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Suggestions within category "Neurology"


46 Study Matches

Investigating Face Processing Behavior and Neural Circuitry

The ability to recognize faces differs across people. We are studying this variability in behavior and in brain responses in young adults (ages 18-25 years) in the Lab of Developmental Neuroscience at Penn State. If eligible, you will do face recognition tasks on the computer and answer survey questions. You may also be asked to participate in another session in which we take pictures of your brain using MRI. Volunteers are paid $10/hr for time in the lab. Interested participants can start the screening processing by clicking on this confidential screening link here: https://pennstate.qualtrics.com/jfe/form/SV_9NPJ20bQAPd0VKZ
Dr. Suzy Scherf at suzyscherf@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-25 years of age
Native English speaker
Free of neurological and psychiatric disorders
Free of concussions with loss of consciousness
Exclusion Criteria:
Family history of autism spectrum disorders (in parents or full siblings)
Neurology, Mental & Behavioral Health, Vision & Eyes
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Location
State College, PA

Predicting Ipsilesional Motor Deficits in Stroke with Dynamic Dominance Model

This study will test the hypothesize that the combination of low-moderate to severe paresis and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the less-impaired arm should improve functional independence.
Candice Maenza at CMaenza@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Right handed (pre-stroke)
Motor impairment in the arm
Had a stroke confirmed by neurology
Chronic stage of stroke
Over the age of 18
Exclusion Criteria:
neurological disease other than stroke
a major psychiatric diagnosis (e.g., schizophrenia, major affective disorder)
hospital admission for substance abuse
peripheral disorders affecting sensation or movement of the arms,
currently taking prescription drugs with known sedative properties that interfere with sensory-motor function
Neurology
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Location
Hershey, PA

Standard Chemotherapy versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients with Recurrent Glioblastoma Multiforme (GBM). CSCRGBM

The investigational purpose of this study is to screen chemotherapy drugs currently used for the care of recurrent glioblastoma (a form of brain cancer) and to determine the most effective treatment based on results from a chemosensitivity assay. Chemosensitivity drug assay refers to testing a patient's own cancer cells in the laboratory to drugs that are to be used to treat the patient's cancer. Following surgery, you will be treated either as per chemotherapy agents chosen by the physician or with chemotherapies as suggested by the results of the chemosensitivity testing. The study is looking to determine if patients treated with drugs predicted by the chemosensitivity test have better outcomes than patients treated with drugs chosen by the treating physician.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03632135
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Inclusion Criteria:
Histopathologically confirmed WHO grade IV recurrent astrocytoma (recurrent GBM)
Recurrent surgically resectable tumor
Estimated survival of at least 3 months;
Exclusion Criteria:
Subjects with newly diagnosed GBM
Pregnant women or nursing mothers cannot participate in the study. Women of childbearing age must have a negative pregnancy test within 72 hours prior to study entry.
Neurology, Cancer
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Hershey, PA

BHV-0223 Expanded Access Protocol in Patients with Amyotrophic Lateral Sclerosis

This is an Expanded Access Protocol (EAP) to provide a new version of riluzole that is placed under the tongue (sublingual) rather than swallowed.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03520517
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Inclusion Criteria:
Diagnosed with ALS
Swallowing difficulties OR choking at least once per week
Exclusion Criteria:
Pregnancy
Other serious medical condition that would interfere with your participation
Neurology
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Hershey, PA

Examining Cortical Lateralization of Motor Learning through High Definition Transcranial Direct Current Stimulation

The aim of this study is to understand how brain stimulation affects learning of a novel task on a virtual reality system. Participation involves playing virtual reality games during non-invasive brain stimulation.
Brooke Fosaaen at brooke.fosaaen@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
right-handed
18-40 years old
Exclusion Criteria:
left handed or ambidextrous
neurological disease
movement disorder
major psychiatric diagnosis
orthopedic damage to the arms
Neurology, Mental & Behavioral Health
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Hershey, PA
State College, PA

Remediation of the Non-Paretic Arm to Improve Functional Independence in Chronic Stroke Survivors

