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Study matches: 46

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric And Young Adult Patients with Previously Treated Solid Tumors

A study of the safety and effectiveness of cobimetinib in patients with previously treated solid tumors.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A solid tumor that has not responded to previous treatment.
Age must be 6 months or older to younger than 18 years of age.
Disease must be measurable by accepted tests.
Availability of tumor tissue at study enrollment is mandatory.
Exclusion Criteria:
Prior treatment with cobimetinib or other similar drug.
Treatment with high-dose chemotherapy and stem-cell rescue within 3 months prior to the study.
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NCT02639546
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Hershey, PA

Characterizing the gait mechanics of adolescents

The purpose of this study is to characterize the effect of weight on walking and running in adolescents. A better understanding of the mechanical consequences of weight will allow us to design training programs to minimize injuries and improve participation in physical activity.
Allison Singles at ara5093@psu.edu or 610-396-6152
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between 12 and 16 years old
Exclusion Criteria:
Any major injuries or surgeries
Cannot walk or run independently
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N/A
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Location
Reading, PA

A Phase 2 Study of the JAK1/JAK2 Inhibitor Ruxolitinib With Chemotherapy in Children With De Novo High-Risk CRLF2-Rearranged and/or JAK Pathway–Mutant Acute Lymphoblastic Leukemia

A study of the safety and efficacy of ruxolitinib with routine chemotherapy for children with leukemia with specific genetic changes.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
A diagnosis of leukemia, specifically de novo high B-ALL with eligible genetic changes.
Age must be greater than 1 year old and less than or equal to 21 years old at leukemia diagnosis.
Have completed an acceptable induction therapy either on study or by hospital standard of care.
Exclusion Criteria:
Had any other chemotherapy before induction therapy, with exceptions.
Down Syndrome.
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NCT02723994
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Hershey, PA

A Single-arm, Prospective Study of Remestemcel-L, Ex-vivo Cultured Adult Human Mesenchymal Stromal Cells, for the Treatment of Pediatric Patients who Have Failed to Respond to Steroid Treatment for Acute GVHD

A study of the safety and effectiveness of remestemcel-L in pediatric subjects with acute Graft versus Host Disease (aGVHD) following transplant (HSCT) that has failed to respond to steroid treatment.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
A diagnosis of acute GVHD.
2 months of age and older to under 18 years of age.
Patient has failed to respond to steroid treatment.
Exclusion Criteria:
Has had any second line therapy to treat aGVHD.
Severe hepatic veno-occlusive disease (VOD).
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NCT02336230
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Hershey, PA

The Role of Parental Emotion Regulation in Parent-Child Conflicts

This study seeks to examine parenting skills in responses to child misbehavior. Parents complete rating scales about their child's symptoms and behaviors and also participate in computer tasks to measure brain wave activity through EEG. There is an optional section where parent and child will be video recorded while completing activities together. Following the testing sessions are 8 weeks of counseling sessions for parents to help better manage their child's attention and behavior symptoms.
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Parent of a child aged 5-12 with ADHD
Child must have mild to moderate symptoms of ODD
Exclusion Criteria:
Not having a child ages 5-12 with ADHD
Non-English speaking
Child with ADHD has diagnosis of mental retardation or prominent traits of autism
No additional child in the family can be enrolled simultaneously in this study
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N/A
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Location
Hershey, PA

Improving Autism Screening with Brain-Related miRNA

The central aim of this project is to characterize the expression of exosomal microRNA (miRNA) in children with autism spectrum disorder (ASD). We propose to measure the expression of extracellular miRNA in children with ASD. Expression levels of miRNA from blood and saliva will be compared between children with autism and normally developing controls. The goal of this study will be to identify genetic regulatory mechanisms involved in ASD and provide potential biomarkers for diagnostic screening.
Julie Vallati at jvallati@pennstatehealth.psu.edu or 7175313049
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Age: 24 Months
•6 Years
Confirmed Diagnosis of Autism or Developmental Delay or Healthy Child
Exclusion Criteria:
Wards of the state
Underlying Seizure Disorder
Underlying Genetic Disorder
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NCT02712853
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Development of a caregiver-report instrument to assess child behavior.

