Search Results within category "Muscle & Bone"
Search all categoriesSuggestions within category "Muscle & Bone"
16
Study Matches
A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.
The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
NCT01957722
Sports Medicine, Muscle & Bone
Tongue movement in adults with motor speech disorder
Tongue movement in adults with motor speech disorder
Jimin Lee at jxl91@psu.edu or 814-863-5338
All
18 year(s) or older
N/A
Neurology, Muscle & Bone, Language & Linguistics
Prediction of Muscle Force Generation using Ultrasound Imaging and Computational Simulations
The objective of this study is to develop and validate a method to predict force production of individual muscles from ultrasound measurements of muscle stiffness, size, and structure. We will place acupuncture needles to the muscles and applied a small amount of current to induce contraction. Force and ultrasound measurements will be performed during muscle contraction. This process will be done in three muscles, one in the arm and two in the leg.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
N/A
Muscle & Bone
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of CC-220 in Subjects with Active Systemic Lupus Erythematosus
This study is for patients with SLE (systemic lupus erythematosus) to determine the effectiveness and safety of drug CC-220 on improving SLE and to see how well the body tolerates the medication.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-0003, ext=283833
All
18 year(s) or older
NCT03161483
Infectious Diseases & Immune System, Arthritis & Rheumatic Diseases, Muscle & Bone
Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities
We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
N/A
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
AWS-PSU: Active Women's Study at Penn State University
AWS-PSU: Active Women's Study at Penn State University
This research study is being conducted to evaluate the impact of exercise and reproductive function on bone strength. Eligible young women (age 18-30) are those that are generally healthy and either a) exercising and experiencing regular or irregular menstrual cycles, or b) not exercising and experiencing regular menstrual cycles.
Nicole Aurigemma at nca11@psu.edu or 814-863-4488
Female
18 year(s) or older
N/A
Food & Nutrition, Muscle & Bone, Women's Health
Interlimb differences in Motor Control and Learning
This study examines how each brain hemisphere contributes to motor control and coordination. Participants play virtual reality/computer games to look at how their arms move during different activities.
Brooke Fosaaen at sainburglab@psu.edu or 814-865-7937
All
18 year(s) or older
N/A
Neurology, Sports Medicine, Muscle & Bone
The Effects of Aircraft Seat Width on Passenger Comfort
The objective of this research is to determine the relationship between aircraft seat width and passenger comfort. Airlines are reducing the sizes of seats and improving their ability to fly planes at or near capacity. The combined effect is to decrease the quality of the experience of passengers. This work will help us to understand the degree to which comfort has been reduced.
Ritwik Biswas at AirplaneResearch@psu.edu
All
18 year(s) or older
N/A
Muscle & Bone, Mental & Behavioral Health
Functional and Mechanical Changes Following Total Ankle Arthroplasty
Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle.
The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
N/A
Men's Health, Muscle & Bone, Women's Health
In Vivo Assessment of the Effect of Bench Press Exercise on Glenohumeral Cartilage Deformation
The goal of this project is to investigate the impact of high-load exercise, like the bench press with a large amount of weight as opposed to an exercise like the push-up, on the shoulder joint cartilage , tissue on the ends of our bones that cushion and protect them from damage, as well as assess how well qualitative assessments of personal pre- and post-exercise pain coordinate with cartilage structure. We predict that there will be a significant difference in pre- and post-exercise cartilage thickness.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
N/A
Muscle & Bone
Randomized Control Trial of Dietary Supplementation with Dried Plums on Bone Density, Geometry and Estimated Bone Strength in Postmenopausal Women
This 12-month study aims to assess the impact of dried plum consumption of 0-12 dried plums per day on bone density, bone geometry, and bone strength in postmensopausal women. We are recruiting women between the ages of 55 and 75 with normal to low bone mass who are not currently taking osteoporosis medication. Participation in the study involved random assignment to one of 3 different treatment groups (0, 6, or 12 dried plums per day) and participants are asked to visit the lab monthly for various testing procedures.
Kristen Koltun at kxk87@psu.edu or 814-863-4488
Female
18 year(s) or older
NCT02822378
Food & Nutrition, Muscle & Bone, Women's Health
Evaluation of injuries in the ulnar collateral ligament (UCL) in baseball and javelin athletes
The objective of this study is to establish possible relationships between changes in the mechanical properties of the ulnar collateral ligament and symptoms and functionality of the arm in baseball players and javelin athletes. For comparison purposes, healthy subjects will also be evaluated.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
All
N/A
Sports Medicine, Muscle & Bone
Evaluation of mechanical properties of the anterior cruciate ligament (ACL) of the knee using ultrasound elastography.
Healthy subjects and athletes needed for the study. Athletes will be evaluated several times over the course of season. Additionally, patients with ACL injury or ACL surgery will be recruited. Several images will be taken from your knees using ultrasound. In total, we expect the imaging session to take about 15 minutes. Additionally, strength tests will be performed in both of your legs. We expect that the strength tests will take about 30 minutes. Compensation is available.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
N/A
Arthritis & Rheumatic Diseases, Sports Medicine, Muscle & Bone
A volunteer study to determine the anatomical distribution of injectate, the extent of sensory block, and the pharmacokinetics of ropivacaine following Erector Spinae Plane (ESP) blocks.
This study will recruit healthy volunteers to determine the effect of a peripheral nerve block. The participants will get an injection in their back muscle after an intravenous line is placed in their hand or arm. After the injection they will have two MRI done at 30 and 90 minute time intervals. A half tablespoon of blood also will be taken through the IV line already placed 6 times during the study period starting just before to Peripheral nerve block placement up to four hours post injections. They will be discharged from the study after half an hour of the last blood sample. During this whole process they will be monitored for their blood pressure, oxygen saturation and other effects related to the procedure.
Astoria Huller at ahuller@pennstatehealth.psu.edu or 717-531-0003, ext=282465
All
18 year(s) or older
NCT03476642
Prevention, Muscle & Bone, Pain Management
Foot mechanics during gait with load carriage and toe elevation
This experimental study will investigate foot joint function during walking and running. Participants will walk and run with mass added to their body and a plastic wedge secured to the underside of their toes.
Daniel Davis at djd426@psu.edu or 307-680-8816
All
18 year(s) or older
N/A
Sports Medicine, Muscle & Bone
Effect of Blood Flow Restriction Therapy on Anterior Cruciate Ligament Reconstructed Patient Outcomes
This study is seeking to enroll participants who are between the ages of 18-35 that are physically active and with and without a history of an ACL reconstruction. Eligible participants will complete laboratory testing related to knee function, which will include hamstring strength assessment, hamstring tendon stiffness and muscle thickness analysis via ultrasound, and complete questionnaires related to overall knee function. Participants will be assigned to one of three groups. Depending on group assignment, participants will either complete a 4-week hamstring training program using a technique called blood flow restriction (BFR) therapy, or will receive no treatment/intervention and complete normal daily activities. The BFR therapy intervention will consist of three sessions per week (twelve sessions total) that will focus on increasing hamstring strength. Following the 4-week period, all participants will return to the laboratory to repeat similar laboratory testing. Comparisons of the data collected will be made between groups and limbs before and after the 4-week intervention period
Giampietro Vairo at glv103@psu.edu or 814-865-2725
All
18 year(s) or older
N/A
Sports Medicine, Muscle & Bone