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Suggestions within category "Heart & Vascular"


41 Study Matches

Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis. To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim. To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02089217
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Inclusion Criteria:
Age >/=35 years
Do you have documented stenosis of your carotid?
Have you had any neurologic symptoms on the same side as your stenosis
No medical history of stroke or TIA on the same side as the stenotic vessel in the previous 180 days
If female, not pregnant
Exclusion Criteria:
Prior stroke with residual disability
Symptomatic ICH within past 12 months
Chronic afib
Ejection fraction < 30%
Do you use an anticoagulant? What medication?
Heart & Vascular, Neurology
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Location
Hershey, PA

Penn State Hershey Sitting and Health Study

This study aims to examine the effect of pedaling a compact elliptical device at the desk on employees' work productivity. This study also aims to evaluate the effect of different types of incentives on promoting desk-based pedaling.
Liza Rovniak at activitystudy@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03274635
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Inclusion Criteria:
Penn State Hershey full time employee
Overweight or obese
Spend at least 5 hours per day sitting at a desk
Have eligible overweight/obese coworker who can do study together with you
18-70 years old
Exclusion Criteria:
Currently pregnant
Planned surgical or medical treatment that will prevent ability to complete study
Heart condition, or chest pain during physical activity
Planned travel or relocation during study period
Already have desk cycling device or treadmill at desk
Heart & Vascular, Prevention, Mental & Behavioral Health
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Hershey, PA

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Women, Ages 18-45
Do or do not have endometriosis
Have normal blood pressure
Exclusion Criteria:
Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
High Blood Pressure
Abnormal liver function
Known allergy statins (Lipitor)
Pregnant or Breastfeeding
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Location
State College, PA

A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit in Subjects with Hypertension

The purpose of this study is to evaluate the safety and effectiveness of renal denervation while still on blood pressure medications. Renal denervation is the destruction of nerve fibers that run along the kidney blood vessels. This causes an interruption of nerve signals that may cause high blood pressure. Therefore, the effectiveness of the study catheter and the alcohol (Peregrine Kit) will be assessed by how well the treatment reduces blood pressure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02910414
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Inclusion Criteria:
age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
Exclusion Criteria:
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder
Heart & Vascular
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Location
Hershey, PA

Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04137757
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Inclusion Criteria:
Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Exclusion Criteria:
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)
Heart & Vascular, Neurology
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Location
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Exercise Ability

To determine if the sympathetic and blood pressure (BP) responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease (PAD).
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
healthy females and males
all minorities and ethnicies included
free of acute or chronic medical conditions
over 21 years old
Exclusion Criteria:
Females who are pregnant or lactating
under 21 years old
Decisional impairment
Heart & Vascular
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Location
Hershey, PA

Endometriosis and microvascular dysfunction 3

Endometriosis, is a disorder that occurs in women, is when tissue that should be normally found inside the womb is also found in sites outside of the womb. Endometriosis is a disorder that is associated with systemic inflammation. This disorder impairs the function of the endothelium, the cells that line the body’s blood vessels (endothelium). The endothelium helps to control blood flow in healthy vessels. Women with endometriosis not only have an increased risk for high blood pressure and high cholesterol, they also have an increased risk for cardiovascular disease. With this study, we will learn how systemic inflammation in endometriosis impairs the lining of blood vessels and increases the risk for cardiovascular disease. We will use a short term intervention with a non-steroidal anti-inflammatory to examine how inflammation impact endothelial function in women with endometriosis
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Women, 18-45 years of age
With and without Endometriosis
Exclusion Criteria:
Tobacco consumption (e.g. smoking)
Pregnant and/or breastfeeding
Taking blood pressure medication
Known allergy to Salsalate
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Location
Altoona, PA
Harrisburg, PA
Hershey, PA
State College, PA
Williamsport, PA

Hemodynamic-GUIDEd Management of Heart Failure (GUIDE-HF)