It is commonly agreed that school-aged children display observable attachment behavior, although it is difficult to elicit in laboratory tasks. However, caregivers will observe this behavior on a regular basis when it occurs and can provide useful information regarding the structure and function of that behavior. The goal of the current proposal is to define a potential caregiver-reported instrument assessing early school-age children’s attachment behavior and collect initial data sufficient to examine the factor structure and reliability of the measure. Data collection will utilize anonymous online survey methodology and recruit through schools and preschools.
Brian Allen at ballen1@pennstatehealth.psu.edu or 7175314100
All
Not specified
This study is also accepting healthy volunteers
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Inclusion Criteria:
Adult caregiver of a child between the ages of 4 and 8
Adult caregiver is at least 18 years of age
Adult caregiver is the primary caregiver of the child.
Exclusion Criteria:
Child has an autism spectrum disorder, intellectual disability, or other developmental delay.
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N/A
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Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders

Replication of The Multi-Media Social Skills Project for Adolescents with Autism Spectrum Disorders
Michael Klemick at mklemick@pennstatehealth.psu.edu or 7175310003 x.284923
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Between 13 and 17 years of age or still enrolled in high school
A primary diagnosis of Asperger's Syndrome or high-functioning autism, as confirmed by the Checklist for Autism Spectrum Disorders (CASD; Mayes, 2012)
English as primary language spoken
Ability to fluently speak in full sentences
A verbal IQ of 85 or above on the Kaufman Brief Intelligence Test, Second Edition (KBIT-2; Kaufman & Kaufman, 1990)
Exclusion Criteria:
A significant language delay
Difficulty with aggression directed at peers
A primary thought disorder
A secondary disorder of anxiety or depression so severe as to prevent the individual's participation in the treatment
Low social motivation demonstrated through formalized assessment (SRS) and/or by responses given to screening interviews assessing treatment goals
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N/A
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Location
Altoona, PA
Greater Philadelphia Area, PA
Greater Pittsburgh Area, PA
Hershey, PA
Wilkes-Barre/Scranton Area, PA

A Phase I/II Study of Neratinib in Pediatric Patients with Relapsed/ Refractory Solid Tumors or Hematologic Malignancies

Neratininb for childhood cancer that has returned or is not responding to previous therapy
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Age 6 to 21 Inclusive
Cancer that has returned or is not responding to previous therapy
Has failed at least one prior therapy
Exclusion Criteria:
Certain prior therapies
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NCT02932280
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Location
Hershey, PA

Interoception, the 8th Sensory System, Is it measurable?

Sensory processing is often affected in children and adolescents with ASD (autism). The 8th sensory system, coined interoception, is under studied in how it affects children with autism. Our study will compare children with and without autism (ages 11-18 years) using a tool we are developing. Our study hopes to develop psychometric properties of a tool to measure this new sensory sense.
Cheryl Tierney at ctierney@pennstatehealth.psu.edu or 717-531-8414
All
Not specified
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 11-18
Reading at 5th grade level in English
Healthy controls OR high functioning Autism
Exclusion Criteria:
Unable to read at 5th grade reading level
Under age 11 or over age 18
Cannot read English
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N/A
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Evaluation of SPN-812 ER 400 and 600mg Efficacy and Safety in Adolescents with ADHD - A Double-Blind, Placebo-Controlled, Pivotal Trial

This is a drug study testing the safety and efficacy of a new non-stimulant long lasting ADHD medication. The trial is for teens ages 12-17 with ADHD and will provide up to 8 weeks of treatment with the investigational medication. Investigational means that the drug has not been approved by the United States Food and Drug Association (FDA). Study visits include an intake visit to determine eligibility for the study and weekly visits to adjust the dosage of the medication.
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Children ages 12-17 years with ADHD diagnosis
Participation in one intake appointment designed to determine eligibility for the study
Attend 9weekly visits for medication/ routine check
Exclusion Criteria:
Current neurological disorder including seizure disorder or history of seizures
Allergy or history of allergy to viloxazine or related drugs
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NCT03247556
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Location
Hershey, PA

