Search Results within category "Children's Health"
Search all categoriesSuggestions within category "Children's Health"
A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia
A study of the safety and efficacy of ruxolitinib with routine chemotherapy for children with leukemia with specific genetic changes.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT02723994
Children's Health, Cancer
Improving Autism Screening with Brain-Related miRNA
The central aim of this project is to characterize the expression of exosomal microRNA (miRNA) and nucleic acids in children with autism spectrum disorder (ASD). We propose to measure the expression of extracellular miRNA and nucleic acids in children with ASD. Expression levels of miRNA and nucleic acids from blood and saliva will be compared between children with autism and normally developing controls. The goal of this study will be to identify genetic regulatory mechanisms involved in ASD and provide potential biomarkers for diagnostic screening.
Alexandra Confair at aconfair1@pennstatehealth.psu.edu or 717-531-0003, ext=323206
All
Younger than 18 years old
NCT02712853
Children's Health, Mental & Behavioral Health
A Multicenter, 24-Month, Randomized, Open-Label, Active Control, Parallel Arm, Phase 2 Study of Daily Oral LUM-201 in Naïve-to-Treatment, Prepubertal Children with Idiopathic Growth Hormone Deficiency (GHD)
This is a randomized drug study that will examine if there is a difference between a daily oral LUM- 201 (study drug) and the standard of care drug, Norditropin, over a 24 month period in children, who have not received treatment for Growth Hormone Deficiency (GHD)
Brennen Harding at bharding@pennstatehealth.psu.edu or 717-531-5656
All
Younger than 18 years old
NCT04614337
Children's Health, Diabetes & Hormones
Decision-Making in ADHD: An Evaluation of the Subjective Value of Rewards and Costs
Children with attention and behavior problems often need external rewards to motivate them to perform challenging tasks, but we don’t yet know much about how children weigh potential rewards and the effort required to obtain the rewards. This research is being done to find out how children with varying levels of ADHD symptoms value rewards and costs when making decisions about whether or not to perform a difficult task.
Whitney Fosco at abc@pennstatehealth.psu.edu
All
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health
DNA methylation in childhood trauma survivors and subsequent health issues.
This is a qualitative research interview that aims to understand how epigenetic changes linked to childhood trauma may influence the health of trauma survivors. We hope to find what diseases are more prevalent in children who have experienced child abuse than children who have not experienced child abuse. And, if possible what could be the role of DNA methylation in increasing susceptibility to these certain diseases? Participants will share their subjective views on the subject for a 30 minutes semi-structured research interview.
Melissa Cesaire at mvc6174@psu.edu or 561-425-4606
All
18 year(s) or older
N/A
Children's Health, Mental & Behavioral Health
Testing a Biosocial Model of Borderline Personality Features in Youth
In this study, we hope to better understand the neural mechanisms underlying risk for Borderline Personality Disorder (BPD) in adolescent girls. BPD is a condition that is usually found in adults. However, it may be possible to identify risk for the disorder before adulthood. Understanding who is at risk for BPD early in development is important in order to develop preventative interventions.
Dara Babinski at abc@pennstatehealth.psu.edu or 717-531-0003, ext=285968
Female
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health
A Phase I/II Study of Neratinib in Pediatric Patients with Relapsed/ Refractory Solid Tumors
Neratininb for childhood cancer that has returned or is not responding to previous therapy
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT02932280
Children's Health, Cancer
The Role of Parental Emotion Regulation in Parent-Child Conflicts
This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
james waxmonsky at jwaxmonsky@pennstatehealth.psu.edu or 717-531-8646
All
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health
Interoception, the 8th Sensory System, Is it measurable?
Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.
Cheryl Tierney at ctierney@pennstatehealth.psu.edu or 717-531-8414
All
All
N/A
Children's Health, Mental & Behavioral Health
Observations of Family Mealtime Routines
The purpose of this study is to gather information about what family mealtimes look like for families with children between the ages of 3 and 8. Families will be asked to video record their family mealtime, in addition to answer some questions and to complete some questionnaires, some about body image and dieting.
Hannah Mudrick at hxm99@psu.edu or 717-948-6404
All
All
N/A
Children's Health, Food & Nutrition
Prevalence of Avoidant Restrictive Food Intake Disorder (ARFID) traits among children and adolescents with Food Allergy
This study looks at understanding eating behaviors and attitudes toward food in children/adolescents. More specifically the study's goal is to compare those with and without food allergies to gain a better understanding of a possible underlying factor towards certain behaviors. Children and their caregivers will complete a survey composed of a short section on the child's medical history regarding allergies followed with questions in commonly used clinical assessments.
