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Suggestions within category "Heart & Vascular"


43 Study Matches

A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular (CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-GenE trial

The dal-GenE trial is evaluating the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in patients with a documented recent heart attack or hospitalization due to severe coronary artery disease. Dalcetrapib is an investigational drug (not approved by the United States Food and Drug Administration) that has been evaluated in several large clinical trials, most notably dal-OUTCOMES, a study of over 15,000 patients which was designed to evaluate its effect in patients with recent ACS. The results of this large study demonstrated that treatment with dalcetrapib did not change the risk of cardiovascular disease in the majority of patients with recent ACS. However, after the study was over, researchers identified a group of patients that had a significant benefit. Specifically, the group of patients who had a particular variant (AA) of a gene that all humans share (ADCY9) had their risk of having another cardiovascular event reduced by 39%. Approximately 1 in 5 patients studied had this genetic variant. Those individuals with the AA variant of the will continue in the study and will be started on study drug 4-12 weeks after their index event.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02525939
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Inclusion Criteria:
Male or female age 45 or greater
Admitted to hospital due to blockages in arteries of the heart
Exclusion Criteria:
Bypass surgery to treat your most recent heart event
Severe liver and/or kidney disease
Hemoglobin A1c greater than 10%
Triglyceride level greater than 500mg/dL
Heart & Vascular
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Location
Hershey, PA

Crest-2: Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

To assess if the proportion of patients with a primary event differs between patients treated with intensive medical management alone compared to CEA, or to CAS, in patients with high grade asymptomatic carotid stenosis. To assess whether intensive medical management differs from CEA and from CAS to maintain the level of cognitive function at 4 years of follow up To assess if there are treatment differences in major stroke, minor stroke, disabling stroke and tissue based stroke at 4 years, using an analytic approach identical to that for the primary aim. To assess if the CEA or CAS versus intensive medical management difference is affected by patient age, sex, severity of carotid stenosis, restenosis, risk factor level and during of the asymptomatic period
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02089217
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Inclusion Criteria:
Age >/=35 years
Do you have documented stenosis of your carotid?
Have you had any neurologic symptoms on the same side as your stenosis
No medical history of stroke or TIA on the same side as the stenotic vessel in the previous 180 days
If female, not pregnant
Exclusion Criteria:
Prior stroke with residual disability
Symptomatic ICH within past 12 months
Chronic afib
Ejection fraction < 30%
Do you use an anticoagulant? What medication?
Heart & Vascular, Neurology
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Location
Hershey, PA

Penn State Hershey Sitting and Health Study

This study aims to examine the effect of pedaling a compact elliptical device at the desk on employees' work productivity. This study also aims to evaluate the effect of different types of incentives on promoting desk-based pedaling.
Liza Rovniak at activitystudy@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03274635
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Inclusion Criteria:
Penn State Hershey full time employee
Overweight or obese
Spend at least 5 hours per day sitting at a desk
Have eligible overweight/obese coworker who can do study together with you
18-70 years old
Exclusion Criteria:
Currently pregnant
Planned surgical or medical treatment that will prevent ability to complete study
Heart condition, or chest pain during physical activity
Planned travel or relocation during study period
Already have desk cycling device or treadmill at desk
Heart & Vascular, Prevention, Mental & Behavioral Health
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Hershey, PA

Role of microRNA activation of lectin-like oxidized LDL receptor (LOX-1) mechanisms in microvascular dysfunction in women with endometriosis

Endometriosis is a gynecological disorder associated with chronic pelvic pain, pain during intercourse, and infertility. With endometriosis, endometrium-like tissue is found in sites outside the uterine cavity. This disorder affects 6% - 10% of women of reproductive age. It can be as high as 35-50% in women who have pain or infertility. Endometriosis is associated with higher risk of hypercholesterolemia and hypertension that increases risk for cardiovascular disease (CVD). CVD is characterized by dysfunction of the blood vessels of the body. CVD is the leading cause of death in women. Two groups of women complete this study: 1) healthy women between the ages of 18 and 45 years (Controls); 2) women between the ages of 18 and 45 years with endometriosis. The screening and two experiments include blood draws. After passing a medical screening, each subject participates in a microdialysis (MD) experiment before and after 6-9 days of oral atorvastatin therapy (10mg/day). Atorvastatin (brand name: Lipitor) is an FDA-approved drug that physicians prescribe to lower blood cholesterol. The atorvastatin also suppresses substances made by the body that increase the risk of CVD. MD is a procedure in which a thin tube of membrane that mimics a capillary blood vessel is implanted in the skin. Substances of interest are added to the saline flowing through the MD sites and are delivered into small areas of skin. The MD experiments combine the perfusion of the test-substances with local heating of the skin to explore the causes for the dysfunction of blood vessels and increased risk for CVD that occurs with endometriosis.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Women, Ages 18-45
Do or do not have endometriosis
Have normal blood pressure
Exclusion Criteria:
Use of nicotine-containing products (e.g. smoking, chewing tobacco, etc.)
High Blood Pressure
Abnormal liver function
Known allergy statins (Lipitor)
Pregnant or Breastfeeding
Heart & Vascular, Pregnancy & Infertility, Women's Health
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Location
State College, PA

