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24 Study Matches

Cardio-metabolic effects of diets including pecans

The purpose of the study is to examine how the inclusion of 2 oz./day of pecans into a typical American diet and a healthy diet affect risk factors for heart disease and diabetes.
Philip Sapp at pzs5199@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 25-70 years
BMI 25-40 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Not willing to consume all meals and snacks provided for the study
Food & Nutrition
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Location
State College, PA

Examining contextual factors associated with food-related reward and eating restraint

Rates of obesity have risen sharply throughout the world over the past several decades. The increase in the availability of highly palatable, high-calorie foods may be one factor that has contributed to this trend. That is, the availability of such foods may lead to their over-consumption and corresponding weight gain. Currently, relatively little is known about how the availability of foods, per se, affects things such as the motivation to eat and the ability to resist doing so. The current study is designed to help address this knowledge gap by examining the effects of food availability in people with high levels of dietary restraint. Dietary restraint, which refers to the intention to restrict food intake deliberately in order to prevent weight gain or to promote weight, is linked to problematic patterns of eating. This project uses laboratory tasks and brain imaging to study the effects of food availability on various outcomes, including food choices, food craving, and responses in brain areas linked to motivation.
Josie Huang at suh438@psu.edu or 814-867-2333
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Participants must be between the ages of 18 and 45.
Participants must be right handed.
Participants must be fluent English speakers.
Participants must have a body mass index (BMI) >= 25.
Participants must have experienced food eating/weight issues.
Exclusion Criteria:
If participants are currently engaging in active dieting behaviors (e.g., a weight loss program) or they are taking medications that could alter appetite or body weight.
If participant have a lifetime history of diagnosed eating disorders, diabetes, hyperglycemia, high levels of triglycerides, or high cholesterol or other related medical conditions.
If participants have any known risk from exposure to high-field strength magnetic fields (e.g., pace makers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments.
If participants report that they are vegetarian/vegan.
If participants are not willing to refrain from using alcohol for 24 hours or from using nicotine products/recreational drugs for 3 weeks, or unwilling to fast from food for 5 hours prior to two of three lab visits.
Food & Nutrition, Mental & Behavioral Health
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State College, PA

AWS-PSU: Active Women's Study at Penn State University

AWS-PSU: Active Women's Study at Penn State University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 16-29.9
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Food & Nutrition, Muscle & Bone, Women's Health
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Location
State College, PA

The Effect of Evening Almond Butter Consumption on Fasting Blood Glucose

The aim of this study is to determine if giving an individual with type 2 diabetes a serving of natural almond butter before bed improves fasting blood glucose. We will recruit individuals with type 2 diabetes for this study and measure their blood glucose using a continuous glucose monitor.
Emily Johnston at exj22@psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03826472
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Inclusion Criteria:
18-75 years of age
Diagnosis of type 2 diabetes
Without allergy to tree nuts
On stable dose of medication (no dose change for 6 months)
Willing and able to adhere to study protocol
Exclusion Criteria:
Individuals with type 1 diabetes, cardiovascular disease, kidney disease, liver disease, cancer or inflammatory conditions (e.g. GI disorders, rheumatoid arthritis)
Pregnant or breastfeeding
Taking insulin or sulfonylureas
Tree nut allergy
Allergy to Dexcom CGM adhesive
Food & Nutrition, Diabetes & Hormones
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State College, PA

Influence of Diet on Body Odor and Social Judgments

We are interested in a broader assessment of how changes in body odor influence social judgments outside of the mating context. The main question this project seeks to answer is whether we are able to change body odor through diet (e.g., aromatic foods) and how these changes affect group identity and social judgments.
Jessica Gaby at jessica.gaby@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Non-smoker
English fluency
Willing to return to the testing facility for multiple visits
Normal sense of smell
Willing to smell t-shirts of other humans
Exclusion Criteria:
Current smoker
Pregnant or breastfeeding
Reported deficiency in smell function
Taking medication that might interact with body odor production
Allergy to rice or curry spices
Food & Nutrition
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Location
State College, PA

Investigation of pulse starch impact on the gut microbiome

We are investigating how the starch from pulse crops (chickpeas, lentils and dry peas) affects the gut microbiome, particularly with regards to the production of butyrate, a microbial metabolite with a number of known health benefits. We are recruiting people from two groups, those that consume a lot of these pulses and those who rarely consume them. These participants will then track their food intake for 48 hours before collecting a fecal sample which they will return to the lab. We will then use these fecal samples to conduct laboratory fermentations with pulse starches processed in a number of different ways to see what factors are important for determining the amount of butyrate that is produced. This will serve as pilot data for designing future human clinical trials.
Darrell Cockburn at dwc30@psu.edu or 814-863-2950
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-65 years of age
Either consume pulses twice or more per week or consume them once a month or less. Pulses are dry legumes such as chickpeas(Garbanzo beans), lentils or other dry peas and beans
Exclusion Criteria:
Currently or in the past month taking antibiotics
Taking a fiber supplement
Bowel problems such as IBD, IBS, chronic diarrhea or constipation
Pregnancy
Food & Nutrition
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Location
State College, PA

