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Suggestions within category "Muscle & Bone"


Study matches: 23

Here are the studies that match your search criteria. If you are interested in participating, please reach out to the contact listed for the study. If no contact is listed, contact us and we'll help you find the right person.


Establishing a Normal Database for Comparison to Specialized Populations; Oxygen consumption

This study will examine the cardiovascular and respiratory responses to exercise testing on a treadmill, stationary bike or arm bike to determine overall aerobic fitness capacity. This will contribute to a database of healthy adults to compare to persons with disabilities.
Kristin Slavoski, MS at PMR_research@pennstatehealth.psu.edu or 7175310003 x283816
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy Adults
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
Claustrophobia
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N/A
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Hershey, PA

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
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NCT01957722
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Hershey, PA

Evaluating changes of muscle stiffness in patients with compartment syndrome

The objective of this study is to determine if ultrasound shear wave elastography (SWE) can be used as a non-invasive method for diagnosis of compartment syndrome (CS). If so, shear wave elastography can potentially replace the need of using needle manometry as diagnostic technique.
Daniel Cortes at researchsubjects@mne.psu.edu or 8148633103
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Exertional Compartment Syndrome (Leg)
Needle Manometry
Exclusion Criteria:
Sensitivity to Ultrasound Gels
Compartment Release Surgery
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N/A
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Hershey, PA
State College, PA

Tongue movement in adults with motor speech disorder

Tongue movement in adults with motor speech disorder
Elizabeth Rodriguez at ezr16@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
be a native speaker of American English
have normal hearing
between 18 and 40 years of age
have no known speech, language, learning or neurological disorders
have very little experience in communicating with people that have motor speech disorders
Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
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State College, PA

Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury

This research is being done to examine the relationship between body composition, metabolism, and dietary needs in people with Spinal Cord Injury.
Slavoski at PMR_research@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
C4-T4 Spinal Cord Injury greater than 12 months
Motor Complete (AIS A & B) spinal cord injury
<5% change in body weight over the past 12 months
Exclusion Criteria:
<22% body fat
Coronary artery disease
Type 1 Diabetes or insulin requiring Type 2 Diabetes
Hypothyroidism
Renal Disease
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N/A
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Location
Hershey, PA

Evaluating changes in mechanical properties in the herniated intervertebral disc

Low back pain is a major cause of disability, especially in the working-age population. Intervertebral disc (IVD) degeneration is thought to play a major role in chronic back and neck pain. Magnetic Resonance Elastography (MRE) is an imaging method to quantify mechanical properties from soft tissues. We developed a protocol (hardware and software) needed to apply MRE to human spine in-vivo. The objective of this study to apply MRE to patients with disc herniation, a common IVD pathology.
Daniel Cortes at dhc13@psu.edu or 814-863-3103
All
18 year(s) or older
This study is NOT accepting healthy volunteers
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Inclusion Criteria:
Herniated Disc in the Lumbar Spine
Ruptured Disc in the Lumbar Spine
Exclusion Criteria:
Contraindications to MRI scanning
Pacemarker
Clasutrophobia
Boby weight more than 250 lb
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NCT03340545
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State College, PA

Variation of muscle stiffness induced by blood pressure changes

Blood pressure is the amount of force created inside the arteries and veins, this force varies between a maximum and minimum value during the cardiac cycle. Blood pressure may affect mechanical properties of muscles (particularly the ones near arteries) due to the variation of internal force in the tissue. In order to accurately evaluate muscle stiffness, and to diagnose several cardiovascular diseases is necessary to describe the relationship between of blood pressure on muscle stiffness. The objective of this study is to quantify changes in lower-leg muscle stiffness using ultrasound shear wave elastography (SWE) in healthy subjects by changing intramuscular blood pressure (IMP) through changes in elevation of the leg, different body positions and using a blood pressure cuff around the thigh. Intramuscular pressure may also be measured through a needle inserted in the muscle (under local anesthesia)
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy subject between 18
•45 years old
Exclusion Criteria:
allergic reaction to ultrasound gels
cardiovascular diseases
diabetes
individuals who can easily bruise
pregnant women
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N/A
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Location
State College, PA