Isometric Handgrip Training as an Alternative Approach to Blood Pressure Regulation in African American Men and Women

This study will test the ability of 4 weeks of isometric handgrip exercise training performed 5 days per week to lower brachial and aortic blood pressures, and improve measures of vascular health in a group of African American men and women.
David Moore at djm411@psu.edu or 717-948-6847
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Man or premenopausal woman of African American or black African descent
18-59 years of age
Exclusion Criteria:
Diagnosed with cardiovascular, kidney, metabolic, neuromuscular, or lung disease
Current or recent (past 6 months) smoker
Removal of both ovaries
Removal of uterus
Heart & Vascular, Prevention, Sports Medicine
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Location
Harrisburg, PA
Hershey, PA

Story Circles as a Methodology: Exploring Illness Perceptions in Advanced Heart Failure

We will utilize Story Circles with persons living with advanced heart failure to explore their experiences, their illness perceptions, and how these perceptions might influence goals of care and decision making. There is a gap in our current understanding of how persons living with an advanced life-limiting illness such as heart failure perceive their illness and how this might influence decision-making. New knowledge regarding a person’s illness perceptions has important implications for future work including goals of care conversations and decision making for heart failure throughout the illness trajectory and especially at the end of life.
Lisa Kitko at lkitko@psu.edu or 814-863-2228
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years of age or greater
Diagnosis of heart failure
English speaking
Exclusion Criteria:
Unable to provide informed consent
Heart & Vascular
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Location
Altoona, PA
Hershey, PA
State College, PA

A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System Kit in Subjects with Hypertension

The purpose of this study is to evaluate the safety and effectiveness of renal denervation while still on blood pressure medications. Renal denervation is the destruction of nerve fibers that run along the kidney blood vessels. This causes an interruption of nerve signals that may cause high blood pressure. Therefore, the effectiveness of the study catheter and the alcohol (Peregrine Kit) will be assessed by how well the treatment reduces blood pressure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02910414
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Inclusion Criteria:
age 18-80
Have high blood pressure despite taking blood pressure medicine
You have not donated a kidney
Exclusion Criteria:
You have had removal of a kidney or kidney transplant
You have type 1 diabetes or severe type 2
Have severe untreated obstructive sleep apnea
Bleeding disorder
Heart & Vascular
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Location
Hershey, PA

Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome

Postural tachycardia syndrome (POTS) is a chronic syndrome in which the heart beats too quickly when standing. POTS primarily affects young women. People with POTS also experience symptoms such as feeling faint, fatigue, nausea, and mental clouding or "brain fog." “Brain fog” is one of the most bothersome symptoms of POTS and it is unknown why people with POTS experience this symptom. Some studies have shown that POTS patients have problems with attention, memory and executive function (ability to plan, organize information, and adapt to changes) while seated and when upright. In this study, we will evaluate how brain function during mental tasks is affected in people with POTS compared to healthy volunteers. All volunteers will complete mental tasks while lying down and standing. If eligible, we will measure brain activity using functional magnetic resonance imaging (fMRI).The findings from this study will increase our understanding of the mental complaints in people with POTS, to hopefully help with development of new treatments.
Amanda Miller at aross1@pennstatehealth.psu.edu or 717-531-7676
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT04137757
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Inclusion Criteria:
Men and women of all races
18- 60 years old
Previously Diagnosed with POTS or healthy people without chronic illness
Capable of giving informed consent
Exclusion Criteria:
Age <18 years or >60 years
Pregnant or breastfeeding women
Other potential causes for tachycardia (e.g. prolonged bed rest, dehydration)
Taking stimulant medications within the past 3 months as these may alter cognition
Unable to tolerate an MRI scanner (e.g. claustrophobia, implanted metal)
Heart & Vascular, Neurology
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Location
Hershey, PA

