Search Results within category "Neurology"
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ALS
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Neuropathy
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Stroke
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Memory and Aging Study
This research is being done to find out more about changes in the brain as we age and to determine if MRI, genetic (DNA) variations, and neuropsychological tests can be used to evaluate memory loss and cognitive impairment.
Lauren Spreen at lspreen@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Neurology
Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis.
To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up
To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim.
To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
Deborah Hoffman at dhoffman1@pennstatehealth.psu.edu or 717-531-0003, ext=283063
All
18 year(s) or older
NCT02089217
Heart & Vascular, Neurology
Deprexis Study: An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial
An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial
Deprexis Team Roman at mhc147@psu.edu or 814-865-5578
All
18 year(s) or older
NCT02740361
Neurology, Mental & Behavioral Health
Tongue movement in adults with motor speech disorder
Tongue movement in adults with motor speech disorder
Jimin Lee at jxl91@psu.edu or 814-863-5338
All
18 year(s) or older
N/A
Neurology, Muscle & Bone, Language & Linguistics
Asymmetric neurodegeneration of central olfactory system in early-stage Parkinson’s disease
This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with H&Y stage 1 or 2 Parkinson’s disease compared to that of healthy volunteers.
Lauren Spreen at lspreen@pennstatehealth.psu.edu or 717-531-5857
All
18 year(s) or older
N/A
Neurology
Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities
We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
N/A
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome
Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
NCT04137757
Heart & Vascular, Neurology
Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub Protocol
The Muscular Dystrophy Association (MDA) wants to collect information about individuals with neuromuscular disease to better understand the disease progression and ultimately improve the medical care, quality of life, and survival of those with neuromuscular disease. To collect this information, MDA has created a data registry called the Neuromuscular Observational Research Data Hub (referred to as the “MOVR Data Hub”). The MOVR Data Hub is a kind of database — a way of collecting and storing information.
Anne Haulman at ahaulman@pennstatehealth.psu.edu or 717-531-0003, ext=289123
All
All
N/A
Neurology
Site for Poly-omic predictors of symptom duration and recovery for adolescent concussion
Using micro-RNA in saliva coupled with survey data as a prognostic tool with the ability to guide clinical management of concussions
Brennen Harding at bharding@pennstatehealth.psu.edu or 717-531-5656
All
All
NCT04582682
Neurology, Sports Medicine
A Phase 3b, Multicenter, Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Oral Edaravone Administered for a Period of 48 Weeks in Subjects with Amyotrophic Lateral Sclerosis (ALS)
The main purpose of this research study is to test whether an experimental drug called edaravone, is effective as treatment against ALS, and if it is safe and well tolerated when given to patients with your illness. The study will compare the efficacy and safety of an oral form of edaravone (a liquid solution that you will swallow) when given in 2 different ways.
Anne Haulman at ahaulman@pennstatehealth.psu.edu or 717-531-0003, ext=289123
All
18 year(s) or older
NCT04569084
Neurology
Physical Activity, Imaging, and Ambulatory Testing
The PHIAT study is designed to examine the role of daily and momentary variation in cognition in engagement in health promoting behaviors. The project will recruit younger, middle-aged, and older adults for a research protocol involving MR-based imaging of brain structure and function, repeated ultra-brief cognitive assessment and surveys delivered on smart phones, and objective monitoring of physical activity via accelerometers. Key research questions involve determining whether age-differences and individual-differences in brain function and cognitive variation predict the likelihood of translating health promotion intentions into daily behaviors.
Jessie Alwerdt at jua244@psu.edu or 618-267-1044
All
18 year(s) or older
N/A
Neurology
Assessment of nocturnal hypoventilation in amyotrophic lateral sclerosis
The overall goals of this study are to identify how measurement of carbon dioxide during sleep can improve recognition of respiratory distress in neuromuscular disease and thus improve timely access to respiratory therapies which prolong survival.
Subjects in this study will participate for up to one year, during which their carbon dioxide levels will be measured in clinic and in their homes during sleep.
Andrew Geronimo at ageronimo@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Neurology
Remote pulmonary function testing in amyotrophic lateral sclerosis (ALS)
The specific objective of this proposal is to validate the practice of remote pulmonary function testing (rPFT) through home measurement of breathing function. The central hypothesis is that guided home assessment of breathing function is a valid method for detecting respiratory distress. This study has the potential to transform the current practice of conducting breathing assessments every three months, resulting in timelier detection and management of respiratory distress.
The study has two parts.
[CLOSED TO ENROLLMENT] The first part is a self-controlled study which will enroll 40 patients from the ALS clinic. On the day of their clinical visit, study participants will perform both a standard PFT with a respiratory therapist and a simulated rPFT. The primary hypothesis is that there is no difference in the results of PFT and rPFT.
