will be used as part of learning, particularly focusing on functions of converting text to images, storybooks, and videos.

If you participate, you will complete a survey, participate in an AI-integrated STEM learning session, and complete an interview (2 hours in total) on Penn State University Park campus or Penn State Hazleton campus.

$75

Participants will be asked to use a nicotine pouches, with either 3, 6, or 9mg of nicotine, in the laboratory while blood samples are collected. The study will measure the nicotine delivery and related effects of using nicotine pouches among current tobacco product users.

Participants will be asked to attend one study visit lasting approximately 1.5 hours. Participants will be asked to use a nicotine pouch in either 3, 6, or 9mg of nicotine while blood samples are collected.

175

The purpose of this Expanded Access Program is to determine the safety of cretostimogene in patients with BCG -unresponsive high-risk Non Muscle Invasive Bladder Cancer and to determine the Complete Response rate at any time of cretostimogene in patients with BCG-unresponsive CIS with or without HG Ta/T1 papillary NMIBC

Eligible participants will receive the study drug, Cretostimogene every week for 6 treatments, followed by a maintenance period as directed by the Investigator. There are 3 phases in the study: Screening Phase, Treatment Phase, and Follow-Up Phase. The Screening Phase will last up to 16 weeks (4 months). The Treatment Phase can continue for up to 2 years from the start of study treatment unless your cancer gets worse or recurs. The Follow-Up Phase will include one visit every 3 months after the last study treatment. If your cancer has not come back but you stop treatment before the end of the Treatment Phase, you will also have a study visit every 3 months in the Follow-Up Phase to confirm whether your cancer gets worse or recurs, until 2 years after the start of treatment. If your cancer has gotten worse or recurs at any point during the study, you will not be scheduled to return to the clinic/hospital for the study after the final visit, but you will be contacted approximately every 6 months.

Physical activity is the cornerstone of overall health and well-being and is associated with better survival and survivorship outcomes in pediatric cancer patients. This research is being conducted to identify biomarkers associated with the physical activity status of 90 children diagnosed with leukemia undergoing therapy.

During the first visit, you will answer demographic questions and provide medical history. You will then be asking to wear a Fitbit for at least 7 consecutive days, and participating in a second visit to collect saliva and blood samples

This trial will examine if the dose of drug determined in the Phase `1 portion can stop the cancer from growing.

There will be a screening period after you sign consent. You will have labs drawn and scans done to make sure it is safe for you to participate in this study. During the first 2 cycles, you will need to come to the clinic a total of 6 times. We do this to make sure you are feeling ok while taking these study medications. From C3 onward you will only need to come into the clinic twice. You will need to keep all of your clinic appointments, tell the study doctor how you are feeling and make sure that you tell them about any and all medications you are taking.

This a pilot study that will evaluate how feasible it is to use a questionnaire on paper, tablet or QR code to assess what barrier patient face to enroll in clinical trials at PSCI

Patient will fill out a 5 minute survey either on paper, tablet or on their own device.

The purpose of this clinical trial is to check the effect RBS2418 in combination with tremelimumab and durvalumab (referred to as STRIDE) may have on cancer and to determine which of the two RBS2418 doses is better and will be selected for further investigation.

Participation may last up to approximately 27-30 months and require several visits depending on how you do on the study, with each visit expected to take 2-4 hours unless you agree to participate in the subgroup that requires more blood collection. Blood will be drawn at each visit. Participants may also have to provide urine samples. A tumor specimen will be required at the screening visit. Optional specimens may be taken over the course of the study, if agreed upon. Every 6-8 weeks, a tumor scan will be completed. If the participant is assigned to Arm A or B, they will take the study drug daily, and all participants will have one infusion of tremelimumab and monthly infusions of durvalumab.

