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Search Results within category "Muscle & Bone"

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Suggestions within category "Muscle & Bone"


14 Study Matches

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT01957722
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
Sports Medicine, Muscle & Bone
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Hershey, PA

Tongue movement in adults with motor speech disorder

Tongue movement in adults with motor speech disorder
Jimin Lee at jxl91@psu.edu or 814-863-5338
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
be a native speaker of American English
have normal hearing
between 18 and 40 years of age
have no known speech, language, learning or neurological disorders
have very little experience in communicating with people that have motor speech disorders
Exclusion Criteria:
younger than 18 years of age; older than 40 years of age
Not a speaker of American English only
With hearing impairment
have neurologic and/or speech/language disorders
have extensive experience in communicating with people that have motor speech disorders
Neurology, Muscle & Bone, Language & Linguistics
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Hershey, PA
State College, PA

Prediction of Muscle Force Generation using Ultrasound Imaging and Computational Simulations

The objective of this study is to develop and validate a method to predict force production of individual muscles from ultrasound measurements of muscle stiffness, size, and structure. We will place acupuncture needles to the muscles and applied a small amount of current to induce contraction. Force and ultrasound measurements will be performed during muscle contraction. This process will be done in three muscles, one in the arm and two in the leg.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy individuals without history of muscle disease or injury
Exclusion Criteria:
Pregnant women
Allergy to ultrasound gels
contraindications to MRI scans
Muscle & Bone
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State College, PA

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of CC-220 in Subjects with Active Systemic Lupus Erythematosus

This study is for patients with SLE (systemic lupus erythematosus) to determine the effectiveness and safety of drug CC-220 on improving SLE and to see how well the body tolerates the medication.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03161483
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Inclusion Criteria:
Diagnosis of Systemic Lupus Erythematosus
Exclusion Criteria:
Diagnosis of Fibromyalgia
Active or history of recurrent bacterial, viral or fungal infections
History of latent or active tuberculosis
History of blood clots in the past year
Infectious Diseases & Immune System, Arthritis & Rheumatic Diseases, Muscle & Bone
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Hershey, PA

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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AWS-PSU: Active Women's Study at Penn State University

AWS-PSU: Active Women's Study at Penn State University This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Regular or irregular menstrual cycles
Age 18-30
BMI between 16-29.9
No hormonal contraception for 6 months
Exclusion Criteria:
Smoking
Currently using medication impacting bone
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA

Interlimb differences in Motor Control and Learning

This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
over the age of 18
Exclusion Criteria:
neurological disease
upper-extremity orthopedic injuries that interfere with participation
Neurology, Sports Medicine, Muscle & Bone
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Hershey, PA
State College, PA

The Effects of Aircraft Seat Width on Passenger Comfort

The objective of this research is to determine the relationship between aircraft seat width and passenger comfort. Airlines are reducing the sizes of seats and improving their ability to fly planes at or near capacity. The combined effect is to decrease the quality of the experience of passengers. This work will help us to understand the degree to which comfort has been reduced.
Ritwik Biswas at AirplaneResearch@psu.edu
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
We are particularly interested in small and large participants.
You must be a healthy adult aged 18 years or older.
Exclusion Criteria:
Individuals under 18 years of age are not eligible.
Muscle & Bone, Mental & Behavioral Health
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State College, PA

Functional and Mechanical Changes Following Total Ankle Arthroplasty

Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle. The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
No recent history (< 1 year) of injuries to Achilles tendon
No history of lower limb reconstruction or surgery
age 70 year or older
Exclusion Criteria:
History of any previous surgery to lower limb
History of rheumatoid arthritis or other degenerative joint disease
Non English speaking
Inability to provide consent
Men's Health, Muscle & Bone, Women's Health
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Location
State College, PA

Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women

This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
This study is also accepting healthy volunteers
NCT02822378
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Inclusion Criteria:
Age 55-75
Postmenopausal
Not taking osteoporosis medication
Normal to low bone density
Willing to add dried plums to diet
Exclusion Criteria:
Currently using osteoporosis medication
Other medications known to impact bone health
Extremely low or high bone density
Food & Nutrition, Muscle & Bone, Women's Health
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State College, PA

Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes

The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
All
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy throwing athletes (baseball, javelin, football)
Athletes with Ulnar Collateral Ligament Injury
Ulnar Collateral Ligament Surgery
Tommy John's Surgery
Exclusion Criteria:
Sensibility to Ultrasound Gels
Sports Medicine, Muscle & Bone
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State College, PA

Evaluation of mechanical properties of the anterior cruciate ligament (ACL) of the knee using ultrasound elastography.

Healthy subjects and athletes needed for the study. Athletes will be evaluated several times over the course of season. Additionally, patients with ACL injury or ACL surgery will be recruited. Several images will be taken from your knees using ultrasound. In total, we expect the imaging session to take about 15 minutes. Additionally, strength tests will be performed in both of your legs. We expect that the strength tests will take about 30 minutes. Compensation is available.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy Individuals 18 years or older
Athletes (soccer, football, other) 18 years or older
Patient with ACL injury
Patient with ACL surgery
Exclusion Criteria:
Pregnant women
Cognitive deficits
17 years old or younger
Arthritis & Rheumatic Diseases, Sports Medicine, Muscle & Bone
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State College, PA

Effect of radiofrequency ablation and posterior fusion on the function of the lumbar multifidus

The objective of this study is to evaluate changes in function of the multifidus muscle in patients who have undergone radiofrequency ablation (RFA) or posterior lumbar fusion procedures (PLIF). Male and female patients in the age range of 18 to 80 years old who have recently (less than a year) undergone PLIF or RFA in the lumbar spine are being recruited. Compensation of $50 is available.
Daniel Cortes at researchsubjects@mne.psu.edu
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
posterior fusion surgery lumbar spine
radiofrequency ablation lumbar spine
Exclusion Criteria:
younger than 18
older than 80
pregnant women
other neuromuscular conditions
Muscle & Bone
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Hershey, PA
State College, PA

A volunteer study to determine the anatomical distribution of injectate, the extent of sensory block, and the pharmacokinetics of ropivacaine following Erector Spinae Plane (ESP) blocks.

This study will recruit healthy volunteers to determine the effect of a peripheral nerve block. The participants will get an injection in their back muscle after an intravenous line is placed in their hand or arm. After the injection they will have two MRI done at 30 and 90 minute time intervals. A half tablespoon of blood also will be taken through the IV line already placed 6 times during the study period starting just before to Peripheral nerve block placement up to four hours post injections. They will be discharged from the study after half an hour of the last blood sample. During this whole process they will be monitored for their blood pressure, oxygen saturation and other effects related to the procedure.
All
18 year(s) or older
This study is also accepting healthy volunteers
NCT03476642
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Inclusion Criteria:
Healthy adults ages 18 to 60
Weight between 55kgs (~120lbs) and 100kgs (~220lbs)
Height 160cms (~5ft 3in) to 190cms (~6ft 3in)
Exclusion Criteria:
Pregnant females, chronic medical condition requiring medication
History of previous major spinal, abdominal or thoracic surgery, 4. Congenital abnormalities of the spine, back, thorax or abdomen
History of major trauma to the thorax or abdomen; 6. Allergy to ropivacaine or other amide local anesthetics
The presence of any metallic implant in their body, 9. Allergy to Gadolinium radiological contrast agent
Any contraindication to magnetic resonance imaging as determined by completion of a standard questionnaire administered to all patients undergoing magnetic resonance imaging.
Prevention, Muscle & Bone, Pain Management
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Hershey, PA