The second part is a two-arm randomized intervention in 40 patients with ALS. All subjects will perform weekly home respiratory testing for up to a year, and complete questionnaires at regular intervals during this period. Part 2 also incorporates a nurse health coaching component, with subjects randomized to a group that recieves monthly nurse coaching, and one that does not.
Wint Nandar at wnandar@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Neurology
Digital tools for assessment of motor functions and falls in ALS
This is a 48-week single arm study that incorporates digital tools for assessing motor function in amyotrophic lateral sclerosis (ALS).
During the study, neck- and wrist-worn “activity sensors” (PAMSys, BioSensics, Newton, MA) will be worn by subjects while performing tasks of daily living. Subjects will also complete a motor, speech, and handwriting assessment during site visits. They will complete a digital home assessments of speech, handwriting, and pattern tracing tasks throughout the study, and report any falls which occur on the study tablet.
We will explore whether sensor-based functional changes are sensitive to self-reported changes over the length of the study.
Wint Nandar at wnandar@pennstatehealth.psu.edu
All
18 year(s) or older
NCT05271435
Neurology
Eye-hand coordination during upright stance
The study will determine how the brain controls eye and hand movements during quiet upright stance.
Tarkeshwar Singh at tsingh@psu.edu or 814-865-7851
All
18 year(s) or older
N/A
Neurology, Vision & Eyes
The impact of COVID-19 on cognitive and neuropathological processes leading to Parkinson’s Dementia and other Alzheimer’s Disease Related Dementias (ADRD)
Our objective is to understand potential factors, such as COVID-19, that influence the development and/or progression of Parkinson’s disease and related disorders. We will engage previous, ongoing, and future Translational Brain Research Center (TBRC) research participants to obtain information regarding exposure, current clinical and functional status, motor/cognitive daily activities, and COVID-19 history.
Mike Klemick at mklemick@pennstatehealth.psu.edu or 717-531-0003, ext=283769
All
18 year(s) or older
N/A
COVID-19, Neurology
Predicting Concussion Outcomes with Salivary miRNA
The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children.
The primary endpoints of this study are as follows:
1) Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years.
2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Brennen Harding at bharding@pennstatehealth.psu.edu or 717-531-5656
All
All
NCT02901821
Children's Health, Neurology, Sports Medicine
RESTORE: A clinical study of patients with symptomatic neuRogenic orthostatic hypotEnsion to assess Sustained effecTs Of dRoxidopa thErapy
This is a multi-site, placebo-controlled, double-blind, time to intervention study designed to evaluate the clinical efficacy and safety of droxidopa versus placebo over a 12-week double-blind treatment period in patients with symptomatic NOH who have previously received up to 16 weeks of open-label treatment with an individually optimized dose of droxidopa (randomized withdrawal design).
Anne Haulman at ahaulman@pennstatehealth.psu.edu or 717-531-0003, ext=289123
All
18 year(s) or older
NCT02586623
Neurology
Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study
This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation.
Children and their parents will complete questionnaires. Children will complete computer tasks during EEG and in an MRI scanner. Parents can also complete the MRI scan if interested.
Michael West at ABC@pennstatehealth.psu.edu or 717-531-0003, ext=285968
All
Younger than 18 years old
N/A
Children's Health, Neurology, Mental & Behavioral Health
Interlimb differences in Motor Control and Learning
This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
N/A
Neurology, Sports Medicine, Muscle & Bone
Asymmetries in Cognitive Aspects of Motor Control and Learning
This study will improve our understanding of movement control and how strokes of different sides affect overall independence. Participants will complete the visit seated at a chair with sensors connected to the less-affected arm. They will then play a short virtual reality game and complete several questionnaires and assessments.
Shanie Jayasinghe at sjayasinghe@pennstatehealth.psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
N/A
Neurology
Prion Disease Registry at Penn State Health
This research is being done to help us better understand prion disease. The goal of the study is to establish a registry of patients with rapidly progressive dementia, suspected prion disease, or confirmed prion disease.
A disease registry is an extensive collection of data related to patients with a specific diagnosis that plays an important role in the surveillance of a disease.
Prion disease has poor prognosis, yet there is currently no approved treatment. The collection of information from prion patients will help us gather information to help advance the study of this pathology and potentially help contribute to treatments and preventative methods in the future.
All
18 year(s) or older
N/A
Neurology
Multimodal MR imaging of the midbrain for early Parkinson’s progression
This longitudinal MRI study aims to assess two novel MRI markers for early Parkinson's disease progression. Early stage Parkinson's patients, as well as healthy volunteers of similar ages, are eligible to be enrolled into the study.
