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Suggestions within category "Mental & Behavioral Health"


Study matches: 49

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
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N/A
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Location
Hershey, PA

Parental Stress and Coping Post-NICU Discharge: Perceptions of Daily Stress and Psychobiological Patterns of Response to Stress Challenge

Parental stress levels following discharge from the neonatal intensive unit (NICU) can have impacts on mental health and relationship functioning. The current practice and understanding of Family-centered NICU care often does not address interventions to facilitate parental means to cope with this stress, be it through religious/spiritual means or traditional forms of coping, both of which are tied to their babies’ functioning outside of the NICU. Thus, parental experiences of stress as assessed through self-perceptions and biological and behavioral indicators of stress and coping strategies is an important first-step in future development of a psychospiritual intervention, which is thus far lacking in family-centered NICU care.  
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Parent of a former preterm infant hospitalized in NICU within the past 12 months with parental custody of the infant
Fluent in written and spoken English
Exclusion Criteria:
Chronic illness impacting cardiovascular or autonomic stress measurement (autoimmune disorders- e.g., Lupus, RA, Crohn’s disease)
Advanced cardiovascular disease (e.g., CHD, CHF, arrhythmia, pacemaker, history of MI)
Individuals with endocrine disorders impacting stress hormonal measures (e.g., Cushing’s Disease, Addison’s Disease, IDDM)
Mental illness (e.g., schizophrenia, psychosis, panic disorder)
Pregnant women
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N/A
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Location
Hershey, PA

A Pilot Trial of Subtyping Pediatric Conduct Problems by the Presence of Severe Persistent Irritability and Callous Unemotional Traits

Youth with irritable and aggressive behaviors, or conduct problems, are thought to be sensitive to rewards and insensitive to punishments. Parents and children will complete rating scales and computer tasks that will assess for sensitivity to rewards and punishments. This study will help to target interventions for treating children with conduct problems.
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Ages 7--12 years
Elevated degree of conduct problems
IQ greater than 80
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, ASD, or a pervasive developmental disorder
Sever suicidality
Visual or hearing impairments
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N/A
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Location
Hershey, PA

Development of a caregiver-report instrument to assess child behavior.

It is commonly agreed that school-aged children display observable attachment behavior, although it is difficult to elicit in laboratory tasks. However, caregivers will observe this behavior on a regular basis when it occurs and can provide useful information regarding the structure and function of that behavior. The goal of the current proposal is to define a potential caregiver-reported instrument assessing early school-age children’s attachment behavior and collect initial data sufficient to examine the factor structure and reliability of the measure. Data collection will utilize anonymous online survey methodology and recruit through schools and preschools.
Brian Allen at ballen1@pennstatehealth.psu.edu or 7175314100
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Adult caregiver of a child between the ages of 4 and 8
Adult caregiver is at least 18 years of age
Adult caregiver is the primary caregiver of the child.
Exclusion Criteria:
Child has an autism spectrum disorder, intellectual disability, or other developmental delay.
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N/A
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Deprexis Study: An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial

An online program to reduce depression in MS – a phase III international multicenter randomized controlled trial
Deprexis Team Roman at mhc147@psu.edu or 814-865-5578
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Diagnosis of Multiple Sclerosis
Current Depression
No current treatment for depression
Internet access
Between the ages of 18-65
Exclusion Criteria:
No diagnosis of MS
No current psychotherapy for depression
No substantial neurocognitive impairments
Started anti-depressants in the last 2 months
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N/A
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Location
State College, PA

Penn State Hershey Sitting and Health Study

This study aims to examine the effect of pedaling a compact elliptical device at the desk on employees' work productivity. This study also aims to evaluate the effect of different types of incentives on promoting desk-based pedaling.
Liza Rovniak at activitystudy@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Penn State Hershey full time employee
Overweight or obese
Spend at least 5 hours per day sitting at a desk
Have eligible overweight/obese coworker who can do study together with you
18-70 years old
Exclusion Criteria:
Currently pregnant
Planned surgical or medical treatment that will prevent ability to complete study
Heart condition, or chest pain during physical activity
Planned travel or relocation during study period
Already have desk cycling device or treadmill at desk
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NCT03274635
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Location
Hershey, PA

Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders

Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between 13 and 17 years of age or still enrolled in high school
A primary diagnosis of Asperger's Syndrome or high-functioning autism, as confirmed by the Checklist for Autism Spectrum Disorders (CASD; Mayes, 2012)
English as primary language spoken
Ability to fluently speak in full sentences
A verbal IQ of 85 or above on the Kaufman Brief Intelligence Test, Second Edition (KBIT-2; Kaufman & Kaufman, 1990)
Exclusion Criteria:
A significant language delay
Difficulty with aggression directed at peers
A primary thought disorder
A secondary disorder of anxiety or depression so severe as to prevent the individual's participation in the treatment
Low social motivation demonstrated through formalized assessment (SRS) and/or by responses given to screening interviews assessing treatment goals
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N/A
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Study Locations

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Location
Altoona, PA
Greater Philadelphia Area, PA
Greater Pittsburgh Area, PA
Hershey, PA
Wilkes-Barre/Scranton Area, PA

Interoception, the 8th Sensory System, Is it measurable?

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.
Cheryl Tierney at ctierney@pennstatehealth.psu.edu or 717-531-8414
All
All
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism
Exclusion Criteria:
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English
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N/A
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Evaluation of SPN-812 ER 400 and 600mg Efficacy and Safety in Adolescents with ADHD - A Double-Blind, Placebo-Controlled, Pivotal Trial

This is a drug study testing the safety and efficacy of a new non-stimulant long lasting ADHD medication. The trial is for teens ages 12-17 with ADHD and will provide up to 8 weeks of treatment with the investigational medication. Investigational means that the drug has not been approved by the United States Food and Drug Association (FDA). Study visits include an intake visit to determine eligibility for the study and weekly visits to adjust the dosage of the medication.
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Children ages 12-17 years with ADHD diagnosis
Participation in one intake appointment designed to determine eligibility for the study
Attend 9weekly visits for medication/ routine check
Exclusion Criteria:
Current neurological disorder including seizure disorder or history of seizures
Allergy or history of allergy to viloxazine or related drugs
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NCT03247556
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Location
Hershey, PA

Study driving behaviors in connected and autonomous vehicles with a driving simulator

This is a behavioral study that will examine the effect of different messages designs and driver characteristics on driver behavior using a driving simulator. The driving simulator will be used to simulate various traffic events and record driver behavior and performance in the simulated connected vehicles and autonomous vehicle environments. All you need to do is driving on a driving simulator and complete questionnaires.
Yiqi Zhang at yuz450@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
You must possess a valid and unrestricted driver’s license, and display it to the experimenter
You must not be under the influence of alcohol, and have abstained from drinking alcohol for no less than 8 hours prior to participating in this study
Exclusion Criteria:
Participants who doesn't possess a valid driver license will be excluded from the study
Participants who drinks alcohol within the 8 hours before the study will be excluded from the study
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N/A
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Study Locations

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Location
State College, PA

Patterns of brain function associated with the Affective Processing and Executive Control (APEC) Task

In this pilot study, we wish to test the effectiveness of a novel functional imaging measure that combines affective processing and cognitive control components. The measure (i.e., the Affective Processing and Executive Control (APEC) task) has been designed for use in a large study in children and brings together measures that are developmentally appropriate and have been well established in the literature. However, the combination of measures is unique and so we wish to ensure that patterns of performance and indices of functional activation associated with the paradigm components are as expected. We will do this by examining brain function and behavior during performance of the task while participants undergo functional magnetic resonance imaging. Participants in this pilot study will be healhty adults (N=20, >18 years old, 50% male).
Emma Rose at ejr5384@psu.edu or 8148650114
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Aged 18
•65 years
Generally healthy
Right-handed
Exclusion Criteria:
History of drug or alcohol abuse
History of head injury or neurological disease
Current or past psychiatric or neurodevelopmental illness
Claustrophobia
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N/A
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Study Locations