Nasality characteristics in adults with motor speech disorder

The goal of this proposed study is to understand nasality characteristics in individuals with dysarthria (motor speech disorder) secondary to ALS. The research question the proposed study seeks to answer is how does the perception of speakers’ hypernasality relate to the severity of their dysarthria and their nasalance scores.
Elizabeth Rodriguez at ezr16@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
are 18-40 years of age
are a speaker of American English only
have normal hearing
have no neurologic and/or speech/language disorders
have very little experience in communicating with people that have motor speech disorders
Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
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N/A
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Location
State College, PA

Prediction of Muscle Force Generation using Ultrasound Imaging and Computational Simulations

The objective of this study is to develop and validate a method to predict force production of individual muscles from ultrasound measurements of muscle stiffness, size, and structure. We hypothesize that there is a linear relationship between muscle size, shear modulus and force generated by the muscle.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Healthy individuals without history of muscle disease or injury
Exclusion Criteria:
Pregnant women
Allergy to ultrasound gels
contraindications to MRI scans
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N/A
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Location
State College, PA

AWS-PSU: Active Women's Study at Penn State University and AWS-Lincoln: Active Women’s Study Lincoln University

AWS-PSU: Active Women's Study at Penn State University and Lincoln University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Emily Southmayd at eas5377@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 18 and 30
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Current diagnosis of an eating disorder
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Location
State College, PA

E-cigarette Use among College-Age Individuals in Association with Biomarkers of Bone Health

Vitamin D and cigarette use are well-known to influence bone health. However, we know little about whether e-cigarettes may also play a role. We invite you to help us learn more about whether e-cigarette use may influence vitamin D levels and/or bone health. Participation requires one in-person visit (approximately 20 minutes in length) and questionnaire completion (approximately 40 minutes in length).
Cyndi Flanagan at chf117@psu.edu or 814-863-7126
Female
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Age 18 to 35
Female
e-Cigarette User
Exclusion Criteria:
Cancer
Liver Disease
Kidney Disease
Taking Drugs that Interfere with Vitamin D Metabolism
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Location
State College, PA

Neurobiology of Inhibitory Motor Control in Adults with ADHD

The proposed research represents the first examination of motor, cognitive, and neural mechanisms of inhibitory control in adults with ADHD. This study will extend previous work that describes motor impairments in children with ADHD by providing a quantitative analysis of grip force control in adults with ADHD.
Marissa Reynolds at mlr5246@psu.edu or 814-867-5024
Male
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Your are 18-25 years old and have symptoms of ADHD or ADD
You speak English as your native (first) language
You have, at minimum, a high school diploma or GED
You have no previous concussions that resulted in loss of consciousness for more than 10 minutes
If you take stimulant medication for your ADHD or ADD, you must be willing to not take the medication for 24 hours before your visit to our lab
Exclusion Criteria:
You are under age 18 or over age 25 or do not have symptoms of ADHD or ADD
English was not the first language you spoke
You have less than a high school education
You have had a concussion that resulted in loss of consciousness for more than 10 minutes
You, or someone in your immediate family, has been diagnosed with seizures, epilepsy, encephalitis, meningitis, musculoskeletal, neurological, autism spectrum, or psychological disorder involving psychosis
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N/A
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Altoona, PA
DuBois, PA
State College, PA
Williamsport, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
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NCT02822378
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State College, PA

Spinal Cord Injury Exercise and Nutrition Conceptual Engagement (SCIENCE)

This study will evaluate and compare the health benefits of using functional electrical stimulation for lower extremity exercise with diet versus diet alone in adults with spinal cord injury.
Kristin Slavoski, MS at PMR_research@pennstatehealth.psu.edu or 717-531-0003 x283816
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
C4-T4 Spinal Cord Injury greater than 12 months
Motor Complete (AIS A & B) spinal cord injury
<5% change in body weight over the past 12 months
Exclusion Criteria:
Participation in an FES or ACE exercise program within the past 3 months
Uncontrolled autonomic dysreflexia
Deep vein thrombosis
<22% body fat
Diabetes or coronary artery disease
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Location
Hershey, PA

Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes

The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 8148633103
All
18 year(s) or older
This study is also accepting healthy volunteers
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Inclusion Criteria:
Healthy throwing athletes (baseball, javelin, football)
Athletes with Ulnar Collateral Ligament Injury
Ulnar Collateral Ligament Surgery
Tommy John's Surgery
Exclusion Criteria:
Sensibility to Ultrasound Gels
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Location
State College, PA

Patient Centered Exercise Coaching into Primary Care

This 36-month study will enroll 2,100 adults who are 65 years old or older, and who have had a fragility fracture (typically due to osteoporosis, or weak bones). The study will compare future fragility fractures and serious fall-related injuries in participants who are randomly assigned to either a coached exercise program, or a control group. Participants will also be asked about a variety of topics, including their ability to do daily tasks, concerns about falling, loneliness, and depression. All participants will receive educational materials. Participants will visit the Hershey Medical Center twice (at the beginning and end of the study), and be asked to complete a brief phone survey related to falls and injuries every 4 months. Participants may also receive a bone density scan. Participants in the coached exercise program will work with a coach and do moderate-intensity strength and balance training, and light aerobic activity, either in a community-based group setting, or in their home.
Abbey Fisher at wisestudy@pennstatehealth.psu.edu or 844-598-9598
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
65 years and older
Previous fragility fracture in past 10 years
Willing to try exercising
Exclusion Criteria:
Blood pressure reading is equal or greater to 180 systolic or equal or greater to 110 diastolic or heart rate is equal or greater to 120 bpm
Health care professional has told you to not exercise or only exercise when supervised by a professional
Unable to obtain PCP's consent to participate
Unable to walk 100 feet without using special equipment (eg. walker)
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NCT02714257
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Hershey, PA

A phase 2b, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a Staphylococcus aureus 4-antigen vaccine (SA4Ag) in adults undergoing elective open posterior fusion procedures with multilevel instrumentation. Protocol Number: B3451002

Vaccine to decrease or prevent MRSA infection in spinal surgery patients
Deborah Hoffman at dhoffman1@pennstatehealth.psu.edu or 717 531 0003 x283063
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Elective instrumented fusion of at least 3 levels
•cervical to lumbar
scheduled procedure must be at least 10 days after vaccine
Open posterior procedure
18 to 86 years old
Exclusion Criteria:
spinal fusion within past 6 months
major surgery within the last 3 months or anticipate major surgery
recent vaccination or infection
malignancy
staged spinal surgery
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NCT02388165
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Hershey, PA

Motor Synergies in Neurological Disorders

The main purpose of this study is to examine changes in motor synergies that accompany common neurological disorders such as Parkinson's disease, stroke, olivo-ponto-cerebellar atrophy, essential tremor, amyotrophic lateral sclerosis, multiple sclerosis, and spinal cord injury. Patients and control subjects will be asked to perform simple motor tasks such as pressing, manipulating a hand-held object, reaching, standing quietly, swaying, and initiating a step. Analysis of multi-digit, multi-joint, and multi-muscle synergies will be performed using the framework of the uncontrolled manifold hypothesis. The study will have two main objectives. First, to better understand the neurophysiological mechanisms involved in motor coordination. Second, to identify and quantify disorders of motor coordination specific for particular disease states and their changes with disease progression and treatment.
Tyler Corson at tcorson@pennstatehealth.psu.edu or 717-531-0003
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
No sensory deficit
No major cognative deficit
No history of arthritis, carpal tunnel syndrome, or any other disease which would hinder peripheral movement
No history of drug or alcohol abuse
Exclusion Criteria:
Unable to complete study test
Evidence of severe memory or cognitive decline
History or arthritis, carpal tunnel or any other peripheral disease which would hinder movement
History of alcohol or drug abuse
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N/A
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Hershey, PA
State College, PA