Autumn Collier at TBRC@pennstatehealth.psu.edu or 717-531-0003, ext=281168
All
18 year(s) or older
N/A
Neurology
Linking olfactory deficits to memory impairment and AD neurodegeneration
The purpose of this voluntary research study is to find out more about changes in the brain as we age. This study is trying to determine if magnetic resonance imaging (MRI), genetic variations, amyloid positron emissions tomography (PET), neuropsychological testing, and smell tests can be used to evaluate memory loss and cognitive impairment.
Rommy Elyan at relyan@pennstatehealth.psu.edu
All
18 year(s) or older
N/A
Neurology
A multisensory evoked potential brain-computer interface for communication in ALS
A brain-computer interface (BCI) is a device that has the potential to restore communication by direct translation of brain signals. The BCI used in this study, the P300 Speller, relies on the generation of a P300 evoked potential when a user is presented a rare and unpredictable target stimulus amidst a larger pool of non-target stimuli. This evoked potential is used to perform selections on the computer.
Those with advanced ALS demonstrate decreased capacity for BCI control using the P300 speller. With this study, we aim to use a combination of eye tracking and sensory testing to quantify sensory and cognitive processes necessary for the generation of a P300 response. We will test the performance of a multisensory P300 spelling task, where brain potentials are evoked using a combination of visual, auditory, and tactile stimuli. The goal is to demonstrate the perceptual benefits of multisensory integration and generate evidence for its use in this patient group.
Andrew Geronimo at ageronimo@pennstatehealth.psu.edu or 717-531-0003, ext=282576
All
18 year(s) or older
N/A
Neurology
Interventional, Randomized, Double-blind, Parallel-group, Placebo-controlled, Multi-centre Study to Assess the Efficacy, Safety and Tolerability of Lu AF82422 in Patients with Multiple System Atrophy (MSA)
18331A (AMULET - Delay Multiple System Atrophy) is a Phase 2, placebo-controlled trial designed to assess the efficacy, safety and tolerability of Lu AF82422 in subjects with MSA MSA-C or MSA-P). The study is planned to consist of a screening period of 4 weeks, a randomization period of 2 weeks and a double-blind treatment period of 48 to 72 weeks . Approximately 60 subjects are planned to be randomized in a 2:1 ratio to receive either Drug A, or placebo.
Michael Klemick at TBRC@pennstatehealth.psu.edu or 717-531-5233
All
18 year(s) or older
NCT05104476
Neurology
Brain Mechanisms of Overeating in Children
Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kyle Hallisky at kmh6587@psu.edu or 814-865-5169
All
Younger than 18 years old
NCT03341247
Food & Nutrition, Prevention, Neurology
Long-Term Nicotine Treatment of Mild Cognitive Impairment
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in people experiencing mild memory problems (referred to in this study as “mild cognitive impairment” or MCI).
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain. This chemical substance, acetylcholine, is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our attention. In people with MCI (and Alzheimer’s disease), the level of acetylcholine may be changed, and this may impair brain functioning. Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimer’s disease (AD). It has been known for many years that nicotine imitates many of the actions of acetylcholine.
By administering nicotine over a longer period of time to participants with MCI, we hope to better understand whether nicotine may act to improve memory loss symptoms over the longer term and whether it may help to delay the progression of memory loss symptoms.
The amount of nicotine in each patch used in this study is the same as patches that are FDA approved for use in people who are trying to quit smoking.
All
18 year(s) or older
NCT02720445
Neurology, Mental & Behavioral Health
A Pilot Study to evaluate the pharmacokinetic, pharmacodynamic, and resistance profile to trametinib and dabrafenib in BRAF-V600E mutated recurrent gliomas
This research is being done to understand how much of two drugs (dabrafenib and trametinib) is able to enter brain tumors and how well the drugs are able to turn off this pathway in brain tumors. The study will also look at how tumors lose sensitivity to this treatment. People with primary brain tumors who are already taking dabrafenib and trametinib and who need a brain surgery are eligible for this study. Biospecimens (tissue, blood, and cerebrospinal fluid (CSF)) taken during the surgery will help us understand how much of these two study drugs actually get into the brain, their effect, and how the tumors become resistant to treatment.
All
18 year(s) or older
N/A
Neurology, Cancer
Interactions between the olfactory, auditory, visual, and trigeminal systems
The purpose of this study is to use fMRI to identify and characterize the olfactory, auditory, visual and trigeminal-related brain networks. This research will then be use to enhance human health by laying the foundation to develop sensitive biomarkers to identify people who are at risk of developing brain disorders such as Alzheimer’s disease and Parkinson’s disease, where olfactory deficits are known preclinical symptoms.
Lauren Spreen at lms553@psu.edu or 717-531-5857
All
18 year(s) or older
N/A
Neurology