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Search Results within category "Heart & Vascular"

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Suggestions within category "Heart & Vascular"


38 Study Matches

Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Reduced Ejection Fraction (ANTHEM-HFrEF)

To assess the safety and efficacy of the VITARIA System when added to stable, guideline directed medical therapy for patients with heart failure and reduced left ventricular ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03425422
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Inclusion Criteria:
Have an Ejection Fraction (EF) ≤ 35%
Exclusion Criteria:
Chronic (permanent) atrial fibrillation, or previous ablation for atrial fibrillation
Pregnant, planning on getting pregnant, or breastfeeding during the study
Previous or current implanted system or lead for vagus or other nerve stimulation
Heart failure due to congenital heart disease, hypertrophic obstructive cardiomyopathy, or infiltrative cardiomyopathy (e.g. amyloidosis, sarcoidosis)
Heart & Vascular
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Location
Hershey, PA

Pilot Study to Assess Medication Adherence, Health Literacy, and Technological Literacy among African Americans and Latinos with Hypertension

This pilot study aims explore the health literacy and medication adherence found among African Americans and Latinos with hypertension receiving care at Hamilton Health Center in Harrisburg PA. We also aim to determine the feasibility of the iPad or smartphone as a tool for accessing health related information among African American and Latino patients with hypertension receiving care at clinics at Hamilton Health Center in Harrisburg PA. The expected outcomes of this project are to obtain a better understand of the literacy levels and adherence behaviors of African Americans and Latinos in Harrisburg, Pennsylvania. The findings from this study will provide valuable insights into the health management behaviors of this community and determine if there is a need to develop a mobile health application for the management of hypertension.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-2044
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with high blood pressure
Prescribed medication for high blood pressure
African American/Black (Hispanic or Non-Hispanic) or White (Hispanic)
21 years and older
Able to speak and read English
Exclusion Criteria:
Unable to provide consent to participate in the study
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Assessment of Endothelial Function in Post-Menopausal Women with Depression

The goal of this project is to understand the contribution of depression on blood vessel function in post-menopausal women, a population at heightened risk for cardiovascular disease. Currently, little is known about the combined impact of depressive symptoms and the effects of reproductive aging on blood vessel function. As such, there is a greater need to characterize blood vessel function in post-menopausal women with depressive symptoms. Participants depressive symptoms will be assessed and non-invasive vascular measures will be performed.
Jigar Gosalia at jzg691@psu.edu or 814-863-3182
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Post-menopausal women who are at least 1 year removed from their final menstrual period and between the ages of 50 and 80
Postmenopausal women with moderate to severe depression
Non-depressed post-menopausal women are needed as well for control group comparisons
Free from blood-pressure lowering medication and lipid lowering medication
Exclusion Criteria:
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s).
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals taking hormone therapy
Individuals with a BMI > 35
Heart & Vascular, Mental & Behavioral Health, Women's Health
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Location
State College, PA

fMRI based mapping of the supraspinal projections of the exercise pressor reflex

This study will examine how the brain controls blood pressure responses during exercise, and will include 2 separate visits. In one visit, you will perform a series of handgrip exercises followed by inflation of a blood pressure cuff while we collect muscle nerve activity and blood pressure. In the other two sessions you will perform a similar task while laying in an MRI machine.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
age between 21 and 40 years
healthy
able to perform handgrip execise
normal blood pressure
Exclusion Criteria:
claustrophobic
have metal implants
taking heart medication
pregnant/nursing
smoker
Heart & Vascular
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Study Locations

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Location
Hershey, PA

Identification of Critical Thermal Environments for Aged Adults

The earth’s climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely exercise in warm and/or humid conditions. It is important to learn about safe limits of heat and humidity for older adults to exercise. Also, nearly 40% of adults over age 50 take aspirin to lower their risk for heart disease. Our lab has shown that aspirin lowers the control of body heat. In this study, we will determine critical temperature and humidity environments above which normal body temperature cannot be maintained in young and older adults. We will also look at how aspirin may change critical temperature and humidity thresholds in older adults.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04284397
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Inclusion Criteria:
Healthy subjects 18-35 or 40-85 years of age
Asymptomatic and no signs/symptoms of disease
Exclusion Criteria:
Have any conditions to advise against low-intensity physical activity
History of Crohn's disease, diverticulitis, or other similar gastrointestinal disease
Medications that could alter cardiovascular responses or body temperature regulation during exercise (blood pressure reducers, fever reducers, anti-depressants, etc.)
Tobacco or recreational drug use
Post-menopausal women taking hormone replacement therapy
Heart & Vascular, Sports Medicine
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Location
State College, PA

Novel Therapies to Improve Cardiac and Skeletal Muscle O2 Supply-Demand Mismatch in Older Adults with Peripheral Arterial Disease: Esmolol infusion

This research is being conducted to determine how oxygen delivery to the heart and leg muscles is altered when beta-1 receptors (receptors involved in the “fight or flight” response) are temporarily blocked through a medication infused into an arm vein (compared to when a simple saline solution is infused). This will help us determine whether the medication, Esmolol, a beta-1 blocker, can eventually be used in the evaluation or treatment of PAD.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04181606
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Inclusion Criteria:
Men and women age 21-85 years
Healthy
Not currently taking medications affecting heart rate or contractility
Exclusion Criteria:
Females who are pregnant or lactating
Bleeding or clotting disorder
HIstory of angina or recent heart attack
Diabetes or hypertension
Heart & Vascular
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Study Locations

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Location
Hershey, PA

The effectiveness of a community-based steps challenge on cardiovascular health outcomes in adults

The purpose of this study is to determine the effect of Blair County’s Active Living Steps Challenge on cardiovascular health in adults participating in the intervention compared to a control group of adults also living in Blair county who are not participating in the Steps Challenge.
Nicole Gilbertson at nmg46@psu.edu or 814-949-5016
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Males and Females
Ages 18-65 years old
Currently living and/or working in Blair County, Pennsylvania
Ability to walk for >10 minutes at a time
Exclusion Criteria:
Known cardiovascular disease, chronic obstructive pulmonary disease, cancer, diabetes, or renal disease
Conditions associated with cognitive impairment or medical instability that puts the subject at risk
Signs or symptoms suggestive of cardiovascular, metabolic, or renal disease
Females currently pregnant or breastfeeding
Currently involved in a program to gain or lose weight
Heart & Vascular, Prevention
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Study Locations

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Location
Altoona, PA

Endometriosis and microvascular dysfunction

Endometriosis, is a disorder that occurs in women, is when tissue that should be normally found inside the womb is also found in sites outside of the womb. This disorder impairs the function of the endothelium, the cells that line the body’s blood vessels (endothelium). The endothelium helps to control blood flow in healthy vessels. Women with this disorder not only have an increased risk for high blood pressure and high cholesterol, they also have an increased risk for cardiovascular disease. They have a higher risk for cardiovascular disease, too. With this study, we will learn how endometriosis impairs the lining of blood vessels and increases the risk for disease. We will test two different intervention strategies to reduce long-term cardiovascular disease risk in women with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05059626
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Inclusion Criteria:
Women, 18-45 years of age
Endometriosis
Exclusion Criteria:
Tobacco consumption (e.g. smoking)
Pregnant and/or breastfeeding
Taking blood pressure medication
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Study Locations

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Location
Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA
Williamsport, PA