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Location
State College, PA

Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism

We are developing and testing a computer game to help adolescents with autism improve social skills. In this game, players become a teenage pet detective. They interact with animals and human characters, navigate worlds, find objects, and solve mysteries. The game teaches players to attend to nonverbal social cues and use them to solve pet mysteries. Participants get to play the game from their own home! Adolescents and their families visit the lab prior to the intervention and after the intervention so that we can assess the impact of the game on behavior and social skills.
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-867-2921
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Autism Spectrum Diagnosis
Ages 10-18
Speaks in full sentences
Can follow written and oral instructions
Can use a computer in a basic way
•click mouse for responses and use arrow keys on keyboard to navigate
Exclusion Criteria:
Uncorrected vision or hearing problems
Seizures within last 2 years
Does not have minimum of 2nd grade reading level
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NCT02968225
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Location
State College, PA

Evaluation of Concert Hall Acoustics Stimuli

The overall goal of the project is to better understand how people subjectively perceive differences in concert hall acoustics. Subjects will listening to musical passages, side-by-side, in aural simulations of being in different concert halls or rooms. Subjects will then be asked to provide subjective data about the different rooms in which they are listening. The passages may be rated on subjective parameters such as preference, reverberance, warmth, clarity, envelopment, intimacy, brightness, etc. The results from this research will help to better understand how concert-goers perceive different room, and will help acoustic consultants to better design concert hall in the future to produce more pleasing acoustic environments.
Matthew Neal at mtn5048@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Must have normal hearing thresholds (tested at beginning of test)
Minimum 5 years of combinbed musical training (i.e. private lessons, ensembles, etc.)
Must be actively studying music or involved in a musical ensemble or group.
Exclusion Criteria:
Cannot have sigificant hearing loss (tested at beginning of test)
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N/A
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Study Locations

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Location
State College, PA

Feasibility and acceptability of mind-body strategies to increase physical activity and reduce health disparities in rural breast cancer survivors

The purpose of this study is to explore feasibility and acceptability of mind-body strategies to increase physical activity and reduce health disparities in rural cancer survivors and inform the cultural-adaptation of a physical activity intervention for rural breast cancer survivors.
Hannah Guthrie at hdpar@psu.edu or 8148630132
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
At least 18 years of age
Received a cancer diagnosis previously
Lives in central Pennsylvania
Exclusion Criteria:
Below the age of 18
No history of cancer
Lives outside of the Penn State Cancer Institute's 28-county catchment area
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N/A
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Illuminating the neurocognitive contributors to nicotine addiction and relapse among adults with and without Attention Deficit Hyperactivity Disorder

This study aims to better understand how mood, thinking and brain processes change when cigarette smokers stop smoking, and use this information to find out why adults with ADHD are at a higher risk for smoking relapse during quit attempts.
Alexander Weigard at asw5097@psu.edu or 7173816873
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Must be a regular cigarette smoker, ages 18-45
Must be right handed
Must have no contraindications to MRI examinations
Must be willing to go without smoking for 12 hours (overnight)
Exclusion Criteria:
Failure to meet any inclusion criteria
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N/A
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Study Locations

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Location
State College, PA

Emerging relations between attention and negative affect in the first two years of life

The CAT Lab focuses on the ways in which emotion and attention interact to shape how children navigate through their social world. We do this through questionnaires and observations of behavior in our laboratory. This particular study will examine how children respond to emotional and social events. We ask infants and their parents to visit our lab 5 times, each visit being 4-6 months apart and usually lasting a little over an hour. During each visit to our lab, we ask infants to look at pictures of people and animals on a computer monitor while we record where their eyes are looking on the screen. Children also participate in several different games and play with different toys (just like those found in a common household such as balls, puppets, plastic animals, etc.). Some of these activities involve parents and some do not, but we do ask parents to stay in the room with their child for the full visit. During visits 2-5, we would also like to collect electroencephalogram (EEG) and respiratory sinus arrhythmia (RSA) data from your child. EEG measures the electrical activity in the brain using small metal sensors placed on the head with gel. RSA measures heart rate and breathing by placing small sensors on the torso. These procedures do not hurt, are low-risk, and provide real-time measurement of your child’s autonomic nervous system signals, much like an arm cuff measures blood pressure. When the sensors are removed, some children may feel like a bandage is being pulled off.
Norbert Promagan at nup21@psu.edu or 814-867-2322
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
infant is 4-months of age
infant born within +/- 3 weeks of due date
Infants without any serious medical complications
Infants of a healthy birth weight (>2500g; >5 lbs, 8 oz.)
Exclusion Criteria:
infant older or younger than 4 months of age
infant not of healthy gestational age
infants <2500g; <5lbs, 8 oz at birth
Infants who experienced any serious medical complications
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N/A
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Study Locations

