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Search Results within category "Muscle & Bone"

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Suggestions within category "Muscle & Bone"


8 Study Matches

Functional and Mechanical Changes Following Total Ankle Arthroplasty

Walking is important for the health of older people. Older adults have been found to walk more slowly as they age. Walking too slowly limits what an older person can do, makes them more likely to fall, and seems to go along with health problems. The calf muscles and the structure of the foot and ankle may be important for walking speed. The calf muscles allow you to push your body off the ground during walking. Foot and ankle structure affect how the calf muscles operate at the ankle. The properties of muscle, tendon, and even ankle structure have been found to change with age and this might reduce walking ability. Older adults often have weaker muscles that may limit their ability to walk faster. Some surgeries may change the ankle structure and affect the ability to move. This study looks at the effect of ankle structure on walking ability in older adults. The findings may help determine who is at risk for mobility loss and ways to prevent such losses.
Lauren Hickox at walkingstudy@psu.edu or 814-954-0676
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
No recent history (< 1 year) of injuries to Achilles tendon
No history of lower limb reconstruction or surgery
age 70 year or older
Exclusion Criteria:
History of any previous surgery to lower limb
History of rheumatoid arthritis or other degenerative joint disease
Non English speaking
Inability to provide consent
Men's Health, Muscle & Bone, Women's Health
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Location
State College, PA

Evaluation of mechanical properties of the anterior cruciate ligament (ACL) of the knee using ultrasound elastography.

Healthy subjects and athletes needed for the study. Athletes will be evaluated several times over the course of season. Additionally, patients with ACL injury or ACL surgery will be recruited. Several images will be taken from your knees using ultrasound. In total, we expect the imaging session to take about 15 minutes. Additionally, strength tests will be performed in both of your legs. We expect that the strength tests will take about 30 minutes. Compensation is available.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy Individuals 18 years or older
Athletes (soccer, football, other) 18 years or older
Patient with ACL injury
Patient with ACL surgery
Exclusion Criteria:
Pregnant women
Cognitive deficits
17 years old or younger
Arthritis & Rheumatic Diseases, Sports Medicine, Muscle & Bone
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Study Locations

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Location
State College, PA

Effect of Blood Flow Restriction Therapy on Knee Flexor Strength in Healthy Young Adults

This study is seeking to enroll participants who are between the ages of 18-35 that are healthy, physically active. Eligible participants will complete laboratory testing related to knee function, which will include hamstring strength assessment, hamstring tendon stiffness and muscle thickness analysis via ultrasound, hamstring flexibility, and single leg jump testing. Participants will be assigned to one of three groups. Depending on group assignment, participants will either complete a 4-week knee flexor focused training program using a technique called blood flow restriction (BFR) therapy in one limb and normal high intensity training in the other limb (same exercises within each group), or will receive no treatment/intervention and complete normal daily activities. The BFR therapy intervention will consist of three sessions per week (twelve sessions total) that will focus on increasing hamstring strength. Following the 4-week period, all participants will return to the laboratory to repeat similar laboratory testing. Comparisons of the data collected will be made between groups and limbs before and after the 4-week intervention period
Giampietro Vairo at glv103@psu.edu or 814-865-2725
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
All genders age 18-35
No history of significant knee pathology or lower extremity injury that required surgery in either limb
No history of hamstring strains or musculoskeletal injuries in past three months
No history of back pain in past 3 months
Physically active/ good general health
Exclusion Criteria:
History of lower extremity injury or fracture that required surgery
History of acute musculoskeletal injury in past 3 months for both limbs
History of hypertension (blood pressure greater than 130/80 mmHg), diabetes mellitus, compromised vascular circulation, or cancer
Individuals with neurological or other health condition that would limit their ability to flex the knee beyond 90 degrees
Participants with an allergic reaction to ultrasound gels
Sports Medicine, Muscle & Bone
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Location
State College, PA

Foot mechanics during gait with load carriage and toe elevation

This experimental study will investigate foot joint function during walking and running. Participants will walk and run with mass added to their body and a plastic wedge secured to the underside of their toes.
Daniel Davis at djd426@psu.edu or 307-680-8816
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Age 18-35
Run > 10 kilometers/week for past 6 months
Exclusion Criteria:
Have had previous lower limb surgery
Experienced pain with walking or running in past 6 months
Have had plantar fasciitis
Have osteoarthritis in lower limb
Sports Medicine, Muscle & Bone
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Location
State College, PA

A Phase 3 Prospective, Randomized, Partially Blinded Multi-Center Study to Measure the Safety and Efficacy of NOVOCART® 3D, Compared to Microfracture in the Treatment of Articular Cartilage Defects.

The purpose of this research study is to assess the pain, stiffness and physical function of the knee in patients with an articular cartilage defect of the knee. Participants will receive one of two possible surgical procedures. One surgical procedure, which is the investigational procedure under study, utilizes the Novocart® 3D autologous cartilage implant system. The other possible procedure is called Microfracture and is one of the current standard of care options to treat this condition. Both surgical procedures will be followed by pain and knee function assessments and a course of physical rehabilitation.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT01957722
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Inclusion Criteria:
age 18 to 65
symptomatic knee pain indicative of articular cartilage defects
inadequate response to conservative treatment
Full range of motion of the affected joint
Normally functioning contralateral knee
Exclusion Criteria:
Severe obesity (BMI > 40)
Surgery on the contralateral knee within 6 months prior to the scheduled arthoscopy
intra-articular injections within 1 month of surgery
Prior release and excision of scar tissue except isolated lateral release on target knee
Prior surgical treatment using mosaicplasty, autologous chondrocyte implantation and/or microfracture on target knee (Note: prior debridement and lavage are acceptable if more than three months have passed.)
Sports Medicine, Muscle & Bone
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Location
Hershey, PA

In Vivo Assessment of the Effect of Bench Press Exercise on Glenohumeral Cartilage Deformation

The goal of this project is to investigate the impact of high-load exercise, like the bench press with a large amount of weight as opposed to an exercise like the push-up, on the shoulder joint cartilage , tissue on the ends of our bones that cushion and protect them from damage, as well as assess how well qualitative assessments of personal pre- and post-exercise pain coordinate with cartilage structure. We predict that there will be a significant difference in pre- and post-exercise cartilage thickness.
Andrea Horne at ahorne@pennstatehealth.psu.edu or 717-531-7127
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy adults between the ages of 18-35
English speaking
Exclusion Criteria:
Previous injury or surgery to either shoulder
Inability to undergo MRI
Inability to perform exercise protocol
Pregnant
Under the age of 18 or over the age of 35
Muscle & Bone
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Study Locations

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Location
Hershey, PA

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of CC-220 in Subjects with Active Systemic Lupus Erythematosus

This study is for patients with SLE (systemic lupus erythematosus) to determine the effectiveness and safety of drug CC-220 on improving SLE and to see how well the body tolerates the medication.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03161483
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Inclusion Criteria:
Diagnosis of Systemic Lupus Erythematosus
Exclusion Criteria:
Diagnosis of Fibromyalgia
Active or history of recurrent bacterial, viral or fungal infections
History of latent or active tuberculosis
History of blood clots in the past year
Infectious Diseases & Immune System, Arthritis & Rheumatic Diseases, Muscle & Bone
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Study Locations

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Location
Hershey, PA