Brain Mechanisms of Overeating in Children

Reducing intake from large portions is of critical importance to preventing obesity. People consistently eat more when they are served larger portions, a phenomenon known as the portion size effect. The mechanisms of the portion size effect are not well understood, and investigating the underlying neurobiology that drives this phenomenon may inform the development of more effective obesity prevention programs. The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical pre-adolescent period. We expect results to confirm the hypothesis that reduced function of brain inhibitory pathways and increased activity in brain reward pathways in response to portion size cues contributes to excess intake with large portions and greater weight gain over time, particularly in children who have higher risk for obesity. The proposed studies will characterize the relationship between brain response to portion size and eating behavior and will allow us to determine whether brain and behavioral responses predict body fat gain during pre-adolescence. These studies will contribute essential information to our understanding of the pathways implicated in overeating and obesity and will facilitate the characterization of “at risk” phenotypes that can be targeted by prevention programs.
Kara Hickok at kih5334@psu.edu or 814-865-5169
All
Younger than 18 years old
This study is also accepting healthy volunteers
NCT03341247
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Inclusion Criteria:
The child must be age 7-8 when the first study visit is completed
The child must not have any food allergies to foods used in the study, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia.
The child must not be taking any medications known to influence cognitive function, taste, appetite or blood flow
The child's BMI must be below the 90th percentile at the first visit
The biological mother and father must have a BMI between 18.5-25 kg/m2 (low-risk group) or greater than or equal to 30 kg/m2 for mothers and greater than or equal to 25 kg/m2 for fathers (high-risk group) and 1 parent must attend all visits.
Exclusion Criteria:
Children will be excluded if they are not within the age requirements (< than 7 years old or > than 8 years-old at the first visit).
Children will be excluded if they have any food allergies, learning disabilities, psychological diagnoses, red/green color blindness, or claustrophobia
Children will be excluded if they are taking cold or allergy medication, or other medications known to influence cognitive function, taste, appetite, or blood flow
Children will be excluded if their BMI is above the 90th percentile at the first visit
Families will be excluded if the biological mother or father do not fit the BMI requirements
Food & Nutrition, Prevention, Neurology
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State College, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT02822378
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Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA

The Child Health Study

We want to understand how a child's environment affects biology in ways that impact child health
Megann Koegler at childhealthstudy@psu.edu or 888-924-4535
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Children 8-13 years of age
Speak and understand English
Participation of a legal guardian
Exclusion Criteria:
Intellectual or learning disability
Children's Health, Food & Nutrition, Education
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Location
State College, PA

Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.
Yasina Somani at yfs5057@psu.edu or 814-954-2930
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03644472
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Inclusion Criteria:
Women within 1-5 years following menopause
Exclusion Criteria:
Individuals taking hormone therapy
Individuals with resting blood pressure > or = 130/80 mmHg
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
Food & Nutrition, Heart & Vascular, Women's Health
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State College, PA

Site For HAT Trial

Site For HAT Trial
Erin Hammett at ehammett@psu.edu or 717-531-1510
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
>25 years of age
not currently eating >2 avocados per month
increased waist circumference (35+ inches for women, 40+ inches for men)
Exclusion Criteria:
does not eat or is allergic to avocados
not willing to undergo MRI scans
unstable medical conditions
lost/gained 10 or more pounds in past year
Food & Nutrition
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Location
Hershey, PA

Diet and stress responses in low-income rural adults under the dynamics of food insecurity

The study is recruiting adults in rural Central Pennsylvania to understand how their food environment in fall and winter predicts diet, stress, mood, and health in everyday life. Participants will use a provided survey phone to answer the survey questions and will use a provided chest belt to measure heart rate for 5 mins every day in the morning during the study period. There will be up to 2 training session in State College, PA or a community center in Woodland, PA. Data collection will take place at participant's home. Study compensation and travel compensation will be provided.
Muzi Na at muzi.na@psu.edu or 814-865-2919
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Adults between 20-50 years
In general good health
If female, prior to menopause
Household income <= 185% of the poverty level
Exclusion Criteria:
Has any physical, mental or emotional disabilities
Is pregnant
Non-English speaking
Food & Nutrition, Heart & Vascular, Mental & Behavioral Health
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Location
DuBois, PA
State College, PA