This study examines how individuals use general-purpose AI chatbots (e.g., ChatGPT, Gemini, Claude) when responding to personal, emotional, or difficult experiences, including experiences of victimization. Participants complete an anonymous online survey taking approximately 15–20 minutes covering patterns of chatbot use, emotional responses to these interactions, and help-seeking behavior. The study is open to all adults 18 and older. Participants may optionally enter a raffle for one of ten $25 Amazon e-gift cards.

Completing a brief, anonymous online survey that takes approximately 15–20 minutes.

This trial are looking at GIREDESTRANT to see if that combined with another drug, will work better and keeping breast cancer in remission after progressing on a CDK inhibitor.

Participants must come into the clinic to learn about the study and sign consent. Once it has been determined that it is safe to participate, participants must come to the clinic every other week for the first two cycles for a check up to see how they are feeling. This way the study doctors knows that it is safe to continue the study drugs. After the first two cycles you will come to the clinic once a month. You will have a physical exam, blood drawn and periodically through the study, scans to see how your cancer is responding to the study treatment. You will continue on the study therapy until your cancer no longer responds to it, you do not want to take the treatment any more or the study doctor feels it is unsafe for you to continue the study treatment.

To see if giving ovarian suppression subcutaneously at a different dose will adequately cause ovarian suppression in HR+ HER2 negative women

Once it has been determined that it is safe for your to participate, you will come in to the clinic about 5 times over the course of 168 days. On days one and 85 you will receive a shot of the study drug. You will need to tell the study team how you feel and all medications that you are taking.

$46/visit for travel reimbursement. You will need to provide receipts.

The purpose of this voluntary research study is to find out if cemiplimab and fianlimab with or without ipilimumab can shrink or stop advanced or metastatic clear cell kidney cancer from growing. This research study will include a screening period, a treatment period, and a follow up period, and participation may last up to five years

Participant will need to complete several screening tests. If participant qualifies for the study, participant will be asked to receive one of the study treatment combinations. Cemiplimab, fianlimab, and ipilimumab, or Cemiplimab and fianlimab, or Ipilimumab and nivolumab. Participant will continue receiving assigned combination for up to 96 weeks (about 22 months). Have regular tests and assessments, which may include physical exams, blood tests, imaging scans, and other procedures needed for your safety and for study purposes.

This is a Phase 3 study for Induction treatment of ulcerative colitis to evaluate safety and efficacy of duvakitug. The subjects are going to be enrolled in either the open label induction (Study-1), or placebo controlled induction (Study-2) across the study sites. All the participants who respond to treatment can be randomized into maintenance treatment.. The participants who do not respond to treatment will be eligible for an extended induction. The subjects must sign the informed consent before any procedures. the screening period will be for 5 weeks, and the Induction treatment will last 12 weeks. There will be six drug administrations in the induction treatment by subcutaneous injections. The participants will have in person visits, and will have procedures done such as blood draws, physical examination, endoscopy with biopsies, and completing questionnaires.

Participants will attend in person visit at the research clinical facility in Hershey, PA. If they sign the informed consent and want to participate, they will have vital checked, physical examination done. They will provide specimens such as blood and stool. They will answer questionnaires at home and in the clinic. The endoscopy will be done with biopsy to evaluate the disease response to the treatment. The drug will be administered by subcutaneous injection in the clinic. There will be a compensation for every completed visit.

$1400

The goal of this project is to better understand identity construction during the transition to parenthood and examine factors that facilitate the development of supportive coparenting relationships. Additionally, this study will leverage an AI tool to conduct AI-moderated interviews with new parents.

New parents will be asked to complete an AI-moderated interview about their experiences as a new parent and an online survey.

25

Everyday actions like typing, playing an instrument, or reaching for a series of objects require the brain to hold a plan in memory and then carry it out as a smooth sequence of movements. This study examines how people use vision, short-term (working) memory, and attention to plan and coordinate sequences of reaching movements. Participants memorize short sequences of targets shown on a screen and then reach to them in order on a robotic device while the researchers record their eye movements and hand movements (and, in some sessions, brain activity using a non-invasive EEG cap). The goal is to better understand how memory and movement work together — knowledge that may help improve training, rehabilitation, and assistive technology.