This study will test the hypothesize that the combination of low-moderate to severe paresis (Upper Extremity Fugl-Meyer Score ≤35) and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the non-paretic arm should improve functional independence. We propose a randomized study design with two tracts, two periods and four assessments.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
> 3 months post unilateral stroke
Age 21-85
Demonstrates cognitive abilities
Exclusion Criteria:
hospitalization for substance abuse and/or psychiatric diagnosis
non-stroke neurological diseases
certain peripheral movement restrictions
brainstem/cerebellar damage
Neurology, Mental & Behavioral Health
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Location
Hershey, PA

eLLiPSIS—A Longitudinal, Observational Study to Examine the Measurement Characteristics of the Pompe Disease Symptom Scale and the Pompe Disease Impact Scale

The purpose of this non-interventional study is to measure the performance of the Pompe Disease Symptom Scale (PDSS) and the Pompe Disease Impact Scale (PDIS), which are disease-specific patient reported outcome (PRO) instruments exclusively for Pompe disease.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with late-onset Pompe disease
Enzyme Replacement Therapy Infusions occur no more frequently than every two weeks
Exclusion Criteria:
Patients who are wheelchair dependent OR unable to ambulate 50 meters (approximately 160 feet) without stopping and without an assistive device
Patients who require invasive-ventilation (non-invasive ventilation is allowed)
Patients currently on investigational drug/clinical trials
Neurology
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Location
Hershey, PA

Regional Brain Manganese Accumulation and Functional Consequences in Welders

This study is looking at the effects of welding fumes on brain health. Our group has found brain structure and functional changes using brain MRI and other tests for movement and function in active welders. Now, we are very interested to see if the brain function and structural changes persist in welders, particularly after they retire. This is an independent study sponsored by the National Institute of Environmental Health Sciences, with no affiliation to any private entities such as law firms. In this study participants will be asked to undergo clinical tests (blood draw, motor examination, memory tests), complete lifestyle questionnaires, and undergo an MRI scan during a baseline visit and again for an 18 month follow-up visit.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Welders: Boilermakers, pipefitters, etc.
Controls: No past exposure to welding
Controls: Males ages 40-70
Fluent in English
Consent to MRI
Exclusion Criteria:
Severe memory impairment or signs of dementia
Claustrophobia or unwillingness to participate in a MRI
Significant medical and neurological defects
Significant recreational drug use or alcohol abuse
Neurology
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Hershey, PA

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Intravenously Administered BIIB092 in Participants with Progressive Supranuclear Palsy

This study is for patients who have been diagnosed with Progressive Supranuclear Palsy (PSP) which is a rare brain disorder that causes serious and progressive problems with control of walking and balance, eye movement and thinking. This research is being done to see how well an investigational medicine compared to placebo and the long-term safety and tolerability of the drug in patients with PSP. The study will also measure the amount of study drug in your blood after taking the drug, determine how your immune system reacts to BIIB092 and check other areas of health and disease that may be related to the study drug.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03068468
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Inclusion Criteria:
Patients diagnosed with Progressive Supranuclear Palsy (PSP)
Must have a caregiver who is willing to attend clinic visits with you
Be able to walk independently or with assistance (ability to take at least 10 steps with a walker or 10 steps without a walker/cane with the assistance of another person)
Able to tolerate MRI testing
Exclusion Criteria:
Presence of other significant neurologic or psychiatric disease
Diagnosis of ALS or other motor neuron disease
History of rapid eye movement sleep behavior disorder
Considering major surgery prior to study enrollment
Neurology
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Hershey, PA

Examining elderly traumatic brain injury and risk for neurodegeneration

The purpose of this proposal is to understand the risk factors for Alzheimer’s disease after TBI, including time since diagnosis, ethnicity, and genetic predictors. In Aim 1 the goal is to collect data in a large group of individuals with TBI to understand these interacting factors in predicting cognitive decline. Then in Aim 2, in a sub-group of individuals we use brain imaging methods in order to determine the network response associated with neurodegeneration decades post TBI. Ultimately, the ability to monitor the neural network response to injury-specific factors in combination with risk/resiliency factors (e.g., genetic, health) may bring greater precision to rehabilitation in TBI and aid in identifying patients at risk for neurodegeneration years prior to onset. Three specific aims were designed to clarify the role of neural recruitment in recovery from TBI: 


Frank Hillary at fgh3@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
>54 years of age
sustained a traumatic brain injury
Exclusion Criteria:
<55 years of age
history of neurological disorder such as stroke, epilepsy, or multiple sclerosis
history of bipolar
Neurology
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Location
State College, PA