Associations of dietary preferences with management of HS symptoms

We will be examining the diets of people with hidradenitis suppurativa to see if they consume different amounts of foods like dairy, tomatoes, or gluten.
Melissa Butt at mbutt1@pennstatehealth.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
People who have a history of hidradenitis suppurativa
Seen at Penn State Health within the past year
18 years of age or older
Can read/write in English
Have access to the internet
Exclusion Criteria:
Those who do not meet inclusion criteria
Skin Conditions, Food & Nutrition
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Identity Fusion and "Vladimir's Choice": An Exploration of Costly Decision Making

This study will experimentally determine if individuals who identify more strongly with their political party are more likely to make decisions that cause discomfort and possible pain when faced with opposition and competition from individuals with opposing views. This goal will be accomplished in the laboratory via a game between individuals with opposing views that can be won by taking a shot of hot sauce.
Connor Somgynari at cjs72@psu.edu or 224-637-5504
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Over age 18
No food allergies
English Speaker
Exclusion Criteria:
Under age 18
Food allergies
Non-English Speakers
Food & Nutrition, Education, Mental & Behavioral Health
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State College, PA

Investigating the impact of food form on children’s ability to compensate for energy

This study is looking at how different apple products (apple juice, apple sauce, and apple slices) might affect children's hunger and fullness. During 5 visits to our laboratory at Penn State, children will participate in a variety of games and tasks, and will eat meals and snacks with a research assistant. Children must be between the ages of 4.5-6 years old to participate in this study.
Nicole Reigh at nar5235@psu.edu
All
Younger than 18 years old
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Between age of 4.5-6.0 years-old
No food allergies
Exclusion Criteria:
Taking medication that can affect taste or appetite
Children's Health, Food & Nutrition
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Location
State College, PA

The role of probiotics in attenuating inflammation and improving gut health in obese adults

We are conducting a clinical study that is investigating the effects of yogurt on markers of inflammation and gut health in older adults (55-75 years old) with an elevated BMI. The participants will be given yogurt for 4 weeks and yogurt with added probiotics for 4 weeks. The order of the yogurt treatments will be random, meaning some participants will get plain yogurt first, and others will get yogurt with probiotics first. The participants will be asked to consume one 8-ounce serving of the given yogurt each day during the four weeks. At the beginning and end of each four-week period, the participants will have clinical evaluations so we can determine the impact of the yogurt on markers of inflammation and gut health. The compensation for this study is $300.
Hannah VanEvery at hqv5028@psu.edu or 814-863-3919
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03418857
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Inclusion Criteria:
Overweight/obese
age 55-75
Non-smoking
Not currently taking cholesterol- or glucose- lowering medication
Not currently taking anti-hypertensive medication
Exclusion Criteria:
Smoking and/or use of other tobacco products
Fasting glucose > 126 mg/dL
Diastolic blood pressure > 100 mm Hg
Systolic blood pressure: ≥160 mm Hg
Clinical diagnosis of Inflammatory Bowel Disease (IBD) e.g. Crohn’s Disease or ulcerative colitis
Food & Nutrition
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State College, PA

Site For Habitual Diet and Avocado Trial (HAT)

Site For Habitual Diet and Avocado Trial (HAT)
Kristin Davis at kmd74@psu.edu or 814-863-0856
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
25 years of age or older
Increased waist circumference defined as ≥35 inches for women, ≥40 inches for men
Not currently eating more than 2 avocados per month
Exclusion Criteria:
Does not eat avocados
Not willing or unable to undergo MRI scans
Pregnant, lactating, intention of pregnancy
Food & Nutrition, Heart & Vascular
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Location
State College, PA

Habit Learning in Adolescents and Young Adults

This research seeks to exam behavioral and neural differences in the formation and maintenance of habit behavior in adolescents and adults.
Daniel Petrie at djp67@psu.edu or 814-863-5124
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy adolescents between the ages of 13 to 17
Health adults between the ages of 25 to 40
Not currently taking medications known to influence body weight, task, food intake, behavior, or blood flow
Exclusion Criteria:
Outside of age ranges specified
Left handed
Diagnosed neurological or psychological condition including anxiety or depression
Currently or planning to follow a diet for weight loss
Non-removable body piercings, pacemaker, or other metal implants that would preclude safe completion of an MRI
Addiction & Substance Abuse, Food & Nutrition, Mental & Behavioral Health
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State College, PA