The GUIDE-HF Randomized arm is to determine if PA pressure-guided HF management using CARDIOMEMS improves health outcomes in NYHA Class II, III or IV heart failure patients with either elevated NT-proBNP and/or a prior heart failure hospitalization. The GUIDE=HF Single Arm is to determine the equivalence of the effect of PA pressure-guided HF management on health outcomes between NYHA Class III heart failure patients with elevated NT-proBNP only and those with a prior heart failure hospitalization only.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03387813
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Inclusion Criteria:
heart failure
heart failure hospitalization within 1 year
Medicare
Currently patient of HMC
Exclusion Criteria:
Currently on dialysis
Heart & Vascular
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Location
Hershey, PA
Reading, PA

Site For Trial to Access Chelation Therapy TACT2

Site For Trial to Access Chelation Therapy TACT2
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02733185
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Inclusion Criteria:
History of diabetes
History of myocardial infarction
Equal to or greater than 50 years of age
Exclusion Criteria:
Myocardial infarction within the past 6 weeks
Heart failure hospitalization within the past 6 months
Cigarette smoking within the past 3 months
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Angiotensin-(1-7) and Energy Expenditure in Human Obesity

We will investigate the effects of the hormone angiotensin-(1-7) on energy expenditure in patients with obesity.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03777215
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Inclusion Criteria:
Men and women of all races
Age 18-60 years
Body mass index between 30-40 kg/m2
Capable of giving informed consent
Exclusion Criteria:
Age less than 18 years or greater than 60 years
Pregnant or nursing women
Current smokers
Type I or type II diabetes
History of major cardiovascular or cerebrovascular disease, immune diseases, impaired kidney or liver function
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
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Location
Hershey, PA

Effects of heating on exercise pressor reflex in peripheral artery disease: Sympathetic Response

The purpose of this study is to examine if nervous system and blood pressure responses to exercise will be less with heat exposure in patients with peripheral artery disease (PAD) and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
At least 21 years old
free of acute medical conditions
any race or ethnicity
women or men
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
age < 21 years old
Heart & Vascular
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Location
Hershey, PA

Heart Rate Variability in Orthostatic Hypertension

The study will examine a condition known as orthostatic hypertension, which is a sudden increase in blood pressure when a person stands up. Orthostatic hypertension is a recognized risk factor for cardiovascular diseases.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
21 – 80 years of age
Are capable of giving informed consent
Are of any race or ethnicity
Can stand for over 10 minutes
Exclusion Criteria:
Age < 21 years of age or > 80 years of age.
Are pregnant or nursing women
Have a history of low blood pressure with standing or passing out.
Cannot stand for 10 minutes
History of blood clots
Men's Health, Heart & Vascular, Women's Health
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Location
Hershey, PA

Evaluating the consequences of mistimed light-emitting device use on cardiac activity and sleep health

The study is being done to find out whether wearing blue light-blocking glasses in the evening improves subsequent sleep. This is a 21-day study where participants will be asked to wear a sleep-monitoring “actiwatch” and an activity monitor, as well as to provide screenshots of their smartphone’s screen time app for three weeks. Participants will also be asked to wear a heart tracker on their wrist and a blood pressure cuff on their arm for three days during the second and third week, for a total of six days.
David Reichenberger at phonesleep@psu.edu or 817-521-0634
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT05342662
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Inclusion Criteria:
Healthy, sighted individuals
Own an iOS or Android smartphone
Willingness to update smartphone to access the current version of the Screen Time or StayFree application, depending on smartphone operating system
Willingness to participate in surveys, wear health monitoring devices, and provide screenshots of their smartphone’s screentime application throughout the entire study
Age 18 to 29 years old
Exclusion Criteria:
Individuals who are blind or wear corrective lenses
Taking prescribed medications that affect sleep
Recent shift work
Sleep disorder diagnosis or any cardiovascular disease
Heart & Vascular, Sleep Management, Vision & Eyes
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Location
State College, PA

Cardiovascular Effects of Angiotensin 1-7 in Obesity Hypertension

The purpose of this study is to see if the hormone angiotensin-(1-7) improves the function of blood vessels and lowers blood pressure in obese subjects with hypertension.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03604289
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Inclusion Criteria:
Age 18-60 years
Obesity (defined as body mass index between 30-40 kg/m2)
Hypertension (defined as seated blood pressure greater than 130/80 mmHg)
Able and willing to give informed consent
Exclusion Criteria:
Pregnant or breastfeeding women
Current smokers
Type I or type II diabetes
History of major cardiovascular disease, immune or liver diseases, impaired renal or liver function
Age less than 18 years or greater than 60 years
Heart & Vascular
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Location
Hershey, PA

Postmenopausal women and their endothelium: Is dietary nitrate supplementation protective?