Application of graph theory to both resting-state and task-based fMRI data to uncover brain-behavior relationships related to therapy outcomes in aphasia

This project will use fMRI to examine changes in the brain related to behavioral therapy outcomes in persons with aphasia. We aim to recruit twenty persons with aphasia. Each participant will receive 4 MRI scans. Between scan 1 and scan 2, no therapy will be provided (10 week break). Between scan 2 and scan 3, ten weeks of word finding therapy will be provided. Between scan 3 and scan 4, no therapy will be provided (10 week break). The therapy used is abstract word retrieval training. The results of this project will help inform rehabilitation practices in aphasia.
Chaleece Sandberg at cws18@psu.edu or 814-863-2006
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Diagnosis of aphasia
Sustained stroke at least 6 months ago
Right-handed
Native English speaker
Completed at least a high school education
Exclusion Criteria:
History of neurodegenerative disease (e.g., Alzheimer's)
History of other acquired neurological disorder (e.g., TBI)
History of developmental disorder (e.g., autism)
History of psychological disorder (e.g., schizophrenia)
Unsafe to receive MRI (e.g., pacemaker)
Neurology, Language & Linguistics
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Location
Hershey, PA

Functional magnetic resonance imaging (fMRI) and psychophysical studies of sensory perception and cognition

The purpose of this study is (1) to understand how the brain processes sensory information and (2) how this is affected by factors like blindness or synesthesia. In addition to behavioral testing, the study will use functional magnetic resonance imaging (fMRI) which enables us to take pictures of the brain while you are doing a task, using an instrument called an MRI scanner.
Simon Lacey at slacey2@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy adults over 18 years old
Normal or corrected-to-normal vision
No other sensory deficits
Adults who experience synesthesia
Must pass MRI safety screen (if applicable)
Exclusion Criteria:
Pregnant women (excluded from fMRI studies)
Minors under the age of 18
Individuals who fail the MRI safety screen (may still do behavioral studies)
Neurology, Language & Linguistics, Vision & Eyes
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Location
Hershey, PA

Perception of Brain Injuries: Viewpoints from college students

The purpose of this study is to learn more about the knowledge, thoughts, and experiences of college students regarding brain injuries through a semi-structured interview.
Nicole Etter at nme2@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18 years and older
Current college student
English and Hearing sufficient to complete a semi-structured interview
Exclusion Criteria:
Does not meet inclusion criteria
Education, Neurology, Sports Medicine
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Learning about Girls’ Emotions Study

In this study, we hope to better understand whether certain behaviors, reactions and feelings associated with Borderline Personality Disorder (BPD) are found in girls, and how these things may or may not be related to ADHD and brain activity patterns. BPD is a condition that usually is found in adults, and is linked to emotional and behavior problems in children. In doing so, we are asking girls between the ages of 8-12 years and their parents to participate in our research.
Attention and Behavior Clinic Research Group at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285966
Female
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Ages 8-12 years
Female
With or without ADHD Diagnosis
Speak fluent English
Exclusion Criteria:
Younger than 8 years old
Older than 12 years old
Male
Neurology, Mental & Behavioral Health
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Location
Hershey, PA

EAT-10 Implementation in Amyotrophic Lateral Sclerosis (ALS) Clinic

This study will evaluate the implementation of a clinical tool (EAT-10) within the Penn State Hershey ALS Center. Participation in the study requires completion of 2 surveys - one during an ALS clinic visit and another one 6 weeks later. This will be repeated at up to 10 visits.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years old
Diagnosed with motor neuron disease, including but not limited to amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), or progressive muscular atrophy (PMA)
Receive care at the Penn State Hershey ALS Center
Exclusion Criteria:
Significant cognitive impairment
Neurology
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NSF Proposal 2000047: Understanding the contribution of individual differences to domain-general and domain-specific components of false memories in both young and older adults

This research study investigates the neural processes underlying how people process, store, and remember visual or auditory information.
Nancy Dennis at nad12@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Ages 18-30
Ages 60-80
High school education
Exclusion Criteria:
Neurological Disorders
Neurology, Mental & Behavioral Health
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Study Locations

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Location
State College, PA