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Suggestions within category "Heart & Vascular"


44 Study Matches

The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-40 years
Exclusion Criteria:
• Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
• Individuals that use nicotine-containing products
Illicit or recreational drug-use
• Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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Location
State College, PA

The effect of pistachios on blood sugar control, heart and gut health

The purpose of the study is to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk factors for heart disease. This study will also investigate how pistachios affects gut health.
Terry Riley at tmr359@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 30-75 years
BMI 25-45 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Night shift-workers and and those who cannot consume a snack in the evening
Food & Nutrition, Heart & Vascular
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State College, PA

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects with Heart Failure with Reduced Ejection Fraction and Decreased Exercise Tolerance (METEORIC-HF)

The study will evaluate the effect of treatment with omecamtiv mecarbil compared with placebo on exercise capacity as determined by cardiopulmonary exercise testing following 20 weeks of treatment with omecamtiv mecarbil or placebo.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03759392
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Inclusion Criteria:
age 18 to 85
taking medications for heart failure for at least 3 months
Exclusion Criteria:
severe heart valve disease
organ transplant
ongoing or planned cardiac rehab
pregnant, planning to be pregnant, or breast feeding
Heart & Vascular
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Hershey, PA

The Muscle Reflex: MRI Studies

This research is being done to examine how the response to leg exercise measured with MRI is different between patients with Peripheral Arterial Disease (PAD) and healthy volunteers.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
have ferromagnetic metal implants
are claustrophobic
Heart & Vascular
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Location
Hershey, PA

Beneficial effects of moderate heating on cardiovascular control in heart failure

The purpose of this project, is to examine if moderate whole body heating will effect the resting muscle sympathetic nerve activity (MSNA) and the MSNA response to the stimulation of muscle mechanoreceptors in chronic heart failure patients.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
non-smoker
Heart failure patients
•may be on medications
Healthy subjects
•no blood pressure or cholesterol meds
Exclusion Criteria:
pregnant or nursing women
uncontrolled blood pressure
recent heart attack in past 6 months
on kidney dialysis
Heart & Vascular
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Location
Hershey, PA

The peripheral vascular effects of sulfhydryl-containing antihypertensive pharmacotherapy on microvascular function and vessel remodeling in hypertensive humans

High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have poor results with medical treatment for hypertension. We examine the impact of different classes of drugs that doctors use to treat high blood pressure (hypertension) on blood vessel remodeling. Some drugs that doctors prescribe for their patients contain a “sulfhydryl group” (a sulfur atom bonded to a hydrogen atom). Drugs that have the sulfhydryl group may reduce blood vessel remodeling more that drugs that do not. For this study, participants who have high blood pressure perform the experiments, take a drug for 16-weeks to lower blood pressure, and repeat the experiments. We randomly assign one of three drugs to participants who have high blood pressure: a diuretic (“water pill”), a drug containing a sulfhydryl group, or a drug that does not contain a sulfhydryl group. Participants who do not have high blood pressure perform the experiments, but do not take any of the drugs. In some of our experiments, we use a technique called “microdialysis” (MD). With MD, we perfuse some research drugs into the skin on the forearm through tiny tubing that mimics capillaries. These MD drugs mimic or block substances the body naturally makes to control the small blood vessels in the skin. The drugs remain in nickel-sized areas around the tubing and do not go into the rest of the body. We also analyze very small skin samples (skin biopsy) obtained from the forearm. Lastly, we use a standard technique called “flow mediated dilation” (FMD) that uses blood pressure cuffs and ultrasound to look at the health of larger blood vessels in the body. FMD includes placing a small tablet of nitroglycerin under the tongue during part of the test.
Susan Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03179163
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Inclusion Criteria:
Women and men
40-65 years
May or may not have high blood pressure
Women who are post-menopausal are not taking hormone replacement therapy
· May or may not be taking a drug to lower blood pressure
Exclusion Criteria:
Current medications which could conceivably alter the cardiovascular or thermoregulatory control or responses (e.g. beta blockers, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers)
Allergy to latex
Use of tobacco products
Use of illegal/recreational drugs
Pregnancy or breastfeeding
Heart & Vascular
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Location
State College, PA