The Influence of Estrogen-Status and Cardiorespiratory Fitness on Endothelial Signaling Pathways

Cardiovascular disease is the leading cause of death in women. Aerobic fitness is generally considered protective of vascular (blood vessel) health, but it is unclear whether this is true in postmenopausal women. The goal of this study is to understand whether aerobic fitness is beneficial for vascular health after menopause by evaluating signaling pathways that may be influenced by both menopause and fitness. Participants in this study will be healthy postmenopausal women who are either non-exercisers or regular exercisers. For the study, we will ask participants to complete 4 study visits at Penn State University. This will include health screenings, an exercise test, as well as measures of vascular health before and after 1 week of estrogen treatment.
Susan Slimak at sks31@psu.edu or 814-863-8556
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Postmenopausal women (1-5 years postmenopausal)
50-60 years old
Regular Exerciser
Non-Exerciser
Healthy
Exclusion Criteria:
Cardiovascular Disease
Hormone Therapy Use or Long-term Menstrual Irregularities
High Blood Pressure or High Cholesterol
Smoker
Cardiovascular-related medications (blood pressure, cholesterol)
Heart & Vascular, Women's Health
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Location
State College, PA

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction

The study is looking to find out more about how an investigational study drug called omecamtiv mecarbil works in people with heart failure. Omecamtiv mecarbil is also known as AMG 423. Omecamtiv mecarbil is an investigational medicine that increases the heart’s ability to pump.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02929329
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Inclusion Criteria:
Hospitalized or an urgent ER visit for heart failure within the last 12 months.
Exclusion Criteria:
Age greater than 85 at the time of first study visit
Require dialysis
Require use of oxygen
Cancer requiring treatment within the last 5 years (Some exceptions may apply)
Unable to swallow pills
Heart & Vascular
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Location
Hershey, PA

The effect of hyperoxia on coronary arterial collateral circulation

To examine the effect of 100% oxygen on the coronary blood flow of patients with coronary artery disease
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
over 21 years of age
Patients with CAD who had recent heart cath
Healthy subjects
•no blood pressure or cholesterol meds
Healthy matched by gender, age, and BMI to CAD patients
Exclusion Criteria:
pregnant or nursing women
Chest pain or recent heart attack less than 6 months
Kidney disease
Chronic lung condition
Uncontrolled blood pressure
Heart & Vascular
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Location
Hershey, PA

Hemodynamic-GUIDEd Management of Heart Failure (GUIDE-HF)

The GUIDE-HF Randomized arm is to determine if PA pressure-guided HF management using CARDIOMEMS improves health outcomes in NYHA Class II, III or IV heart failure patients with either elevated NT-proBNP and/or a prior heart failure hospitalization. The GUIDE=HF Single Arm is to determine the equivalence of the effect of PA pressure-guided HF management on health outcomes between NYHA Class III heart failure patients with elevated NT-proBNP only and those with a prior heart failure hospitalization only.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03387813
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Inclusion Criteria:
heart failure
heart failure hospitalization within 1 year
Medicare
Currently patient of HMC
Exclusion Criteria:
Currently on dialysis
Heart & Vascular
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Location
Hershey, PA
Reading, PA

Site For Trial to Access Chelation Therapy TACT2

Site For Trial to Access Chelation Therapy TACT2
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02733185
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Inclusion Criteria:
History of diabetes
History of myocardial infarction
Equal to or greater than 50 years of age
Exclusion Criteria:
Myocardial infarction within the past 6 weeks
Heart failure hospitalization within the past 6 months
Cigarette smoking within the past 3 months
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Experimental determination of the neurogenic contribution to skin flowmotion

The purpose of this study is to use spectral analysis to measure blow flow changes in superficial vessels of the arm. This study will explore how skin blood flow changes in response to heat and nerve inhibition. We will be locally heating the skin and blocking nerves of the skin with a topical numbing cream and measuring the resulting skin blood flow. Skin blood flow is measured by a machine that shines a harmless laser light onto the skin. The machine produces a signal that looks like a wave moving up and down. There is a known, and previously used, algorithm that can identify the neurogenic input-wave from the total skin blood flow-wave.
Zachary Lichter at zzl5229@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Men and women aged 18-85
English speaking individuals
Exclusion Criteria:
individuals diagnosed cardiovascular, metabolic, or dermatological conditions
nicotine use (e.g. smoking, chewing tobacco, etc)
pregnancy or breastfeeding
illicit or recreational drug use
allergies to lidocaine or prilocaine
Heart & Vascular, Neurology
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Location
State College, PA

