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Search Results within category "Heart & Vascular"

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Suggestions within category "Heart & Vascular"


8 Study Matches

Hemodynamic-GUIDEd Management of Heart Failure (GUIDE-HF)

The GUIDE-HF Randomized arm is to determine if PA pressure-guided HF management using CARDIOMEMS improves health outcomes in NYHA Class II, III or IV heart failure patients with either elevated NT-proBNP and/or a prior heart failure hospitalization. The GUIDE=HF Single Arm is to determine the equivalence of the effect of PA pressure-guided HF management on health outcomes between NYHA Class III heart failure patients with elevated NT-proBNP only and those with a prior heart failure hospitalization only.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03387813
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Inclusion Criteria:
heart failure
heart failure hospitalization within 1 year
Medicare
Currently patient of HMC
Exclusion Criteria:
Currently on dialysis
Heart & Vascular
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Location
Hershey, PA
Reading, PA

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF)

This is a registry based clinical trial to assess whether the initiation of spironolactone plus standard of care compared to standard care alone improves outcomes in patients with heart failure with preserved ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02901184
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Inclusion Criteria:
Diagnosed with heart failure by a physician
Ejection fraction 40% or higher
Exclusion Criteria:
Currently taking the medication Spironolactone
Pregnant or able to become pregnant
Using home oxygen
Currently on dialysis
Known significant heart valve disease
Heart & Vascular
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Location
Hershey, PA

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction

The study is looking to find out more about how an investigational study drug called omecamtiv mecarbil works in people with heart failure. Omecamtiv mecarbil is also known as AMG 423. Omecamtiv mecarbil is an investigational medicine that increases the heart’s ability to pump.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02929329
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Inclusion Criteria:
Hospitalized or an urgent ER visit for heart failure within the last 12 months.
Exclusion Criteria:
Age greater than 85 at the time of first study visit
Require dialysis
Require use of oxygen
Cancer requiring treatment within the last 5 years (Some exceptions may apply)
Unable to swallow pills
Heart & Vascular
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Location
Hershey, PA

A Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects with Heart Failure with Reduced Ejection Fraction and Decreased Exercise Tolerance (METEORIC-HF)

The study will evaluate the effect of treatment with omecamtiv mecarbil compared with placebo on exercise capacity as determined by cardiopulmonary exercise testing following 20 weeks of treatment with omecamtiv mecarbil or placebo.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03759392
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Inclusion Criteria:
age 18 to 85
taking medications for heart failure for at least 3 months
Exclusion Criteria:
severe heart valve disease
organ transplant
ongoing or planned cardiac rehab
pregnant, planning to be pregnant, or breast feeding
Heart & Vascular
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Location
Hershey, PA

Beneficial effects of moderate heating on cardiovascular control in heart failure

The purpose of this project, is to examine if moderate whole body heating will effect the resting muscle sympathetic nerve activity (MSNA) and the MSNA response to the stimulation of muscle mechanoreceptors in chronic heart failure patients.
Cheryl Blaha at cblaha@pennstatehealth.psu.edu or 717-531-1605
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
non-smoker
Heart failure patients
•may be on medications
Healthy subjects
•no blood pressure or cholesterol meds
Exclusion Criteria:
pregnant or nursing women
uncontrolled blood pressure
recent heart attack in past 6 months
on kidney dialysis
Heart & Vascular
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Location
Hershey, PA

REducing Lung congestion symptoms using the V-wavE shunt in advanced heart failure (RELIEVE-HF)

The objective of the study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System to improve clinical outcomes in a certain high-risk group of symptomatic patients suffering from heart failure.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03499236
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Inclusion Criteria:
18 years of age or older
Diagnosed by a physician and told that I have Heart Failure
Currently on medications for the treatment of HF
Have symptoms of HF such as shortness of breath, fatigue, inability to lie flat or reduced ability to exert myself
Have been hospitalized or treated in an emergency department within the past year for my HF
Exclusion Criteria:
Presently on kidney dialysis
Presently enrolled in another clinical research study for an investigational drug or device
Have had a heart transplant or am presently on a waiting list for a transplant
Have an implanted mechanical heart assist device (pump)
Heart & Vascular
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Location
Hershey, PA

Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Reduced Ejection Fraction (ANTHEM-HFrEF)

To assess the safety and efficacy of the VITARIA System when added to stable, guideline directed medical therapy for patients with heart failure and reduced left ventricular ejection fraction.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03425422
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Inclusion Criteria:
Have an Ejection Fraction (EF) ≤ 35%
Exclusion Criteria:
Chronic (permanent) atrial fibrillation, or previous ablation for atrial fibrillation
Pregnant, planning on getting pregnant, or breastfeeding during the study
Previous or current implanted system or lead for vagus or other nerve stimulation
Heart failure due to congenital heart disease, hypertrophic obstructive cardiomyopathy, or infiltrative cardiomyopathy (e.g. amyloidosis, sarcoidosis)
Heart & Vascular
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Location
Hershey, PA

Story Circles as a Methodology: Exploring Illness Perceptions in Advanced Heart Failure

We will utilize Story Circles with persons living with advanced heart failure to explore their experiences, their illness perceptions, and how these perceptions might influence goals of care and decision making. There is a gap in our current understanding of how persons living with an advanced life-limiting illness such as heart failure perceive their illness and how this might influence decision-making. New knowledge regarding a person’s illness perceptions has important implications for future work including goals of care conversations and decision making for heart failure throughout the illness trajectory and especially at the end of life.
Lisa Kitko at lkitko@psu.edu or 814-863-2228
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years of age or greater
Diagnosis of heart failure
English speaking
Exclusion Criteria:
Unable to provide informed consent
Heart & Vascular
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Study Locations

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Location
Altoona, PA
Hershey, PA
State College, PA