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Search Results within category "Arthritis & Rheumatic Diseases"

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Suggestions within category "Arthritis & Rheumatic Diseases"


8 Study Matches

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of CC-220 in Subjects with Active Systemic Lupus Erythematosus

This study is for patients with SLE (systemic lupus erythematosus) to determine the effectiveness and safety of drug CC-220 on improving SLE and to see how well the body tolerates the medication.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03161483
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Inclusion Criteria:
Diagnosis of Systemic Lupus Erythematosus
Exclusion Criteria:
Diagnosis of Fibromyalgia
Active or history of recurrent bacterial, viral or fungal infections
History of latent or active tuberculosis
History of blood clots in the past year
Infectious Diseases & Immune System, Arthritis & Rheumatic Diseases, Muscle & Bone
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Hershey, PA

Physical Therapists Role in Promoting Physical Activity for People with Chronic Physical Disabilities

We plan to conduct a qualitative study exploring perspectives of physical therapists and people with disability regarding physical activity promotion
Jacob Corey at jjc6062@psu.edu or 814-865-1691
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
At least 18 years of age
Fluent in english
Individual with a physical disability (eg. limb amputation, spinal cord injury, spinabifida, cerebralpalsy, arthritis, motor impairment)
Has participated in physical therapy in the last year
Exclusion Criteria:
Under the age of 18
Does not speak fluent english
does not have a physical disability
Has not participated in physical activity in the last year
Arthritis & Rheumatic Diseases, Neurology, Muscle & Bone
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Investigation of Remission in Rheumatoid Arthritis

This is an experimental observation study of Rheumatoid arthritis that will examine remission in rheumatoid arthritis by (1) collecting biospecimens of rheumatoid arthritis subsets with collection of clinical data and (2) investigation of etiology of immune tolerance in rheumatoid arthritis.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Diagnosis of Rheumatoid Arthritis by a Rheumatologist
Patient of Penn State Hershey Rheumatology
Exclusion Criteria:
No other connective tissue autoimmune disease other than Sjogren's Syndrome
Arthritis & Rheumatic Diseases
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Hershey, PA

Study of Antimalarials in Incomplete Lupus Erythematosus (SMILE)

This is a study to test whether a widely-used drug, hydroxychloroquine, might slow the progression of lupus like features in individuals who are at high risk for developing systemic lupus erythematosus. This will be measured by the accumulation of clinical and laboratory features of lupus. The study will randomize subjects to the active drug, hydroxychloroquine, or placebo, with an equal chance of receiving either treatment. The study treatment lasts approximately 2 years with visits approximately every 3 months.
Jamie Carter at jcarter3@pennstatehealth.psu.edu or 717-531-4921
All
All
This study is NOT accepting healthy volunteers
NCT03030118
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Inclusion Criteria:
Positive for ANA (antinuclear antibodies)
Age 18 to 45 years, inclusive
Have never taken hydroxychloroquine
Exclusion Criteria:
Previous use of immunosuppressive drugs
Diagnosis of systemic lupus erythematosus
Arthritis & Rheumatic Diseases
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Hershey, PA

A Phase 2, Double-blind, Randomized, Placebo-controlled Multicenter Study to Evaluate Efficacy, Safety, and Tolerability of JBT-101 in Systemic Lupus Erythematosus

This study is for patients with Systemic Lupus Erythematosus (SLE) to test the effect, safety, and tolerability of the experimental drug JBT-101 in people with SLE to see if JBT-101 stops inflammation and how well JBT-101 is tolerated. The study will evaluate whether JBT-101 will decrease the pain associated with active arthritis or tendonitis in SLE patients.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT03093402
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Inclusion Criteria:
Be willing to not start or stop any NSAID or disease modifying treatments for SLE during the study
Be wiling to not use any legal or illegal cannabinoids, including FDA-approved cannabinoids during study participation
If female of child-bearing potential must be willing to use highly effective contraception during study participation
Exclusion Criteria:
Treatment with steroids in the past 28 days
Actively listed on organ transplant list or have received an organ transplant other than a corneal transplant
Have active or chronic infections
Have a history of cancer (except cervical treated successfully with curative therapy or basal cell carcinoma)
Have a history of significant heart disease
Arthritis & Rheumatic Diseases
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Hershey, PA

Evaluation of mechanical properties of the anterior cruciate ligament (ACL) of the knee using ultrasound elastography.