REducing Lung congestion symptoms using the V-wavE shunt in advanced heart failure (RELIEVE-HF)

The objective of the study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System to improve clinical outcomes in a certain high-risk group of symptomatic patients suffering from heart failure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03499236
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Inclusion Criteria:
18 years of age or older
Diagnosed by a physician and told that I have Heart Failure
Currently on medications for the treatment of HF
Have symptoms of HF such as shortness of breath, fatigue, inability to lie flat or reduced ability to exert myself
Have been hospitalized or treated in an emergency department within the past year for my HF
Exclusion Criteria:
Presently on kidney dialysis
Presently enrolled in another clinical research study for an investigational drug or device
Have had a heart transplant or am presently on a waiting list for a transplant
Have an implanted mechanical heart assist device (pump)
Heart & Vascular
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Location
Hershey, PA

Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Reduced Ejection Fraction (ANTHEM-HFrEF)

To assess the safety and efficacy of the VITARIA System when added to stable, guideline directed medical therapy for patients with heart failure and reduced left ventricular ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03425422
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Inclusion Criteria:
Have an Ejection Fraction (EF) ≤ 35%
Exclusion Criteria:
Chronic (permanent) atrial fibrillation, or previous ablation for atrial fibrillation
Pregnant, planning on getting pregnant, or breastfeeding during the study
Previous or current implanted system or lead for vagus or other nerve stimulation
Heart failure due to congenital heart disease, hypertrophic obstructive cardiomyopathy, or infiltrative cardiomyopathy (e.g. amyloidosis, sarcoidosis)
Heart & Vascular
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Hershey, PA

Pilot Study to Assess Medication Adherence, Health Literacy, and Technological Literacy among African Americans and Latinos with Hypertension

This pilot study aims explore the health literacy and medication adherence found among African Americans and Latinos with hypertension receiving care at Hamilton Health Center in Harrisburg PA. We also aim to determine the feasibility of the iPad or smartphone as a tool for accessing health related information among African American and Latino patients with hypertension receiving care at clinics at Hamilton Health Center in Harrisburg PA. The expected outcomes of this project are to obtain a better understand of the literacy levels and adherence behaviors of African Americans and Latinos in Harrisburg, Pennsylvania. The findings from this study will provide valuable insights into the health management behaviors of this community and determine if there is a need to develop a mobile health application for the management of hypertension.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-2044
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosed with high blood pressure
Prescribed medication for high blood pressure
African American/Black (Hispanic or Non-Hispanic) or White (Hispanic)
21 years and older
Able to speak and read English
Exclusion Criteria:
Unable to provide consent to participate in the study
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Assessment of Endothelial Function in Post-Menopausal Women with Depression

The goal of this project is to understand the contribution of depression on blood vessel function in post-menopausal women, a population at heightened risk for cardiovascular disease. Currently, little is known about the combined impact of depressive symptoms and the effects of reproductive aging on blood vessel function. As such, there is a greater need to characterize blood vessel function in post-menopausal women with depressive symptoms. Participants depressive symptoms will be assessed and non-invasive vascular measures will be performed.
Jigar Gosalia at jzg691@psu.edu or 814-863-3182
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Post-menopausal women who are at least 1 year removed from their final menstrual period and between the ages of 50 and 80
Individuals with moderate to severe depression as reflected by Patient Health Questionnaire (PHQ-9) score of 10 or greater for the depressed post-menopausal women group
We also need non-depressed healthy post-menopausal women are needed as well for control group comparisons
Free from blood-pressure lowering medication and lipid lowering medication
Exclusion Criteria:
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s).
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals taking hormone therapy
Individuals with a BMI > 35
Heart & Vascular, Mental & Behavioral Health, Women's Health
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Location
State College, PA

fMRI based mapping of the supraspinal projections of the exercise pressor reflex

This study will examine how the brain controls blood pressure responses during exercise, and will include 3 separate visits. In one visit, you will perform a series of handgrip exercises followed by inflation of a blood pressure cuff while we collect muscle nerve activity and blood pressure. In the other two sessions you will perform a similar task while laying in an MRI machine.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
age between 21 and 40 years
healthy
able to perform handgrip execise
normal blood pressure
Exclusion Criteria:
claustrophobic
have metal implants
taking heart medication
pregnant/nursing
smoker
Heart & Vascular
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Location
Hershey, PA