1) Participants complete a brief phone screening, then attend one or more in-person sessions of up to two hours each. 2) At each session, they give consent, answer short readiness and demographic questions, and perform a reaching task on a robotic device — memorizing sequences of targets and reaching to them — while their eye and arm movements (and, in some sessions, their brain activity via a non-invasive EEG cap) are recorded. 3) Some sessions also include brief visual distractions on the screen or gentle forces applied to the hand by the robot.

$30

Ecological momentary assessment (EMA) offers a holistic and naturalistic way to study how the events that unfold in daily life influence the relationship between psychological phenomenon in real time. Additionally, EMA methods allow researchers to collect data over a larger time span, which can provide crucial insights into how psychological symptoms interact over time. As such, the aim of the current study is to test how symptoms of generalized anxiety disorder (GAD), Social Anxiety Disorder (SAD), major depressive disorder (MDD), Panic Disorder (PD), and Post-Traumatic Stress Disorder (PTSD) interact and influence one another longitudinally in clinical and non-clinical groups. Similarly, because GAD, SAD, MDD, PD, and PTSD are thought to be maintained by certain thinking styles that are repetitive and negative in nature, we will examine how such repetitive negative thinking (RNT) styles moderate the severity and interactions between psychological symptoms. More specifically, we will study how RNT maintains and predicts psychological symptoms of GAD, SAD, MDD, PD, and PTSD respectively within clinical and non-clinical groups. Moreover, we will examine how theoretical models of RNT, such as the contrast avoidance (CA) model can influence psychological symptoms transdiagnostically, such that CA may moderate the relationship between RNT styles and symptom interactions of multiple disorders at the same time. Therefore, the primary aim of the proposed study will be to investigate how the CA model of anxiety and depression can moderate RNT styles in clinical and non-clinical groups.

First, participants will be asked to complete a series of questionnaires to determine if they qualify for eligibility. Next, participants will be asked to complete a video-recorded diagnostic interview to confirm their study eligibility. This interview can be completed virtually or in-person (Moore building, UP campus). They will then complete additional baseline questionnaires. Participants will then be prompted to answer 3.5 minutes worth of questions 7 times a day for 7 days. Participants will be debriefed once the study is completed.

The purpose of this study is to find out if full-fat dairy and low-fat dairy have similar effects on risk factors for heart disease and diabetes. The study will take approximately 4 months to complete. During the study, participants will consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. Participants will be provided with all the dairy products. Testing will be conducted on two separate days at the beginning and end of each 6-week study period (a total of 8 testing days).

• The total time commitment for this study is approximately 4 months. It may take up to 7 months to complete the study from the time that you do the clinic screening visit. • During the study, you will be asked to consume two types of dairy products: low-fat dairy (milk, yogurt, and cheese) and full-fat dairy (milk, yogurt, and cheese). We will provide you with the dairy products. • Each type of dairy will be consumed for 6 weeks with a ≥4-week break between. • You will be asked to come to the Penn State Research Kitchen on campus every 7 days during each 6-week period to pick up your dairy products. • We will draw blood from you several times during the study, once at screening, and on two consecutive days at the start and end of each study period (total 9 times). • At the start and end of each period, we will also measure your blood pressure and perform non-invasive tests of artery health. • You will also be asked to collect a stool sample at the beginning and end of each study period (4 total).

$400

The potential participants must have Crohn's disease diagnosis. They should have had previous standard or advanced therapies for CD and have been intolerant or have lost response. They will be asked to sign and understand the informed consent. The volunteers will provide biological specimens blood, urine, stool, and the biopsy during endoscopy. They will answer daily diary questions about the symptoms, and complete questionnaires in the clinic. The screening will involve at least two visit and will last five weeks. They will be treated in the open label sub-study 1, or double-blinded randomization with placebo in the sub-study 2. The non-responders will be eligible for extended induction in sub-study 3. Each sub-study is 12 weeks long.

