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Study matches: 12

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Establishing a Normal Database for Comparison to Specialized Populations; Oxygen consumption

This study located in Hershey, PA, will examine the cardiovascular and respiratory responses to exercise testing on a treadmill, stationary bike or arm bike to determine overall aerobic fitness capacity. This will contribute to a database of healthy adults to compare to persons with disabilities.
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
Claustrophobia
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N/A
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Hershey, PA

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
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NCT01957722
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Hershey, PA

Evaluating changes of muscle stiffness in patients with compartment syndrome

The objective of this study is to determine if ultrasound shear wave elastography (SWE) can be used as a non-invasive method for diagnosis of compartment syndrome (CS). If so, shear wave elastography can potentially replace the need of using needle manometry as diagnostic technique.
Daniel Cortes at researchsubjects@mne.psu.edu or 8148633103
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Exertional Compartment Syndrome (Leg)
Needle Manometry
Exclusion Criteria:
Sensitivity to Ultrasound Gels
Compartment Release Surgery
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N/A
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Location
Hershey, PA
State College, PA

Prevalence of Shoulder Labrum Abnormalities on MRI in a Non-Athletic Asymptomatic Young Adult Population

The purpose of this study is to determine the prevalence of shoulder and specifically labral abnormalities found on 4.5 Tesla Magnetic Resonance Imaging (MRI) sequences in a young non-athletic cohort. We hypothesize that this population will have greater abnormal findings in their dominant shoulder compared to their non-dominant shoulder.
Jessica Wright at jwright3@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
age 18-28
willing to undergo shoulder MRI
No current injury that interferes with daily living
No history of formal competitive athletics
Exclusion Criteria:
Previous shoulder surgery
Contraindication of MRI
Current shoulder injury that interferes with daily living
Younger than 18 or older than 28
Non-English Speaking
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Hershey, PA

Quantifying knee injury risk during a wrestling takedown

This study aims to investigate the mechanics of two different wrestling takedown to determine the knee mechanics of the defensive wrestler. Using motion tracking sensors, three-dimensional mechanics will be quantified during 10 wrestling takedowns and the risk of knee injury during each type will be quantified. The results of this study will be used to inform wrestling training programs and knee brace design specifically for wrestlers, who are at a disproportionately high risk for devastating knee injuries.
Zach Fox at zzf5041@psu.edu
Male
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
At least 1 year of wrestling experience
Between the ages of 18 and 35
Between 165 lbs and 225 lbs
Exclusion Criteria:
No recent lower extremity injuries
No recent lower extremity surgeries
Females
No wrestling experience
Less than 165 lbs and more than 225 lbs
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N/A
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Location
Reading, PA

Predicting Concussion Outcomes with Salivary miRNA

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows: 1) Characterization of brain-related miRNA in the saliva of 100 children with mTBI and 50 age- and gender-matched controls between the ages of five and twenty-one years. 2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Jennifer Stokes at jstokes@pennstatehealth.psu.edu
All
All
This study is also accepting healthy volunteers
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Inclusion Criteria:
5 to 21 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Exclusion Criteria:
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI
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NCT02901821
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Location
Hershey, PA

Ground reaction forces in running: effects of grade and surface

Overuse injuries in running are very common among all levels of running. Although influenced by many factors, two variables that may play a large roll in running injury risk are running surface and grade. A high impact peak on a vertical ground reaction force (GRF) profile is associated with an increased risk of injury. Just recently, has the ability to measure GRF in real world become available. Therefore, this study will investigate the effects of running surface (grass and pavement) and running slope (uphill, downhill) on the vertical GRF profile in recreational runners outdoors.
Heather Porter at hjp9@psu.edu or 724-679-1487
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Aged 18-50 years
No current cardiovascular conditions; heart condition, high blood pressure, chest pain
No lower body musculoskeletal injuries in the previous 3 months
Reports running more than or equal to an average of 10 miles per week for the past year
Exclusion Criteria:
Known or suspected heart disease or angina, and uncontrolled hypertensio
Pregnancy women
Individuals who are not yet adults, all subjects must be over 18 years old
Adults unable to consent -No cognitively impaired adults will be involved in the study
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N/A
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Location
State College, PA

Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes

The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 8148633103
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy throwing athletes (baseball, javelin, football)
Athletes with Ulnar Collateral Ligament Injury
Ulnar Collateral Ligament Surgery
Tommy John's Surgery
Exclusion Criteria:
Sensibility to Ultrasound Gels
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N/A
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Location
State College, PA

The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging

Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sean Shank at sqs6071@psu.edu or 814-863-8557
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Men and Women aged 18-30 and 65-80 years old
Healthy weight
Not taking high cholesterol/high blood pressure medication
Non-diabetic
Exclusion Criteria:
Tobacco use
Illegal/recreational drug use
Pregnant or breastfeeding
Allergy to latex
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N/A
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Location
State College, PA

Establishing a Normal Database for Comparison to Specialized Populations; Biodex

This study located in Hershey, PA, will measure and evaluate the maximal strength and muscle performance of wrists, elbows, shoulders, hips, knees, and ankles on a device called a dynamometer. This will contribute to a database of healthy adults to compare to persons with disabilities.
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
High Blood Pressure
Pregnancy
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N/A
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Location
Hershey, PA

Exercise Time and Intensity: The ideal ratio to prevent overreaching and maximize fitness.

Our goal is to correlate the amount and intensity of an individuals exercise routine with stress hormones in saliva. The study will include collecting heart rate data during your regular training sessions during a 3-week period followed by the completion of 2, high intensity training sessions on a single day. We will collect survey data on your current activity, feelings, and sleep. In addition, we will collect 6 saliva samples during the high intensity session day to analyze substances related to stress.
Jinger Gottschall at jinger@psu.edu or 8144046639
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
between the ages of 20 and 55 years old
exercise for a minimum of 8 hours per week
exercise at an intensity greater than 85% HR max for at least 10 minutes per week
able to perform their typical training routine for 3 weeks
Exclusion Criteria:
heart condition
high blood pressure
chest pain at rest, during daily living, or physical activity
bone or joint problems that could be worsened with physical activity
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N/A
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Location
State College, PA

NASH Fitness Intervention for Thrombosis (NASHFit) Trial

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States. The most advanced forms of NAFLD are associated with increased liver-related mortality and lower overall survival. The current standard of care for NAFLD is lifestyle changes through diet and exercise. The human genome and regulation of gene expression is influenced by physical activity. NAFLD is a prothrombotic state with derangements in all three phases of hemostasis leading to clinically important clotting events. Exercise can improve coagulation in healthy persons. In this proposal, we seek to begin a line of work to answer the question “Can lifestyle changes effectively mitigate the increased risk of clotting in patients with NAFLD?” focusing initially on the at-risk population genetically susceptible to advanced disease.
Jonathan Stine at jstine@pennstatehealth.psu.edu or 717-531-1017
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Nonalcoholic fatty liver disease (NAFLD)
Evidence of hepatic steatosis by imaging
Exclusion Criteria:
>90 minutes/week of at least moderate intensity exercise over the previous three months
Pregnancy
Active cardiac symptoms
Uncontrolled diabetes (changes in medication dosing over the previous three months or hemoglobin A1c >9%)
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NCT03518294
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Location
Hershey, PA