The effect of pistachios on blood sugar control, heart and gut health

The purpose of the study is to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk factors for heart disease. This study will also investigate how pistachios affects gut health.
Terry Riley at tmr359@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 30-75 years
BMI 25-45 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Night shift-workers and and those who cannot consume a snack in the evening
Food & Nutrition, Heart & Vascular
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State College, PA

Food and Mood: Ecological Momentary Assessment of Eating Behaviors in Preadolescent Children

The goal of this study is to determine the feasibility of 8-10 year old children using a smartphone-based survey to measure appetite, mood, and eating behavior "in the moment".
Emily Hohman at foodandmood@psu.edu or 814-865-8078
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Child age 8-10 years old with a parent/guardian
Exclusion Criteria:
Not able to read and answer questions in English
Child has a medical condition impacting eating (e.g. eating disorder, diabetes, extreme food allergy or dietary restriction)
Child does not live with participating parent/guardian
Children's Health, Food & Nutrition, Mental & Behavioral Health
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State College, PA

Lunch Meal Study for Men and Women

The purpose of this study is to gain a better understanding of how food labels can change perceptions about how filling a meal is, and what influence this has on food consumption.
Cara Meehan at cmt5070@psu.edu or 814-863-8482
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Adult 18
•70 years old
BMI between 18.0 and 35.0 kg/m^2
Exclusion Criteria:
< 18 years old
BMI < 18.0 kg/m^2
BMI > 35.0 kg/m^2
> 70 years old
Food & Nutrition
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State College, PA

Measuring the impact of three types of resistant starch on fecal butyrate levels and the gut microbiome in healthy and obese individuals

This is dietary intervention trial that will examine the impact of consuming three different types of resistant starch on the gut microbiome and butyrate levels in normal weight and obese individuals. Participants will consume starch samples daily for 24 weeks, collecting weekly fecal samples that will be returned to the lab. Researchers will analyze the bacterial fermentation products in these samples, particularly butyrate and analyze the microbiome composition. This will allow identification of differences in resistant starch (a dietary fiber) processing between normal weight and obese individuals and will also determine if the three resistant starches tested have differing impacts on the microbiome and butyrate levels.
Darrell Cockburn at dwc30@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
BMI greater than 30
Exclusion Criteria:
Diagnosis of Inflammatory Bowel Disease
Diagnosis of Diabetes
Pregnant
Taking antibiotics
Food & Nutrition
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State College, PA

Study of Angelica gigas dietary supplements (Cogni.Q) and potential effects on human immune cells

This human study will test the impact of dietary supplement vegicaps containing Korean Angelica root extract on 2 types of human immune cells: neutrophils that kill bacteria and other germs and natural killer (NK) cells that kill virus-infected cells and cancers. We had done an earlier study with Korean Angelica supplement and discovered even a single dose of it increased blood neutrophils and NK cells within 24 h. In the new study, Korean Angelica capsules (Cogni.Q) will be compared head-to-head with dummy (placebo) capsules. This is to make sure the immune boosting actions are really from the Korean Angelica supplement. Approximately 40 men will take part in this research study at Hershey Medical Center.
Male
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Male subjects 21 to 65 years of age
Subjects weighing between 110 to 240 pounds; their body mass index (BMI) should be in the range of 19=< BMI >=30
Subjects having normal hepatic, renal function as assessed by history, physical and clinical chemistry analysis (CMP eGFR).
Subjects with normal blood pressure (systolic below 120 mm Hg and diastolic below 80 mm Hg)
Exclusion Criteria:
Subjects positive for HIV, HBV and HCV (self-reported)
Subjects taking any kind of prescription medications regularly or within 10 days of the study will be excluded.
Subjects taking dietary or herbal supplements that contain AGN (e.g. Cogni.Q, Decursinol-50, Ache Action, Fast-Acting Joint Formula, EstroG-100/Profemin) within 10 days of the study.
Non-English-speaking subjects
Infectious Diseases & Immune System, Blood Disorders, Food & Nutrition
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Location
Hershey, PA

Sharing healthy activities among family members: A lightweight photo journaling design experiment

We want to develop and deploy alternative design solutions to examine how non-collocated families exchange support and collaborate on healthy living via online platform in their everyday life.
Jomara Sandbulte at jmb89@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Individuals should be 18 years or older, working adults, financially self-reliant
Individuals should have living family members who would be willing to take part on the study
Individuals should have a computer or tablet with internet access
Individuals should have Facebook account
Individuals should be living geographically distant from family members
Exclusion Criteria:
Non-English speakers
Elderly people cognitively impaired
Minors (age under 18)
Adult children who are not financially independent of their parents
Food & Nutrition, Education, Mental & Behavioral Health
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Location
State College, PA