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers

Molecular-guided therapy for childhood cancer that has returned or is not responding to previous therapy.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 771-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
A diagnosis of pediatric cancer of varying types for which there is no known cure or disease that is not responding to treatment.
Must be over one year of age at enrollment.
Must be less than or equal to 21 years at initial diagnosis.
Must have measurable disease by accepted standards.
Tumor must be accessible for biopsy.
Exclusion Criteria:
Has received chemotherapy within the last 7 days of biopsy.
Has received any radiotherapy to the primary sample site within the last 14 days.
Currently taking any other study drug.
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N/A
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Location
Hershey, PA

Using Serious Game Technology to Improve Sensitivity to Eye Gaze in Autism

We are developing and testing a computer game to help adolescents with autism improve social skills. In this game, players become a teenage pet detective. They interact with animals and human characters, navigate worlds, find objects, and solve mysteries. The game teaches players to attend to nonverbal social cues and use them to solve pet mysteries. Participants get to play the game from their own home! Adolescents and their families visit the lab prior to the intervention and after the intervention so that we can assess the impact of the game on behavior and social skills.
Dr. Suzy Scherf at suzyscherf@psu.edu or 814-867-2921
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Autism Spectrum Diagnosis
Ages 10-18
Speaks in full sentences
Can follow written and oral instructions
Can use a computer in a basic way
•click mouse for responses and use arrow keys on keyboard to navigate
Exclusion Criteria:
Uncorrected vision or hearing problems
Seizures within last 2 years
Does not have minimum of 2nd grade reading level
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NCT02968225
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Location
State College, PA

A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma and Medulloblastoma

A study if the safety and effectiveness of nifurtimox in children with neuroblastoma or medulloblastoma, that has returned or is not responding to treatment.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Ages 0-21 years at the time of diagnosis.
Diagnosis of neuroblastoma or medulloblastoma.
Disease has not responded to previous treatment.
Disease is measurable bu accepted tests.
Exclusion Criteria:
Patients who weigh less than 3.5 kg (7.7 lbs).
Currently receiving another study drug.
Currently receiving other anticancer agents.
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NCT00601003
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Location
Hershey, PA

NMTT- Neuroblastoma Maintenance Therapy Trial Using Difluoromethylornithine (DFMO)

A study of DFMO for patients with neuroblastoma in remission.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
A confirmed diagnosis of neuroblastoma.
Must be in complete remission (CR).
Tests and scans will be required to confirm remission.
Exclusion Criteria:
Patients below the defined minimum of height and weight.
Patients who are currently receiving another study drug may not participate.
Patients who are currently receiving other anticancer agents may not participate.
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NCT02679144
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Location
Hershey, PA

Phase I Study of Carfilzomib in combination with Cyclophosphamide and Etoposide for Children with Relapsed or Refractory Solid Tumors and Leukemias

A study of the safety of carfilzomib for children with solid tumors and leukemias that returned or did not respond to previous treatment.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Not specified
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Diagnosis of relapsed or refractory leukemia or solid timor.
Age 6 months to less than 30 years at enrollment.
Must be fully recovered from effects of previous treatment.
Life expectancy greater than or equal to 3 months.
Exclusion Criteria:
Prior treatment with carfilzomib.
Known allergy to Captisol®.
Down syndrome.
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NCT02512926
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Location
Hershey, PA

A Phase III Randomized, Open Label, Multi-center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B cell) Treated with Pegylated Asparaginase

A study to confirm and expand information on safety and effectiveness of apixaban to prevent blood clots as compared to no prevention treatment in children with newly diagnosed leukemia and lymphoma. This is a randomized study so patients will be selected by chance to be in either the group that receives apixaban or the group that does not receive apixaban.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
New diagnosis of leukemia (de novo ALL) or lymphoma (T or B cell).
An acceptable planned induction chemotherapy.
One year of age and older to less than 18 years of age.
Able to take oral medication or have it given through a tube.
Exclusion Criteria:
Had a blood clot in the past 3 months.
Known inherited bleeding disorder.
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NCT02369653
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Location
Hershey, PA