Jodi Brady-Olympia at jbradyolympia@pennstatehealth.psu.edu or 717-531-1383
All
Younger than 18 years old
N/A
Children's Health, Allergies, Food & Nutrition
Site for The HEALthy Brain and Child Development Study (HBCD)
This multi-site consortium research study, entitled the HEALthy Brain and Child Development (HBCD) study, will prospectively examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally through age 10 years. The study will determine the short- and long-term impacts of a variety of potentially harmful as well as protective environmental factors. These include prenatal substance use, mental health, stress, sociodemographics, biological and genetic factors, and parent/child interaction. The overall goal of this study is to understand the neurodevelopmental trajectories of children growing up in diverse environments. A sample of ~7,500 pregnant women will be recruited from 25 sites across the U.S. and they and their liveborn children will be followed for 10 years.
Megan Zinobile at muz144@psu.edu or 814-863-6018
All
All
N/A
Children's Health, Pregnancy & Infertility, Women's Health
Phase I Study of Carfilzomib in combination with Cyclophosphamide and Etoposide for Children with Relapsed or Refractory Solid Tumors and Leukemias
A study of the safety of carfilzomib for children with solid tumors and leukemias that returned or did not respond to previous treatment.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT02512926
Children's Health, Cancer
Emerging relations between attention and negative affect in the first two years of life
The CAT Lab focuses on the ways in which emotion and attention interact to shape how children navigate through their social world. We do this through questionnaires and observations of behavior in our laboratory. This particular study will examine how children respond to emotional and social events.
We ask infants and their parents to visit our lab 5 times, each visit being 4-6 months apart and usually lasting a little over an hour. During each visit to our lab, we ask infants to look at pictures of people and animals on a computer monitor while we record where their eyes are looking on the screen. Children also participate in several different games and play with different toys (just like those found in a common household such as balls, puppets, plastic animals, etc.). Some of these activities involve parents and some do not, but we do ask parents to stay in the room with their child for the full visit.
During visits 2-5, we would also like to collect electroencephalogram (EEG) and respiratory sinus arrhythmia (RSA) data from your child. EEG measures the electrical activity in the brain using small metal sensors placed on the head with gel. RSA measures heart rate and breathing by placing small sensors on the torso. These procedures do not hurt, are low-risk, and provide real-time measurement of your child’s autonomic nervous system signals, much like an arm cuff measures blood pressure. When the sensors are removed, some children may feel like a bandage is being pulled off.
Caitlin Smith at ces5729@psu.edu or 814-865-3181
All
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health
Caregiver's Perceptions of High-quality Early Education and Care
This is an exploratory study which looks at how caregivers define high-quality early education and care. Participants will fill out a questionnaire containing open-ended and closed-ended questions. It will take participants no longer than 20 minutes to complete.
Hannah Mudrick at hxm99@psu.edu
All
18 year(s) or older
N/A
Children's Health, Education, Mental & Behavioral Health
Pennsylvania Adoptees Longitudinal Study (PALS)
This study will examine various factors within the home of children adopted from the child welfare system between the ages of 4 and 10 that may impact their development. The first visit will occur via Penn State Health Zoom; the second visit is optional will occur within 4 weeks of the first visit at the Transforming Lives of Children Center in Harrisburg, PA; and the third visit will occur one year after the first visit, when research staff will travel to participants' homes. This research will help understand the factors that impact the development of children adopted from the child welfare system and how we may better serve these children and their families.
Rachel Brettler at pals@pennstatehealth.psu.edu or 717-531-0003, ext=321713
All
All
N/A
Children's Health, Mental & Behavioral Health
Using Serious Game Technology to Improve Social Skills in Autism
The goal of this study is to help ASD adolescents improve social skills during face-to-face interactions. We have designed an immersive computer game to help them learn these skills in a fun way. Adolescents play the game at home 3 times a week for 3 months on a computer that we give you. In order to see how well the game is working to teach them, we have to test it against another game that is similar but teaches other skills. We measure your adolescent’s attention in the lab through computer games and by measuring their eye movements. We invite you to answer questions about their social behavior. We are flexible in how we work with families to accommodate busy schedules (e.g., weekend appointments).
Families come to Penn State for three visits. We pay for all travel expenses (mileage, toll, hotel). Families are also compensated up to $450 for their time.
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-204-2272
All
Younger than 18 years old
NCT03690661
Children's Health, Mental & Behavioral Health
Expanding Family Foundations to 2nd-Time Parenthood - Focus Group
This focus group study, funded by Penn State's Social Science Research Institute, brings together couples with preschool-aged firstborns who are pregnant with their 2nd child or who have given birth to their 2nd child within the last 12 months. Couples will be interviewed about how they worked together as a team (as coparents) to prepare their firstborn for the birth of the second child and to prepare themselves for 2nd-time parenthood.
