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Suggestions within category "Neurology"


4 Study Matches

Predicting Ipsilesional Motor Deficits in Stroke with Dynamic Dominance Model

This study will test the hypothesize that the combination of low-moderate to severe paresis and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the less-impaired arm should improve functional independence.
Candice Maenza at CMaenza@psu.edu or 717-531-0003, ext=283146
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Right handed (pre-stroke)
Motor impairment in the arm
Had a stroke confirmed by neurology
Chronic stage of stroke
Over the age of 18
Exclusion Criteria:
neurological disease other than stroke
a major psychiatric diagnosis (e.g., schizophrenia, major affective disorder)
hospital admission for substance abuse
peripheral disorders affecting sensation or movement of the arms,
currently taking prescription drugs with known sedative properties that interfere with sensory-motor function
Neurology
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Location
Hershey, PA

Remediation of the Non-Paretic Arm to Improve Functional Independence in Chronic Stroke Survivors

This study will test the hypothesize that the combination of low-moderate to severe paresis (Upper Extremity Fugl-Meyer Score ≤35) and persistent motor deficits in the non-paretic arm limits functional independence in chronic stroke survivors. We, therefore, predict that intense remediation, focused on improving the speed, coordination, and accuracy of the non-paretic arm should improve functional independence. We propose a randomized study design with two tracts, two periods and four assessments.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
> 3 months post unilateral stroke
Age 21-85
Demonstrates cognitive abilities
Exclusion Criteria:
hospitalization for substance abuse and/or psychiatric diagnosis
non-stroke neurological diseases
certain peripheral movement restrictions
brainstem/cerebellar damage
Neurology, Mental & Behavioral Health
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Location
Hershey, PA

Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis. To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim. To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02089217
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Inclusion Criteria:
Age >/=35 years
Do you have documented stenosis of your carotid?
Have you had any neurologic symptoms on the same side as your stenosis
No medical history of stroke or TIA on the same side as the stenotic vessel in the previous 180 days
If female, not pregnant
Exclusion Criteria:
Prior stroke with residual disability
Symptomatic ICH within past 12 months
Chronic afib
Ejection fraction < 30%
Do you use an anticoagulant? What medication?
Heart & Vascular, Neurology
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Location
Hershey, PA

Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction

This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number of people with large hemispheric infarction (LHI). These studies suggested that the study drug was safe, did not cause serious side effects or discomfort, and may reduce brain swelling, disability, and death in subjects with LHI. In this study, we want to investigate the study drug in a larger number of subjects (hundreds) to know more about it. LHI is a type of stroke. An ischemic stroke occurs when blood flow to parts of the brain is blocked, such as by a blood clot. This can cause damage to the brain. In LHI a large portion of the brain is damaged. People who have LHI can develop swelling of the brain called cerebral edema, which can worsen the symptoms and outcomes of LHI. Currently, there are no medications available to specifically reduce brain swelling caused by LHI. In this study, we want to investigate how well the study drug works to improve functional outcomes (the ability to do normal daily activities, such as walking and getting dressed) in subjects with LHI. This study will also look at the long-term effects of the study drug over time and see how safe the study drug is.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02864953
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Inclusion Criteria:
A clinical diagnosis of acute ischemic stroke in the MCA territory within 10 hours of symptom onset
Aged 18 to 85 years old, inclusive, at the time of informed consent
Screening NIHSS ≥10
Exclusion Criteria:
In the judgment of the Investigator, the subject is likely to have supportive care withdrawn in the first day
Commitment to decompressive craniectomy (DC) prior to enrollment
Evidence (clinical or imaging) of concurrent infarction in the contralateral hemisphere deemed by the Investigator to be sufficiently serious so as to affect functional outcome
Clinical signs of herniation and/or loss of other brain stem reflexes, attributable to edema or herniation according to the Investigator’s judgment
Brain hemorrhage (other than small petechial/punctate hemorrhages) on NCCT/MRI
Neurology
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Study Locations

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Location
Hershey, PA