Identification of Critical Thermal Environments for Aged Adults

The earth’s climate is warming, and the number of heat waves has increased in recent years. At the same time, the number of adults over the age of 65 is growing. Humans sweat and increase blood flow to the skin to cool their body when they get hot. Older adults do not do this as well as young adults. This makes it harder to safely exercise in warm and/or humid conditions. It is important to learn about safe limits of heat and humidity for older adults to exercise. Also, nearly 40% of adults over age 50 take aspirin to lower their risk for heart disease. Our lab has shown that aspirin lowers the control of body heat. In this study, we will determine critical temperature and humidity environments above which normal body temperature cannot be maintained in young and older adults. We will also look at how aspirin may change critical temperature and humidity thresholds in older adults.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy subjects 18-30 or 65-85 years of age
Non-obese
Normal blood glucose (HbA1C <5.7%)
Normal cholesterol (LDL cholesterol <180 mg/dl)
Asymptomatic and no signs/symptoms of disease
Exclusion Criteria:
Have any conditions to advise against low-intensity physical activity
Received a prior diagnosis of cancer, cardiovascular disease, diabetes, or metabolic syndrome
Medications that could alter cardiovascular responses or body temperature regulation during exercise (blood pressure reducers, fever reducers, anti-depressants, etc.)
Tobacco or recreational drug use
Post-menopausal women taking hormone replacement therapy
Heart & Vascular, Sports Medicine
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Location
State College, PA

Novel Therapies to Improve Cardiac and Skeletal Muscle O2 Supply-Demand Mismatch in Older Adults with Peripheral Arterial Disease: Esmolol infusion

This research is being conducted to determine how oxygen delivery to the heart and leg muscles is altered when beta-1 receptors (receptors involved in the “fight or flight” response) are temporarily blocked through a medication infused into an arm vein (compared to when a simple saline solution is infused). This will help us determine whether the medication, Esmolol, a beta-1 blocker, can eventually be used in the evaluation or treatment of PAD.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04181606
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Inclusion Criteria:
Men and women age 21-85 years
Healthy
Not currently taking medications affecting heart rate or contractility
Exclusion Criteria:
Females who are pregnant or lactating
Bleeding or clotting disorder
HIstory of angina or recent heart attack
Diabetes or hypertension
Heart & Vascular
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Hershey, PA

The effectiveness of a community-based steps challenge on cardiovascular health outcomes in previously sedentary adults

The purpose of this study is to determine the effect of Blair County’s Active Living Steps Challenge on cardiovascular health in physically inactive adults participating in the intervention compared to a control group of adults also living in Blair county who are not participating in the Steps Challenge.
Nicole Gilbertson at nmg46@psu.edu or 814-949-5016
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Males and Females
Ages 18-65 years old
Currently living and/or working in Blair County, Pennsylvania
Not currently participating in planned, structured physical activity at least 30 minutes at moderate intensity on at least 3 days/week for at least 3 months
Ability to walk for >10 minutes at a time
Exclusion Criteria:
Known cardiovascular disease, chronic obstructive pulmonary disease, cancer, diabetes, or renal disease
Conditions associated with cognitive impairment or medical instability that puts the subject at risk
Signs or symptoms suggestive of cardiovascular, metabolic, or renal disease
Females currently pregnant or breastfeeding
Currently involved in a program to gain or lose weight
Heart & Vascular, Prevention
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Location
Altoona, PA