Establishing a Normal Database for Comparison to Specialized Populations; Biodex

This study will measure and evaluate the maximal strength and muscle performance of wrists, elbows, shoulders, hips, knees, and ankles on a device called a dynamometer. This will contribute to a database of healthy adults to compare to persons with disabilities.
Kristin Slavoski, MS at PMR_research@pennstatehealth.psu.edu or 7175310003 x283816
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Healthy Adults
Age 18-75
Exclusion Criteria:
Known cardiovascular, pulmonary or metabolic disease
Current orthopedic injuries
High Blood Pressure
Pregnancy
Show full eligibility criteria
N/A
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Location
Hershey, PA

Examining the Influence of Double Support Duration on Walking Gait

This is a biomechanical study that will examine the influence of the double support period (the interval between leg swings) in order to better understand how people walk. In the study subjects will have reflective markers attached to their body and walk on a treadmill. The motion of these attached markers will be captured and analyzed using a motion tracking system. The data collected may have applications in gait rehabilitation therapies and technologies.
Anne Martin at aem34@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Able-bodied
Aged 18 to 40 years
Able to easily walk for 15 minutes total without assistance
Able to follow spoken directions
Exclusion Criteria:
Previous or existing neurological pathologies, injuries or illnesses likely to affect gait or the ability to provide informed consent
Significant lack of visual acuity even after correction
History of neuromuscular disorders or lower limb joint replacements
BMI over 30, since equipment measurements may be inaccurate and affect the results
All vulnerable populations are excluded from participating
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State College, PA

Exercise Time and Intensity: The ideal ratio to prevent overreaching and maximize fitness.

Our goal is to correlate the amount and intensity of an individuals exercise routine with stress hormones in saliva. The study will include collecting heart rate data during your regular training sessions during a 3-week period followed by the completion of 2, high intensity training sessions on a single day. We will collect survey data on your current activity, feelings, and sleep. In addition, we will collect 6 saliva samples during the high intensity session day to analyze substances related to stress.
Jinger Gottschall at jinger@psu.edu or 8144046639
All
18 year(s) or older
This study is also accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
between the ages of 20 and 55 years old
exercise for a minimum of 8 hours per week
exercise at an intensity greater than 85% HR max for at least 10 minutes per week
able to perform their typical training routine for 3 weeks
Exclusion Criteria:
heart condition
high blood pressure
chest pain at rest, during daily living, or physical activity
bone or joint problems that could be worsened with physical activity
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State College, PA

Adaptation of trunk muscles in patients with chronic back-pain

The objective of this study is to evaluate the function of back muscles in patients with chronic back pain, and to understand how back muscles are affected by posterior lumbar surgery. Patients who are candidates for lumbar fusion will be evaluated before and after the surgical procedure.
Daniel Cortes at researchsubjects@mne.psu.edu or 8148633103
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Candidates for Lumbar Fusion Surgery
Exclusion Criteria:
Allergy to ultrasound gels
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N/A
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Location
Hershey, PA
State College, PA

A MULTICENTER OPEN-LABEL STUDY OF ETANERCEPT WITHDRAWAL AND RETREATMENT IN SUBJECTS WITH NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS WHO ACHIEVED ADEQUATE 24 WEEK RESPONSE

To estimate the proportion of subjects who flare within 40 weeks following withdrawal of ETN in subjects who have achieved ASDAS CRP less than 1.3 (inactive disease).
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-0003 Ext. 283833
All
18 year(s) or older
This study is NOT accepting healthy volunteers
Hide eligibility criteria
Inclusion Criteria:
Back Pain
Symptoms longer than 3 months less than 5 years
On a stable NSAID
ages 18-50
Exclusion Criteria:
Radiographic Sacroilitis
Previous treatment with a TNF-a Biologic inhibitor
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NCT02509026
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Hershey, PA