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Suggestions within category "Neurology"


5 Study Matches

Atrophy of Olfactory Bulb in Early-stage Parkinson’s disease

This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with early- stage Parkinson’s disease.
Jianli Wang at jwang2@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
A physician-documented parkinsonian symptom onset between the ages of 40-59 will
Patients should not have reached their 65th birthday.
Patients that have tremor, rigidity, and bradykinesia unilaterally
Exclusion Criteria:
Dementia
Autonomic dysfunction
Parkinson-plus syndrome
Postural instability
History of exposure to substances that cause parkinsonism
Neurology
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Location
Hershey, PA

Asymmetric neurodegeneration of central olfactory system in early-stage Parkinson’s disease

This research is being done to study the deterioration of the central olfactory system (sense of smell system) in the brains of patients diagnosed with H&Y stage 1 or 2 Parkinson’s disease compared to that of healthy volunteers.
Lauren Spreen at lspreen@pennstatehealth.psu.edu or 717-531-5857
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Cognitively-normal H&Y stage 1 PD patients. A physician-documented parkinsonian symptom onset between the ages of 40-59. 1st visit prior to age 65. PD stage I diagnosis must be documented for a min of 2 years.
Cognitively-normal H&Y stage 2 PD patients. H&Y stage 2, as defined by an exam in the practically defined “off” state, and have a diagnosis of PD at the age of 59 or younger. 1st visit prior to age 65
Healthy participants between ages 40-64 at their first visit.
Able and willing to provide informed consent
Fluent in written and spoken English
Exclusion Criteria:
Parkinson-plus syndrome
Dementia
Previous antipsychotic or anti-dopamine drug therapy
Traumatic head injury
Other neurological diseases or disorders
Neurology
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Location
Hershey, PA

Multimodal brain MRI-guided understanding of non-motor outcomes in Parkinson's post DBS

This study will explore the relationship between multimodal brain MRI findings and cognitive/mood outcomes in Parkinson's Disease (PD) patients following Deep Brain Stimulation (DBS). Patients already planning to undergo DBS for PD who choose to take part in this study will have study visits before and after DBS to collect motor, neurobehavioral and physical therapy measurements.
Rachel Dokholyan at TBRC@pennstatehealth.psu.edu or 717-531-5233
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Age at least 18
Diagnosed with Parkinson's Disease
Undergoing DBS as part of standard of care
Able to provide informed consent
Exclusion Criteria:
Age less than 18
General contraindications to surgery
Pregnant or nursing women
Unable to undergo MRI for any reason
Atypical Parkinsonism
Neurology
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Study Locations

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Location
Hershey, PA

Interactions between the olfactory, auditory, visual, and trigeminal systems

The purpose of this study is to use fMRI to identify and characterize the olfactory, auditory, visual and trigeminal-related brain networks. This research will then be use to enhance human health by laying the foundation to develop sensitive biomarkers to identify people who are at risk of developing brain disorders such as Alzheimer’s disease and Parkinson’s disease, where olfactory deficits are known preclinical symptoms.
Lauren Spreen at lms553@psu.edu or 717-531-5857
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy subjects (non-synesthetic) with normal olfactory, visual, and hearing abilities
Healthy subjects (synesthetic) with normal olfactory, visual, and hearing abilities
Clear sinuses
Exclusion Criteria:
Non-English speaking
Pregnant or lactating
Presence of a pacemaker, aneurysm clips or any metal in the body
A history of welding, grinding, and or claustrophobia
Neurological disease (stroke, tumor, Parkinson's) or Psychiatric disorder (bipolar, schizophrenia, etc)
Neurology
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Location
Hershey, PA

Regional Brain Manganese Accumulation and Functional Consequences in Welders

Inhalation of welding fumes has been known to cause tremor, muscle rigidity and abnormal gait similar to what is seen in Parkinson's disease. Previous studies by the Translational Brain Research Center have used measures such as brain MRIs and tests for movement and function to investigate the effect of these welding fumes on brain health in active welders. The center is currently expanding its efforts to investigate brain health in retired welders. This is an independent study sponsored by the National Institute of Environmental Health Sciences, with no affiliation to any private entities such as law firms. In this study participants will be asked to undergo clinical tests (blood draw, motor examination, memory tests), complete lifestyle questionnaires, and undergo an MRI scan during a baseline and 18 month follow-up visit. Participants also will be mailed a welding exposure questionnaire to complete every three months between their baseline and follow-up visit.
Savannah Olimpo at TBRC@pennstatehealth.psu.edu or 717-531-5233
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Active or retired welder (e.g., boilermaker, pipefitter, etc.)
No obvious signs of parkinsonism (e.g., tremor, impaired speech)
Fluent in written and spoken English
No metal eye fragments
Able to tolerate a brain MRI
Exclusion Criteria:
Severe memory impairment or signs of dementia
Claustrophobia or unwillingness to undergo an MRI
Significant medical and neurological deficits (e.g., brain tumor, seizures, stroke, etc.)
Significant recreational drug use or alcohol abuse
History of chronic paint and solvent exposure
Neurology
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Study Locations

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Location
Hershey, PA