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Location
Harrisburg, PA
State College, PA

Young Children’s Representations of Parent-Child Negotiation

The goal of this study is to learn how young children think and tell stories about challenges between parents and children. Children will play games and tell stories using toys while caregivers fill out surveys and talk to researchers. This will occur twice, about 6 months apart. Qualities of children's stories, their language and regulation skills, demographic information about children and caregivers, and parenting behaviors will be examined.
Hannah Mudrick at hxm99@psu.edu or 7179486404
All
All
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Children between the ages of 5 and 7
At least one caregiver of a child between ages 5 and 7
English-speaking
Middle income
Caregiver at least 18 years old
Exclusion Criteria:
Caregivers that are not fluent in English
Children that are not fluent in English
Children who are unable to tell stories with a researcher due to developmental disability or language delay
Children who are younger than 5 or older than 7
Low or high income
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N/A
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Study Locations

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Location
Harrisburg, PA

Effectiveness of Prazosin in Bulimic patients experiencing nightmares due to PTSD

This research is being done to find out how effective Prazosin is in the treatment of bulimic patients experiencing distressing nightmares using subjective and objective measures.
Carrie Criley at ccriley@pennstatehealth.psu.edu or (717)531-4123
Female
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
women age 18-45 years
diagnosis of bulimia nervosa
complaints of nightmares/PTSD
Exclusion Criteria:
Neurological Disorders
Pregnancy
Cardiac abnormalities
Sleep Disorders (sleep apnea, restless legs, narcolepsy)
Substance Abuse
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NCT02382848
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Location
Hershey, PA

Examining mood and social functioning of girls with ADHD

Research has produced sophisticated pharmacological and psychosocial interventions associated with great improvements in academic and behavioral functioning of children with ADHD. However, such treatments are limited in producing improvements in interpersonal problems of children with ADHD and in preventing long-term issues such as depression. Results from this study will inform the development and evaluation of a novel family-based intervention to improve the interpersonal and mood problems characteristic of many girls with ADHD
Female
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
12-16 years of age
Female gender
Female primary caregiver willing to participate
Established or suspect ADHD diagnosis
Exclusion Criteria:
Younger than 12 years of age or older than 16 years of age
Male gender
No signs, symptoms, or diagnosis of ADHD
Diagnosis of Autism, schizophrenia, or intellectual disability disorder
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N/A
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Study Locations

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Location
Hershey, PA

Biobehavioral Health Risk and Resilience in College Students (PSU THRIVE Study)

This protocol is designed to examine biobehavioral health risks, resilience, grit, forgiveness and well-being in college students.
Laura Klein at lcklein@psu.edu or 814.883.8624
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Fulltime undergraduate student
18 to 24 years of age
English is a primary language
Exclusion Criteria:
Not enrolled as a full time undergraduate student
Under age of 18 years
Over age of 24 years
Not comfortable speaking English
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N/A
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Youth's Experiences Study in School Study

This study focuses on African American youth's school experiences. Using a daily diary method this study seeks to identify links between student's experiences of competence, autonomy, and relatedness in their math and English courses and their classroom engagement. Further, we are examining how youth's identity and beliefs about their race and gender are related to their classroom experiences.Students can earn up to $55 for participating in the study.
Olivenne Skinner at ods3@psu.edu or 814-865-0095
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
African American or Black
Currently in Grade 9 or 10
Have access to the internet everyday afterschool
Exclusion Criteria:
Not African American/Black
Does not have access to the internet afterschool
Not currently in Grade 9 or Grade 10
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N/A
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Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study