Angiotensin-(1-7) and Energy Expenditure in Human Obesity

We will investigate the effects of the hormone angiotensin-(1-7) on energy expenditure in patients with obesity.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03777215
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Inclusion Criteria:
Men and women of all races
Age 18-60 years
Body mass index between 30-40 kg/m2
Capable of giving informed consent
Exclusion Criteria:
Age less than 18 years or greater than 60 years
Pregnant, nursing, or post-menopausal women
Current smokers
Type I or type II diabetes
History of major cardiovascular or cerebrovascular disease, immune diseases, impaired kidney or liver function
Heart & Vascular, Diabetes & Hormones
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Location
Hershey, PA

Assessing the Feasibility of Implementing a Storytelling Intervention among African Americans with Hypertension: A Pilot Study

Personal narratives or storytelling is an approach that has been used to promote healthy behaviors among people with diabetes, breast cancer, and high blood pressure. There is a need for low-cost, culturally-tailored interventions that promote healthy behaviors and improve health outcomes in the African American community. The objective of this project is to develop a storytelling intervention for African Americans with high blood pressure. Participants will be filmed sharing their experiences living with high blood pressure, and the videos will be shared with other African Americans with high blood pressure. We are recruiting 6-8 African American adults with high blood pressure, age 18-80, that have been diagnosed with high blood pressure and are taking medications to manage high blood pressure.
Yendelela Cuffee at ycuffee@phs.psu.edu or 717-531-7178
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Diagnosis of hypertension
Prescribed anti-hypertensive medication
Age greater than or equal to 18 years
African American
Exclusion Criteria:
Pregnancy
Unable to speak or read English
Mental status precluding ability to provide informed consent
Heart & Vascular
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Harrisburg, PA
Hershey, PA

Assessing agreement between MRI-PIVOT and traditional measures of skeletal muscle perfusion and oxygenation

The purpose of this voluntary research study is to compare different measurements of skeletal muscle oxygen levels and blood flow.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
between 21 and 40 years old
Healthy
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
any chronic disease
high blood pressure
have metal implants or claustrophobic
Heart & Vascular
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Location
Hershey, PA

Mechanisms of autonomic blood pressure control after acute exercise

This study may help to describe how blood pressure is controlled in healthy adults. Results from this study may be important for designing exercise programs for people who suffer from poor blood pressure control.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
At least 21 years old
healthy
normal blood pressure
can perform 20 continuous min of cycling
Exclusion Criteria:
Females who are pregnant or lactating
Smoker
blood pressure over 150/100
taking medications that affect the heart
unable to perform 20 continuous min of cycling
Heart & Vascular
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Location
Hershey, PA

The Muscle Reflex: Limb blood flow

We will examine whether blood flow responses to exercise (in exercising and non-exercising legs) are different between patients with PAD and healthy subjects.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
At least 21 years old
healthy
•no major medical concerns
women and men of all races
Exclusion Criteria:
Females who are pregnant or lactating
have a chronic medical concern
Heart & Vascular
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Location
Hershey, PA

The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging

Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sue Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Men and Women aged 18-30 and 60-80 years old
Healthy weight
Not taking high cholesterol/high blood pressure medication
Non-diabetic
Exclusion Criteria:
Tobacco use
Illegal/recreational drug use
Pregnant or breastfeeding
Allergy to latex
Heart & Vascular, Prevention, Sports Medicine
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Location
State College, PA

Cardiovascular Effects of Angiotensin 1-7 in Obesity Hypertension

The purpose of this study is to see if the hormone angiotensin-(1-7) improves the function of blood vessels and lowers blood pressure in obese subjects with hypertension.
Aimee Cauffman at acauffman@pennstatehealth.psu.edu or 717-531-1617
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03604289
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Inclusion Criteria:
Age 18-60 years
Obesity (defined as body mass index between 30-40 kg/m2)
Hypertension (defined as seated blood pressure greater than 130/80 mmHg)
Able and willing to give informed consent
Exclusion Criteria:
Pregnant or breastfeeding women
Current smokers
Type I or type II diabetes
History of major cardiovascular disease, immune or liver diseases, impaired renal or liver function
Age less than 18 years or greater than 60 years
Heart & Vascular
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Location
Hershey, PA

Postmenopausal women and their endothelium: Is acute dietary nitrate supplementation protective?