A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant

A study to confirm and expand information on safety and effectiveness of defibrotide compared to best standard care to prevent veno-occlusive disease of the liver in adult and pediatric transplant patients. This is a randomized study so patients will be selected by chance to be in either the group that receives defibrotide or the group that does not receive defibrotide.
Suzanne Treadway, MS, RN, CCRP at streadway@pennstatehealth.psu.edu or 717-531-3097
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Must be older than 1 month of age.
Scheduled for a stem cell transplant and be at high risk of veno-occlusive disease.
Be at high risk of veno-occlusive disease.
Exclusion Criteria:
Unstable blood pressure.
Episodes of bleeding.
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NCT02851407
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Location
Hershey, PA

Emerging relations between attention and negative affect in the first two years of life

The CAT Lab focuses on the ways in which emotion and attention interact to shape how children navigate through their social world. We do this through questionnaires and observations of behavior in our laboratory. This particular study will examine how children respond to emotional and social events. We ask infants and their parents to visit our lab 5 times, each visit being 4-6 months apart and usually lasting a little over an hour. During each visit to our lab, we ask infants to look at pictures of people and animals on a computer monitor while we record where their eyes are looking on the screen. Children also participate in several different games and play with different toys (just like those found in a common household such as balls, puppets, plastic animals, etc.). Some of these activities involve parents and some do not, but we do ask parents to stay in the room with their child for the full visit. During visits 2-5, we would also like to collect electroencephalogram (EEG) and respiratory sinus arrhythmia (RSA) data from your child. EEG measures the electrical activity in the brain using small metal sensors placed on the head with gel. RSA measures heart rate and breathing by placing small sensors on the torso. These procedures do not hurt, are low-risk, and provide real-time measurement of your child’s autonomic nervous system signals, much like an arm cuff measures blood pressure. When the sensors are removed, some children may feel like a bandage is being pulled off.
Norbert Promagan at nup21@psu.edu or 814-867-2322
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
infant is 4-months of age
infant born within +/- 3 weeks of due date
Infants without any serious medical complications
Infants of a healthy birth weight (>2500g; >5 lbs, 8 oz.)
Exclusion Criteria:
infant older or younger than 4 months of age
infant not of healthy gestational age
infants <2500g; <5lbs, 8 oz at birth
Infants who experienced any serious medical complications
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N/A
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Location
Harrisburg, PA
State College, PA

Predicting Concussion Outcomes with Salivary miRNA

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows: 1) Characterization of brain-related miRNA in the saliva of 100 children with mTBI and 50 age- and gender-matched controls between the ages of five and twenty-one years. 2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Jennifer Stokes at jstokes@pennstatehealth.psu.edu
All
Not specified
This study is also accepting healthy volunteers
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Inclusion Criteria:
5 to 21 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Exclusion Criteria:
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI
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NCT02901821
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Location
Hershey, PA

Examining mood and social functioning of girls with ADHD

Research has produced sophisticated pharmacological and psychosocial interventions associated with great improvements in academic and behavioral functioning of children with ADHD. However, such treatments are limited in producing improvements in interpersonal problems of children with ADHD and in preventing long-term issues such as depression. Results from this study will inform the development and evaluation of a novel family-based intervention to improve the interpersonal and mood problems characteristic of many girls with ADHD
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003 ext. 285968
Female
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
12-16 years of age
Female gender
Female primary caregiver willing to participate
Established or suspect ADHD diagnosis
Exclusion Criteria:
Younger than 12 years of age or older than 16 years of age
Male gender
No signs, symptoms, or diagnosis of ADHD
Diagnosis of Autism, schizophrenia, or intellectual disability disorder
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N/A
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Location
Hershey, PA