This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation. Children and their parents will complete questionnaires. Children will complete computer tasks during EEG and in an MRI scanner. Parents can also complete the MRI scan if interested.
Ashley Carroll at acarroll@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 12--16 years
Fluent in English
No history of treatment for psychiatric disorders
Exclusion Criteria:
Intellectual or developmental disabilities
Visual or hearing impairments
Inability to complete MRI scan due a pacemaker, aneurysm clips or any metal in body (e.g., braces, surgical devices)
Currently pregnant or lactating
Neurological disease (e.g., stroke, tumor, Parkinson’s disease, etc.)
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N/A
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Location
Hershey, PA

Stress, Gene Expression, &amp; Disease Susceptibility

This research is being done to investigate the mechanisms linking early life stress to disease susceptibility. In order to better understand the underlying mechanism, we need to identify how target cells respond and adapt to stress. One way to test this mechanism is to see how specific genes are activated over a short period of time.
Megan Zinobile at muz144@psu.edu or 814-689-9017
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Between the ages of 18 and 25
Must currently be a non-smoker
Cannot use medications on a regular basis besides oral contraceptives
Females must use oral contraceptives
Exclusion Criteria:
Cannot have a significant medical illness or endocrine illness
Cannot have had a recent infection or illness
Females cannot be pregnant or breastfeeding
Cannot be a current smoker
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N/A
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Location
State College, PA

Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial

This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Brian Allen at ballen1@pennstatehealth.psu.edu or 717-531-4100
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Child between the ages of 6 and 17
Child has a history of physical abuse, sexual abuse, or other type of maltreatment
Child displays posttraumatic stress symptoms
Primary caregiver willing to participate in treatment
Exclusion Criteria:
Child has a developmental or intellectual delay.
Uncontrolled allergy to or fear of dogs on part of either the child or caregiver.
CHild or caregiver has a history of aggression toward animals
Show full eligibility criteria
NCT03135119
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Location
Harrisburg, PA

The Implementation and Evaluation of the Autism Spectrum Ambassador Program (ASAP)

We are evaluating the implementation and the effectiveness of a medical student staffed support program (ASAP) for children diagnosed with Autism Spectrum Disorder coming into Penn State Children's Hospital for a medical procedure. The ASAP program involves training and assigning a medical student as an Ambassador to help advocate for the special needs of a child with ASD. This study is designed to compare patient satisfaction of children and their families who are assigned an Ambassador to those who are not assigned an Ambassador to accompany them during the procedure. The secondary objectives are to measure overall medical student satisfaction with the program, medical student career interests before and after participation, and medical student comfort level interacting with children with ASD before and after participation.
Cheryl Tierney at ctierney@pennstatehealth.psu.edu or 17175318414
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
autism
surgery
Exclusion Criteria:
older than 18
healthy
Show full eligibility criteria
NCT02842671
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Location
Hershey, PA

Neurobiology of Inhibitory Motor Control in Adults with ADHD

The proposed research represents the first examination of motor, cognitive, and neural mechanisms of inhibitory control in adults with ADHD. This study will extend previous work that describes motor impairments in children with ADHD by providing a quantitative analysis of grip force control in adults with ADHD.
Marissa Reynolds at mlr5246@psu.edu or 814-867-5024
Male
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Your are 18-25 years old and have symptoms of ADHD or ADD
You speak English as your native (first) language
You have, at minimum, a high school diploma or GED
You have no previous concussions that resulted in loss of consciousness for more than 10 minutes
If you take stimulant medication for your ADHD or ADD, you must be willing to not take the medication for 24 hours before your visit to our lab
Exclusion Criteria:
You are under age 18 or over age 25 or do not have symptoms of ADHD or ADD
English was not the first language you spoke
You have less than a high school education
You have had a concussion that resulted in loss of consciousness for more than 10 minutes
You, or someone in your immediate family, has been diagnosed with seizures, epilepsy, encephalitis, meningitis, musculoskeletal, neurological, autism spectrum, or psychological disorder involving psychosis
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N/A
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Study Locations

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Location
Altoona, PA
DuBois, PA
State College, PA
Williamsport, PA