Heart disease is the leading cause of death in the United States. The loss of estrogen from menopause puts women at a greater risk of developing heart disease. The purpose of this study is to determine the effects of drinking beetroot juice on measures of blood vessel health and blood pressure. Participants will drink beetroot juice and placebo juice each for one week followed by blood pressure measurements and ultrasound imaging of an artery in the upper arm. A sub-aim of this study is to investigate the effects of estrogen status on blood vessel function between pre- and post-menopausal women.
Jocelyn Delgado at jmd956@psu.edu or 408-679-8390
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03644472
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Inclusion Criteria:
Post-menopausal women
BMI <35
Blood pressure <130/80
Premenopausal women
Exclusion Criteria:
Individuals taking hormone therapy
Individuals with resting blood pressure > or = 130/80 mmHg
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
Food & Nutrition, Heart & Vascular, Women's Health
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Altoona, PA
State College, PA

Site For CLOVERS

Site For CLOVERS
Nancy Campbell RN at ncampbell1@pennstatehealth.psu.edu or 717-531-1707, ext=3
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT00343402
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Inclusion Criteria:
Age > 18 years
Suspected or confirmed infection
Sepsis induced hypotension
Exclusion Criteria:
> 4 hours from start of hypotension
> 3 L intravenous fluids
Pregnancy
Severe volume depletion
Immediate surgical intervention planned
Infectious Diseases & Immune System, Heart & Vascular
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Location
Hershey, PA

Modulating Role of Vitamin D in Oxidative Stress-Induced Vascular Dysfunction

Cardiovascular disease (CVD) is a leading cause of sickness and death. Studies have shown higher risk of CVD in African Americans (AA). The reasons for this higher risk are not well understood. Vitamin D may play a role in blood vessel health and reduce risk of CVD. Darker skin absorbs light from the sun, and reduces the amount of vitamin D made by the body. We think that lower vitamin D in AA may lead to reduced blood vessel health and increased risk of CVD. We also think that risk of low vitamin D levels in those with increasingly darker skin pigmentation may predispose them to vascular dysfunction over time. This study will look at differences in nitric oxide that helps blood vessels relax across individuals with a wide range of skin pigmentation. We will also look at “oxidant stress,” which can reduce nitric oxide. In this study, we will examine the function of blood vessels in the skin. The blood vessels in the skin are a model for blood vessels in other organs in the body. We will also look at the function of other, larger blood vessels in the body. This research is being done to find out why blood vessel function is reduced in young AA adults who are healthy, and to determine if reduced vitamin D in those with darker skin may cause reduced blood vessel function. The research is also being done to find out if vitamin D will improve blood vessel function. Approximately 30 people will take part in this study at the Noll Lab.
Tony Wolf at saw85@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18
•35 years old
Normal blood pressure
Normal cholesterol
Normal blood glucose
Exclusion Criteria:
Smoking
Use of illegal/recreational drugs
Known skin allergies
Diagnosed or suspected metabolic or cardiovascular disease
Current pregnancy or breastfeeding
Heart & Vascular
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Location
State College, PA

A double-blind randomized placebo-controlled study on the analgesic properties of amiloride in exercise-induced skeletal muscle pain

To determine if the drug Amiloride will reduce exercise related muscle pain and improve exercise tolerance in healthy volunteers.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
healthy males and females
between 21-40 years old
any race or ethnicity
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
high blood pressure
opiod use
taking amiloride or similar medication
Heart & Vascular
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Location
Hershey, PA

The changes in insulin resistance and metabolic health among young, middle aged, and older adults meeting the current aerobic exercise training recommendations.