Cardiovascular disease is the leading cause of death in the United States. Due to the loss of estrogen, women experience a unique accelerated rise in cardiovascular disease risk factors following menopause. Postmenopausal women represent a population at heightened risk for cardiovascular disease development. The purpose of this study is to test the effects of a one time dose of beetroot juice on blood vessel function and resting blood pressure in healthy, postmenopausal women who are within 5 years of menopause. Participants will drink beetroot juice and a placebo juice on separate visits where blood pressure and blood vessel function will be measured.
Yasina Somani at yfs5057@psu.edu or 814-954-2930
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT03644472
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Inclusion Criteria:
Women within 1-5 years following menopause
Exclusion Criteria:
Individuals taking hormone therapy
Individuals with resting blood pressure > or = 130/80 mmHg
Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
Individuals with any overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
Food & Nutrition, Heart & Vascular, Women's Health
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State College, PA

Site For CLOVERS

Site For CLOVERS
Nancy Campbell RN at ncampbell1@pennstatehealth.psu.edu or 717-531-1707, ext=3
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT00343402
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Inclusion Criteria:
Age > 18 years
Suspected or confirmed infection
Sepsis induced hypotension
Exclusion Criteria:
> 4 hours from start of hypotension
> 3 L intravenous fluids
Pregnancy
Severe volume depletion
Immediate surgical intervention planned
Infectious Diseases & Immune System, Heart & Vascular
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Location
Hershey, PA

Modulating Role of Vitamin D in Oxidative Stress-Induced Vascular Dysfunction

Cardiovascular disease (CVD) is a leading cause of sickness and death. Studies have shown higher risk of CVD in African Americans (AA). The reasons for this higher risk are not well understood. Vitamin D may play a role in blood vessel health and reduce risk of CVD. Darker skin absorbs light from the sun, and reduces the amount of vitamin D made by the body. We think that lower vitamin D in AA may lead to reduced blood vessel health and increased risk of CVD. This study will look at differences in nitric oxide that helps blood vessels relax. We will also look at “oxidant stress,” which can reduce nitric oxide. In this study, we will examine the function of blood vessels in the skin. The blood vessels in the skin are a model for blood vessels in other organs in the body. We will also look at the function of other, larger blood vessels in the body. This research is being done to find out why blood vessel function is reduced in young AA adults who are healthy. The research is also being done to find out if vitamin D will improve blood vessel function. Approximately 24 people will take part in this study at the Noll Lab.
Tony Wolf at saw85@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
18
•35 years old
Normal blood pressure
Normal cholesterol
Normal blood glucose
African or European American descent
Exclusion Criteria:
Smoking
Use of illegal/recreational drugs
Known skin allergies
Diagnosed or suspected metabolic or cardiovascular disease
Current pregnancy or breastfeeding
Heart & Vascular
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Location
State College, PA

Diet and stress responses in low-income rural adults under the dynamics of food insecurity

The study is recruiting adults in rural Central Pennsylvania to understand how their food environment in fall and winter predicts diet, stress, mood, and health in everyday life. Participants will use a provided survey phone to answer the survey questions and will use a provided chest belt to measure heart rate for 5 mins every day in the morning during the study period. There will be up to 2 training session in State College, PA or a community center in Woodland, PA. Data collection will take place at participant's home. Study compensation and travel compensation will be provided.
Muzi Na at muzi.na@psu.edu or 814-865-2919
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
Show full eligibility criteria
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Inclusion Criteria:
Adults between 20-50 years
In general good health
If female, prior to menopause
Household income <= 185% of the poverty level
Exclusion Criteria:
Has any physical, mental or emotional disabilities
Is pregnant
Non-English speaking
Food & Nutrition, Heart & Vascular, Mental & Behavioral Health
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Location
DuBois, PA
State College, PA

The Role of Obesity on the Phenotype and Function of Human Monocytes and their Role in Atherosclerotic Risk