Central Mechanisms of Neurovascular Dysfunction in Human Depression

Our goal is to identify what leads to the increased risk of cardiovascular disease and stroke in adults with depression. This study may help identify treatments or preventative strategies that will work best to reduce the risk of cardiovascular disease, stroke, and death in these patients. Subjects will be between 18 and 40 years. Three subject groups will be recruited: 1. Healthy control (HC) subjects will not have a family history of Major Depressive Disorder (MDD) or major psychiatric illness 2. MDD patients will have clinically significant depression (non-medicated) 3. Selective serotonin reuptake inhibitor (SSRI)-treated adults (MDD in remission; monotherapy) will have been treated for at least 8 weeks prior to study enrollment A medical screening determines study eligibility. The screening includes a physical exam and medical history, height, weight, and waist circumference measurements, and recording the electrical activity of the heart (ECG). Screening also includes a blood draw for basic blood biochemistry, including a lipid profile and assessment of liver and kidney function. Subject-groups are matched for age and sex. During the experiments, we assess nervous system activity and blood pressure continuously. The experiments include intravenous infusion of substances that alter dilation or constriction of blood vessels. These substances work by promoting or blocking certain steps in the signaling pathways that control blood flow. This technique allows us to compare differences between subject-groups in the mechanisms governing the nervous system input in the control of blood flow. This project includes blood draws and the recording of nerve activity in the leg.
Susan Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Men and women 18 – 40 years
Blood pressure <140 / <90 mmHg; body mass index <30 kg∙m-2
Healthy control (HC) subjects: no family history of Major Depressive Disorder (MDD) or major psychiatric illness
MDD patients: have clinically significant depression (non-medicated)
SSRI-treated adults (MDD in remission; monotherapy): treated for at least 8 weeks prior to study enrollment
Exclusion Criteria:
psychiatric illness aside from MDD (including bipolar disorder, panic disorder, schizophrenia)
psychiatric treatment with drugs other than SSRIs
cardiovascular, renal, or metabolic disease (hypertension, heart disease, diabetes, hyperlipidemia)
medications that could alter neurovascular function
Pregnant or post menopausal
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N/A
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Location
State College, PA

Development of Adolescent and Young Adult Social Health (DASH)

Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time in the lab and for the neuroimaging session.
Marly Laubach at mll5405@psu.edu or 814-863-2528
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All
This study is also accepting healthy volunteers
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Inclusion Criteria:
Native English speaker
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
Exclusion Criteria:
Family history of autism spectrum disorders (in parents or full siblings)
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces
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N/A
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State College, PA

Imaging and Depression with or without MS

A study looking at the neural and genetic correlates of depression. Presently, the current study is looking to recruit individuals for two separate groups: 1. MS but NO history of depression 2. Depression but NO history of MS or neurological disease. The purpose of the study is to look at patterns of brain structure and function in individuals with depression and compare them to those with MS. We will explore how any differences we find contribute to more problems with depression in MS and see how such differences might lead to better treatment options for depression.
Cristina Roman at car342@psu.edu or 814-865-5578
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18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Between the ages of 30-65
Able and willing to undergo an MRI
Able to travel to State College for the Study
Exclusion Criteria:
Current psychotherapy treatment for depression
Started anti-depressant medication in the last 2 months
Diagnosis of bipolar disorder, schizophrenia, or significant neurocognitive impairment
Very severe depression that would interfere with the ability to participate or suicidal ideations
Unable to undergo an MRI (metal in your body)
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N/A
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Study Locations

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Location
State College, PA

Neurophysiological Markers of Pediatric Irritability and its Response to Intervention

This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.
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Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Children between the ages of 5 and 12
Children diagnosed with ADHD or suspected ADHD Symptoms
Children who are able to stop ADHD medication for testing days
Parent/child fluent in English
Exclusion Criteria:
Children younger than 5 year or older than 12 years
Children with a latex allergy
Children with visual or hearing deficits or sensitivity to loud noise
Neurological conditions such as active seizure disorder
Prominent traits or diagnosis of Autism, marked developmental delay, mania, psychoses, or suicidal ideation.
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NCT03279952
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Study Locations

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Location
Hershey, PA