The overall purpose of this research is to evaluate the difference the national cardiorespiratory exercise recommendations have on metabolic and cardiovascular health over 6 weeks in previously sedentary young, middle aged, and older adults matched for obesity. The participants will complete moderate intensity exercise for 30 minutes per day, 5 days per week for 6 weeks. Pre- and post-intervention testing will be completed to evaluate changes in metabolic and cardiovascular health.
Nicole Gilbertson at nmg46@psu.edu or 814-949-5016
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Ages 19-24 and 45-79 years
Physically inactive
Able to walk for at least 30 minutes
Obese
Exclusion Criteria:
Currently participating in planned, structured physical activity
Lost or gained more than 10 lbs in 6 months
Females currently pregnant or breastfeeding
Currently smoking/using tobacco products or have within the past 6 months
Having signs/symptoms or diagnosed with cardiovascular, lung, kidney, metabolic, or mental health disease
Heart & Vascular, Sports Medicine, Diabetes & Hormones
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Location
Altoona, PA

Cardiometabolic effects of including pecans as a snack to improve diet quality: a randomized controlled study

The purpose of this study is to identify the effects of pecans replacing one snack daily on heart health, diet quality and blood sugar control. Participants will be randomized into one of two groups. Group 1 will consume ½ cup of pecans per day in place of normally consumed snacks for 12 weeks. Group 2 will be asked to continue consuming their current snacks for 12 weeks. Measures to evaluate heart health and blood sugar will be taken at the beginning and end of the 12 weeks.
Tricia Hart at tkh5422@psu.edu or 866-778-3438
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT05071807
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Inclusion Criteria:
25-70 years of age
BMI 25-40 kg/m^2
Exclusion Criteria:
Current use of tobacco-containing products or (≤6 months) cessation
Allergy/dislike of pecans
Pregnant or nursing individuals
Diagnosis of heart disease, stroke, kidney or liver disease
Food & Nutrition, Heart & Vascular
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Location
State College, PA

Effects of acid sensing ion channels blockade with amiloride on exercise pressor reflex in patients with peripheral artery disease

The purpose of the study is to determine the effects of amiloride on the blood pressure response during exercise, and exercise tolerance in patients with PAD and healthy controls.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
Hide eligibility criteria
Inclusion Criteria:
Men and women age 21- 85 years
Any race or ethnicity
Healthy: Free of acute medical conditions
PAD: Diagnosis of PAD, no pain at rest
Exclusion Criteria:
Pregnant or nursing women
Resting blood pressure of 150/100 or higher
Already taking amiloride
Recent heart attack or epilepsy
Peripheral neuropathy
Men's Health, Heart & Vascular, Women's Health
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Location
Hershey, PA

Autonomic Control of the Circulation and the Venous Distension Reflex

This study is looking at how blood pressure control is altered by increased volume in veins.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03513770
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Inclusion Criteria:
21-40 years old
Fluent in written and spoken English
Capable of giving informed consent
Free of acute or chronic medical conditions such as hypertension, heart disease, lung disease, neuromuscular disease, kidney disease, diabetes or cancer
Able to visit Penn State Health Milton S. Hershey Medical Center in Hershey, Pa. for study visits
Exclusion Criteria:
Currently smoking
Pregnant or nursing
Currently using opioids or undergoing treatment for opioid use disorder
Living with a chronic disease such as hypertension, heart disease, lung disease, neuromuscular disease, kidney disease, diabetes or cancer
Men's Health, Heart & Vascular, Women's Health
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Location
Hershey, PA

Site For Habitual Diet and Avocado Trial (HAT)

Site For Habitual Diet and Avocado Trial (HAT)
Kristin Davis at kmd74@psu.edu or 814-863-0856
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
25 years of age or older
Increased waist circumference defined as ≥35 inches for women, ≥40 inches for men
Not currently eating more than 2 avocados per month
Exclusion Criteria:
Does not eat avocados
Not willing or unable to undergo MRI scans
Pregnant, lactating, intention of pregnancy
Food & Nutrition, Heart & Vascular
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Location
State College, PA

The role of nuclear factor from activated T-cells (NFAT) in microvascular dysfunction

