12-23 years old
<250 lbs
First-degree relative diagnosed with Bipolar I Disorder
Less than 20/40 far acuity (corrected or uncorrected)
Neurological injury or disease
Pregnant women
Current substance dependence

>= age 13
read and speak English
neurological disorders
developmental disorders
Autism

18-25 years old
Weigh less than 250 lbs.
Fluent English speaker
Metal in body
Neurological disorder (autism, developmental disorder)
Current pregnancy
Less than 20/40 far acuity (corrected or uncorrected)

Patients diagnosed with Progressive Supranuclear Palsy (PSP)
Must have a caregiver who is willing to attend clinic visits with you
Be able to walk independently or with assistance (ability to take at least 10 steps with a walker or 10 steps without a walker/cane with the assistance of another person)
Able to tolerate MRI testing
Presence of other significant neurologic or psychiatric disease
Diagnosis of ALS or other motor neuron disease
History of rapid eye movement sleep behavior disorder
Considering major surgery prior to study enrollment

Participants must be between the ages of 18 and 45.
Participants must be right handed.
Participants must be fluent English speakers.
Participants must have a body mass index (BMI) >= 25.
Participants must have experienced food eating/weight issues.
If participants are currently engaging in active dieting behaviors (e.g., a weight loss program) or they are taking medications that could alter appetite or body weight.
If participant have a lifetime history of diagnosed eating disorders, diabetes, hyperglycemia, high levels of triglycerides, or high cholesterol or other related medical conditions.
If participants have any known risk from exposure to high-field strength magnetic fields (e.g., pace makers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments.
If participants report that they are vegetarian/vegan.
If participants are not willing to refrain from using alcohol for 24 hours or from using nicotine products/recreational drugs for 3 weeks, or unwilling to fast from food for 5 hours prior to two of three lab visits.

infant is at least 3.5 months of age
infant born within +/- 3 weeks of due date
Infants without any serious medical complications
Infants of a healthy birth weight (>2500g; >5 lbs, 8 oz.)
infant not of healthy gestational age
infants <2500g; <5lbs, 8 oz at birth
Infants who experienced any serious medical complications

Children aged 8-12
Children outside of the 8-12 age range
History of seizures or photosensitive epilepsy

Over the age of 18
Monolingual speaker of English OR
Bilingual speaker of English and at least one other language
Normal hearing
Right-handed
Under the age of 18
Does not speak English
Hearing loss
History of head injury, stroke, TBI, or seizure

Patient must have a subjective memory concern as reported by patient, study partner, or clinician
Age 55-90 (inclusive)
Study Partner is available who has frequent contact with the patient (e.g. an average of 10 hours per week or more), and can accompany the patient to most visits to answer questions about the patient
Must speak English fluently
Good general health with no additional diseases/disorders expected to interfere with the study
Any use of tobacco or nicotine products within the past year
Any significant neurologic disease such as Alzheimer’s disease dementia, Parkinson’s disease, multi-infarct dementia, brain tumor, seizure disorder, etc.
History of alcohol or substance abuse or dependence within the past 2 years

Histopathologically confirmed WHO grade IV recurrent astrocytoma (recurrent GBM)
Recurrent surgically resectable tumor
Estimated survival of at least 3 months;
Subjects with newly diagnosed GBM
Pregnant women or nursing mothers cannot participate in the study. Women of childbearing age must have a negative pregnancy test within 72 hours prior to study entry.

Between the ages of 30-65
Able and willing to undergo an MRI
Able to travel to State College for the Study
Current psychotherapy treatment for depression
Started anti-depressant medication in the last 2 months
Diagnosis of bipolar disorder, schizophrenia, or significant neurocognitive impairment
Very severe depression that would interfere with the ability to participate or suicidal ideations
Unable to undergo an MRI (metal in your body)

18-55 years of age
Right Handed
Smokes cigarettes
under 18 years of age or over 55 years of age
Left Handed
non-smokers

Native English speaker
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
Family history of autism spectrum disorders (in parents or full siblings)
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces

Male subjects 21 to 65 years of age
Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in the range of 19=< BMI >=30
Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR).
Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg)
Subjects positive for HIV, HBV and HCV (self-reported)
Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded.
Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study.
Non-English-speaking subjects

Graduate Students
Major in disciplines related to Earth Sciences (e.g., Geosciences, Geography, and Environmental Science)
Younger than 18 years old