Douglas Teti at dmt16@psu.edu or 814-863-9570
All
18 year(s) or older
N/A
Children's Health, Prevention, Mental & Behavioral Health
Predicting Concussion Outcomes with Salivary miRNA
The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children.
The primary endpoints of this study are as follows:
1) Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years.
2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Brennen Harding at bharding@pennstatehealth.psu.edu or 717-531-5656
All
All
NCT02901821
Children's Health, Neurology, Sports Medicine
Saliva microRNA signatures in infants with wheezing associated respiratory illness
Wheezing is a common symptom of respiratory distress in infants and children. Infants who wheeze are at increased risk of being diagnosed with asthma, the most common chronic disease of childhood. This study will aims to yield an objective measure of asthma risk using molecular markers obtained from saliva. Saliva miRNA (markers used in this study) levels will be measured using HiSeq technology. Refinement and validation of this measure in future large-scale studies could allow clinicians to accurately predict for families an infant’s risk of asthma and optimize medical management to prevent future hospitalizations.
Ramin Beheshti at rbeheshti@pennstatehealth.psu.edu or 727-324-9947
All
Younger than 18 years old
N/A
Infectious Diseases & Immune System, Children's Health, Allergies
Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers
Molecular-guided therapy for childhood cancer that has returned or is not responding to previous therapy.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 771-531-3097
All
All
NCT02162732
Children's Health, Cancer
NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)
A study of DFMO for patients with neuroblastoma in remission.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT02679144
Children's Health, Cancer
Site for Strong Foundations: Intervening to Promote Co-Parenting in Expectant Parents and Healthy Child Development.
Our goal is to examine the efficacy of Strong Family Foundations parenting classes in reducing couple conflict, promoting co-parenting quality, parental sensitivity, and child development outcomes within families. We hope to enroll 220 couples in our parenting program. Participants will participate in parenting classes before and after the birth of their child, and research assessments 6 and 12 months postpartum.
Jenna Sassaman at jnk5173@psu.edu or 814-865-6902
All
18 year(s) or older
NCT04441307
Children's Health, Pregnancy & Infertility, Women's Health
A Randomized, Double-Blind, Placebo-Controlled Multiple-Center, Efficacy and Safety Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents with Fragile X Syndrome - RECONNECT
The purpose of this study is to investigate how effective and safe ZYN002, a transdermal gel, is in patients with FXS in managing behavioral symptoms.
Patricia Gordon at pgordon@pennstatehealth.psu.edu
All
Younger than 18 years old
NCT04977986
Children's Health, Mental & Behavioral Health
A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma and Medulloblastoma
A study if the safety and effectiveness of nifurtimox in children with neuroblastoma or medulloblastoma, that has returned or is not responding to treatment.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
All
NCT00601003
Children's Health, Cancer
Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study
This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation.
Children and their parents will complete questionnaires. Children will complete computer tasks during EEG and in an MRI scanner. Parents can also complete the MRI scan if interested.
Michael West at ABC@pennstatehealth.psu.edu or 717-531-0003, ext=285968
All
Younger than 18 years old
N/A
Children's Health, Neurology, Mental & Behavioral Health
The Child Health Study
We want to understand how a child's environment affects biology in ways that impact child health
Megann Koegler at childhealthstudy@psu.edu or 888-924-4535
All
Younger than 18 years old
N/A
Children's Health, Food & Nutrition, Education
Development of Adolescent and Young Adult Social Health (DASH)
Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time (between $185-630) in the lab and for the neuroimaging session.
If you are a parent and want to begin the screening process for you child, please go here
https://pennstate.qualtrics.com/jfe/form/SV_51lN8sODiukYOON
If you are an adult, and want to begin the screening process please go here:
https://pennstate.qualtrics.com/jfe/form/SV_5cXMng6ybKe0WwJ
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-954-0112
All
All
N/A
Children's Health, Education, Mental & Behavioral Health
Neurophysiological Markers of Pediatric Irritability and its Response to Intervention
This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.
Vanessa Cao at vcao@pennstatehealth.psu.edu or 717-531-0003, ext=285966
All
Younger than 18 years old
NCT03279952
Children's Health, Mental & Behavioral Health
Attention and Emotional Development in Children
Children with attention problems often feel anxious or worried, and likewise, children who are anxious or worried often have problems with attention. We are looking for children aged 8-12 who may or may not have problems with attention or anxiety to help us understand what happens in the brain that could explain why. You will receive up to $100 gift card for your participation, and informal clinical feedback on your child.
Christina Hlutkowsky at ChildAttention@psu.edu or 814-863-0250
All
Younger than 18 years old
N/A
Children's Health, Mental & Behavioral Health