Healthy subjects and athletes needed for the study. Athletes will be evaluated several times over the course of season. Additionally, patients with ACL injury or ACL surgery will be recruited. Several images will be taken from your knees using ultrasound. In total, we expect the imaging session to take about 15 minutes. Additionally, strength tests will be performed in both of your legs. We expect that the strength tests will take about 30 minutes. Compensation is available.
Daniel Cortes at researchsubjects@mne.psu.edu or 814-863-3103
All
18 year(s) or older
This study is also accepting healthy volunteers
N/A
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Inclusion Criteria:
Healthy Individuals 18 years or older
Athletes (soccer, football, other) 18 years or older
Patient with ACL injury
Patient with ACL surgery
Exclusion Criteria:
Pregnant women
Cognitive deficits
17 years old or younger
Arthritis & Rheumatic Diseases, Sports Medicine, Muscle & Bone
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Location
State College, PA

Observational Study for Pediatric Rheumatic Diseases: The CARRA Registry

The original Childhood Arthritis & Rheumatology Research Alliance (CARRA) Registry was first established in 2010 to advance alliance infrastructure,facilitate expanded clinical and translational pediatric research, and transform the culture of pediatric rheumatology toward universal participation in research. Continuation of the CARRA Registry as described in the protocol attached to this IRB submission will support data collection on patients with pediatric-onset rheumatic diseases. The CARRA Registry will form the basis for future CARRA studies. In particular, this observational registry will be used to answer pressing questions about therapeutics used to treat pediatric rheumatic diseases, including examining safety questions. The Duke Clinical Research Institute (DCRI) is serving as the CARRA Clinicaland Data Coordinating Center (CDCC) for this protocol.
Jessica Beiler at jbeiler@hmc.psu.edu
All
Younger than 18 years old
This study is NOT accepting healthy volunteers
N/A
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Inclusion Criteria:
Onset of rheumatic disease prior to age 16 years for Juvenile Idiopathic Arthritis
Onset prior to age 19 years for all other rheumatic diseases
Willing to participate in a registry you will be followed during your treatment and have information about you disease and treatment collected.
Exclusion Criteria:
More than 21 years of age.
Arthritis & Rheumatic Diseases
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Hershey, PA

Tolerization Reduces Intolerance to Pegloticase and Prolongs the Urate Lowering Effect (TRIPLE)

This study is for people who have chronic gout and their signs and symptoms of gout are not well controlled by their current medications. This study has two arms of treatment: one is using an approved medication for treatment of gout and the other uses the same approved medication in conjunction with an oral medication (immunosuppressant drug) which is commonly used to prevent rejection from kidney transplant and to treat patients with signs and symptoms of rheumatoid arthritis. The use of the immunosuppressant drug in this study is considered experimental. This research is being done to see whether a new dosing regimen of the approved medication helps to improve gout symptoms and reduces side effects due to the infusions.
All
18 year(s) or older
This study is NOT accepting healthy volunteers
NCT02598596
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Inclusion Criteria:
Chronic Gout with symptoms that are not well controlled
Taking gout flare prophylaxis
Exclusion Criteria:
Have CHF, uncontrolled heart rhythms, treatment for chest pain/ heart attack/ unstable chest pain syndrome
Hospitalized for CHF in the past 3 months
Uncontrolled blood pressure or blood sugars
Solid organ transplant recipient
Currently on dialysis
Arthritis & Rheumatic Diseases
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Study Locations

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Location
Hershey, PA