Participants will attend in person visit at the research clinical facility in Hershey, PA. If they sign the informed consent and want to participate, they will have vitals checked, and physical examination done. They will provide specimens such as blood and stool. They will answer questionnaires at home and in the clinic. The endoscopy will be done with biopsy to evaluate the disease response to the treatment at screening and week 12, or week 24 for the extended induction if applicable. The drug will be administered by subcutaneous injection in the clinic or at home. There will be a compensation for every completed clinic visit.

TBD

Exercise conducted above the shoulders (i.e., overhead exercise) can reduce blood flow and oxygen delivery to the exercising muscle due to the effects of gravity. This ultimately leads to greater muscle fatigue during overhead exercise tasks which can lead to fatigue-related injuries in occupational settings. Cold-water exposure increases blood pressure (i.e., cold pressor response) and could increase blood flow to exercising muscle by increasing muscular perfusion pressure (i.e., pressure that pushes blood into the muscle) during overhead exercise. This has the potential to reduce muscle fatigue during overhead exercise. However, no studies to date have investigated the effect of cold-water exposure on muscle fatigue during overhead exercise.

There will be 4 in person visits at Penn State Altoona for this study. The first visit will be ~1 hour and the other 3 visits will be ~30 minutes. Participants will complete questionnaires, undergo body composition measurements, and resting blood pressure and heart rate measurements during visit 1. Participants will complete a handgrip exercise test during each visit and their arm will be placed in different positions (overhead or straight in front) during the exercise test. Blood pressure, muscle oxygen levels, and blood flow will be measured during the exercise test. During two of the visits, the participant's foot will be exposed to cold water (~40 degrees F) with a cold-water foot sleeve for a brief period of time (1-3 minutes).

$25

This is a behavioral and biological research study that will examine how first-time parents’ interactions, brain activity, and hormone levels during pregnancy are related to later parenting and infant development. Participants will complete questionnaires, take part in video-recorded interaction tasks, wear a non-invasive brain activity monitor, and provide saliva samples. At a follow-up visit, parents and their infant will participate in similar activities together.

There will be two in-person lab visits for first-time expectant father–mother couples: one during pregnancy and one when the baby is about 8 months old. During both visits, participants will complete questionnaires, take part in interaction tasks, wear a soft headband to measure brain activity, and provide saliva samples. At the second visit, parents will complete similar activities together with their baby, including parent–infant interaction tasks.

Up to $375 per family (including travel reimbursement)

This trial will see if bevacizumab, in combination with carboplatin, paclitaxel, and pembrolizumab is better than carboplatin, paclitaxel, and pembrolizumab (the control arm) or carboplatin, paclitaxel, and bevacizumab in prolonging survival.

After it has been determined that it is safe for you to participate, you will be randomized to one of three treatment combinations. All of the arms will use real drug to treat your cancer. You will need to come to the clinic every three or every six weeks for treatment. You will continue treatment until your cancer comes back, you do not want treatment any more or the doctor feels it is not safe for you to continue. You will then be followed for five years once you complete all treatment.

This qualitative research study uses the Interpretative Phenomenological Analysis (IPA) method to explore the lived experiences of first-generation adult students who have graduated from fully online college degree programs. The primary goal is to gain a deeper understanding of how these individuals made meaning of their academic journeys, the challenges they faced as first-generation students, and the factors that contributed to their success in an online learning environment. Participants will engage in one-hour open-ended interviews with the researchers held via Zoom videoconference

All participants will complete a brief 5-minute screening process via Zoom to determine eligibility. If participants meet the study criteria and are interested in moving forward with the study, an approximately 60-minute Zoom interview will be conducted. The interview will discus their experiences as first-generation adult graduates of fully online bachelor’s degree programs. A brief follow-up interview may be requested if clarification is needed.

$50 Amazon Gift Card