A diagnosis of leukemia, specifically de novo high B-ALL with eligible genetic changes.
Age must be greater than 1 year old and less than or equal to 21 years old at leukemia diagnosis.
Have completed an acceptable induction therapy either on study or by hospital standard of care.
Had any other chemotherapy before induction therapy, with exceptions.
Down Syndrome.

Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study

Age: 1-4 years
Confirmed Diagnosis of Autism or Developmental Delay or Healthy Child
Wards of the state
Sensory Impairment (blindness/deafness)
Confounding neurological condition (cerebral palsy, epilepsy)
Gastrostomy Tube Dependence
Active Peridontal Disease

Age 3 to 21 Inclusive
Cancer that has returned or is not responding to previous therapy
Has failed at least one prior therapy
Certain prior therapies

Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English

Between 13 to 29 years of age
Able to read, speak, and understand English
Must own or be the sole user of a smartphone
The smartphone owned or used by the participant must be iPhone version 5S or later or an Android less than 5 years old
Participant must be residing in the state of Pennsylvania
Currently limiting smartphone use

At least one adult who is the caregiver of at least one child between age 3 and 8 (e.g., at least one parent-child dyad)
Adults age 18 and older
Children, ages 3-8
Individuals fluent in English
Non-family members, as defined individually by each family
Caregivers who are under the age of 18
Individuals who are not fluent in English
Families without at least one child age 3 to 8

Have an established diagnosis of PGHD. Eligible subjects must be naïve-to-treatment and be prepubertal.
At Screening, be age ≥ 3.0 years and age < 10.0 years for girls and < 11.0 years for boys
Have normal thyroid function. Subjects diagnosed with hypothyroidism must have documented successful treatment for at least 30 days prior to Day 1.
A diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) and/or use of medication to treat ADHD
Evidence or history of an intracranial mass

Children 10 to 13 year olds
Girls
With or without a current or past history of mental health disorder
Fluent in English
Children who are younger than 10 years of age and children who are older than 13 years of age
Diagnosis of intellectual or developmental disabilities (e.g., Autism, Asperger's) , or any psychotic disorders (e.g., schizophrenia, bipolar disorder)
Males
Not fluent in English

Child age 12-17 years old (inclusive)
Child self identifies as Black/African/African-American/Afro-Caribbean
Child resides in the United States
Fluent in spoken and written English
Parent/legal guardian consents to child's participation in the study
Child age <12 or >17
Child does not self identify as Black/African/African-American/Afro-Caribbean
Child does not reside in the United State
Parent/legal guardian unwilling to consent to child's participation
Parent/legal guardian < 18 at time of enrollment

Children ages 8 to 12 years old
Children with normal or corrected vision
Caregiver and child must be fluent in written and spoken English
Willing to stop stimulant medications, when appropriate, for research testing
Children who are younger than 8 years of age and children who are older than 12 years of age.
Current or past diagnosis of autism spectrum disorder, schizophrenia or other psychotic disorders.
Current use of non-stimulant medication due to its extended washout period.
Physical disabilities that are incompatible with completing laboratory tasks such as hearing impairments, or visual impairments that cannot be corrected with visual aids (i.e., glasses, contacts).

A diagnosis of pediatric cancer of varying types for which there is no known cure or disease that is not responding to treatment.
Must be over one year of age at enrollment.
Must be less than or equal to 21 years at initial diagnosis.
Must have measurable disease by accepted standards.
Tumor must be accessible for biopsy.
Has received chemotherapy within the last 7 days of biopsy.
Has received any radiotherapy to the primary sample site within the last 14 days.
Currently taking any other study drug.

Ages 0-21 years at the time of diagnosis.
Diagnosis of neuroblastoma or medulloblastoma.
Disease has not responded to previous treatment.
Disease is measurable bu accepted tests.
Patients who weigh less than 3.5 kg (7.7 lbs).
Currently receiving another study drug.
Currently receiving other anticancer agents.

A confirmed diagnosis of neuroblastoma.
Must be in complete remission (CR).
Tests and scans will be required to confirm remission.
Patients below the defined minimum of height and weight.
Patients who are currently receiving another study drug may not participate.
Patients who are currently receiving other anticancer agents may not participate.

