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Search Results within category "Sports Medicine"

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14 Study Matches

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT01957722
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
Sports Medicine, Muscle & Bone
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Location
Hershey, PA

Evaluating changes of muscle stiffness in patients with compartment syndrome

The objective of this study is to determine if ultrasound shear wave elastography (SWE) can be used as a non-invasive method for diagnosis of compartment syndrome (CS). If so, shear wave elastography can potentially replace the need of using needle manometry as diagnostic technique.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Exertional Compartment Syndrome (Leg)
Needle Manometry
Exclusion Criteria:
Sensitivity to Ultrasound Gels
Compartment Release Surgery
Sports Medicine, Muscle & Bone
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Hershey, PA
State College, PA

Isometric Handgrip Training as an Alternative Approach to Blood Pressure Regulation in African American Men and Women

This study will test the ability of 4 weeks of isometric handgrip exercise training performed 5 days per week to lower brachial and aortic blood pressures, and improve measures of vascular health in a group of African American men and women.
David Moore at djm411@psu.edu or 717-948-6847
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Man or premenopausal woman of African American or black African descent
18-59 years of age
Exclusion Criteria:
Diagnosed with cardiovascular, kidney, metabolic, neuromuscular, or lung disease
Current or recent (past 6 months) smoker
Removal of both ovaries
Removal of uterus
Heart & Vascular, Prevention, Sports Medicine
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Location
Harrisburg, PA
Hershey, PA

Predicting Concussion Outcomes with Salivary miRNA

The purpose of this study is to identify changes in salivary micro ribosomal nucleic acid (miRNA) expression that are predictive of symptom duration and severity following mild traumatic brain injury (mTBI) in children. The primary endpoints of this study are as follows: 1) Characterization of brain-related miRNA in the saliva of 250 children with mTBI and 200 age- and gender-matched controls between the ages of five and twenty-three years. 2) Identification of a set of salivary miRNAs that is predictive of duration and severity of mTBI symptoms.
Jennifer Stokes at jstokes1@pennstatehealth.psu.edu
All
All
This study is also accepting healthy volunteers
NCT02901821
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Inclusion Criteria:
5 to 23 years of age
Seen in the Penn State Pediatric Concussion Clinic within 2 weeks of most recent concussion
Exclusion Criteria:
Does not speak english
Periodontal disease
Ongoing seizure disorder, or other neurologic disorder
Drug or alcohol dependency
clinical diagnosis of severe TBI
Children's Health, Neurology, Sports Medicine
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Location
Hershey, PA

Do recreational runners have similar running biomechanics when comparing indoor and outdoor running using drone video capture?

To date, the correlation of treadmill running to over-ground running is contested in the literature. Providing recommendations for altering gait based on treadmill gait analysis may prove to be harmful if it does not approximate running in a natural environment. Prior research on over-ground kinematics has traditionally used still cameras and force plates to obtain short segments of running for analysis. Drones are starting to become user assistive technologies. With the advent of improved facial recognition algorithms and computer vision techniques, drones can be made to track and follow individuals. Customizable drone technology, aimed at following a runner at a specific distance and height, would allow for analysis of gait mechanics in natural outdoor running environments. This would provide clinicians with information to make recommendations to runners based on their natural running environment. In addition to clinical applications, this technology could provide advancement in biomechanical running research by allowing assessment of gait analysis parameters in natural running environments.
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
 Male and female runners age 18 to 65 years old
 Running at least 15 kilometers (9.3 miles) per week for 3 months prior to study
 Prior treadmill experience
 No running injury currently or in the preceding 3 months
 English speaking
Exclusion Criteria:
 Current musculoskeletal injury
 Running related injury in the preceding 3 months
 Running less than 15 kilometers (9.3 miles) per week for 3 months prior to study
 Currently under medical supervision and not cleared for participation in running program
 No prior treadmill experience
Sports Medicine
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Location
Hershey, PA

Modeling Speed Transitions in Healthy Human Walking

This study will examine how healthy humans walk and naturally transition between walking speeds.
Claire Rodman at chr33@psu.edu or 541-231-6412
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Able-bodied and capable of walking continuously for 15 minutes at varying speeds
At least 18 years old
Able to follow verbal instruction
Exclusion Criteria:
Previous or existing neuromuscular or neurological pathologies, injuries, or illnesses affecting gait
Previous or existing musculoskeletal injuries or conditions
BMI > 30; high BMI can affect equipment accuracy, introducing errors
Sports Medicine, Muscle & Bone
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Study Locations

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Location
State College, PA

Ground reaction forces in running: effects of shoe cushioning and surface grade.