High blood pressure can lead to cardiovascular disease (CVD). CVD is a leading cause of illness and death in the United States. This research explores some of the ways high blood pressure impairs blood vessel function. This study uses minimum-risk procedures (flow meditated dilation, skin biopsy, and microdialysis) to explore the mechanisms underlying the impaired blood vessel function. We conduct experiments before and after 7-day treatment with FDA-approved drugs Telmisartan (prescribed to treat high blood pressure) and Tacrolimus (prescribed to treat eczema). The results of this study could suggest new ways to diagnose and treat high blood pressure. The expression of NFAT isoforms are altered in essential hypertensive vascular tissue and that short term telmisartan decreases NFAT-mediated cytokine production in hypertensive adults. We predict that 10 days of Telmisartan will alter the expression profiles of NFATc1 and NFATc3 and improve endothelial function and vascular smooth muscle cell responsiveness.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Men and women, 18-70 years of age
Normal or high blood pressure
Non-obese, BMI ≤ 39.9
Normal HbA1C of <6.5%
Not pregnant or breastfeeding
Exclusion Criteria:
Rash, skin disease, disorders of pigmentation
Diabetes, kidney, liver disease
Taking heart and blood pressure drugs
Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
Low blood pressure, < 90/60 mmHg
Heart & Vascular
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Location
State College, PA

The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-40 years
Exclusion Criteria:
• Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
• Individuals that use nicotine-containing products
Illicit or recreational drug-use
• Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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State College, PA

The effect of pistachios on blood sugar control, heart and gut health

The purpose of the study is to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk factors for heart disease. This study will also investigate how pistachios affects gut health.
Terry Riley at tmr359@psu.edu or 866-778-3438
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04056208
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Inclusion Criteria:
Age 30-65 years
BMI 25-45 kg/m2
Not taking anti-hypertensive, lipid lowering, glucose lowering drugs, steroids, or antibiotics
Not currently using tobacco products or smoking
Exclusion Criteria:
Established heart disease, stroke, diabetes, liver, kidney, autoimmune diseases or inflammatory conditions such as gastrointestinal disorders or rheumatoid arthritis
Tree nut allergy
Pregnant, lactating, planning to become pregnant or have given birth in the past year
Weight loss of ≥10% of body weight within the past 6 months
Night shift-workers and and those who cannot consume a snack in the evening
Food & Nutrition, Heart & Vascular
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State College, PA

The Muscle Reflex: MRI Studies

This research is being done to examine how the response to leg exercise measured with MRI is different between patients with Peripheral Arterial Disease (PAD) and healthy volunteers.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
have a chronic medical concern
females who are pregnant or lactating
have ferromagnetic metal implants
are claustrophobic
Heart & Vascular
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Hershey, PA

COVID-19 and microvascular function

This study will investigate the link between previous COVID-19 infection and future heart disease risk.
Gabrielle Dillon at GAD27@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-70 years of age
HAD COVID-19
DID NOT HAVE COVID-19
Non-Obese
Non-Smoker
Exclusion Criteria:
Tobacco consumption (e.g. smoking)
Pregnant and/or breastfeeding
Taking blood pressure medication
COVID-19, Heart & Vascular
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Altoona, PA
Harrisburg, PA
State College, PA
Williamsport, PA

Characterization of passive whole-body heat stress responses in obese and non-obese adults

Primary aging is associated with impairments in the body's responses to heat stress. Additionally, higher body mass may be associated with reduced tolerance to heat stress. Adults over the age of 65 are the most at-risk population for heat-related illness; however, less is known about the development of such vulnerability in middle-aged adults. This study aims to characterize heat stress responses in middle-aged adults (aged 40-65 yrs) with body mass index (BMI)&gt;30 and BMI&lt;25 during whole-body heating.
S. Tony Wolf at saw85@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Aged 40-65 years
Body mass index <25 or >30
Exclusion Criteria:
Pregnant or planning to become pregnant in next 12 months
Concurrently participating in another study involving physical activity or weight loss
Medicine that could alter cardiovascular or thermoregulatory responses
Tobacco use
Illegal/recreational drug use
Heart & Vascular
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State College, PA