Diagnosis of relapsed or refractory solid tumor.
Age 6 months to less than 30 years at enrollment.
Must be fully recovered from effects of previous treatment.
Life expectancy greater than or equal to 3 months.
Prior treatment with carfilzomib.
Known allergy to Captisol®.
Down syndrome.

New diagnosis of leukemia (de novo ALL) or lymphoma (T or B cell).
An acceptable planned induction chemotherapy.
One year of age and older to less than 18 years of age.
Able to take oral medication or have it given through a tube.
Had a blood clot in the past 3 months.
Known inherited bleeding disorder.

infant is at least 3.5 months of age
infant born within +/- 3 weeks of due date
Infants without any serious medical complications
Infants of a healthy birth weight (>2500g; >5 lbs, 8 oz.)
infant not of healthy gestational age
infants <2500g; <5lbs, 8 oz at birth
Infants who experienced any serious medical complications

5 to 23 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI

Ages 12--16 years
Fluent in English
No history of treatment for psychiatric disorders
Intellectual or developmental disabilities
Visual or hearing impairments
Inability to complete MRI scan due a pacemaker, aneurysm clips or any metal in body (e.g., braces, surgical devices)
Currently pregnant or lactating
Neurological disease (e.g., stroke, tumor, Parkinson’s disease, etc.)

New breastfeeding mother
Mothers ages 18-50
healthy baby < 7 days old
seeking care at a Penn State Pediatric Clinic
Term baby 37-42 weeks at birth
plan to move out of central PA within 1 year
plan to stop breastfeeding before baby is 4 months old

Adults age 18 and older
Adults who are fluent in English
Adults who are regular caregivers of children between birth and age 5
Individuals who can read and respond to written close- and open-ended survey questions electronically
Individuals who live in the United States
Individuals under the age of 18
Individuals who are not fluent in English
Individuals who are not regular caregivers of children between birth and age 5
Individuals with poor reading comprehension and are otherwise limited in their ability to read and respond to survey questions
Individuals who do not currently live in the United States of America

Child age between 4 and 10
Child legally adopted by the caregiver
The same caregiver will participate in each of 2 in-home assessment sessions
Child diagnosed with intellectual disability
A legally adoptive caregiver is a biological relative of the child

10-18 years old
autism spectrum disorder
corrected vision and hearing at normal levels
can speak in full sentences
stable internet connection in the home
active seizure disorder in last 2 years
non-native English speaker

Healthy pregnant women age 49 or less
No significant fetal anomalies noted on ultrasound at at least 18 weeks gestation
HIV, syphilis, and hepatitis b negative
Planning to deliver at Hershey Medical Center
Willing to consent for infant to participate in study
Pre-pregnancy BMI >40
History of severe adverse/allergic reaction to vaccination
Current pregnancy resulting from in vitro fertilization
Current or past pregnancy complications or abnormalities

Pregnant/Expecting Couples
First time parents
18 years of age or above
English speaking
Both parents living together
Below 18 years of age
Not pregnant with first child
Parents not living together

1. Two-caregiver families, any race or ethnicity, with one or two children: a. One subgroup with one child < 6 years of age and pregnant with a 2nd child b. One subgroup with one child < 6 years of age and an infant between 1-to-12 months of age.
2. Each caregiver is over 18 years of age.
3. Caregivers are living together in the same household and are either married or living with a partner.
4. Families living independent of parents’ families of origin.
5. Both caregivers fluent in communicating in English.
1. One or the other caregiver cannot understand or speak English
2. Caregivers are under 18 years of age.
3. Caregivers not living together
4. Caregivers not living independently of their families of origin
5. Single-parent families with no live-in partner.

Children 8-13 years of age
Speak and understand English
Participation of a legal guardian
Intellectual or learning disability

Native English speaker
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
Family history of autism spectrum disorders (in parents or full siblings)
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces

Children between the ages of 5 and 12
Children diagnosed with ADHD or suspected ADHD Symptoms
Children who are able to stop ADHD medication for testing days
Parent/child fluent in English
Children younger than 5 year or older than 12 years
Children with visual or hearing deficits or sensitivity to loud noise
Neurological conditions such as active seizure disorder
Prominent traits or diagnosis of Autism, marked developmental delay, mania, psychoses, or suicidal ideation.

Children aged 8-12
Children outside of the 8-12 age range
History of seizures or photosensitive epilepsy