Youth's Experiences Study in School Study

This study focuses on African American youth's school experiences. Using a daily diary method this study seeks to identify links between student's experiences of competence, autonomy, and relatedness in their math and English courses and their classroom engagement. Further, we are examining how youth's identity and beliefs about their race and gender are related to their classroom experiences.Students can earn up to $55 for participating in the study.
Olivenne Skinner at ods3@psu.edu or 814-865-0095
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
African American or Black
Currently in Grade 9 or 10
Have access to the internet everyday afterschool
Exclusion Criteria:
Not African American/Black
Does not have access to the internet afterschool
Not currently in Grade 9 or Grade 10
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N/A
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Monetary Reward Processing and Emotion Regulation in Adolescence: An fMRI pilot Study

This research is being done to identify patterns of brain activation underlying monetary reward processing and emotion regulation in adolescence, as well as correspondence between parent and adolescent neural activation. Children and their parents will complete questionnaires. Children will complete computer tasks while in an MRI scanner. Parents can also complete the MRI scan if interested.
Ashley Carroll at acarroll@pennstatehealth.psu.edu or 717-531-0003
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Ages 12--16 years
Fluent in English
No history of treatment for psychiatric disorders
Exclusion Criteria:
Intellectual or developmental disabilities
Visual or hearing impairments
Inability to complete MRI scan due a pacemaker, aneurysm clips or any metal in body (e.g., braces, surgical devices)
Currently pregnant or lactating
Neurological disease (e.g., stroke, tumor, Parkinson’s disease, etc.)
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N/A
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Location
Hershey, PA

Bioactive RNA in Infant Nutrition: A Novel Regulator of Developmental Origins and Allergic Response

Characterize longitudinal changes in immune-related ribonucleic acids (RNAs) during the first four months after birth (a critical period when protective breastfeeding benefits are conferred) and compare breast milk RNA exposure between atopic and non-atopic infants. Atopy, the genetic tendency to develop allergic diseases such as asthma and atopic dermatitis (AD), is present in nearly one-third of children. Atopy results from activation of the immune response to environmental exposures. The developmental origins that influence this response are not completely understood. Infants who breastfeed beyond three months have lower atopy risk. What factors in maternal breast milk (MBM) confer these health benefits and why is breastfeeding beyond three months so critical? The answer may be a bioactive factor in MBM called microRNA (miRNA). MiRNAs are small non-coding molecules that regulate gene expression across multiple tissues. There are nearly 1,000 types of miRNAs in MBM. The majority are found in the lipid or cellular milk fractions, and evidence suggests that they regulate metabolic and immune pathways. Studies by our lab and others demonstrate that MBM miRNA composition is influenced by both maternal factors (delivery method and weight) and infant factors (prematurity). Animal studies suggest nutritional miRNA influences the immune system through immune-modulation. Thus, breast milk miRNA exposure may mitigate infant atopy risk.
jessica Beiler at jbeiler@pennstatehealth.psu.edu or 717-531-5656
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
New breastfeeding mother
ages 18-35
healthy baby < 7 days old
seeking care at a Penn State Pediatric Clinic
Exclusion Criteria:
plan to move out of central PA within 1 year
plan to stop breastfeeding before baby is 4 months old
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N/A
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Location
Hershey, PA

Integrating AAT into TF-CBT for Maltreated Youth: A Randomized Feasibility Trial

This is a randomized clinical trial designed to test the feasibility of integrating Animal-Assisted Therapy (AAT) into standard Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) for the treatment of posttraumatic stress and associated symptoms of maltreated youth.
Brian Allen at ballen1@pennstatehealth.psu.edu or 717-531-4100
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Child between the ages of 6 and 17
Child has a history of physical abuse, sexual abuse, or other type of maltreatment
Child displays posttraumatic stress symptoms
Primary caregiver willing to participate in treatment
Exclusion Criteria:
Child has a developmental or intellectual delay.
Uncontrolled allergy to or fear of dogs on part of either the child or caregiver.
CHild or caregiver has a history of aggression toward animals
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NCT03135119
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Location
Harrisburg, PA