The purpose of this study is to determine the effect that shoe cushioning and surface grade have on the forces acting directly on the bottom of the foot during treadmill running.
Heather Porter at hjp9@psu.edu or 724-679-1487
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
age 18-50
Must be able to run at 3 m/s comfortably
Must fit in women’s size 7.5 or 8.5 running shoe or a men’s 9.5 or 10.5 running shoe
Reports running more than or equal to an average of 10 miles per week for the past year.
Current running routine includes varying surface angles
Exclusion Criteria:
No lower body musculoskeletal injuries in the previous 3 months
Sports Medicine, Muscle & Bone
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Study Locations

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Location
State College, PA

Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
over the age of 18
Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
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Location
Hershey, PA
State College, PA

Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes

The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy throwing athletes (baseball, javelin, football)
Athletes with Ulnar Collateral Ligament Injury
Ulnar Collateral Ligament Surgery
Tommy John's Surgery
Exclusion Criteria:
Sensibility to Ultrasound Gels
Muscle & Bone, Sports Medicine
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Study Locations

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Location
State College, PA

The effects of habitual physical activity on EDHF-mediated vasodilation in healthy aging

Cardiovascular disease remains the leading cause of death in the United States. Increased age is the leading risk factor for cardiovascular disease. Aging is associated with decreased vessel function. Nitric oxide, a substance produced by our bodies, is responsible for making our vessels increase their diameter and allow blood to flow. However, other substances may also cause our blood vessels to get larger. We are doing this research project to understand how physical activity affects these other substances.
Sue Slimak at sks31@psu.edu or 814-863-8556
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Men and Women aged 18-30 and 60-80 years old
Healthy weight
Not taking high cholesterol/high blood pressure medication
Non-diabetic
Exclusion Criteria:
Tobacco use
Illegal/recreational drug use
Pregnant or breastfeeding
Allergy to latex
Heart & Vascular, Prevention, Sports Medicine
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Location
State College, PA

Evaluation of mechanical properties of the anterior cruciate ligament (ACL) of the knee using ultrasound elastography.

Healthy subjects and athletes needed for the study. Athletes will be evaluated several times over the course of season. Additionally, patients with ACL injury or ACL surgery will be recruited. Several images will be taken from your knees using ultrasound. In total, we expect the imaging session to take about 15 minutes. Additionally, strength tests will be performed in both of your legs. We expect that the strength tests will take about 30 minutes. Compensation is available.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy Individuals 18 years or older
Athletes (soccer, football, other) 18 years or older
Patient with ACL injury
Patient with ACL surgery
Exclusion Criteria:
Pregnant women
Cognitive deficits
17 years old or younger
Arthritis & Rheumatic Diseases, Sports Medicine, Muscle & Bone
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Location
State College, PA

NASH Fitness Intervention for Thrombosis (NASHFit) Trial

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States. The most advanced forms of NAFLD are associated with increased liver-related mortality and lower overall survival. The current standard of care for NAFLD is lifestyle changes through diet and exercise. The human genome and regulation of gene expression is influenced by physical activity. NAFLD is a prothrombotic state with derangements in all three phases of hemostasis leading to clinically important clotting events. Exercise can improve coagulation in healthy persons. In this proposal, we seek to begin a line of work to answer the question “Can lifestyle changes effectively mitigate the increased risk of clotting in patients with NAFLD?” focusing initially on the at-risk population genetically susceptible to advanced disease.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03518294
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Inclusion Criteria:
Nonalcoholic fatty liver disease (NAFLD)
Evidence of hepatic steatosis by imaging
Exclusion Criteria:
>90 minutes/week of at least moderate intensity exercise over the previous three months
Pregnancy
Active cardiac symptoms
Uncontrolled diabetes (changes in medication dosing over the previous three months or hemoglobin A1c >9%)
Blood Disorders, Digestive Systems & Liver Disease, Sports Medicine
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Location
Hershey, PA

Feasibility of biomechanical running gait analysis study using an autonomous drone

Using an autonomous drone developed in State College, PA, this study will investigate the feasibility of using this technology to follow runners on an outdoor track and perform subsequent biomechanical gait analysis.
Jessica Wright at jwright3@pennstatehealth.psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18-50 years old
No prior or current running injuries in the past 3 months
Runs at least 15 km per week
Able to speak English
Exclusion Criteria:
Age less than 18 years old or greater than 24 years old
Current musculoskeletal injury
Currently under medical supervision
Pregnant
Cognitively impaired
Sports Medicine
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Location
Hershey, PA

Perception of Brain Injuries: Viewpoints from college students

The purpose of this study is to learn more about the knowledge, thoughts, and experiences of college students regarding brain injuries through a semi-structured interview.
Nicole Etter at nme2@psu.edu or 814-863-2021
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
18 years and older
Current college student
English and Hearing sufficient to complete a semi-structured interview
Exclusion Criteria:
Does not meet inclusion criteria
Neurology, Sports Medicine
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Study Locations

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Location
State College, PA