We are conducting a study that is comparing the distribution of monocyte subsets (i.e. classical, intermediate and non-classical monocyte) between adults aged 55-75 with obesity/metabolic syndrome and healthy controls. The participants will have one screening visit and one study visit, and both will involve a blood draw. Each visit should take an hour or less, and the compensation for this study is $10. Lab results from screening will also be provided to participants at no cost.
Ester Oh at sxo35@psu.edu or 814-867-3720
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
55-75 years old
Non-smoker
BMI between 18.5 – 35 kg/m2
Exclusion Criteria:
Systolic BP > 160 mmHg or diastolic BP > 100 mmHg
Fasting glucose > 126 mg/dL
Use of cholesterol/lipid-lowering medications
Use of anti-hypertensive medications
Use of glucose lowering medications
Infectious Diseases & Immune System, Heart & Vascular, Prevention
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State College, PA

Site For Habitual Diet and Avocado Trial (HAT)

Site For Habitual Diet and Avocado Trial (HAT)
Kristin Davis at kmd74@psu.edu or 814-863-0856
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
25 years of age or older
Increased waist circumference defined as ≥35 inches for women, ≥40 inches for men
Not currently eating more than 2 avocados per month
Exclusion Criteria:
Does not eat avocados
Not willing or unable to undergo MRI scans
Pregnant, lactating, intention of pregnancy
Food & Nutrition, Heart & Vascular
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State College, PA

The role of nuclear factor from activated T-cells (NFAT) in microvascular dysfunction

High blood pressure can lead to cardiovascular disease (CVD). CVD is a leading cause of illness and death in the United States. This research explores some of the ways high blood pressure impairs blood vessel function. This study uses minimum-risk procedures (flow meditated dilation, skin biopsy, and microdialysis) to explore the mechanisms underlying the impaired blood vessel function. We conduct experiments before and after 7-day treatment with FDA-approved drugs Telmisartan (prescribed to treat high blood pressure) and Tacrolimus (prescribed to treat eczema). The results of this study could suggest new ways to diagnose and treat high blood pressure. The expression of NFAT isoforms are altered in essential hypertensive vascular tissue and that short term telmisartan decreases NFAT-mediated cytokine production in hypertensive adults. We predict that 7 days of Telmisartan will alter the expression profiles of NFATc1 and NFATc3 and improve endothelial function and vascular smooth muscle cell responsiveness.
Susan Slimak at sks31@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women, 40-70 years of age
Normal or high blood pressure
Non-obese, BMI ≤ 32
Normal HbA1C of <6.5%
Not pregnant or breastfeeding
Exclusion Criteria:
Rash, skin disease, disorders of pigmentation
Diabetes, kidney, liver disease
Taking heart and blood pressure drugs
Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
Low blood pressure, < 90/60 mmHg
Heart & Vascular
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State College, PA

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF)

This is a registry based clinical trial to assess whether the initiation of spironolactone plus standard of care compared to standard care alone improves outcomes in patients with heart failure with preserved ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02901184
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Inclusion Criteria:
Diagnosed with heart failure by a physician
Ejection fraction 40% or higher
Exclusion Criteria:
Currently taking the medication Spironolactone
Pregnant or able to become pregnant
Using home oxygen
Currently on dialysis
Known significant heart valve disease
Heart & Vascular
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Hershey, PA

The effects of local negative pressure on forearm and skin blood flow in humans

This study continues our exploration into the mechanisms underlying the control of blood flow. During the experiments, we noninvasively measure skin blood flow (SkBF) and forearm blood flow (FBF) with a FLPI and venous occlusion plethysmography (VOP), respectively. The FLPI uses a low energy laser to measure SkBF. VOP uses blood pressure cuffs on the upper arm and wrist, and an elastic strain gauge encircling the forearm between the cuffs to measure the change in forearm-circumference over time from which we calculate FBF. For each experiment, we collect SkBF and FBF data for a 20-minute baseline, expose the skin of the forearms to negative pressure and then collect SkBF and FBF data for an additional 30-90 minutes. Each subject participates in 2 experiments that differ only in the protocol for the application of negative pressure (i.e. continuous, pulse).
Gabie Dillon at gad27@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and women aged 18-40 years
Exclusion Criteria:
• Diagnosed cardiovascular, metabolic, or dermatological conditions that may impact the outcome measures of interest.
• Individuals that use nicotine-containing products
Illicit or recreational drug-use
• Taking corticosteroids, anticoagulants, NSAIDS, or blood thinners
Pregnancy
Heart & Vascular
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State College, PA