Pilot testing of fMRI protocols in children

Pilot testing of fMRI protocols in children
Marissa Reynolds at mlr5246@psu.edu or 8148655285
All
Younger than 18 years old
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Children must be between the ages of 6-10 years-old at the time they participate in the phone screening.
All children will be physically healthy and without diagnosed learning disorders.
Exclusion Criteria:
Children will be excluded if they are younger than age 6 or older than age 10 years.
Children will be excluded if they have a diagnosed learning disorder or are not physically healthy.
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NCT03338634
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Location
State College, PA

The Child Health Study

We want to understand how a child's environment affects biology in ways that impact child health
Cheri McConnell at cln3@psu.edu or 1-844-296-4666
All
Younger than 18 years old
This study is also accepting healthy volunteers
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Inclusion Criteria:
Children 8-13 years of age
Speak and understand English
Participation of a legal guardian
Exclusion Criteria:
Intellectual or learning disability
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N/A
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Location
State College, PA

A Joint Intervention for Behavior and Sleep in School aged Children (JIBS)

It is well known that many children with ADHD also have problems sleeping and that not getting enough sleep can make a child’s behavior worse. This research is being done to find out how to best treat children with both behavior and sleep problems. Parents will complete assessments of their child's behaviors and sleeping patterns and attend 4 therapy sessions that assist with problematic behaviors in their child.
Sara Mills at smills1@pennstatehealth.psu.edu or 17175310003285968
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Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Ages 5-10 years
Diagnosis of ADHD, Conduct Disorder, and/or Oppositional Defiant Disorder
Difficulty falling or staying asleep
Exclusion Criteria:
Diagnosis of an intellectual disability, psychosis, Autism, or a pervasive developmental disorder
Diagnosis of sleep disordered breathing (e.g. sleep apnea) or other medical condition (e.g. asthma)
Use of anti-psychotic medications
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N/A
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Location
Hershey, PA

Development of Adolescent and Young Adult Social Health (DASH)

Adolescence is a unique developmental period that prepares individuals for adulthood. We are studying the behavioral and brain basis of this important time, particularly in terms of how adolescents understand and think about other people. To study this important developmental transition, we are inviting typically developing children (6-8 yrs), adolescents (10-14 yrs), and young adults (18-22 yrs) to help us with this study. Participants answer questionnaires, play games of face recognition, and have pictures of their brains taken in a neuroimaging session. Child and adolescent participants also have physical exams. Volunteers are compensated for time in the lab and for the neuroimaging session.
Marly Laubach at mll5405@psu.edu or 814-863-2528
All
Not specified
This study is also accepting healthy volunteers
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Inclusion Criteria:
Native English speaker
Normal vision and hearing (with correction)
Free of neuroneurologic, psychiatric, endocrinology disorders
Free of concussions with loss of consciousness
Exclusion Criteria:
Family history of autism spectrum disorders (in parents or full siblings)
History of working with metal
Irremovable metallic implants in the body (e.g. braces)
Pregnancy
Weigh more than 250lbs or get claustrophobic in small spaces
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N/A
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Study Locations

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Location
State College, PA

Neurophysiological Markers of Pediatric Irritability and its Response to Intervention

This study uses specific computer tasks to predict irritability in children with Attention Deficit/Hyperactivity Disorder (ADHD), as well as the effect of ADHD medication (stimulants) on irritability symptoms in children with ADHD. Children ages between the ages of 5 and 12 years are eligible and must have an established diagnosis of ADHD or suspected symptoms of ADHD.
Sara Mills at smills1@pennstatehealth.psu.edu or 717-531-0003 ext 285968
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Children between the ages of 5 and 12
Children diagnosed with ADHD or suspected ADHD Symptoms
Children who are able to stop ADHD medication for testing days
Parent/child fluent in English
Exclusion Criteria:
Children younger than 5 year or older than 12 years
Children with a latex allergy
Children with visual or hearing deficits or sensitivity to loud noise
Neurological conditions such as active seizure disorder
Prominent traits or diagnosis of Autism, marked developmental delay, mania, psychoses, or suicidal ideation.
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NCT03279952
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Study Locations

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Location
Hershey, PA